Brain Research Bulletin最新文献

{"title":"IL-2/anti-IL-2 complexes attenuates neuroinflammation and neurodegeneration in mice of experimental Parkinson's disease","authors":"Lanxin Li ,&nbsp;Weiwei Gao ,&nbsp;Ning Ren ,&nbsp;Lei Chen","doi":"10.1016/j.brainresbull.2025.111273","DOIUrl":"10.1016/j.brainresbull.2025.111273","url":null,"abstract":"<div><div>Parkinson’s disease (PD) is the second most common neurodegenerative disease, with motor and non-motor symptoms being its main clinical manifestations. Neuroinflammation has been shown to involve in pathogenesis of PD. Regulatory T cells (Tregs) in PD exhibited reduction in number and suppressive activity. Existing methods to increase the Tregs remains challenging for clinical application because of the difficulty in Tregs expanding or serious side-effects. Therefore, new approaches still need to be explored to balance the amount and activity of Tregs. In this study, we assessed the protective effects of IL-2/anti-IL-2 complexes (IL-2C) on mouse models of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). And the results showed that IL-2C significantly increased the number of Tregs both in spleen and brain, accompanied by reduced nigral dopaminergic neuron loss and behavioral defects. Besides, IL-2C also attenuated neuroinflammation as observed by diminished glial activation, fewer infiltration of CD4⁺ and CD8⁺ T cells and reduced pro-inflammatory cytokines releasing in the nigral region. Moreover, the protective effects of IL-2C were abolished by pre-treatment of anti-CD25 antibody (PC61), which was used to delete the Tregs. In summary, our results demonstrate that IL-2C-induced Tregs expansion attenuates the dopaminergic neurons loss and the neuroinflammatory response <em>in vivo</em>, suggesting that IL-2C maybe a promising therapeutic target for PD.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"223 ","pages":"Article 111273"},"PeriodicalIF":3.5,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alpha-2 receptor mediates the endogenous antagonistic regulation of itch and pain via descending noradrenaline pathway from the locus coeruleus","authors":"Dan-Dan Hu ,&nbsp;Wu Shi ,&nbsp;Xin Jia ,&nbsp;Fu-Ming Shao ,&nbsp;Ling Zhang","doi":"10.1016/j.brainresbull.2025.111270","DOIUrl":"10.1016/j.brainresbull.2025.111270","url":null,"abstract":"<div><div>Pain and itch are sensations that are regulated antagonistically; painful stimulation suppresses itch, while the inhibition of pain enhances itch. However, the central neural circuit underlying this antagonistic regulation remains elusive. The noradrenaline (NA) pathway from the locus coeruleus (LC) to the spinal cord (SC) constitutes an important component of endogenous descending pain inhibitory system. While the pathway of LC:SC has been extensively studied on pain modulation, its role in itch regulation remains poorly understood. We employed behavioral assays for itch and pain, immunofluorescence, electrophysiology, and chemogenetic techniques to investigate the role of noradrenergic (NAergic) neurons of LC (LC^NA neurons)and their pathways in modulating itch and pain. Our study has demonstrated that LC^NA neurons encode signals for both itch and pain. Inhibition of LC^NA neurons had no effect on itch but enhanced pain behaviour. Surprisingly, inhibition of the NAergic projection of LC:SC increased pain and suppressed itch. Furthermore, intrathecal injection of an α2 adrenergic receptor antagonist, but not α1 or β receptor antagonists, produced effects similar to those observed when the LC:SC pathway was inhibited. Our research suggests that the descending NAergic pathway from LC to SC exerts endogenous antagonistic regulation on itch and pain through α2 receptors.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"223 ","pages":"Article 111270"},"PeriodicalIF":3.5,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular dynamics study of stiffness and rupture of axonal membranes","authors":"Maryam Majdolhosseini ,&nbsp;Svein Kleiven ,&nbsp;Alessandra Villa","doi":"10.1016/j.brainresbull.2025.111266","DOIUrl":"10.1016/j.brainresbull.2025.111266","url":null,"abstract":"<div><div>Diffuse axonal injury (DAI), characterized by widespread damage to axons throughout the brain, represents one of the most devastating and difficult-to-treat forms of traumatic brain injury. Different theories exist about the mechanism of DAI, among which one hypothesis states that membrane poration of the axons initiates DAI. To investigate the hypothesis, molecular models of axonal membranes, incorporating 25 different lipids distributed asymmetrically in the leaflets, were developed using a coarse-grain description and simulated using molecular dynamics techniques. Different protein concentrations were embedded inside the lipid bilayer to describe the different sub-cellular parts in myelinated and unmyelinated axons. The models were investigated in equilibration and under deformation