BMC Urology最新文献

{"title":"Pelvic floor muscle training for pelvic organ prolapse: A systematic review and meta-analysis of randomized controlled trials.","authors":"Zhicheng Cong, Zhao Wang, Junyi Sun, Zhengyan Tang, Wenjie Yan","doi":"10.1186/s12894-026-02230-1","DOIUrl":"10.1186/s12894-026-02230-1","url":null,"abstract":"<p><strong>Background: </strong>Pelvic organ prolapse (POP) substantially affects women's health and quality of life. Pelvic floor muscle training (PFMT) is a promising conservative treatment for POP, but evidence from randomized controlled trials (RCTs) remains diversity. This systematic review and meta-analysis aimed to evaluate the effectiveness of PFMT for POP.</p><p><strong>Methods: </strong>We conducted a systematic review by using the PICOS framework, including RCTs that aimed to compare PFMT with other conservative treatments for POP. Outcomes included POP Symptom Score (POP-SS), POP Quantification (POP-Q), self-reported symptom improvement, and pelvic floor muscle function (sEMG-MVC, endurance, Modified Oxford Grading).</p><p><strong>Results: </strong>A total of 16 studies were included in this meta-analysis. Compared with the control group, PFMT group was associated with lower POP-SS, higher sEMG-MVC, and greater pelvic floor muscle endurance. PFMT also improved self-reported symptom improvement, overall POP-Q stage, and anterior vaginal wall prolapse. No clear benefit was seen for posterior vaginal wall prolapse or Oxford grade. Short-term PFMT (≤ 6 months) showed beneficial effects, whereas long-term efficacy (> 6 months) and effects in individuals aged ≥ 55 years were not statistically significant.</p><p><strong>Conclusions: </strong>PFMT may improve short-term symptoms and pelvic floor muscle function in women with POP. However, long-term efficacy and effects in older women remain uncertain and require further investigation.</p><p><strong>Trial registration: </strong>Not applicable.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13632309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The doctors of the future: the competition of ChatGPT-4, ChatGPT-4 omni, and Gemini 2.0 Flash in andrology.","authors":"Umit Uysal, Ergun Alma, Adem Altunkol, Hakan Ercil, Mert Hamza Özbilen, Hakan Anıl, Kazım Yelsel, Burak Sağmak, Gökay Çetinkökü","doi":"10.1186/s12894-026-02248-5","DOIUrl":"10.1186/s12894-026-02248-5","url":null,"abstract":"<p><strong>Objectives: </strong>Large language models (LLMs) are increasingly being used in medical research and as clinical decision-support tools. This study aimed to compare the accuracy and reliability of responses generated by large language models in response to andrology-related questions.</p><p><strong>Materials and methods: </strong>Seventy questions concerning diagnosis, treatment, and general information were developed on the basis of the 2024 Andrology Guidelines of the European Association of Urology (EAU). These questions were submitted to three large language models, namely ChatGPT-4, ChatGPT-4o, and Google Gemini 2.0 Flash. The responses were independently evaluated by three senior urologists using a four-point rating scale. A total score (TS) > 9 indicated a good response, 6 ≤ TS ≤ 9 indicated a moderate response, and TS < 6 indicated a poor response. In addition, the self-correction capabilities of the models were evaluated, and changes in response accuracy after re-evaluation were analyzed.</p><p><strong>Results: </strong>ChatGPT-4o achieved the highest total scores in the diagnosis and treatment categories (p < 0.001). Google Gemini 2.0 Flash generated the longest responses but demonstrated the lowest accuracy. ChatGPT-4o also showed the greatest improvement following the self-correction process (Cohen's d = - 1.214, p < 0.01). Fleiss' kappa coefficient values ranged from 0.61 to 0.80, indicating substantial interrater agreement among the urologists.</p><p><strong>Conclusion: </strong>ChatGPT-4o emerged as the most reliable model for andrology-related questions, providing responses that are were highly consistent with current clinical guidelines. The self-correction capabilities of the models improved response accuracy, suggesting that error-awareness mechanisms in large language models have the potential for further refinement. Nevertheless, expert supervision remains essential for the safe implementation of AI-assisted systems in clinical practice.