Brain Research Bulletin最新文献

筛选
英文 中文
Advanced imaging and localization techniques in brain tumor resection: A review for precision tumor removal 脑肿瘤精确切除的先进成像和定位技术综述
IF 3.7 3区 医学
Brain Research Bulletin Pub Date : 2025-09-02 DOI: 10.1016/j.brainresbull.2025.111533
Xizi Song , Peishan Huang , Xiuyun Liu , Huijie Yu , Jin Wei , Dong Ming
{"title":"Advanced imaging and localization techniques in brain tumor resection: A review for precision tumor removal","authors":"Xizi Song ,&nbsp;Peishan Huang ,&nbsp;Xiuyun Liu ,&nbsp;Huijie Yu ,&nbsp;Jin Wei ,&nbsp;Dong Ming","doi":"10.1016/j.brainresbull.2025.111533","DOIUrl":"10.1016/j.brainresbull.2025.111533","url":null,"abstract":"<div><div>Brain tumors are one of the most dangerous cancers with serious effects on human health. The primary treatment approach involves a combination of surgery, supplemented by postoperative radiotherapy. The growth pattern of malignant tumor is typically infiltrative, posing a challenge in visually distinguishing the tumor from the surrounding normal brain tissue during surgery. In order to mitigate the risk of potential neurological damage, an increasing number of imaging and localization techniques and devices are being employed. Commonly used preoperative functional neuroimaging techniques, such as magnetic resonance imaging (MRI) and transcranial magnetic stimulation (TMS), have proven to be powerful tools in neurosurgery. MRI aids in visualizing important functional areas involved in the tumor as well as the conduction pathways, and TMS assists in assessing cortical function. This enhanced preoperative information contributes to refining surgical planning and reduced risks in the surgery. The application of intraoperative functional neuroimaging techniques (neuronavigation (NN), intraoperative ultrasound (IOUS), fluorescence guided technique (FGT) and intraoperative neurophysiological monitoring (IONM)), has improved the gross total removal (GTR) of glioma in functional brain regions. NN, IOUS and FGT enable real-time exploration of tumor structures, providing valuable guidance for resection. Concurrently, IONM is employed to highlight the relationship between tumor and the functional cortex, with the aim of preventing or minimizing neurological deficits. These approaches ensure precision in tumor resection and help safeguard neurological function during surgery. This paper discusses the potential advantages and limitations of these techniques used in glioma surgery, and provides directions for the development of techniques.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"230 ","pages":"Article 111533"},"PeriodicalIF":3.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabotropic glutamate receptor 1-mediated Ca2+ response is potentiated by activation of metabotropic glutamate receptor 3 in the rat hippocampal marginal zone 代谢性谷氨酸受体1介导的Ca2+反应通过激活代谢性谷氨酸受体3在大鼠海马边缘区增强。
IF 3.7 3区 医学
Brain Research Bulletin Pub Date : 2025-09-02 DOI: 10.1016/j.brainresbull.2025.111535
Megumi Taketo
{"title":"Metabotropic glutamate receptor 1-mediated Ca2+ response is potentiated by activation of metabotropic glutamate receptor 3 in the rat hippocampal marginal zone","authors":"Megumi Taketo","doi":"10.1016/j.brainresbull.2025.111535","DOIUrl":"10.1016/j.brainresbull.2025.111535","url":null,"abstract":"<div><div>Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCRs) that mediate slow glutamatergic signal transduction and regulate cell excitability in the central nervous system. Group I mGluRs are coupled to G<sub>q/11</sub> proteins and mobilize intracellular Ca<sup>2+</sup>. Group II mGluRs are coupled to G<sub>i/o</sub> proteins and inhibit adenylyl cyclase. Hippocampal Cajal-Retzius (CR) cells which regulate neural migration during pre- and post-natal development, express group I and group II mGluRs. Although interactions between GPCRs have been reported, studies on the interactions between GPCRs in native tissues remain insufficient. Previous studies have demonstrated that mGluR1, which belongs to group I mGluRs, mobilizes intracellular Ca<sup>2+</sup> in CR cells, and this Ca<sup>2+</sup> response is potentiated by activation of the G<sub>i/o</sub>-coupling adenosine A<sub>1</sub> receptor. In this study, the potentiation of intracellular Ca<sup>2+</sup> mobilization through mGluR1 by the activation of group II mGluRs was demonstrated in hippocampal CR cells. Ca<sup>2+</sup> imaging in hippocampal slices showed that activation of groupII mGluRs did not induce elevation of intracellular Ca<sup>2+</sup> concentration, but potentiated mGluR1-induced Ca<sup>2+</sup> responses. This potentiation was sensitive to a negative allosteric modulator of mGluR3, and several G-protein inhibitors. These results reveal cooperative modulation of intracellular Ca<sup>2+</sup> mobilization by the two subtypes of mGluRs in hippocampal CR cells.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"231 ","pages":"Article 111535"},"PeriodicalIF":3.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
