International journal of immunology and immunotherapy最新文献

{"title":"Budesonide Modulates the Immune Cross-Talk between Mononuclear and Colon Cancer Cells","authors":"D. Meir, B. Hanna","doi":"10.23937/2378-3672/1410029","DOIUrl":"https://doi.org/10.23937/2378-3672/1410029","url":null,"abstract":"Background: The introduction of corticosteroids in the therapeutic armamentarium has been a great contribution to human health. Budesonide, a semi-synthetic glucocorticoid derivative gained its popularity due to its anti-inflammatory, immunosuppressive and even anti-carcinogenic properties. In this study we examine the effect of budesonide on the immune dialogue between peripheral blood mononuclear cells and colon carcinoma cells from two human lines. Methods: Unstimulated peripheral blood mononuclear cells or cells stimulated with either lipopolysaccharide or phorbol myristate acetate/ionomycin were incubated without or with budesonide at 10-8 M, 10-7 M and 10-6 M and the production of TNFα, IL-1β, IL-6, IFNγ, IL-2, IL-1ra and IL-10 was examined applying ELISA method. In another set of experiments peripheral blood mononuclear cells were co-cultured with HT-29 or RKO colon carcinoma cells in the absence or presence of budesonide and the secretion of the abovementioned cytokines was evaluated. Results: Budesonide caused reduced proliferation of peripheral blood mononuclear cells, HT-29 or RKO at 10-8 M as tested by XTT test, but had no effect at higher concentrations. The secretion of TNFα, IL-1β and IL-6 by non-stimulated peripheral blood mononuclear cells or cells stimulated with either lipopolysaccharide or cells from both colon cancer lines was inhibited upon incubation with budesonide at concentrations between 10-8 M and 10-6 M. The production of IL-2 by phorbol myristate acetate/ionomycin treated peripheral blood mononuclear cells or cells stimulated with HT-29 colon cancer cells was suppressed by budesonide, but IL-2 secretion by RKO stimulated peripheral blood mononuclear cells was not affected. Budesonide did not influence the secretion of IFNγ by non-stimulated peripheral blood mononuclear cells or by cells stimulated with PMA/ionomycin. However, HT-29 and RKO-induced production of IFNγ was inhibited by the three budesonide concentrations. Budesonide caused reduced secretion of IL-10 by non-stimulated peripheral blood mononuclear cells, or by cells stimulated with either lipopolysaccharide or RKO cancer cells, whereas that induced by HT-29 cells was not affected. IL1ra synthesis by non-stimulated peripheral blood mononuclear cells or cell stimulated with HT-29 colon cancer cells was inhibited upon 24 hrs incubation with budesonide, while that produced by lipopolysaccharide or RKO stimulated PBMC was not affected. Conclusions: It appears that the capacity of budesonide to modify the immune dialogue between mononuclear and certain types of cancer cells may be one of the ways by which this glucocorticosteroid may affect tumorigenesis.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49563443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of Positive Anti-Ro/SSA and Anti-La/SSB Antibodies Among Infants with Prolonged Skin Lesions and Its Relation to Autoimmune Disease in the Mother","authors":"M. Makhlouf, Suzan Fahim Ghobashy, H. F. Mohamed, Ikram I. Alyan, Fawzy Aly Abualfadl","doi":"10.11648/j.iji.20180602.12","DOIUrl":"https://doi.org/10.11648/j.iji.20180602.12","url":null,"abstract":"Many literatures reported that neonatal lupus erythematosus and its associated abnormalities mainly, cutaneous lupus lesions, congenital heart block (CHB), hematologic cytopenias, hepatobiliary disease and cardiomyopathy are associated with anti-Ro/SSA and anti-La/SSB antibodies. With skin findings occur in nearly 95% of NLE infants, others reported that 100% of NLE infants with CHB were positive for anti Ro/SSA antibodies and 90.2% of infants with skin NLE were positive for anti Ro/SSA. And long-term follow-up of children with neonatal lupus and their unaffected siblings revealed that 12.24% of NLE children identified definite rheumatic/autoimmune diseases after more than 8 years. Aim of the study: The aim of this study was to determine the incidence of positive anti-Ro/SSA and anti-La/SSB antibodies in infants with recurrent prolonged skin lesions and their mothers to determine asymptomatic mothers at risk to develop autoimmune disease. Subjects and methods: a total of 90 infants with recurrent prolonged skin lesions below the age of 6 months and their mothers attending pediatric screening and follow up clinic at Al Galaa Teaching Hospital in Cairo, Egypt were investigated for positivity of anti