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13625468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148403617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of microRNAs-23b and 27b in migration, invasion and proliferation of T24 bladder cancer cells.","authors":"Felipe Fakhouri, Patrícia Candido, Ruan Pimenta, Vanessa R Guimarães, Guilherme Nebó, Carlo Passerotti, Carlos Eduardo da Silva, William C Nahas, Kátia Ramos Moreira Leite, Sabrina T Reis","doi":"10.1186/s12894-026-02241-y","DOIUrl":"10.1186/s12894-026-02241-y","url":null,"abstract":"<p><strong>Background: </strong>Bladder cancer (BC) is the sixth most common cancer among men worldwide and represents a significant cause of morbidity and mortality. High-grade BC is associated with an increased risk of progression to muscle-invasive and metastatic disease, negatively impacting patient prognosis. Despite advances in molecular characterization, therapeutic strategies remain limited, and the identification of novel molecular targets is essential. MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation and play critical roles in tumor development and progression. Among them, miRNA-23b and miRNA-27b have been implicated in several malignancies; however, their functional role in high-grade BC remains incompletely understood. This study aimed to evaluate the expression levels of miRNAs-23b and 27b in a high-grade BC cell line and to investigate their effects on cell migration, invasion, and proliferation, exploring their potential therapeutic relevance.</p><p><strong>Methods: </strong>The high-grade BC T24 cell line was used. Cells were divided into four groups: Control (no transfection), negative control (Scramble), miRNA-23b mimic, and miRNA-27b mimic. Relative miRNA expression levels were determined by quantitative polymerase chain reaction (qPCR). Functional assays included wound healing (migration), Matrigel invasion assay, and colony formation assay (proliferation). Statistical analyses were performed to compare groups, and p-values < 0.05 were considered statistically significant.</p><p><strong>Results: </strong>Transfection resulted in significant overexpression of miRNA-23b and miRNA-27b compared to both Scramble (p = 0.0344 and p = 0.0386, respectively) and Control groups (p = 0.0343 and p = 0.0390, respectively). Both miRNA-23b and miRNA-27b significantly reduced cell migration compared to Scramble (p = 0.0286). Additionally, miRNA-23b significantly decreased invasion compared to Scramble and Control (p < 0.0001), with similar findings observed for miRNA-27b (p < 0.0001). No statistically significant differences were observed in colony formation among groups.</p><p><strong>Conclusions: </strong>Overexpression of miRNA-23b and miRNA-27b significantly reduced migration and invasion in a high-grade BC cell line, without affecting proliferation. These findings suggest that both miRNAs may act as tumor suppressors in high-grade BC and represent promising candidates for future therapeutic development in bladder cancer.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13613786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual reality-based 3D prostate models for robot-assisted radical prostatectomy: a prospective exploratory study of membranous urethral length and early urinary continence recovery.","authors":"Raed A Azhar, Ahmad M Albarakaty, Shady Saikali, Mohamed Elkoushy","doi":"10.1186/s12894-026-02245-8","DOIUrl":"10.1186/s12894-026-02245-8","url":null,"abstract":"<p><strong>Objectives: </strong>To prospectively explore the feasibility and histopathological concordance of virtual reality (VR)-based 3D prostate models in robot-assisted radical prostatectomy (RARP) and to evaluate the association between VR-derived membranous urethral length (MUL) and early urinary continence recovery.</p><p><strong>Methods: </strong>VR-based 3D prostate models were generated for 35 patients with localized prostatic adenocarcinoma who underwent RARP. Tumor localization, extraprostatic extension (EPE), and seminal vesicle invasion (SVI) on the 3D models were compared with the final histopathology using Cohen's kappa coefficient and standard diagnostic accuracy measures. Urinary continence was assessed using the Expanded Prostate Cancer Index Composite (EPIC) survey, with social continence defined as the use of no pads or one safety pad per day and complete continence defined as zero pad use. Continence recovery was evaluated at 1, 3, and 6 months.