International journal of immunology and immunotherapy最新文献

{"title":"Pregnancy Specific Beta-1 Glycoprotein, Pro- and Anti-inflammatory Cytokines in Eclampsia in Kaduna State, Nigeria","authors":"Jim Monday Banda","doi":"10.11648/j.iji.20190701.12","DOIUrl":"https://doi.org/10.11648/j.iji.20190701.12","url":null,"abstract":"","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"186 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77014784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Levels of IgE and IgG and the Activity of Complement Comparatively in Blood and Lymph in the Experimental Arthus and Overy Phenomenon","authors":"Aliyeva Tarana Rzakuli","doi":"10.11648/j.iji.20190703.12","DOIUrl":"https://doi.org/10.11648/j.iji.20190703.12","url":null,"abstract":"","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73034599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar","authors":"Rakotomalala Toky Randriamahazo, Zoliarisoa Ramihajamanana, Anjatiana Annick Raherinaivo, M. Rasamindrakotroka, D. Rajaonatahina, O. R. Alson, A. Rasamindrakotroka","doi":"10.11648/J.IJI.20190704.13","DOIUrl":"https://doi.org/10.11648/J.IJI.20190704.13","url":null,"abstract":"Currently, there are 122 hemophiliacs in Madagascar followed at the hemophiliac treatment center of the Joseph Ravoahangy Andrianavalona University Hospital Center (JRA UHC), 55 present hemophilia B and 67 of hemophilia A. In hemophilic patients, the diagnosis of hemarthrosis is obviousin front of articular inflammation. It’s important to determinate the main risk factor as well as predisposition indicators tothe occurrence of \"spontaneous\" hemarthrosis in hemophiliacsfor prevention andearly careanticipation. In this prospect, the search for potentpredisposition indicator such as immunologicalfactorsis important. This is a case control study on all hemophiliacs seen at (JRA UHC) with hemarthrosis for 7 months. We have descriptively studied the qualitative and quantitative variables consisting in the determination of rheumatoid factors (RF) and the titer of antistreptolysin O (ASLO). Then we studied the statistical correlations. During the study period, we included 30 hemophiliac subjects with hemarthrosis who had an average age of 16.8 years. We had as much hemophiliac A as hemophiliac B; 23.3% practiced sporting activity; 10% had history of angina, involvement of the knee joint predominated at 44% (left 24%). RF positive were present in 26.7% (8/30) predominant in hemophiliacs aged from 19 to 36 (62.5%). The ASLO positive titer was found in 43.3% (13/30) predominant in children from 5 to 13 years (38.5%) with a maximum rate of 1600IU / l. There was no significant relationship between the positivity of the parameters with the presence or absence of hemarthrosis with a value of p = 0.231 and p = 0.06 respectively (p > 0.05). A large number of hemophiliac patients had a combination of clinical and biological signs in relation to diagnose rheumatic fever and rheumatoid arthritis which must be monitored as this could predict the occurrence in the short and medium term of these diseases which could be mistaken for hemarthrosisrelated to hemophilia.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87766462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Determinants of Pre-diabetes and Latent Tuberculosis Infection Among Apparently Healthy Adults in Three Communities in Southern Nigeria","authors":"Benson Olu Akinshipe, Edirin Omorigho Yusuf, Felix Oladapo Akinshipe, Muyiwa Adeleye Moronkeji, Anthony Chukwuka Nwaobi","doi":"10.11648/j.iji.20190702.11","DOIUrl":"https://doi.org/10.11648/j.iji.20190702.11","url":null,"abstract":"","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73752269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Caspase-11 Non-Canonical Inflammasome in Macrophage-Mediated Inflammatory Responses","authors":"Yi Young-Su","doi":"10.23937/2378-3672/1410034","DOIUrl":"https://doi.org/10.23937/2378-3672/1410034","url":null,"abstract":"Inflammation is a complex biological response mediated by macrophages to protect the body from the pathogens and danger signals. The inflammatory response is initiated by priming, a process increasing the expression of inflammatory genes by extracellular pattern-recognition receptor (PRR)mediated detection of pathogens, followed by triggering, a process detecting cytosolic pathogens by intracellular PRRs. Triggering induces the formation of intracellular PRR complexes called inflammasomes composed of two main groups; canonical and