State-dependent alterations in neural activity induced by the personalized ventrolateral prefrontal cortex stimulation during viewing emotional film clips 观看情绪性电影片段时,个性化腹外侧前额叶皮层刺激诱导的神经活动状态依赖性改变。
IF 3.7 3区 医学
Brain Research Bulletin Pub Date : 2025-08-31 DOI: 10.1016/j.brainresbull.2025.111534
Changyue Hou , Meihua Yan , Haonan Pei , Yuting Deng , Sisi Jiang , Hechun Li , Huan Huang , Yufan Zhou , Roberto Rodríguez-Labrada , Cheng Luo
{"title":"State-dependent alterations in neural activity induced by the personalized ventrolateral prefrontal cortex stimulation during viewing emotional film clips","authors":"Changyue Hou ,&nbsp;Meihua Yan ,&nbsp;Haonan Pei ,&nbsp;Yuting Deng ,&nbsp;Sisi Jiang ,&nbsp;Hechun Li ,&nbsp;Huan Huang ,&nbsp;Yufan Zhou ,&nbsp;Roberto Rodríguez-Labrada ,&nbsp;Cheng Luo","doi":"10.1016/j.brainresbull.2025.111534","DOIUrl":"10.1016/j.brainresbull.2025.111534","url":null,"abstract":"<div><div>Emotion regulation is crucial for maintaining normal social interactions and individual psychological health. Using transcranial magnetic stimulation (TMS) to modulate emotional regulation may be a powerful method for neurological or psychiatric disorders. However, TMS efficacy varies between protocols and individuals, with the brain's state during treatment being an often-overlooked factor. This study aimed to explore the influence of emotional brain state on TMS effects. Ninety-nine healthy participants were randomly assigned to three groups: one watched neutral film clips and received active TMS (neutral group), while the other two watched sadness film clips and received either active or sham TMS (sad and sham groups, respectively). The amplitude of low-frequency fluctuations (ALFF) and functional connectivity (FC) were investigated using resting-state functional magnetic resonance imaging. Compared with the neutral group, the sad group showed different changes in neural activity (as measured by ALFF) in the right superior occipital gyrus and right middle frontal gyrus after TMS. In the neutral group, the ALFF change in the right superior occipital gyrus was correlated with the baseline FC between this region and the TMS target. Additionally, changes in neural activity in the right superior occipital gyrus and right middle frontal gyrus were related to changes in depression scale scores in the sad group. These findings may suggest that TMS during different emotional states can induce state-dependent alterations in neural activity. By combining emotional induction, TMS, and fMRI, this study offers a unique perspective on state-dependent effects and may improve TMS treatment outcomes.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"230 ","pages":"Article 111534"},"PeriodicalIF":3.7,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pre-iTBS alleviates perioperative neurocognitive disorders by inducing long-term neuroprotection against inflammatory injury 预itbs通过诱导长期的神经保护来减轻围手术期神经认知障碍
IF 3.7 3区 医学
Brain Research Bulletin Pub Date : 2025-08-30 DOI: 10.1016/j.brainresbull.2025.111532
Binhua Zou , Tingting Chen , Jianzhong Fan , Renhong He