</p><p><strong>Results: </strong>The mean patient age in the cohort was 63.2 years, the mean prostate-specific antigen (PSA) concentration was 13.36 ng/mL, and the mean prostate volume was 52.7 cc. Nerve-sparing surgery was performed in 74.3% of the patients, and extended pelvic lymph node dissection was performed in 20%. Pathologic stage ≥T3a occurred in 45.7% of patients, with a Gleason score ≤ 7 in 71.4%, an SVI in 14.3%, and positive margins in 2.9%. Perioperative complications were minimal (5.7%), with no transfusions. Continence recovery occurred in 85.7% of the patients at 3 months and 91.4% at 6 months. MUL correlated negatively with pad use at 3 months (Spearman's ρ = - 0.52), and a 14-mm MUL cutoff was associated with early continence recovery (AUC = 0.86). VR 3D models showed almost perfect agreement with the final histopathology for extraprostatic extension (EPE) (κ = 0.88; accuracy 94.3%) and perfect agreement for SVI (κ = 1.00).</p><p><strong>Conclusions: </strong>VR-based 3D prostate models may represent a useful adjunct for surgical planning in RARP and could help inform nerve-sparing strategies. MUL, as measured by these models, may be a valuable factor associated with early urinary continence recovery. These exploratory findings should be interpreted with caution and require confirmation in larger, multicenter prospective studies with longer follow-up periods.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information quality and reliability of pheochromocytoma-related videos on tiktok and Kwai: a cross-sectional study.","authors":"Jun Luo, Ziliang Chen, Runfu Cao, Kaihong Wang","doi":"10.1186/s12894-026-02242-x","DOIUrl":"10.1186/s12894-026-02242-x","url":null,"abstract":"<p><strong>Background: </strong>Short-video platforms are major sources of health information, yet the quality of pheochromocytoma-related content is unclear. We assessed and compared the quality and reliability of related videos on TikTok and Kwai.</p><p><strong>Methods: </strong>Using the Chinese keyword \",\" we searched TikTok and Kwai (24-25 Dec 2025) with a newly created account and retrieved the first 120 videos from each platform under the default \"comprehensive\" ranking. After exclusions, 178 videos were included (TikTok, n = 100; Kwai, n = 78). Video metrics, uploader characteristics, and content features were extracted. Quality and reliability were assessed using GQS (1-5) and mDISCERN (0-5) by two blinded reviewers, with disagreements resolved by a third reviewer. We compared video characteristics and GQS/mDISCERN scores between TikTok and Kwai, and performed subgroup analyses by uploader identity and physician specialty. Nonparametric tests and Spearman correlation analyses were conducted using R 4.1.3.</p><p><strong>Results: </strong>Median video length was 73.0 s; median GQS and mDISCERN were both 2.0, indicating generally low quality and reliability. Most videos were posted by healthcare personnel (81.5%), predominantly urologists (50.6%). TikTok videos were longer and had higher likes, comments, and collections (all P < 0.001). mDISCERN was higher on TikTok (P = 0.047), while GQS did not differ (P = 0.580). Video length correlated with GQS (r = 0.46) and mDISCERN (r = 0.41), whereas engagement metrics were not reliable proxies for credibility.</p><p><strong>Conclusions: </strong>Pheochromocytoma-related short videos on TikTok and Kwai show limited quality and reliability despite professional authorship. Improvements should prioritize verifiable sources and decision-relevant risk framing, supported by platform-level quality labeling and distribution strategies.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13602731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early urinary decompression and mortality in septic obstructing ureteral stones: a nationwide comparative-effectiveness study.","authors":"Mohamed Mahmoud Dogha, Atef A Hassan, Osama Mostafa Mohamed, Mahmoud Farag, Islam S Nouh, Mohamed Hamdy Ibrahim, Assem Abdelaziz Mesbah, Mohamed F Elebiary, Nader A Abdelkhalek, Adel Moalwi","doi":"10.1186/s12894-026-02119-z","DOIUrl":"10.1186/s12894-026-02119-z","url":null,"abstract":"<p><strong>Background: </strong>Septic obstructing ureteral stones are a time-critical urological emergency. Although urgent drainage is recommended, uncertainty persists regarding the comparative effectiveness of decompression strategies and the influence of timing in real-world practice.