International journal of immunology and immunotherapy最新文献_第4页

Environmental Quality and Its Attendant Effect on Human Health: New Evidence from Panel Quantile Regression for Anglophone Countries in West Africa 环境质量及其对人类健康的影响:来自西非英语国家小组分位数回归的新证据

International journal of immunology and immunotherapy Pub Date : 2020-12-28 DOI: 10.11648/J.IJI.20200804.14

A. Oyelade, Olamide David Tijani, Mumini Oluwaseyi Wakile, Adeyemi Lookman Kanimodo

{"title":"Environmental Quality and Its Attendant Effect on Human Health: New Evidence from Panel Quantile Regression for Anglophone Countries in West Africa","authors":"A. Oyelade, Olamide David Tijani, Mumini Oluwaseyi Wakile, Adeyemi Lookman Kanimodo","doi":"10.11648/J.IJI.20200804.14","DOIUrl":"https://doi.org/10.11648/J.IJI.20200804.14","url":null,"abstract":"An estimated seven million people per year die from emission-related diseases. These include stroke and heart disease, respiratory illness and cancers. Many health-harmful emission pollutants also damage the climate and reducing emission pollution would save lives and help slow the pace of near-term climate change. This study investigated the environmental quality and its attendant effect on human health from Anglophone countries in West Africa over the period of 1990 to 2013 using panel quantile regression. The result obtained showed that the CO2 emission that can affect the health of Anglophone countries in West Africa are CO2 emissions from gaseous fuel consumption, CO2 emissions from liquid fuel consumption, CO2 emissions from residential buildings and commercial and public services, CO2 emissions from solid fuel consumption, CO2 emissions from transport. Other control variables that have influence on human health were health expenditure, mortality rate and fertility rate. Therefore, the policy makers should implement policies (like energy conservation policies) that will control emission from gaseous fuel consumption, emissions from liquid fuel consumption, emissions from residential buildings and commercial and public services, emissions from solid fuel consumption and emissions from transport. Also, health sector has to be properly cater for by spending more on health and this can only increase the health outcomes in a country.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"25 1","pages":"89"},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76314482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Immunoglobulin E (IgE) Assay for the Diagnosis and Prevention of Pollinosis in the District of Abidjan 免疫球蛋白E (IgE)测定在阿比让地区诊断和预防花粉症

International journal of immunology and immunotherapy Pub Date : 2020-12-28 DOI: 10.11648/J.IJI.20200804.13

Yomanfo Niangbo Serge Pacome, Y. Antoinette, Kassi N’Dja Justin, Koné Mamidou Witabouna, Dosso Mireille

{"title":"Immunoglobulin E (IgE) Assay for the Diagnosis and Prevention of Pollinosis in the District of Abidjan","authors":"Yomanfo Niangbo Serge Pacome, Y. Antoinette, Kassi N’Dja Justin, Koné Mamidou Witabouna, Dosso Mireille","doi":"10.11648/J.IJI.20200804.13","DOIUrl":"https://doi.org/10.11648/J.IJI.20200804.13","url":null,"abstract":"Allergology in Africa is booming. In addition to clinical studies, many studies in biology focus on molecular aspects. This work aims to list the species of the Ivorian flora incriminated in pollinosis and to indicate the pollens that may have molecular similarities with those from Europe. Biological tests using food and mixed allergens were used to search for IgE in 20 patients (14 men and 6 women). The people selected were those who had lived for more than a year close to the target plants and had given their consent for the study. A grid representing cross-allergies ''Food-Pollens'' was used to search for any possible reactions. The plant species of Cote d'Ivoire suspected to be the causes of allergies were Cocos nucifera (Arecaceae), Elaeis guineensis (Arecaceae) and Petersianthus macrocarpus (Lecythidaceae). The same patient may have one or more symptoms. Most of the patients showed ENT (80%), skin (40%), lung (35%), and eye (30%) symptoms. Allergic rhinitis was representative of ENT signs, but allergic asthma has reached 10% of people suffering from lung diseases. During the flowering of Petersianthus macrocarpus, 87% of the respondents present ENT and respiratory symptoms. Biological analyses revealed 70% of patients were sensitized to trophallergens and 60% to pneumallergens. The two patients with no clinical signs were the only negative patients in the biological tests. The most common cross-reactions were between the pollens of Secale cereal ''Rye'' and the fruits of Corylus avellana ''Hazelnut''. The study shows that, the European Panels are useful to start allergological investigations but insufficient to develop a precise diagnosis in Cote d'Ivoire. Therefore, a specific panel composed of Ivorian pollens is being established.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"36 1","pages":"78"},"PeriodicalIF":0.0,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73593786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Cross-Reactivity of Suidasia pontifica with Allergens Blo t 5 from the Blomia tropicalis Mite 蒲公英与热带布洛米螨致敏原Blo ~ 5的交叉反应性评价