{"title":"Pre-iTBS alleviates perioperative neurocognitive disorders by inducing long-term neuroprotection against inflammatory injury","authors":"Binhua Zou ,&nbsp;Tingting Chen ,&nbsp;Jianzhong Fan ,&nbsp;Renhong He","doi":"10.1016/j.brainresbull.2025.111532","DOIUrl":"10.1016/j.brainresbull.2025.111532","url":null,"abstract":"<div><div>Perioperative neurocognitive disorders (PND), encompassing cognitive impairments linked to anesthesia and surgery, significantly impact elderly patients and increase postoperative risks. Intermittent theta burst stimulation (iTBS), a non-invasive neuromodulation protocol, has shown cognitive-enhancing potential in clinical studies. However, its utility for preventing PND remains unexplored. This study investigated whether preoperative iTBS mitigates PND in aged rats undergoing exploratory laparotomy. Eighteen-month-old male rats (n = 5/group) received 10 daily iTBS sessions or sham stimulation (only noise without real stimulation) prior to 3-hour isoflurane anesthesia (3 %) and laparotomy. Cognitive function was assessed via the Morris water maze (MWM) pre- and postoperatively. Rats were euthanized at 72 h post-surgery to quantify hippocampal microglial polarization (Iba1⁺/CD86⁺), pro-inflammatory cytokines (Milliplex cytokine assays), and neuronal apoptosis (Nissl staining). iTBS-treated rats exhibited faster anesthesia recovery (17.4 ± 3.6 min vs. 35.2 ± 11.2 min; <em>P</em> = 0.009) and reduced postoperative cognitive decline (MWM escape latency: 39.5 ± 5.0 s vs. 50.0 ± 5.8 s; <em>P</em> = 0.006). These improvements correlated with decreased M1-polarized microglia (39.0 ± 7.0 vs. 58.8 ± 12.2; <em>P</em> = 0.014), lower TNF-α levels (2690.6 ± 542.2 pg/mL vs. 3532.7 ± 623.8 pg/mL; <em>P</em> = 0.035), and reduced hippocampal apoptosis (87.8 ± 8.3 % vs. 69.1 ± 13.8 %; <em>P</em> = 0.006). Pre-iTBS has potential therapeutic efficacy in perioperative neurocognitive disorders by reducing M1-type pro-inflammatory factors and enhancing neuronal activity and resistance to anesthesia and surgery-induced damage.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"230 ","pages":"Article 111532"},"PeriodicalIF":3.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Moderating role of gender in brain structural changes of long-term high-altitude hypoxia-exposed individuals 性别在长期高原缺氧暴露个体脑结构变化中的调节作用
IF 3.7 3区 医学
Brain Research Bulletin Pub Date : 2025-08-30 DOI: 10.1016/j.brainresbull.2025.111531
Yuan Li , Zhixin Wang , Hailin Ma , Niannian Wang
{"title":"Moderating role of gender in brain structural changes of long-term high-altitude hypoxia-exposed individuals","authors":"Yuan Li ,&nbsp;Zhixin Wang ,&nbsp;Hailin Ma ,&nbsp;Niannian Wang","doi":"10.1016/j.brainresbull.2025.111531","DOIUrl":"10.1016/j.brainresbull.2025.111531","url":null,"abstract":"<div><div>Gender differences play a significant role in human adaptation to both natural and social environments. In high-altitude regions, the reduced oxygen pressure leads to hypoxia, which is reflected in structural changes in the brain. However, the mechanisms by which gender regulates the effects of hypoxia on brain structure remain unclear. In this study, we measured brain morphology using magnetic resonance imaging (MRI) in 129 healthy adult subjects who had long-term migrated to the plateau. The difference test results showed that the volume of the right insula in the high-hypoxic exposure time group was significantly lower than that in the low-hypoxic exposure time group (<em>t</em> = −2.94, <em>p</em> &lt; 0.01, 95% CI = [−1.08, −0.21]). Further moderating effect tests found that after controlling for age, gender moderated the effect of hypoxia exposure time on the relevant cortex. The reduction in the volume of the right insula showed the effect of long-term hypoxia, while Gender differences were associated with a reduction in the atrophy of the right insula volume (<em>β</em> = −0.16, <em>t</em> = −2.12, <em>p</em> &lt; 0.05, 95 % CI = [−0.30, −0.01]), the thickness of the right pars opercularis (<em>β</em> = −0.19, <em>t</em> = −2.06, <em>p</em> &lt; 0.05, 95 % CI = [−0.36, −0.01]), the thickness of the right posterior cingulate (<em>β</em> = −0.24, <em>t</em> = −2.60, <em>p</em> &lt; 0.05, <em>95 %</em> CI = [−0.42, −0.06]), and the thickness of the left caudal anterior cingulate (<em>β</em> = −0.21, <em>t</em> = −2.22, <em>p</em> &lt; 0.05, 95 % CI = [−0<em>.</em>39, −0.02]). The findings of this study provide evidence for gender differences in moderating the adverse effects of long-term hypoxia exposure on the human brain in the high-altitude natural environment.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"230 ","pages":"Article 111531"},"PeriodicalIF":3.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insights into tryptophan metabolism in ischemic stroke: A promising therapeutic target 缺血性卒中中色氨酸代谢的新认识:一个有希望的治疗靶点
IF 3.7 3区 医学
Brain Research Bulletin Pub Date : 2025-08-29 DOI: 10.1016/j.brainresbull.2025.111529
Weixin Chen , Tangyou Mao , Chenchen Sun , Rui Ma, Yuran Dong, Yuxuan Xiong, Wenjun Bao, Ran Han, Le Wang