</p><p><strong>Methods: </strong>We analyzed adults with sepsis or septic shock and obstructing ureteral stones (n = 9,172) from the U.S. HCUP National Inpatient Sample (2016-2022). Exposures included any decompression (ureteral stent or percutaneous nephrostomy [PCN]) versus conservative care, and decompression timing (same-day [day 0] vs. ≥ day 1; ≤ 24 h vs. > 24 h). The primary outcome was in-hospital mortality; secondary outcomes were acute kidney injury (AKI), mechanical ventilation, dialysis, and length of stay. Adjusted associations were estimated using propensity score matching, overlap weighting, instrumental variable (IV) analysis, and landmark/time-dependent survival models with a prespecified 12-variable adjustment set.</p><p><strong>Results: </strong>Overall mortality was 2.5%. Decompression was associated with lower mortality than conservative care (1.6% vs. 4.0%; risk difference - 2.4% [95% CI - 3.2 to - 1.7]; number needed to treat ≈ 41). Late decompression (> 24 h) versus early (≤ 24 h) was associated with higher odds of mortality (OR 2.17 [1.38-3.41]), AKI, ventilation, and dialysis. In exploratory analyses among decompressed patients, PCN showed higher adjusted mortality than stenting (5.5% vs. 2.8%; OR 2.05 [1.31-3.09]); IV results were directionally consistent but likely reflect residual confounding by indication and feasibility.</p><p><strong>Conclusion: </strong>Urgent decompression, particularly within 24 h, was associated with lower in-hospital mortality and fewer organ-failure outcomes. Modality differences should be interpreted as hypothesis-generating; PCN remains essential when retrograde stenting is not feasible.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13335030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The \"perfect storm\" in bladder oncology: a case of diverticular carcinoma with plasmacytoid features and its clinical ramifications.","authors":"Qiuhong Fan, Zhanpei Fu, Xiamo Zheng, Gangping Wang","doi":"10.1186/s12894-026-02236-9","DOIUrl":"10.1186/s12894-026-02236-9","url":null,"abstract":"<p><strong>Background: </strong>Carcinoma arising within a bladder diverticulum is a rare and diagnostically challenging entity. Its management is further complicated by aggressive histological variants such as plasmacytoid urothelial carcinoma (PUC). The anatomical lack of muscularis propria in diverticula predisposes to early extra‑diverticular spread and impedes accurate clinical staging. The coexistence of a diverticular location and plasmacytoid histology creates a high‑risk clinical scenario with limited evidence to guide therapy.</p><p><strong>Case presentation: </strong>A 74‑year‑old male with a history of high‑grade urothelial carcinoma, previously treated with transurethral resection and two cycles of neoadjuvant chemotherapy (gemcitabine plus cisplatin), was found on imaging to have a persistent tumor within a right‑sided bladder diverticulum. He underwent robot‑assisted laparoscopic radical cystectomy. Histopathological examination confirmed high‑grade PUC with 40% squamous differentiation. The tumor invaded peridiverticular adipose tissue (pT3a) and exhibited extensive lymphovascular invasion (> 10 vessels). Immunohistochemistry was positive for GATA3 (weak), p63, CD138 (partial), and CK7 (weak positivity), with PD‑L1 expression (Combined Positive Score = 5), Focal weak membranous E-cadherin staining in approximately 30% of tumor cells, HER2 equivocal (2+). Surgical margins and lymph nodes were negative. The patient was disease‑free at the 3‑month postoperative follow‑up. However, 5 months after surgery, pelvic MRI revealed metastatic lesions, consistent with stage IV disease (rT0N+M1). He subsequently received palliative radiotherapy to the pelvis (200 cGy×25f) and combined targeted therapy (disitamab vedotin 120 mg) plus immunotherapy (toripalimab 240 mg). At the last follow‑up in May 2026 (approximately 7 months postoperatively), he was clinically stable without severe symptoms and continued outpatient radiotherapy.