to characterize the structural and mechanical properties of the membranes, and comparisons were made with other subcellular parts, particularly myelin. Employing a bottom-top approach, the results were coupled with a finite element model representing the axon at the cell level. The results indicate that pore formation in the node-of-Ranvier occurs at a lower rupture strain compared to other axolemma parts, whereas myelin poration exhibits the highest rupture strains among the investigated models. The observed rupture strain for the node-of-Ranvier aligns with experimental studies, indicating a threshold for injury at axonal strains exceeding 10–13 % depending on the strain rate. The results indicate that the hypothesis suggesting mechanoporation triggers axonal injury cannot be dismissed, as this phenomenon occurs within the threshold of axonal injury.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"223 ","pages":"Article 111266"},"PeriodicalIF":3.5,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical simulations of intracerebral hemorrhage expansion show tissue displacement has significant impact on electrical impedance tomography results","authors":"Antti Paldanius ,&nbsp;Jussi Toivanen ,&nbsp;Nina Forss ,&nbsp;Daniel Strbian ,&nbsp;Ville Kolehmainen ,&nbsp;Jari Hyttinen","doi":"10.1016/j.brainresbull.2025.111265","DOIUrl":"10.1016/j.brainresbull.2025.111265","url":null,"abstract":"<div><h3>Objective</h3><div>Intracerebral hemorrhage (ICH) occupies intracranial space and causes brain tissue displacement and fluid volume shifts. We assess how hematoma expansion (HE) affects electrical impedance tomography (EIT) measurements and reconstructed images of the conductivity change caused by HE.</div></div><div><h3>Methods</h3><div>We developed a novel multi-physics model of ICH with mechanical tissue deformation during HE. We simulated EIT measurements with the multi-physics model and a traditional static model using five ICH locations. The effects of tissue deformation on the results of monitoring of ICH with EIT were assessed by comparing the measurement data from the multi-physics and traditional models and by comparing the corresponding reconstructed conductivity change from two image reconstruction algorithms.</div></div><div><h3>Results</h3><div>The simulated measurement data and the reconstructed images of the conductivity change using the multi-physics and the traditional model are radically different regardless of the image reconstruction algorithm used.</div></div><div><h3>Conclusions</h3><div>The effect of tissue displacement caused by HE on EIT monitoring of ICH is significant. Specifically, the displacement of cerebrospinal fluid (CSF) can mask the effects of increased ICH blood volume. However, the effects of displaced CSF could be easier to detect with EIT than the ICH blood volume increase and thus could be used as an indicator of HE in EIT bedside monitoring of ICH and improve the detectability of HE, especially for ICH located deep in the brain.</div></div><div><h3>Significance</h3><div>Currently there are virtually no imaging methods for continuous monitoring of stroke. There has been recent resurgence in interest to develop electrical impedance tomography (EIT) devices and algorithms for monitoring progression of stroke. In-silico studies show promising results, but there are very little clinical results. In-silico models are usually used for development and evaluation of algorithms for EIT image reconstruction. In previous studies the stroke has been usually modeled as local change in electrical conductivity and the fluid and tissue displacement caused by the increased blood volume in ICH has not been considered. In this paper we present a novel multi-physics model of ICH, simulated EIT measurement results and reconstructed images with comparisons to the traditionally used ICH modeling methods. Our multi-physics approach to modeling of ICH shows that the effect of tissue and fluid displacement during HE needs consideration when developing clinical applications of EIT.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"223 ","pages":"Article 111265"},"PeriodicalIF":3.5,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery and validation of CREB1 as a transcription target of icaritin: Implications for the treatment of depressive-like behavior","authors":"Ling Gu ,&nbsp;Lei Li ,&nbsp;Huiying Xu ,&nbsp;Yuyan Ling ,&nbsp;Ruiting Ma ,&nbsp;Meijuan Chen","doi":"10.1016/j.brainresbull.2025.111264","DOIUrl":"10.1016/j.brainresbull.2025.111264","url":null,"abstract":"<div><div>Depression is a prevalent neuropsychiatric disorder characterized by persistent sadness and a lack of interest, significantly impacting the quality of life. Icaritin, a bioactive compound from Herba Epimedii, which has the antidepressant-like effects. However, the potential target of icaritin in the brain, especially concerning transcription factors, is not well understood. In