{"title":"New insights into tryptophan metabolism in ischemic stroke: A promising therapeutic target","authors":"Weixin Chen ,&nbsp;Tangyou Mao ,&nbsp;Chenchen Sun ,&nbsp;Rui Ma,&nbsp;Yuran Dong,&nbsp;Yuxuan Xiong,&nbsp;Wenjun Bao,&nbsp;Ran Han,&nbsp;Le Wang","doi":"10.1016/j.brainresbull.2025.111529","DOIUrl":"10.1016/j.brainresbull.2025.111529","url":null,"abstract":"<div><div>Ischemic stroke is a major cause of disability and mortality worldwide. Dysregulation of tryptophan metabolism has been increasingly implicated in its pathophysiology. Tryptophan is catabolized through three principal pathways: the kynurenine, serotonin, and microbial indole pathways, each producing bioactive metabolites that modulate neuroinflammation, oxidative stress, excitotoxicity, and immune responses following stroke. An elevated quinolinic acid/kynurenic acid ratio reflects enhanced neurotoxicity, while alterations in gut-derived indole metabolites impair gut-brain signaling. This review highlights key enzymes—IDO, TDO, TPH—and receptors such as AHR as potential therapeutic targets. Although preclinical studies are promising, clinical translation remains challenging due to metabolic complexity, blood-brain barrier limitations, and individual variability in gut microbiota. Future research should integrate multi-omics technologies and well-designed clinical trials to develop targeted therapies for ischemic stroke.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"230 ","pages":"Article 111529"},"PeriodicalIF":3.7,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-specific responses to cannabis exposure: Implications for behavior and beyond 对大麻暴露的性别特异性反应:对行为和其他方面的影响。
IF 3.7 3区 医学
Brain Research Bulletin Pub Date : 2025-08-29 DOI: 10.1016/j.brainresbull.2025.111530
Sophia Rogers , Adele M.H. Seelke , Sabrina L. Mederos , Karen L. Bales
{"title":"Sex-specific responses to cannabis exposure: Implications for behavior and beyond","authors":"Sophia Rogers ,&nbsp;Adele M.H. Seelke ,&nbsp;Sabrina L. Mederos ,&nbsp;Karen L. Bales","doi":"10.1016/j.brainresbull.2025.111530","DOIUrl":"10.1016/j.brainresbull.2025.111530","url":null,"abstract":"<div><div>Cannabis is one of the most widely used psychoactive substances worldwide, with a growing interest in its potential therapeutic applications. In recent years, there has been a significant increase in cannabis use, driven by the progressive legalization and acceptance of recreational usage. Despite the expanding legalization and use of cannabis, the effects of this substance on various physiological systems and behaviors are not fully understood. Accumulating evidence suggests that cannabis exposure may elicit sex-specific effects, highlighting the importance of considering sex as a biological variable in cannabis research. Sex can affect many behavioral outcomes, thus these differences should be considered when looking at the continuation of cannabis legalization. Despite the growing recognition of the importance of sex differences in research, the current literature on cannabis use and its effects has not adequately addressed these differences. Understanding sex differences in cannabis use is crucial for developing treatment strategies and informing public health policies. This scoping review aims to address these gaps and highlight instances of sex-specific behavioral responses to cannabis exposure. The purpose of this review is to: 1) give an overview of cannabis, the endocannabinoid system, and sex-differences in scientific literature, 2) provide an overview of the current state of knowledge regarding sex differences in cannabis use, 3) examine how sex differences can influence the behavioral effects of cannabis use. This review will predominantly focus on tetrahydrocannabinol (THC), the principal psychoactive constituent of cannabis. By synthesizing the available literature, this scoping review seeks to identify gaps in our understanding and guide future research efforts in this field.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"230 ","pages":"Article 111530"},"PeriodicalIF":3.7,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Altered lateral geniculate nucleus functional connectivity and its correlation with retinal thickness in primary open-angle glaucoma: A resting-state functional MRI study 原发性开角型青光眼外侧膝状核功能连通性改变及其与视网膜厚度的相关性:静息状态功能MRI研究