Ro/SSA and anti La/SSB antibodies using enzyme linked immunoassay (ELISA). Results: Incidence rate of positive anti Ro/SSA alone and anti La/SSB alone antibodies in infants were 34.4% and 23.3% respectively, and positive both anti Ro/SSA and anti La/SSB antibodies was 21.1%, while in their mothers, positive both anti Ro/SSA and anti La/SSB antibodies was 36.7%. Among the 33 cases with positive antibodies female: male ratio was 2.3:1, and rheumatologic and autoimmune diseases was positive in 14 (42.4%) mothers, while, 19 (57.6%) were asymptomatic mothers, anemia, lymphocytosis, neutropenia with relative lymphocytosis, eosinophilia and thrombocytopenia were found in 6.1%, 9.1%, 3.0%, 9.1% and 12.1% respectively. Liver transaminases were elevated in 4 (12.1%). Positive anti Ro/SSA and anti La/SSB antibodies were statistically significantly correlated with infant age, body weight, body length and head circumference, female sex, infants mothers’ rheumatologic and autoimmune diseases, distribution of skin lesions, positive history of steroid containing cream use, and thrombocytopenia. However, both antibodies showed no statistically significant correlation with infant feeding, rate of recurrent skin lesions, anemia, lymphocytosis, neutropenia with relative lymphocytosis, eosinophilia, positive CRP, and elevated ESR. Conclusion: our infant cases with prolonged skin lesions with positive anti Ro/SSA and anti La/SSB antibodies with their mothers’ especially asymptomatic ones should be investigated and followed up properly for development of NLE and autoimmune diseases.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"41 1","pages":"30"},"PeriodicalIF":0.0,"publicationDate":"2018-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72965733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implication of Biofield Energy Healing Based Vitamin D3 on Osteoblastic Differentiation","authors":"Su Liu, M. Trivedi, A. Branton, Dahryn Trivedi, G. Nayak, M. Gangwar, S. Jana","doi":"10.11648/j.iji.20170506.11","DOIUrl":"https://doi.org/10.11648/j.iji.20170506.11","url":null,"abstract":"Bone is one of the dynamic organ of the endoskeleton, which play a vital role in maintain the structural integrity, blood production, coagulation, mineral reservoirs, and body immunity. The present study investigates the potential of Consciousness Energy Healing based vitamin D3 and DMEM medium on bone health parameters in MG-63 cell line. Vitamin D3 and DMEM medium as test items (TI), were divided into two parts, and each sample received the Consciousness Energy Healing Treatment by Su-Mei Chen Liu and labeled as the Biofield Energy Treated (BT) samples, while the other parts of each sample were denoted as the untreated test items (UT). Bone health parameters such as alkaline phosphatase enzyme (ALP) activity, collagen levels and bone mineralization as bone biomarkers were studied. The cell viability using MTT assay showed more than 84% in test items groups were found to be safe. ALP level was significantly increased by 217% (100 µg/mL), 272.8% (10 µg/mL), and 233.9% (100 µg/mL) in the UT-DMEM+BT-TI, BT-DMEM+UT-TI, and BT-DMEM+BT-TI groups, respectively. Collagen content was significantly increased by 121.6%, 134.3%, and 86% in the UT-DMEM+BT-TI, BT-DMEM+UT-TI, and BT-DMEM+BT-TI groups, respectively at 100 µg/mL as compared with the untreated group. Additionally, the percent of bone mineralization was significantly increased by 213.5% (at 10 µg/mL), 109.5% (at 100 µg/mL), and 283.7% (at 100 µg/mL) in the UT-DMEM+BT-TI, BT-DMEM+UT-TI, and BT-DMEM+BT-TI groups, respectively as compared with the untreated group. In conclusion, the Biofield Energy Treated vitamin D3 and DMEM would play an important role to improve the bone mineralization and calcium absorption. The bone health parameters such as collagen, calcium and ALP were significantly improved and can be used as supplement to improve bone health. Further, it is assumed that the Biofield Energy Treated vitamin D3 could be a powerful alternative dietary sources and supplements to fight against various bone related diseases including low bone density and osteoporosis, Paget’s disease of bone, rickets, deformed bones, osteomalacia, bone and/or joint pain, increased frequency of fractures, osteoma, hormonal imbalance, stress, aging, bone loss, and fractures.