人类继发性白内障发病的荧光组织化学和免疫组织化学新进展

N. Korsakova
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引用次数: 3

摘要

继发性白内障是最常见的术后并发症,即使在晶状体手术成功后,也会导致视力反复明显下降。由于男性继发性白内障具有明显的临床异质性,因此对其纤维性和增生性白内障形成的比较形态学和功能研究对于确定该病的发病机制基础尤为重要。本研究采用形态学、组织化学和临床技术,为营养神经在人类继发性白内障类型形成中的重要作用提供了一些证据。值得注意的是,在不同类型的年龄相关性白内障(皮质型和核型)及其术后并发症(分别为增殖性和纤维型继发性白内障)中,人类晶状体上皮和纤维的生物胺状态、免疫反应性的变化及其相似性可以作为其共同发病机制的重要证据,因此,年龄相关性白内障的类型可作为预测术后某种类型继发性白内障发生风险及早期预防的指标。研究结果首次提出了继发性白内障发病机制的新概念。本章提出的概念强调了医学基本问题的重要性——在各种生理和病理条件下,在神经营养因子的影响下,维持生物体组织分化的稳定性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
New Fluorescent-Histochemical and Immuno-Histochemical Aspects of Secondary Cataract Pathogenesis in Humans
Secondary cataract is the most common postoperative complication, which causes repeated significant reduced visual acuity, even after a successful operation on the lens. Due to significant clinical heterogeneity of secondary cataract of a man a comparative morphological and functional study in the formation of its fibrous and proliferative forms is especially important for identification of pathogenesis foundations of this disease. The used morphological, histochemical and clinical techniques in the conducted study have provided some evidence of the important role of trophic nervous influences on the type formation of secondary cataract in humans. It is important to note that the revealed similarities in changes of bioamine status, immunoreactivity of the epithelium and fibers of the human crystalline lens in different types of age-related cataract (cortical and nuclear) and its postoperative complications (proliferative and fibrous types of secondary cataract, respectively) can serve as an important proof of their common pathogenesis and, consequently, the type of age-related cataract can be offered as an accessible marker for predicting the risk of postoperative secondary cataract of certain type and its early prevention. The results allow for the first time to put forward a new concept of the secondary cataract pathogenesis. The presented in this chapter concept emphasizes the importance of the fundamental problems of medicine – maintaining the stability of tissue differentiation of a living organism in a variety of physiological and pathological conditions, under the influence of neurotrophic factors.
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