IF 3.7 3区 医学
Brain Research Bulletin Pub Date : 2025-08-28 DOI: 10.1016/j.brainresbull.2025.111524
Xuhao Chen , Ning Wu , Shaofen Huang , Yingting Zhu , Zhidong Li , Yangjiani Li , Yue Xiao , Xinyue Shen , Ye Deng , Caibin Deng , Yehong Zhuo , Lingjing Hu , Yiqing Li
{"title":"Altered lateral geniculate nucleus functional connectivity and its correlation with retinal thickness in primary open-angle glaucoma: A resting-state functional MRI study","authors":"Xuhao Chen ,&nbsp;Ning Wu ,&nbsp;Shaofen Huang ,&nbsp;Yingting Zhu ,&nbsp;Zhidong Li ,&nbsp;Yangjiani Li ,&nbsp;Yue Xiao ,&nbsp;Xinyue Shen ,&nbsp;Ye Deng ,&nbsp;Caibin Deng ,&nbsp;Yehong Zhuo ,&nbsp;Lingjing Hu ,&nbsp;Yiqing Li","doi":"10.1016/j.brainresbull.2025.111524","DOIUrl":"10.1016/j.brainresbull.2025.111524","url":null,"abstract":"<div><h3>Background</h3><div>Primary open-angle glaucoma (POAG) is one of the predominant causes of irreversible blindness. Though the glaucomatous transneuronal degeneration pass through the lateral geniculate nucleus (LGN) in the visual pathway, the functional changes associated with the LGN remains elusive. The current study aimed to investigate the seed-based whole-brain functional connectivity (FC) of the LGN and its correlation with retinal thickness in patients with POAG.</div></div><div><h3>Methods</h3><div>T1-weighted scans and resting-state functional magnetic resonance imaging (rs-fMRI) were extracted from 54 patients with POAG and 54 matched healthy controls from the UK Biobank. An automatic LGN segmentation protocol and FC analysis were conducted on the bilateral LGN. The Pearson correlation between retinal thickness and FC was explored.</div></div><div><h3>Results</h3><div>The total LGN volume in patients with POAG was significantly decreased compared with controls (<em>P</em> = 0.042). The patients with POAG showed a pattern of reduced ALFF, fALFF, ReHo, and degree centrality value in brain regions. The left LGN demonstrated an increased FC between the right lingual gyrus and diminished FC with the left middle frontal gyrus (MFG) and left superior parietal lobule, whereas the left middle occipital gyrus exhibited reduced FC with the right LGN in patients with POAG. A positive correlation between the FC in the left MFG and the retinal average thickness (r = 0.292, P = 0.012), retinal nerve fiber layer average thickness (r = 0.272, P = 0.013), and ganglion cell-inner plexiform layer average thickness (r = 0.380, P = 0.001) was found.</div></div><div><h3>Conclusions</h3><div>Patients with POAG exhibited LGN atrophy, reduced resting-state functional activity, and altered FC with the LGN in the regional cortex. The glaucomatous impairment of retinal thickness was associated with LGN volume and its connectivity strength with the left MFG. These findings offer a deeper insight into the LGN cortical connectivity alterations and its association with transneuronal degeneration in patients with POAG.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"230 ","pages":"Article 111524"},"PeriodicalIF":3.7,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosome derived from bone marrow derived mesenchymal stem cells prevents LPS-induced depressive like behaviors 来自骨髓间充质干细胞的外泌体阻止lps诱导的抑郁样行为。
IF 3.7 3区 医学
Brain Research Bulletin Pub Date : 2025-08-28 DOI: 10.1016/j.brainresbull.2025.111527
Hua Liu , Xue-Jun Yan , Juan-li Hu , Hu Pan , Xiao Mao , Yong Cheng
{"title":"Exosome derived from bone marrow derived mesenchymal stem cells prevents LPS-induced depressive like behaviors","authors":"Hua Liu ,&nbsp;Xue-Jun Yan ,&nbsp;Juan-li Hu ,&nbsp;Hu Pan ,&nbsp;Xiao Mao ,&nbsp;Yong Cheng","doi":"10.1016/j.brainresbull.2025.111527","DOIUrl":"10.1016/j.brainresbull.2025.111527","url":null,"abstract":"<div><div>Major depressive disorder (MDD) is a multifaceted mental disorder marked by a spectrum of significant and persistent low mood symptoms. Its etiology involves genetic and environmental factors. In addition, the inflammatory process plays a crucial role in the pathophysiology of depression. Exosomes derived from bone marrow mesenchymal stem cells (BMSCs) have demonstrated significant effects in reducing proinflammatory cytokines. However, there is limited research on whether exosomes can prevent the occurrence of LPS-induced depression. This study aimed to investigate the role of BMSC-derived exosomes in LPS-induced depression and