non-canonical inflammasomes. Unlike canonical inflammasomes, non-canonical inflammasomes were recently discovered, and the knowledge of the roles of non-canonical inflammasomes in inflammatory responses and human diseases is not still enough. Mouse caspase-11 and human caspase-4/5 were identified as non-canonical inflammasomes, and many efforts have been made to demonstrate the regulatory functions of these non-canonical inflammasomes in inflammatory responses and several human diseases. This review discusses the recent research progress to understand the roles of the caspase-11 non-canonical inflammasome in macrophagemediated inflammatory responses, which can provide the insight and contribute to developing potential diagnostic and therapeutic agents to prevent and treat human infectious and inflammatory/autoimmune diseases.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44410651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunotherapy and the Immune Infiltrate in Pediatric Brain Tumors: An Illustration and Review of the Unique Challenges Facing Immunotherapy for Pediatric Oncology","authors":"S. PlantAshley, I. HwangEugene","doi":"10.23937/2378-3672/1410028","DOIUrl":"https://doi.org/10.23937/2378-3672/1410028","url":null,"abstract":"Immunotherapy for pediatric oncology is a robust and prolific area of active research and has changed the face of treatment for some cancers, such as, B cell acute lymphoblastic leukemia (ALL) and neuroblastoma. However, the field faces challenges and hurdles unique to the pediatric population especially in the area of neuro-oncology. Here, clinicians face challenges of using immunotherapy for tumors with some of the lowest mutational burdens in sensitive areas of the brain where surgical intervention is limited and significant immune infiltration is poorly tolerated. Here, we review the current knowledge of the interplay between the immune system and pediatric brain tumors, current clinical trials enrolling patients with pediatric brain tumors, and the challenges unique to this area of research. Early phase clinical trials in pediatric neuro-oncology are plentiful given the rarity of these tumors and efficacy and safety is still to be determined.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"161 22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68748731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Membrane Antigens on Neutrophils from Patients with Pneumonia","authors":"T. Shigeru, Ubagai Tsuneyuki, Koshibu Yoji, K. Takane, Nakano Ryuichi, K. Go, Kikuchi Hirotoshi, Ikeda Hiroto, Uchida Yasuyuki, Sakamoto Tetsuya, Ono Yasuo","doi":"10.23937/2378-3672/1410032","DOIUrl":"https://doi.org/10.23937/2378-3672/1410032","url":null,"abstract":"","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46335616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monoclonal Antibody Avelumab in Non-Resectable Advanced Merkel Cell Carcinoma: Review of Literature","authors":"E. Daniel, K. Richard, Gbadamosi Bolanle, K Douglas-NikitinVonda, Yu Zhou, M. Jeffrey, Stender Michael, Gaikazian Susanna, J. Ishmael","doi":"10.23937/2378-3672/1410030","DOIUrl":"https://doi.org/10.23937/2378-3672/1410030","url":null,"abstract":"Introduction: Merkel cell carcinoma (MCC) is an aggressive form of skin cancer typically associated with a poor prognostic outcome. Case description: A case of non-resectable, advanced Merkel cell carcinoma of the right pelvis and right inguinal region in a 67-year-old man was treated with the anti PD-L1 monoclonal antibody avelumab and Radiation therapy, with maintenance of a durable response 24 months later. The rare presentation of this aggressive form of skin cancer and its clinicopathologic features are presented. Conclusions: Up-to-date information on the clinical management of MCC, including the utilization of human anti-PD-L1 monoclonal antibody, and ongoing clinical trials in both localized and metastatic settings of MCC are discussed.