British journal of anaesthesia最新文献

{"title":"What we used, what we saw, what we did: towards a shared language for videolaryngoscopy.","authors":"Miguel Ángel Fernández-Vaquero, Rajinder Singh Chaggar, Manuel Ángel Gómez-Ríos, Tim Cook","doi":"10.1016/j.bja.2026.03.036","DOIUrl":"https://doi.org/10.1016/j.bja.2026.03.036","url":null,"abstract":"<p><p>Videolaryngoscopy is now recommended as a first-line technique for tracheal intubation in many clinical settings. However, documentation practises continue to rely on concepts developed for direct laryngoscopy, where the laryngeal view was closely linked to intubation success. In videolaryngoscopy, the link between excellent visualisation and ease of tube delivery may be less direct, limiting the interpretative value of view-based descriptors alone. Rather than proposing new classification systems, this editorial advocates a process-based descriptive language structured around three elements: what was used, what was seen, and what was done. This framework has the potential to complement existing grading systems and clinical guidelines and improve the clarity and usefulness of airway documentation in modern practice.</p>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The multifaceted neural architecture of pain modulation by emotion and cognition: a systematic review and meta-analysis.","authors":"Laura M Modernell, Isabelle Faillenot, Luis Garcia-Larrea, Camille Fauchon","doi":"10.1016/j.bja.2026.03.015","DOIUrl":"https://doi.org/10.1016/j.bja.2026.03.015","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to systematically review functional neuroimaging literature on the neural substrates underlying contextual modulation of pain in healthy individuals.</p><p><strong>Methods: </strong>A search was conducted in PubMed-Medline, Cochrane, and Web-of-Science databases (PROSPERO-CRD42024586392). Studies on chronic pain were excluded, and the risk of bias was assessed with Cochrane RoB2. Spatial coordinates of brain regions undergoing activity changes were included in a meta-analysis using both Activation Likelihood Estimation and frequency estimation of activated or deactivated regions in individual studies (convergence analysis).</p><p><strong>Results: </strong>From 224 full texts reviewed and n=100 articles retained (2735 individuals), three broad activity patterns were identified. One involved activation of prefrontal cortical areas, together with a modification of the sensory message in nociceptive cortical areas (deactivated during hypoalgesia and hyperactivated in hyperalgesia), consistent with top-down regulation via descending controls. A second configuration also involved prefrontal mobilisation, but without activity changes in nociceptive areas and was consistent with a 'perceptual decision bias'. A third configuration was associated with irregular ventromedial prefrontal involvement and significant deactivation in dorsolateral and ventrolateral prefrontal areas. While the first two patterns were observed in a range of attentional or expectation manipulations, including placebo/nocebo, the third pattern was essentially observed during tasks involving introspection and self-referential procedures such as meditation, religious prayer or nostalgia.</p><p><strong>Conclusions: </strong>Similar subjective pain changes can coexist with different brain activation patterns, reflecting diverse neural strategies. Whereas prefrontal cortex-driven descending modulation is one mechanism, introspective approaches can alter perception without involving prefrontal activity. This mechanistic diversity supports multiple avenues for behavioural or neuromodulation-based pain control.