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"3 1","pages":"88-96"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80052553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular Contact between Red Blood Cell and Endothelial Cells after High Dose Immunoglobulin Therapy Might Depend on Non-Immunological Mechanism","authors":"Saito Nagahito, Takemori Nobuo, Rewald Enrique, Nagura Hiroshi, Kohgo Yutaka, O. Hong-Kean","doi":"10.23937/2378-3672/1410027","DOIUrl":"https://doi.org/10.23937/2378-3672/1410027","url":null,"abstract":"High dose intravenous immunoglobulin therapy (IVIG) has been performed for increase of platelet to patients with immune-thrombocytopenia (ITP). We observed by standard and immunoelectron microscopy the phenomenon of the direct cell to cell contact between red blood cells (RBCs) and endothelial cells (ECs) in bone marrow (BM) of patients with ITP (ITP-patients) after IVIG and then compared to that of the mice injected human immunoglobulin (IgG). RBCs were observed to adhere directly to the ECs of blood vessels in BM of both the ITP-patients and of the mice injected with high dose human IgG. However, in the mice injected with saline, no RBC was seen adhering to the EC as well as that of ITP-patients before IVIG. We concluded that the direct adherence between RBC and EC in the BM after high dosed human IgG injection is not due to an immunological mechanism at all.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46616998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific IgE for Aero and Food Allergens in Adult Chronic Urticaria Patients Without Other Allergic Diseases","authors":"O. M. A. Latif","doi":"10.11648/J.IJI.20180602.11","DOIUrl":"https://doi.org/10.11648/J.IJI.20180602.11","url":null,"abstract":"Chronic Urticaria (CU) is a diseases characterized by occurrence of spontaneous wheels observed by the patient for more than 6 weeks duration. The prevalence of CU varies from 0.5-5% in adult population. This is a disease of complex etiologies with more areas to be explored by researches. The aim of the study was to detect the Prevalence of allergen sensitizations among adult chronic urticaria patients without other allergic diseases. This study is a cross-sectional case control study. 70 patients with CU without evident cause and 50 healthy control individuals were included in the study. Patients with any other allergic diseases (such as Asthma, allergic Rhinitis, Allergic Conjunctivitis, Drug Allergy, atopic Dermatitis, Anaphylaxis….), patients with other chronic or systemic Diseases (such as Cardiac, respiratory, renal, hepatic, hematological, thyroid or other skin Diseases, etc….) and smokers were excluded from the study. Each patient and control individual was subjected to full medical history, complete medical examination and routine lab test. Determination of allergen-specific IgE (for 20 separate food and 20 aeroallergens) in serum for the patients was done by using EUROLINE Atopy Screen. Each of the patients and control groups were comparable according to age and gender. There was a significant difference between the CU patients and the control group as regard the prevalence of any allergen sensitization (65.7% for CU patients and 18% in control group) p<0.05. There was also a significant difference between the sensitized individual in each group as regard the number of allergens per each individual; for sensitized CU patients the mean was 3 allergens and interquartile range was (2-4), for the sensitized control individuals the mean was 2 and interquartile range was (1-2) with p= 0.014. The mostly frequent allergens were found in the CU sensitized patients was the house dust mite allergens (34.8% of the sensitized CU patients were sensitized to one or more of the two types of mites; dermatophagoides pteronyssinus and or dermatophagoides farinae). The study concluded that; a great prevalence of CU patients proved to be sensitized to common allergens which open the door to start a trials to examine the value of environmental control, food avoidance and specific allergen immunotherapy in this group of patients.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"15 1","pages":"25"},"PeriodicalIF":0.0,"publicationDate":"2018-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81856803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Sickle Cell Among Patients Attending Immunogenetic Diagnostic Laboratory Akwanga, Nasarawa State Nigeria","authors":"R. T. Ada, P. Ode, Stephen Oche Onah","doi":"10.11648/J.IJI.20180601.13","DOIUrl":"https://doi.org/10.11648/J.IJI.20180601.13","url":null,"abstract":"Sickle Cell Disease is an inherited blood disease caused by abnormal haemoglobin. This study was conducted to determine the prevalence of sickle cell among patients attending Immunogenetic Diagnostic Laboratory Akwanga, Nassarawa State. Aseptically, 2mls of blood was collected from the dorsal vein of the patients into Ethylene Diamine Tetra-acetic Acid (EDTA) bottles