this study, we demonstrated that icaritin significantly ameliorated depressive-like behaviors in a chronic corticosterone (CORT)-induced mouse model. This study aimed to investigate the role of icaritin in modulating the activity of cAMP-response element binding protein 1 (CREB1), a crucial transcription factor implicated in neuronal function and mood regulation. Through a combination of virtual screening and molecular docking, we identified CREB1 as a target by intersections of databases, leading to the selection of 43 candidate compounds, among which icaritin exhibited a favorable docking score and previously reported antidepressant effects. Biolayer interferometry (BLI) analysis confirmed the direct binding of icaritin to CREB1, with a dissociation constant (K_D) of 7.02E-06 M. Further mutational analysis revealed that residues Q65 and Q229 of CREB1 were essential for the binding of icaritin. Additionally, Quantitative Real-Time PCR (qRT-PCR) demonstrated that icaritin treatment upregulated the mRNA levels of CREB1 target genes in the hippocampus and cortex. Bioinformatics analysis indicated that CREB1 interacts with several neuroprotective pathways, reinforcing its potential significance in depression. In conclusion, our findings suggest that icaritin may represent a promising therapeutic candidate for depression by enhancing CREB1-mediated neuroprotection, warranting further investigation into its clinical applications and underlying mechanisms.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"222 ","pages":"Article 111264"},"PeriodicalIF":3.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enriched environment improves memory function by promoting synaptic remodeling in vascular dementia rats","authors":"Shuang Lin ,&nbsp;Chuan-Jie Wang ,&nbsp;Peng-Kun Yang ,&nbsp;Bing Li ,&nbsp;Yi Wu ,&nbsp;Ke-Wei Yu","doi":"10.1016/j.brainresbull.2025.111262","DOIUrl":"10.1016/j.brainresbull.2025.111262","url":null,"abstract":"<div><div>Vascular dementia (VaD), attributed to cerebrovascular pathology, is a leading cause of cognitive decline, characterized by memory loss, bradyphrenia, and affective lability, with memory deficits being particularly pronounced. The potential of enriched environment (EE) to ameliorate cognitive impairments by enhancing hippocampal synaptic plasticity, neurogenesis, and white matter remodeling has garnered considerable interest. In this study, we used a rat model for VaD through the procedure of bilateral common carotid artery ligation (BCCAO). We randomly assigned male Sprague-Dawley (SD) rats to three groups: the control sham-operated group (Sham group), the surgery-induced dementia group (BCCAO group), and the surgery-induced dementia group with enriched environment (EE group). The Sham and BCCAO groups were kept under standard lab conditions, whereas the EE group was housed in an enriched setting. Employing a behavioral assay battery, we observed that EE intervention significantly improved the spatial learning and memory performance in the Morris water maze. Subsequent neuromorphological assessments utilizing transmission electron microscopy disclosed an increase in synaptic density and postsynaptic density (PSD) thickness within the hippocampal CA1 region, indicative of structural synaptic modulation. Further probing into the molecular underpinnings revealed that EE upregulated the expression of PSD95, corroborating its role in enhancing cognitive faculties. Additionally, our investigation into the PGC-1α/FNDC5/BDNF pathway demonstrated that EE intervention elevated the expression of these neurotrophic factors, suggesting a mechanistic link to synaptic and cognitive restoration. In summation, our findings elucidate the neurorestorative potential of EE in a preclinical VaD model, presenting a non-pharmacological intervention that modulates synaptic architecture and activates neuroprotective pathways. The observed correlations between synaptic remodeling and cognitive enhancement underscore the therapeutic relevance of EE in VaD, warranting further investigation for clinical applications.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"222 ","pages":"Article 111262"},"PeriodicalIF":3.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aerobic exercise improves clearance of amyloid-β via the glymphatic system in a mouse model of Alzheimer's Disease","authors":"Shengxiang Liang ,&nbsp;Huanhuan Liu ,&nbsp;Xiuxiu Wang ,&nbsp;Huawei Lin ,&nbsp;Ling Zheng ,&nbsp;Yusi Zhang ,&nbsp;Lixin Peng ,&nbsp;Saie Huang ,&nbsp;Lidian Chen","doi":"10.1016/j.brainresbull.2025.111263","DOIUrl":"10.1016/j.brainresbull.2025.111263","url":null,"abstract":"<div><h3>Background</h3><div>Aerobic exercise training can promote the recovery of learning and memory ability in Alzheimer's disease (AD), but the specific mechanism is still unclear. Previous studies have suggested that aquaporin-4 (AQP4)-mediated glymphatic system is an important way to clear β-amyloid (Aβ) in the brain, which is closely related to learning and memory impairment in AD. However, it remains unclear whether AQP4 regulates glymphatic clearance of Aβ which contributes to the beneficial effects of aerobic exercise in AD patients. Here, the goal of this study was to investigate the mechanisms about aerobic exercise whether AQP4 could modulate glymphatic system using APP/PS1 mice.