</p>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propofol inhibits norepinephrine release in vivo at presynaptic varicosities of locus coeruleus neurones in zebrafish larvae. Response to Br J Anaesth 2026; 136: 1700-1701.","authors":"Wenjie Du, Yingwei Wang","doi":"10.1016/j.bja.2026.03.044","DOIUrl":"https://doi.org/10.1016/j.bja.2026.03.044","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostaglandins prevent long-lasting pain in a mouse model of chronic postsurgical pain: reconciling animal and clinical evidence. Comment on Br J Anaesth 2026; 136: 641-52.","authors":"Patrice Forget","doi":"10.1016/j.bja.2026.03.051","DOIUrl":"https://doi.org/10.1016/j.bja.2026.03.051","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative management of patients taking sodium-glucose cotransporter 2 inhibitors: Society for Perioperative Assessment and Quality Improvement (SPAQI) multidisciplinary consensus statement.","authors":"Adriana D Oprea, Basma Mohamed, David L Hepner, Moises Auron, Deborah C Richman, Guillermo E Umpierrez, Daniel Edmonston, Costin Ionescu, Mandeep Kumar, BobbieJean Sweitzer","doi":"10.1016/j.bja.2026.02.031","DOIUrl":"https://doi.org/10.1016/j.bja.2026.02.031","url":null,"abstract":"<p><p>The perioperative management of patients using sodium-glucose cotransporter 2 inhibitors (SGLT2is) remains controversial. The US Food and Drug Administration currently recommends stopping SGLT2is for 3-4 days before surgery, irrespective of a diagnosis of diabetes mellitus. Other multisociety recommendations vary significantly in terms of SGLT2i management, perioperative monitoring, and mitigating strategies for euglycaemic diabetic ketoacidosis. This multidisciplinary consensus statement led by the Society for Perioperative Assessment and Quality Improvement (SPAQI) provides updated recommendations based on a modified Delphi process and supported by a systematic review of the literature. The recommendations include a tailored approach to management of SGLT2is perioperatively based on the presence of diabetes mellitus and other comorbidities, surgical and periprocedural dietary considerations, as well as monitoring and prevention strategies for euglycaemic diabetic ketoacidosis.</p>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase 1 single-centre, placebo and levobupivacaine controlled study in healthy volunteers to assess the safety, tolerability, efficacy, and pharmacokinetics of LL10, a novel long-acting local anaesthetic. Comment on Br J Anaesth 2026; 136:959-69.","authors":"Jing Yang, Weifeng Yao, Sufang Chen","doi":"10.1016/j.bja.2026.03.045","DOIUrl":"https://doi.org/10.1016/j.bja.2026.03.045","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological factors associated with postoperative cognitive outcomes in older adults: reconciling adjusted effect estimates with P-value synthesis. Comment on Br J Anaesth 2026; 136: 1782-94.","authors":"Yimiao Xu, Qingqing Li","doi":"10.1016/j.bja.2026.03.048","DOIUrl":"https://doi.org/10.1016/j.bja.2026.03.048","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sip, don't skip: implementing 1-hour fasting in paediatric anaesthesia. Comment on Br J Anaesth 2026; 136: 812-15.","authors":"Rodrigo Poves-Álvarez, Beatriz Martínez-Rafael, Eduardo Tamayo, Estefanía Gómez-Pesquera","doi":"10.1016/j.bja.2026.03.041","DOIUrl":"https://doi.org/10.1016/j.bja.2026.03.041","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"European Malignant Hyperthermia Group 2025 guidelines for the investigation of malignant hyperthermia susceptibility: the indispensable educational loop from guidelines to rescue. Comment on Br J Anaesth 2026; 136: 653-61.","authors":"Xiaona Lin, Yinyin Qu, Shixian Gu, Xiangyang Guo, Zhengqian Li","doi":"10.1016/j.bja.2026.03.043","DOIUrl":"https://doi.org/10.1016/j.bja.2026.03.043","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astrocyte-neurone crosstalk mediates dexmedetomidine sedation.","authors":"Beverley A Orser, Connor T A Brenna, Mervyn Maze","doi":"10.1016/j.bja.2026.03.025","DOIUrl":"https://doi.org/10.1016/j.bja.2026.03.025","url":null,"abstract":"<p><p>As the clinical applications of dexmedetomidine expand, advances in neuroscientific research have provided further insights into its mechanisms of action. We provide a focused overview of the role that astrocytes play in the changes in neurotransmission that accompany the sedative action of dexmedetomidine. After activation of astrocytic α₂A-adrenergic receptors, the subsequent rise in cytosolic calcium increases the permeability of bestrophin-1 channels, facilitating the release of γ-aminobutyric acid (GABA) that stimulates extrasynaptic GABA_A receptors on glutamatergic neurones. This signalling cascade, involving multiple receptor systems, reduces neuronal excitability.</p>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}