</p><p><strong>Conclusion: </strong>This case highlights the diagnostic and therapeutic complexities of managing high‑grade PUC within a bladder diverticulum. It underscores the essential role of high‑quality cross‑sectional imaging for assessing extra‑diverticular extension, the need for meticulous pathological evaluation to identify this aggressive variant, and the centrality of radical surgery. The presence of lymphovascular invasion and PD‑L1 expression supports the consideration of multimodal strategies and close surveillance. Given the rarity of this dual‑pathology entity, collaborative reporting is crucial to optimize management and improve outcomes.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13595683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of services and patient reported outcomes for prostate cancer in Tanzania: the role of patients' satisfaction from a cross-sectional study.","authors":"Obadia Nyongole, Castory Munishi, Njiku Kimu, Gudila Valentine Shirima, Raphael Z Sangeda, Mark Mseti, Emmanuel Lugina, Frank Kiwara, Nathanael Sirili, Frank Chacha, Bartholomeo Nicholaus, Henry Mruma, Gasto Frumence, Daudi Simba, David Urassa, Bruno Sunguya","doi":"10.1186/s12894-026-02231-0","DOIUrl":"10.1186/s12894-026-02231-0","url":null,"abstract":"<p><strong>Background: </strong>The increasing global burden of prostate cancer challenges the quality of services in low- and middle-income countries (LMICs) due to infrastructure and limitations in human resources for health. Higher quality of services as perceived by patients, is associated with improved health-related quality of life (HRQoL). This study was designed to assess patients' satisfaction with the quality of services and its association with HRQoL among prostate cancer patients.</p><p><strong>Methods: </strong>The hospital-based cross-sectional study was conducted among 248 systematically sampled prostate cancer patients under treatment from five tertiary hospitals in Tanzania. The standard patient satisfaction questionnaire and the Expanded Prostate Cancer Index Composite (EPIC) were used to measure HRQoL. Descriptive analysis was used to determine levels and characteristics of patients' satisfaction with quality of services and HRQoL, while regression analysis was conducted to examine the association between patients' satisfaction and HRQoL.</p><p><strong>Results: </strong>Of the sampled prostate cancer patients, 169 (68.3%) experienced delays in seeking treatment, and a high proportion (85.4%) presented with clinically advanced stage of prostate cancer. Two-thirds of the patients were not satisfied with the quality of services. Key areas of dissatisfaction included long waiting times (75.4%), limited counselling services (77.4%), and a lack of opportunity to discuss their problems with doctors (67.3%). The overall HRQoL score was low (36 out of 60 score), with sexual domain scoring the lowest (5.81%). A unit increase in patient satisfaction was associated with five-times increase in HRQoL β-coefficient 5.25 95%, CI (2.42, 8.08).</p><p><strong>Conclusions: </strong>Patient satisfaction is a primary driver of health-related quality of life, suggesting that system-level improvements are more vital for patients reported outcomes than biological factors alone. Improving these outcomes requires targeted policy shifts, decentralized care, and stronger financial protections for patients. Key areas of improvements include waiting time and tailored counselling services.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13595789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between premature ejaculation and depressive symptoms in HIV-infected men: a multicenter case-control study.","authors":"Oğuz Evlice, Emre Bülbül, Fatih Üstün, Mustafa Deniz, Ahmet Basutçu, Serhat Şahinoğlu, Yusuf Arslan","doi":"10.1186/s12894-026-02235-w","DOIUrl":"10.1186/s12894-026-02235-w","url":null,"abstract":"<p><strong>Background: </strong>Depressive symptoms are common among people living with HIV (PLWH) and may adversely affect sexual function. However, the relationship between HIV infection and premature ejaculation (PE) has not been clearly defined. This study aimed to evaluate depressive symptoms in HIV-infected men and investigate their association with PE.