</div></div><div><h3>Methods</h3><div>In this study, APP/PS1 AD model mice were treated with aerobic exercise intervention through swimming exercise training for 4 weeks, and the two groups of mice were injected with AQP4 inhibition virus and empty virus, respectively. Their learning and memory abilities were assessed using behavioral tests, such as the Barnes maze and Morris water maze tests. Hippocampus was obtained from sacrificed mice and used for histological analysis. Tracer imaging of the cerebellar medullary pool was used to observed the CSF-ISF exchange, immunohistochemistry was used to detect the level of Aβ plaques in the hippocampus of mice in each group; immunoblotting was used to detect the expression of AQP4 protein; immunofluorescence co-labeling was used to detect the polarization distribution of AQP4; qRT-PCR was used to detect the transcription levels of AQP4 and its anchoring proteins.</div></div><div><h3>Results</h3><div>The funding showed that APP/PS1 mice have learning and memory impairment, and the glymphatic system is dysfunction. Swimming training can improve the ability of the glymphatic system to clear Aβ deposition in the hippocampus by up-regulating the transcription levels of Lama1 and Dp71 in the hippocampus, reducing the depolarization distribution of AQP4 in the hippocampus, and enhancing the exchange of CSF-ISF. Thus, improves learning and memory impairment in APP/PS1 mice.</div></div><div><h3>Conclusions</h3><div>Swimming training can rescue the function of the glymphatic system, increase the CSF-ISF exchange, promote the polarization distribution of AQP4, and reduce the deposition of Aβ in the hippocampus, thereby improving the learning and memory ability of APP/PS1 mice.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"222 ","pages":"Article 111263"},"PeriodicalIF":3.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture modulates group neural activity in patients with post stroke sensory impairment: An fMRI study based on inter-subject correlation and inter-subject functional connectivity","authors":"Xunqi Qian ,&nbsp;Hua Zhang ,&nbsp;Jing Peng ,&nbsp;Lei Song ,&nbsp;Qiuyi Lv ,&nbsp;Weihua Jia ,&nbsp;Zhongjian Tan ,&nbsp;Ying Gao ,&nbsp;Yihuai Zou ,&nbsp;Xing Chen","doi":"10.1016/j.brainresbull.2025.111259","DOIUrl":"10.1016/j.brainresbull.2025.111259","url":null,"abstract":"<div><div>Sensory impairment after stroke has become an important health problem that affects the health and quality of life of patients. Acupuncture is a widely accepted method for stroke rehabilitation. The development of fMRI provides a good platform for the study of neural activity patterns induced by acupuncture, and many studies have found that acupuncture can induce special activation of the brain in stroke patients. We introduced the inter-subject functional connectivity(ISFC) method into the study of acupuncture treatment for sensory impairment after stroke to explore the group effects of acupuncture treatment and the specific mode of action of acupuncture for sensory impairment. In this study, 24 stroke patients with limb numbness and 23 healthy controls were included, and three functional magnetic resonance scans were designed, including resting state, acupuncture task state, and acupuncture-retention state(LI11 and ST36 were used during the task fMRI). The main observation was the connection changes in 50 regions of interest, including the sensory-motor network, central executive network, thalamus, cingulate gyrus, and other brain regions. The findings showed that acupuncture could cause certain patterns of neural activity in the patients. These patterns included a significant rise in ISFC within the sensory-motor network and between the sensory-motor network and the thalamus and the central executive network. When different types of acupuncture were compared, it was found that the first effect of acupuncture was mostly large-scale activation of the sensory-motor network and the thalamus. The second effect, on the other hand, was low-intensity activation in a limited range. In general, this study explored the group mechanism of acupuncture for sensory function rehabilitation after stroke and provided some help for understanding neural activity patterns from a cross-subject dimension.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"222 ","pages":"Article 111259"},"PeriodicalIF":3.