International journal of immunology and immunotherapy Pub Date : 2020-11-30 DOI: 10.23937/2378-3672/1410056

Silva Francisca das Chagas Sobral, Silva Daniel Vasconcelos R, Matos Anderson Bruno, Salgado Andrea Medeiros, Queiroz Maria

{"title":"Evaluation of Cross-Reactivity of Suidasia pontifica with Allergens Blo t 5 from the Blomia tropicalis Mite","authors":"Silva Francisca das Chagas Sobral, Silva Daniel Vasconcelos R, Matos Anderson Bruno, Salgado Andrea Medeiros, Queiroz Maria","doi":"10.23937/2378-3672/1410056","DOIUrl":"https://doi.org/10.23937/2378-3672/1410056","url":null,"abstract":"Background: The immunological cross-reactivity between different species of dust mites such as Suidasia pontifica and Blomia tropicalis is a factor that can favor an immunotherapeutic treatment, having so great clinical relevancy. However, the pretreatment of the raw extract can potentialize its response as in the cross-reactivity analysis. Therefore, this paper seeks to pre-treat the Suidasia pontifica extract in order to obtain protein fractions by the “salt out” method and then evaluate the presence of cross-reactivity for the Blo t 5 allergen of Blomia tropicalis. Method: Suidasia pontifica extracts were obtained by the protein precipitation with ammonium sulfate in percentages 0-20%, 20-40%, 40-60%, 60-80%, 80-100% (w/v) at 0 °C. Precipitated fractions were evaluated by protein content, characterized by electrophoresis, and applied in Western Blot and ELISA tests, with positives and negatives controls using the recombinant antigen Blo t 5. Results: With salt saturation level of 80% (w/v), it was achievable to efficiently separate proteins in the raw extract of Suidasia pontifica, resulting in a total content of 13.61 mg mL-1. The immunoassay ELISA exposed the existence of cross-reactivity for Blo t 5 allergen, for crude extract, with allergenic potency of 2.797 ng mL-1. This result was also confirmed by stains obtained in the blot in about 15-16 kDa. For fractions obtained between the percentages of 20 to 100% (w/v) of salt saturation and power was below 1.93 ng mL-1, at the border of the established limit of detection. Conclusion: The “salt out” method is efficient at obtaining concentrated fractions of proteins, as observed when applied in Suidasia pontifica, extract, this being susceptible to cross-interactions, suggesting the possibility of this mite to act as an adjunct in immunotherapy on formulations for desensitization of allergic individuals. ORiginAl ReSeARCh","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91080170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Barrier and Motivation to Exclusive Breast Feeding Amongst Mothers Accessing Care at the University of Abuja Teaching Hospital 在阿布贾大学教学医院获得护理的母亲进行纯母乳喂养的障碍和动机

International journal of immunology and immunotherapy Pub Date : 2020-11-24 DOI: 10.11648/J.IJI.20200804.12

CHRISTIE OMOLOLA ADAMS, Godwin Ewu, V. Ugwu, Ibrahim Shakirat, E. Joseph

{"title":"Barrier and Motivation to Exclusive Breast Feeding Amongst Mothers Accessing Care at the University of Abuja Teaching Hospital","authors":"CHRISTIE OMOLOLA ADAMS, Godwin Ewu, V. Ugwu, Ibrahim Shakirat, E. Joseph","doi":"10.11648/J.IJI.20200804.12","DOIUrl":"https://doi.org/10.11648/J.IJI.20200804.12","url":null,"abstract":"This study was carried out to identify barriers and motivation for exclusive breastfeeding practice amongst mothers accessing care at the University of Abuja Teaching Hospital, ( UATH) — Abuja — Nigeria. The study was a cross-sectional survey that utilized a structured questionnaire in the collation of quantitative data from 288 participants. The data and result showed that approximately 53.5% of the respondents reportedly do not have enough breast milk, 13.9% think that the breast milk will not be enough for their babies because of the size of their breast, 0.69% were the students with attendant challenges, 1.4% were career women, 1.7% said their difficulty was painful nipples, one person was afraid that the baby may refuse other feeds at a later age while one respondent said it was time-consuming. It is captivating to know that, the respondents’ motivation based on whether exclusive breastfeeding is beneficial to baby and mother shows that 99.6% claimed that exclusive breastfeeding is beneficial, and contribute to the good well-being of the baby, while 98.2% declared that exclusive breastfeeding is beneficial to the nursing mother as well. The study evaluated the barriers, and motivations of the mother to tell the benefits of breast milk are natural and renewable food. Therefore, ensuring active support through an efficient health education/promotion as primary prevention in public health/clinical practice and establishing/sustaining the practices that are appropriate among mothers. Generally, the study showed some barriers to exclusive breastfeeding and their associated motivations among mothers.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"8 1","pages":"70"},"PeriodicalIF":0.0,"publicationDate":"2020-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79575042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Praziquantel Treatment for Schistosoma mansoni Infection Among Children in Ethiopia: Systematic Review and Meta-analysis 吡喹酮治疗埃塞俄比亚儿童曼氏血吸虫感染的疗效:系统评价和meta分析