and mixed gently to prevent clotting. A small quantity of haemolysate from each of the subjects was placed on a cellulose acetate membrane and carefully introduced into the Electrophoretic tank containing Tris-EDTA buffer at pH 8.6. Electrophoretic separation was then allowed to take place for 15-20 minutes at an Electromotive Force (EMF) of 160V. A total of three hundred and eighty three (283) patients consisting of 195 (50.9%) males and 188 (49.1%) females were sampled in the study. Questionnaires were administered to the patients involved in the study as to obtain demographic and other relevant information regarding the research. The prevalence of the HbAA, HbAS and HbSS were 72.32%, 25.06% and 2.60% respectively. Statistically, there was a significant difference (p<0.05) between gender, age, locality and the prevalence of the Sickle Cell as observed in this study. The prevalence recorded for HbSS in this study is low compared to the value range of 1-10% expected for Nigeria. Based on the findings from this study, it is recommended that genetic counseling policies should be developed to enable prospective couples make decisions aimed at reducing the sickling gene pool in our population.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"120 1","pages":"17"},"PeriodicalIF":0.0,"publicationDate":"2018-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73379176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Predictive Model for the Risk of Mental Illness in Nigeria Using Data Mining","authors":"Mhambe Priscilla Dooshima, Egejuru Ngozi Chidozie, Balogun Jeremiah Ademola, O. O. Sekoni, Idowu Peter Adebayo","doi":"10.11648/J.IJI.20180601.12","DOIUrl":"https://doi.org/10.11648/J.IJI.20180601.12","url":null,"abstract":"This study identified the risk factors for mental illness and formulated a predictive model based on the identified variables. The study simulated the formulated model and validated the model with a view to developing a model for predicting the risk of mental illness. Following the review of literature in order to understand the body of knowledge surrounding mental illness and their corresponding risk factors, interview with mental experts was conducted in order to validate the identified variables. Naive Bayes’ and the Decision Trees’ Classifiers were used to formulate the predictive model for the risk of mental illness based on the identified and validated variables using the WEKA software. Data was collected from 30 patients with an almost equal distribution of no, low, moderate and high risk of mental illness cases. The results showed that there were three classes of risk factors associated with mental illness, namely: biological factors, psychological factors and environmental factors. The results further showed that the formulation with Decision Trees Classifiers revealed the most relevant variables for the risks of mental illness such as losing anyone close. C4.5 decision trees algorithm with an accuracy of 83.3% outperformed the Naive Bayes’ algorithm which had an accuracy of 76.7%. The study concluded that the variables identified by the C4.5 Decision Trees algorithm can assist mental health experts to apply the rules deduced by the algorithm for the early detection of mental illness.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"80 1","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2018-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77951401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Abscess in Undiagnosed Tetralogy of Fallot","authors":"Kelvin Nemayire, K. Kabulo, Luxwell Jokonya, P. Ntenga, A. Musara, K. Kalangu","doi":"10.11648/j.iji.20180601.11","DOIUrl":"https://doi.org/10.11648/j.iji.20180601.11","url":null,"abstract":"Cardiovascular disease is a leading cause of mortality in all ages worldwide. Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease (CHD) accounting for 10%. There have been several reports of neurological complications associated with TOF. Although it is known, brain abscess (BA) is a serious complication in patients with uncorrected CHD mostly in the age of 4-7 years-old. We report a case of a 7 year old male who presented with a 3 month history of left sided body weakness and a 3 week history of a headache and fever. Patient was chronically unwell since birth where he would experience occasional episodes of exertional dyspnoea which was never investigated. Chest xray showed a globular-shaped heart. CT scan brain showed a 1,8 x 1,3 x 1,5 cm ring-enhancing lesion in the right parietal region with minimal perilesional vasogenic edema communicating with the body of the lateral ventricle, with enhancement of the ependymal lining of the ventricle; echocardiography revealed ventricular septal defect (VSD), overriding of aorta, obstruction to right ventricular outflow tract and hypertrophy of right ventricle consistent with a diagnosis of TOF. We elected to manage the patient conservatively on intravenous antibiotics, Patient improved significantly neurologically and was transferred to the cardiothoracic surgeons for further management of TOF.