explore the underlying mechanisms. We administered exosomes to LPS-induced depression mice via the caudal vein and evaluated their effects on depressive-like behaviors. Our findings indicate that four injections of exosomes (200 µl at a concentration of 1.4 ×10 ¹¹ particles/mL, administered every three days) significantly prevented depressive-like behaviors in LPS-induced depression mice. Further analyses revealed that exosome treatment reduced levels of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) and increased anti-inflammatory cytokine IL-10. Additionally, exosome treatment markedly reduced oxidative stress in both the central and peripheral nervous systems of LPS-treated mice. Moreover, our data suggest that exosome treatment increased astrocyte proliferation and neurogenesis in the hippocampus of LPS mice. In summary, our results demonstrate the antidepressant effects of BMSC-derived exosomes in LPS-induced depression mice, suggesting a potential new therapeutic target for major depressive disorder (MDD).</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"231 ","pages":"Article 111527"},"PeriodicalIF":3.7,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-mortem 11.7 T DTI validation of myeloarchitectural changes in glioblastoma infiltration: Correlation with histology and PLI 死后11.7 T DTI对胶质母细胞瘤浸润骨髓结构改变的验证:与组织学和PLI的相关性
IF 3.7 3区 医学
Brain Research Bulletin Pub Date : 2025-08-28 DOI: 10.1016/j.brainresbull.2025.111526
Rik van den Elshout , Jenny Schoenmakers , Andor Veltien , Lucas Boer , Benno Küsters , Geert Litjens , Frederick Anton Meijer , Anja van der Kolk , Tom Scheenen , Maximilian Wiesmann , Dylan Henssen
{"title":"Post-mortem 11.7 T DTI validation of myeloarchitectural changes in glioblastoma infiltration: Correlation with histology and PLI","authors":"Rik van den Elshout ,&nbsp;Jenny Schoenmakers ,&nbsp;Andor Veltien ,&nbsp;Lucas Boer ,&nbsp;Benno Küsters ,&nbsp;Geert Litjens ,&nbsp;Frederick Anton Meijer ,&nbsp;Anja van der Kolk ,&nbsp;Tom Scheenen ,&nbsp;Maximilian Wiesmann ,&nbsp;Dylan Henssen","doi":"10.1016/j.brainresbull.2025.111526","DOIUrl":"10.1016/j.brainresbull.2025.111526","url":null,"abstract":"<div><div>Ultra-high field MRI is believed to hold potential for detecting microstructural changes that occur in light of tumor infiltration in glioblastoma patients, although studies with histological validation are lacking. This study, therefore, used 11.7 T diffusion tensor imaging (DTI) to determine the extent of infiltration in post-mortem glioblastoma-affected brain with histological validation. Three post-mortem specimens with glioblastoma underwent 11.7 T DTI from which mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD) and fractional anisotropy (FA) were extracted. Tissue samples were also investigated using hematoxylin-eosin (HE) and luxol fast blue (LFB) stains, as well as Polarized Light Imaging (PLI) microscopy. Regions of interest (ROIs) of normal white matter (NWM) and tumor infiltration were generated on HE stain-based nucleus density maps. The metrics of the NWM ROIs were compared to the metrics of the ROIs covering the regions with tumor infiltration. Metrics were subjected to a correlation analysis to assess the correlation between nucleus density data, diffusion-, PLI- and LFB data. Significant differences were found between NWM and regions of tumor infiltration for MD-, RD-, LFB- and PLI-retardance values (p = 0.036, p = 0.010, p = 0.007 and p &lt; 0.001, respectively). A correlation between nucleus density and diffusivity metrics was found, but not with measures for myeloarchitectural changes (LFB and PLI). Also, a significant correlation between PLI-retardance values and LFB values was found (p &lt; 0.001). Based on DTI metrics and histological validation methods, myeloarchitectural alterations (e.g., fiber displacement) were considered the prime driver of measurable changes in the regions of tumor invasion in glioblastoma patients. Although this study shows the potential of ultra-high field MRI in detecting microstructural changes caused by glioblastoma infiltration, future studies are needed to assess these results in the clinical setting.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"230 ","pages":"Article 111526"},"PeriodicalIF":3.7,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144918068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信