</p><p><strong>Methods: </strong>This multicenter case-control study included 112 HIV-infected men and 110 age-matched healthy controls who presented to infectious diseases outpatient clinics between March and September 2025. All participants completed the Turkish validated versions of the Premature Ejaculation Diagnostic Tool (PEDT) and the Beck Depression Inventory (BDI). PE was defined as a PEDT score ≥ 11.</p><p><strong>Results: </strong>The mean age of PLWH was 36.3 ± 11.9 years, compared with 39.6 ± 10.8 years in the control group. Both PEDT and BDI scores were significantly higher in PLWH than in controls (p < 0.001 for both). PE was present in 49 (43.8%) HIV-infected men and 23 (20.9%) controls (p < 0.001). Among PLWH, those with PE had significantly higher BDI scores than those without PE (16.8 ± 10.1 vs. 10.7 ± 8.9, p = 0.009). In multivariable logistic regression analysis, BDI score remained independently associated with PE after adjustment for erectile function, age, and disease duration.</p><p><strong>Conclusions: </strong>HIV-infected men demonstrated higher rates of PE and more severe depressive symptoms compared with healthy controls. Among PLWH, depressive symptom severity remained significantly associated with PE after adjustment for erectile function, age, and disease duration.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13595770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of robot-assisted laparoscopic radical cystectomy combined with urinary diversion: preoperative indicators and survival outcomes analysis at a single center.","authors":"Conggui Liu, Yongpan Zhu, Yuanjian Liao, Xinqi Yang, Changyong Zhao, Neng Zhang","doi":"10.1186/s12894-026-02177-3","DOIUrl":"10.1186/s12894-026-02177-3","url":null,"abstract":"<p><strong>Objective: </strong>To compare the preoperative indexes and survival outcomes between da Vinci robot-assisted radical cystectomy (RARC) and laparoscopic radical cystectomy (LRC), and to analyze the clinical differences among the three types of urinary diversion modalities, namely, intracorporeal ileal neobladder (Studer type), Bricker's procedure, and ureterocutaneostomy.</p><p><strong>Methods: </strong>A total of 194 patients who underwent minimally invasive radical cystectomy in the Department of Urology of the Affiliated Hospital of Zunyi Medical University from January 2010 to December 2024 were retrospectively analyzed and divided into the laparoscopic group (152 patients) and the robotic group (42 patients) according to surgical modalities. Perioperative indexes and survival outcomes of the two groups were compared, and the clinical differences among the three urinary diversion modalities were analyzed.</p><p><strong>Results: </strong>The duration of surgery was significantly shorter in the robotic group than in the laparoscopic group (5.17 h vs. 6.75 h, P<0.001), but there was no significant difference in overall survival and complication rates between the two groups. Among the urinary diversion modalities, the median survival was the longest in the intracorporeal ileal neobladder group (55 months), which was significantly better than that of the Bricker procedure (25 months) and ureterocutaneostomy (13 months) (P<0.001). Multifactorial analysis showed that elevated ASA classification (HR=14.99-20.16) and male gender (HR=1.96) were independent risk factors in the laparoscopic group, whereas prolonged operative duration was associated with a reduced risk (HR=0.56). In patients with the Bricker procedure, ASA classification (P=0.001) and gender (P=0.032) significantly influenced prognosis.</p><p><strong>Conclusion: </strong>Robot-assisted radical cystectomy (RARC) has significant short-term surgical advantages over laparoscopic radical cystectomy (LRC). Among different urinary diversion methods, intracorporeal ileal neobladder is associated with longer survival, although this largely reflects patient selection bias. The choice of specific surgical approach should be based on a comprehensive consideration of the patient's individual circumstances.</p>","PeriodicalId":9285,"journal":{"name":"BMC Urology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13602760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}