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VTA dopaminergic neurons involved in chronic spared nerve injury pain-induced depressive-like behavior","authors":"Ludi Zhang ,&nbsp;Menghan Ji ,&nbsp;Yufei Sun ,&nbsp;Qingwu Wang ,&nbsp;Mingyang Jin ,&nbsp;Shuling Wang ,&nbsp;Hui Sun ,&nbsp;Hailin Zhang ,&nbsp;Dongyang Huang","doi":"10.1016/j.brainresbull.2025.111261","DOIUrl":"10.1016/j.brainresbull.2025.111261","url":null,"abstract":"<div><div>Affective disorders, such as depression, are commonly associated with the development of chronic pain, but the underlying mechanisms still remain unclear. The dopaminergic system, located in the midbrain, is considered one of the regions where algesia and emotional processing overlap. This suggests a structural basis hypothesis for the comorbidity of chronic pain and depression, highlighting the interplay between nociceptive and affective processing. But there are more and more evidences show that somatic and head/facial pain involve different neuronal overlap. In previous study, the research show that VTA dopaminergic system involved in pIONT surgery induced depressive-like behaviors in mice. But there still no evidence shows if chronic somatic pain will induce depressive-like behaviors and which neuronal circle pathway is underly. In this study, we assessed depressive-like behaviors and performed artificial interference of VTA (ventral tegmental area) dopaminergic neurons in a mouse model of chronic peripheral neuropathic pain induced by the spared nerve injury (SNI) model. After a 4-week duration of hyperalgesia and allodynia resulting from SNI surgery, social withdraw and other depressive-like behaviors were observed in the SNI group. Furthermore, the dopaminergic cells’ excitability in VTA were significantly increased in SNI mice. The excitability alteration was improved play a key role in the development and modulation of the chronic peripheral neuropathic pain-induced depressive-like behaviors. It has been shown pain and affections have structural and functional circuits to interact with each other, therefore the neuroplastic changes and functional role of VTA dopaminergic neurons within these circuits may serve as potential targets for understanding and therapeutically addressing the development of depressive-like symptoms accompanied by prolonged pain syndromes in humans.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"222 ","pages":"Article 111261"},"PeriodicalIF":3.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive gains and cortical thickness changes after 12 weeks of resistance training in older adults with low and high risk of mild cognitive impairment: Findings from a randomized controlled trial","authors":"Simona Kušleikienė ,&nbsp;Gal Ziv ,&nbsp;Wouter A.J. Vints ,&nbsp;Erika Krasinskė ,&nbsp;Milda Šarkinaite ,&nbsp;Orgesa Qipo ,&nbsp;Ivan Bautmans ,&nbsp;Uwe Himmelreich ,&nbsp;Nerijus Masiulis ,&nbsp;Vida J. Česnaitienė ,&nbsp;Oron Levin","doi":"10.1016/j.brainresbull.2025.111249","DOIUrl":"10.1016/j.brainresbull.2025.111249","url":null,"abstract":"<div><h3>Background</h3><div>In this randomized controlled trial, we assessed the neuroprotective effect of a 12-week resistance training (RT) program on executive control and cortical thickness of the prefrontal, temporal, parietal, and central cortex, regions prone to structural decline in individuals with mild cognitive impairment (MCI).</div></div><div><h3>Methods</h3><div>Seventy older adults (aged 60–85 y old, 38 females and 32 males) were randomly allocated to a 12-week lower limb RT program or a waiting list control group. The Montreal Cognitive Assessment (MoCA) was used to stratify participants screened for high (&lt; 26) or low (≥ 26) MCI risk. Cognitive measurements consisted of the two-choice reaction time, Go/No-go, mathematical processing, and memory search tests. Cortical thickness was estimated from 3D T1-weighted MR images.</div></div><div><h3>Results</h3><div>Complete randomized controlled trial data was obtained from 50 individuals (24 with high MCI risk). Significant Group x Time interactions were found for response on the Go/No-go task and cortical thickness of the right parahippocampal gyrus [F ≥ 5.3, p ≤ 0.03; η²_p ≥ 0.12]. An inspection of these observations revealed an increase in cortical thickness (+1.18 %) and a decrease in response time (-4.35 %) in individuals with high MCI risk allocated to the exercise group (both uncorrected p = 0.08). Decreased response time on the Go/No-go task was associated with increased cortical thickness in the right entorhinal gyrus (uncorrected p = 0.01).</div></div><div><h3>Conclusions</h3><div>Our study demonstrated that 12 weeks of RT intervention may effectively improve cognitive performance and slow neuronal loss in the hippocampal complex of older adults at high MCI risk. Findings support evidence for the neuroprotective effects of resistance training and its potential role in cognitive health.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"222 ","pages":"Article 111249"},"PeriodicalIF":3.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}