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45929843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers in Relation to Disease Manifestations in Psoriatic Arthritis","authors":"Juneblad Kristina, R. Solbritt, Alenius Gerd-Marie","doi":"10.23937/2378-3672/1410033","DOIUrl":"https://doi.org/10.23937/2378-3672/1410033","url":null,"abstract":"Background: In psoriatic arthritis (PsA), a complex disease with a lack of measurable laboratory parameters, there is a need for diagnostic and prognostic tools to meet the challenge of early diagnosis and assessment of disease severity. Objective: To analyze whether soluble biomarkers could discriminate between disease phenotypes in PsA. Methods: Two-hundred and seventy-four patients with established disease and 30 healthy controls were included in this cross-sectional study. Thirty-nine different serological biomarkers were investigated in relation to disease activity, disease manifestations and in comparison with controls. In addition to standard statistical methods, orthogonal partial least squares discriminant analysis (OPLS-DA) was used to investigate different phenotypes of PsA. Results: Psoriatic arthritis activity was significantly associated with CRP (pc = 0.0008), IL-6 (pc = 0.001), IL-16 (pc = 0.007), calprotectin (pc = 0.014), IL-12/IL-23p40 (pc = 0.02), and ICAM-1 (pc = 0.045). Different PsA disease phenotypes were associated with different biomarkers, e.g., axial disease (with or without peripheral disease) was associated with IL-6 (pc = 0.044), IL-16 (pc = 0.044), MIP-1β (pc = 0.039) and polyarthritis was associated with IL-6 (pc = 0.0006), SAA (pc = 0.009), CRP (pc = 0.012) and IL-8 (pc = 0.04), although it was not possible to statistically separate the different phenotypes with OPLSDA. An association was also seen in patients with PsA who, at any time had been prescribed bDMARD, (TNFβ (pc = 0.0001), TNFα (pc = 0.0003), calprotectin (pc = 0.0009), CRP (pc = 0.016) and lower levels of Tie-2 (pc = 0.027)). No significant differences were detected when PsA patients were compared with healthy controls. Conclusions: In this study, inflammatory/pro-inflammatory biomarkers were associated with different disease phenotypes in PsA, however the impact of the various biomarkers is not evident as OPLS-DA analyses could not separate between groups.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47943233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"pTregs or iTregs are the Potent Tolerance Inducer for the growth and Metastasis of Cancer","authors":"Hegde Upendra P, Jellison Evan R, Chakraborty Nitya G","doi":"10.23937/2378-3672/1410031","DOIUrl":"https://doi.org/10.23937/2378-3672/1410031","url":null,"abstract":"It remains a wonder how Tregs induce tolerance for the development of cancer. Previously we have shown with melanoma patients that, increase in peripherally induced Tregs (pTregs) number in blood is related to the poor prognosis of the disease. In vitro induced Tregs (iTregs) and pTregs are remarkably similar and significantly different in functionality from tTregs. Here, we worked with 12 melanoma patientssix HLA A2 positive and six HLA A2 negative. PBL and tumor cells were obtained from the patients with informed consent. Treg cells were generated and isolated from four different culture conditions: 1) Isolated from tumor +PBL IVC, 2) Mart-1 A2 or 3) Flu A2 pulsed DC + PBL IVC and 4) purified CD4+CD25cells stimulated with anti CD3 and antiCD28 plus IL-2. We used these different Treg generation conditions (self vs. non-self) to understand how induced Tregs behave phenotypically and functionally that would open number of avenues to over come their negative effects. Here we show some phenotypic and functional characteristics of the induced Treg (iTreg) cell in cultures with PBL from the patients. We analyzed those Tregs for their suppressive function in separate CTL generation assays. We observed that iTreg cells under different conditions do not uniformly express CD25, FoxP3, PDL-1 or CTLA 4 as the known surface markers. When analyzed for their functionality, with adjusted number of cells, in suppressing the anti tumor CTL response, a significant difference was observed. The most effective Tregs cells were found to be those isolated from autologous tumor +PBL IVC or from Mart-1 peptide pulsed DC + PBL IVC. Those cells completely blocked the CTL induction and secreted huge amount of IL-10 upon re-stimulation. Further analysis with these different types of iTreg cells in terms of various gene expressions and corresponding protein secretion will be useful to find a target molecule to block such expansions of iTregs or pTregs cells for better therapeutic outcome. Abbreviations Treg: T Regulatory Cells; tTre: Thymus Derived Natural T Regulatory Cells; pTreg: Peripherally Induced T Regulatory Cells; iTre: In Vitro Induced T Regulatory Cells; PBL: Peripheral Blood Lymphocytes; DC: Dendritic Cells; IVC: In Vitro Co Culture; TAA: Tumor Associated Antigen","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68748807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}