International journal of immunology and immunotherapy Pub Date : 2020-11-16 DOI: 10.11648/J.IJI.20200804.11

Habtye Bisetegn, Yonas Erkihun

{"title":"Efficacy of Praziquantel Treatment for Schistosoma mansoni Infection Among Children in Ethiopia: Systematic Review and Meta-analysis","authors":"Habtye Bisetegn, Yonas Erkihun","doi":"10.11648/J.IJI.20200804.11","DOIUrl":"https://doi.org/10.11648/J.IJI.20200804.11","url":null,"abstract":"Background: Schistosomiasis is a chronic neglected tropical disease of poverty caused by blood dwelling trematodes of Schistosoma species. Praziquantel (PZQ) is the current drug of choice for the treatment of human schistosomiasis. The existence of Praziquantel resistance by Schistosoma species is a threat and an alarm for strict monitoring and periodic evaluation of its efficacy. Method: We searched PubMed, PubMed Center, Google Scholar, Web of Science, Google, Science Direct, MEDLINE and proceedings of a professional association to identify studies published in English and assessed the efficacy of Praziquantel against Schistosoma mansoni infection in children. Studies reporting the efficacy of Praziquantel in both adult and children as study participants and studies which investigated the efficacy of Praziquantel combined with other antischistosomal drugs were excluded. Result: Since there was significant heterogeneity, the random effect model was used. A total of 9 papers involving 1,412 participants, that assessed the cure rate and 8 papers that assessed egg reduction rate of Praziquantel were included in the meta-analysis. The pooled cure rate of Praziquantel was 86.65% with 95% CI; 83.4-93.9. There was high heterogeneity (I2=93.4%). Subgroup analysis showed slightly higher Cure rate of Praziquantel in Amhara regional state compared to Oromia regional state (88.58% vs 84.79%). The egg reduction rate was 87.95% and 99.85% using geometric and arithmetic mean of egg count respectively. The prevalence of Schistosoma mansoni decreased from 55.77% to 11.29% after administration of Praziquantel. Conclusion: According to the result of this review, standard dose of Praziquantel was effective against Schistosoma mansoni infection among children in Ethiopia. The cure rate of Praziquantel was slightly higher in Amhara regional state compared to Oromia regional state. The drug showed a great reduction in egg count and intensity of infection.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"17 1","pages":"61"},"PeriodicalIF":0.0,"publicationDate":"2020-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77217796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Induced Abortion and Its Predictors Among Hawassa University Female Students 哈瓦萨大学女生人工流产及其预测因素

International journal of immunology and immunotherapy Pub Date : 2020-10-28 DOI: 10.11648/j.iji.20200803.13

Yohannes Fikadu Geda, Walelign Animut Tirfe, Molalign Mesele Gessese

{"title":"Induced Abortion and Its Predictors Among Hawassa University Female Students","authors":"Yohannes Fikadu Geda, Walelign Animut Tirfe, Molalign Mesele Gessese","doi":"10.11648/j.iji.20200803.13","DOIUrl":"https://doi.org/10.11648/j.iji.20200803.13","url":null,"abstract":"Global incidence of unsafe abortion among University students is increasing; and still frequent and worrisome in Universities of Ethiopia. There are a few studies on induced abortion among university students. There for this study was aimed to determine magnitude and predictors of induced abortion among Hawassa University female students. Institution based cross-sectional study was conducted from May 1-15, 2019 and 741 participants were selected from Hawassa University regular undergraduate female students. For entry and analysis EPidata and SPSS was used respectively. Association between dependent and independent variables were measured by adjusted odds ratio. Variables with p <0.25 on bivariate were used for multivariable analysis and p<0.05 were considered significant. Magnitude of induced abortion among Hawassa University students was 9.6%. From the respondents 68% of them age greater or equal to 20 (AOR=0.32, 95% CI: 0.14, 0.74) were less likely to have induced abortion compared to those respondents with age less than or equal to 19. Married respondents were 3.32 times (AOR=3.32, 95% CI: 1.51, 7.28) more likely to have induced abortion compared to not married respondents. From the respondents 95% of them who have heard only about short term contraceptive (AOR=1.95, 95% CI: 1.04, 3.66) were more likely to have induced abortion compared to those who have heard only about long term contraceptives. Respondents who have used methods to avoid pregnancy currently were 5.41 times (AOR=5.41, 95% CI: 2.73, 10.72) more likely to have induced abortion compared to who haven’t used any method. Induced abortion among Hawassa university female student was high compared to other studies. This study showed the independent predictors of abortion among Hawassa University students were age, marital status, type of contraceptive they know and using any method to avoid pregnancy currently.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89365524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Immunoinformatics Design of Novel Multi-Epitope Subunit Vaccine for SARS-CoV-2 by Exploring Virus Conserved Sequences of the Spike Glycoproteins 基于刺突糖蛋白保守序列的新型SARS-CoV-2多表位亚单位疫苗的免疫信息学设计