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"88 12 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2018-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83450123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visions of the Hereafter: Releasing the Brakes of the Immune System by Checkpoint Inhibition Immunotherapy","authors":"Isabel C. Hageman","doi":"10.23937/2378-3672/1410026","DOIUrl":"https://doi.org/10.23937/2378-3672/1410026","url":null,"abstract":"Activation and control of the immune system is regulated by costimulatory molecules as well as by checkpoint inhibitors. Checkpoints are essential in maintaining self-tolerance and minimizing collateral damage by modulating the immune response. Evasion of the immune system, one of the hallmarks of cancer, has been found to include interference with checkpoints by tumor cells as one of the evasive mechanisms. Tumor cells express molecules that when bound to their respective ligand or receptor, send out inhibitory signals that block T-cell activation. Specific antibodies have been engineered against these immunosuppresive molecules (mainly CTLA-4 and PD-1) such that the T-cells can exert cytotoxic anti-tumor effects. These antibody therapies have been found to be very effective for a number of malignancies, especially melanoma and lung cancer. The downside is that this therapy comes with serious adverse immune-mediated events, a direct consequence of releasing the brakes of the immune system. In comparison with patients with a deficiency in the Autoimmune Regulator (AIRE) transcription factor, the side effects however are manageable and certainly acceptable in light of the otherwise fatal underlying disease. Combination of different checkpoint inhibition antibodies, including novel immunoregulatory molecules may further enhance the effectiveness of this form of therapy and broaden the range of susceptible tumors. The vision of the hereafter for immunotherapy by checkpoint inhibition therefore looks bright.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81275330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Fluorescent-Histochemical and Immuno-Histochemical Aspects of Secondary Cataract Pathogenesis in Humans","authors":"N. Korsakova","doi":"10.11648/j.iji.20170505.11","DOIUrl":"https://doi.org/10.11648/j.iji.20170505.11","url":null,"abstract":"Secondary cataract is the most common postoperative complication, which causes repeated significant reduced visual acuity, even after a successful operation on the lens. Due to significant clinical heterogeneity of secondary cataract of a man a comparative morphological and functional study in the formation of its fibrous and proliferative forms is especially important for identification of pathogenesis foundations of this disease. The used morphological, histochemical and clinical techniques in the conducted study have provided some evidence of the important role of trophic nervous influences on the type formation of secondary cataract in humans. It is important to note that the revealed similarities in changes of bioamine status, immunoreactivity of the epithelium and fibers of the human crystalline lens in different types of age-related cataract (cortical and nuclear) and its postoperative complications (proliferative and fibrous types of secondary cataract, respectively) can serve as an important proof of their common pathogenesis and, consequently, the type of age-related cataract can be offered as an accessible marker for predicting the risk of postoperative secondary cataract of certain type and its early prevention. The results allow for the first time to put forward a new concept of the secondary cataract pathogenesis. The presented in this chapter concept emphasizes the importance of the fundamental problems of medicine – maintaining the stability of tissue differentiation of a living organism in a variety of physiological and pathological conditions, under the influence of neurotrophic factors.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"47 1","pages":"80"},"PeriodicalIF":0.0,"publicationDate":"2017-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89679453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}