International journal of immunology and immunotherapy Pub Date : 2020-10-28 DOI: 10.11648/J.IJI.20200803.12

I. Ekaidem, A. Moses, Y. Tatfeng

{"title":"Immunoinformatics Design of Novel Multi-Epitope Subunit Vaccine for SARS-CoV-2 by Exploring Virus Conserved Sequences of the Spike Glycoproteins","authors":"I. Ekaidem, A. Moses, Y. Tatfeng","doi":"10.11648/J.IJI.20200803.12","DOIUrl":"https://doi.org/10.11648/J.IJI.20200803.12","url":null,"abstract":"Sars-CoV-2 infection also called COVID-19 is characterized by fever and signs of acute respiratory distress syndrome (ARDS). It is currently a global pandemic with high mortality rate in those with severe disease. Lack of effective vaccine and approved drug for treatment created a disastrous condition among the global communities. This study was designed as a step ahead in the path of protein-based subunit vaccine development. The primary amino acid sequence of SARS-CoV-2 spike glycoprotein was used to design a protein subunit vaccine construct. The molecular weight of vaccine protein was 58.4 kDa with a total number of 8170 atoms and 584 amino acid residues. The theoretical pI was found to be 8.54 showing its slightly basic nature while the total number of negative and positive charged residues were 29 and 33 respectively. The peptide vaccine construct has 147 (25.17%) polar residues and 375 (64.21%) hydrophobic residues. The vaccine construct has cytotoxic T lymphocyte (CTL), helper T lymphocyte (HTL) and B cell epitopes of varying lengths having great potential to stimulate high levels of IFN-γ production. It has potent antigenic properties but lacked allergenicity. It is stable and have a good binding affinity for the TLR-4 receptor. In general, this modelling applied a series of immunoinformatics tools in a sequential manner to find an effective vaccine that may be used effectively in fighting against the COVID-19 pandemic. This modelling, however, needs real life experimental validation to prove the workability of the computational work.","PeriodicalId":92912,"journal":{"name":"International journal of immunology and immunotherapy","volume":"67 1","pages":"42"},"PeriodicalIF":0.0,"publicationDate":"2020-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88923218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Exposure to Mould and Moisture Damage Is a Potential Risk Factor for the Development of Respiratory Diseases Opinion 暴露于霉菌和湿气损害是呼吸道疾病发展的潜在危险因素

International journal of immunology and immunotherapy Pub Date : 2020-08-10 DOI: 10.11648/J.IJI.20200803.11

J. Lohi, T. Tuomela, T. Tuuminen

引用次数: 0

Thymalin as a Potential Alternative in the Treatment of Severe Acute Respiratory Infection Associated with SARS-CoV-2 胸腺苷作为治疗SARS-CoV-2相关严重急性呼吸道感染的潜在替代品

International journal of immunology and immunotherapy Pub Date : 2020-08-08 DOI: 10.23937/2378-3672/1410055

A. L. Sergey, I. K. Boris, G. Konstantin, K. Vladimir, N. S. Yuri, K. Pavel, K. Yuri, A. Valery, E. Magen

引用次数: 1

Durable and Effectiveness of Immunotherapy in the Treatment of Metastatic Gastroesophageal Junction Cancer 免疫疗法治疗转移性胃食管结癌的持久性和有效性

International journal of immunology and immunotherapy Pub Date : 2020-07-09 DOI: 10.23937/2378-3672/1410053

F. Moreira, Camilo Gustavo Bittencourt, Dias Eleusa Nogueira, Oliveira Bianca Lopes de, Schanuel Carlos Murilo, Vasconcellos Juliana Abreu de, Assis EmÍlio Campos Augusto Pereira de

引用次数: 0