British journal of anaesthesia最新文献

{"title":"C1q-mediated synapse loss by microglial phagocytosis is associated with postoperative neurocognitive disorder in mice.","authors":"Jingjing Lv, Liang Yao, Lili Tang, Qibing Li, Lixia Wang, Xunchuan Yan, Mengmeng Li, Wenjing Peng, Huiwen Zhang, Jiaxin Guo, Juntao Weng, Bin Mei, Jiqian Zhang, Zhilai Yang, Qiying Shen, Yao Lu, Yongquan Chen, Jun Hu, Mervyn Maze, Xuesheng Liu","doi":"10.1016/j.bja.2026.02.024","DOIUrl":"https://doi.org/10.1016/j.bja.2026.02.024","url":null,"abstract":"<p><strong>Background: </strong>Perioperative neurocognitive disorders (PNDs) are common complications in elderly surgical patients. Possible pathogenic mechanisms for the development of PNDs include loss of synaptic connections mediated by microglial activation, although the precise mechanisms are not fully understood.</p><p><strong>Methods: </strong>Male and female C57BL/6J or male Cx3cr1-CreERT2 mice, aged 8-12 weeks, were subjected to aseptic tibial fracture surgery, and cognitive tests were carried out 3 days after surgery. Through a combination of bulk RNA sequencing, Western immunoblotting, immunofluorescence, and Golgi staining of the hippocampus, we investigated the role of complement C1q in activating microglia and phagocytosing synaptic connections in the pathogenesis of postoperative neurocognitive disorder.</p><p><strong>Results: </strong>Postoperative mice displayed memory deficits in both the Y-maze (P<0.001) and the trace fear conditioning (TFC) paradigms (P=0.002); these memory deficits were associated with increased microglial activation, complement C1q upregulation, classical complement pathway transcriptomic upregulation, and synapse loss (all P<0.05). After surgery, there was a ∼2-fold increase in colocalisation of C1qa with Homer1 (excitatory) or gephyrin (inhibitory) synaptic proteins in microglia (P<0.001). Postoperative memory decline and synapse loss did not occur after treatment with microglial activity inhibitor minocycline, after exposure to C1q neutralising antibody JL-1, or after C1q depletion from CA1 microglia. Activation of NF-κB was correlated with elevated levels of complement C1q in models, and selective inhibition of NF-κB activation with pyrrolidinedithiocarbamate ammonium (PDTC) attenuated the surgery-induced elevation of C1q and improved cognitive function.</p><p><strong>Conclusions: </strong>The results demonstrate that hippocampal microglia prune both excitatory and inhibitory synapses in a C1q-dependent manner, contributing to postoperative synapse loss and cognitive dysfunction. Targeting C1q and NF-κB activation could be a promising therapeutic intervention to ameliorate perioperative neurocognitive disorders.</p>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A minimally invasive anaesthetic approach for transcatheter aortic valve implantation: is this really supported by the evidence?","authors":"Matthias Heringlake, Lennart H Muras, Simon Schemke","doi":"10.1016/j.bja.2026.03.035","DOIUrl":"https://doi.org/10.1016/j.bja.2026.03.035","url":null,"abstract":"<p><p>In association with growing operator experience and increasingly sophisticated delivery systems and valve prostheses, the anaesthetic management of patients undergoing transfemoral transcatheter aortic valve implantation (TAVI) has changed in many centres from general anaesthesia with invasive monitoring to local anaesthesia with conscious sedation or solely local anaesthesia. In a recent issue of the British Journal of Anaesthesia, a group of Italian experts in cardiac anaesthesia, cardiology, and cardiac surgery present an interdisciplinary consensus on the anaesthetic management of TAVI patients, recommending that a minimally invasive approach should be favoured in most cases. We critically evaluate the observational data supporting this consensus in comparison with the evidence from the available randomised controlled trials and highlight the need for an individual approach for anaesthetic management best suited to ensure safe and successful TAVI procedures.</p>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low cardiac index during periods of arterial hypotension and risk of acute kidney injury in cardiac surgery.","authors":"Lee A Goeddel, Lily Koffman, Xinkai Zhou, Marina Hernandez, Angela Zhao, Chetan Pasrija, Amit K Saha, John Muschelli, Chirag R Parikh, Ciprian M Crainiceanu, Charles Brown, Ashish K Khanna, Nauder Faraday","doi":"10.1016/j.bja.2026.02.037","DOIUrl":"https://doi.org/10.1016/j.bja.2026.02.037","url":null,"abstract":"<p><strong>Background: </strong>Cardiac index (CI) and mean arterial pressure (MAP) are concurrent determinants of renal perfusion. Hypotension is associated with acute kidney injury (AKI), but clinical trials focused solely on raising intraoperative MAP showed no benefit. Whether CI provides useful clinical information is controversial. We evaluated the association between AKI and low CI during periods of hypotension in cardiac surgery. Length of stay (LOS) was a secondary outcome.</p><p><strong>Methods: </strong>In adults undergoing coronary artery bypass (CAB) surgery with cardiopulmonary bypass, MAP and CI were recorded every minute. Duration of exposure to eight joint ranges of MAP (< or ≥65 mm Hg) and quartiles of CI were calculated. Logistic regression estimated odds ratios (ORs) with 95% confidence intervals for AKI adjusted for all covariates, time in each joint MAP/CI range, and duration of hypotension.</p><p><strong>Results: </strong>Among 1272 participants (67 [50-90] yr, 21% female), 379 (30%) were exposed to ≥5 min of joint hypotension/low CI (CI≤2 L min^-1 m^-2). Joint hypotension/CI≤2 was associated with an 11% increased risk of AKI (adjusted OR=1.11 per 5-min, 95% confidence interval: 1.02-1.22, P=0.021) independent of all covariates. Adjustment for duration of hypotension had no impact on results, and hypotension was not associated with AKI in adjusted models. Hypotension/CI≤2 was associated with increased ICU LOS (adjusted time ratio = 1.04 per 5-min, 95% confidence interval: 1.02-1.07, P=0.002) and hospital LOS (adjusted time ratio = 1.02, 95% confidence interval: 1.00-1.03, P=0.009); hypotension/CI>2 was not.</p><p><strong>Conclusions: </strong>Joint exposure to hypotension/CI≤2 during cardiac surgery was associated with AKI and increased LOS, whereas exposure to hypotension/CI>2 was not. Prospective interventional trials are needed to evaluate whether the relationship between CI and AKI is indeed causal and whether CI-guided therapy can help reduce AKI.</p>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The environmental footprint and ecotoxicity of sevoflurane and propofol anaesthesia: a retrospective observational modelling study.","authors":"Matthieu Bernat, Alain Kalmar, Philippe Cuvillon, Manon Roche, Anne Remacle, Bruno Pastene, Marc Leone, Lionel Bouvet, Hans Peter H Arp, Laurent Zieleskiewicz","doi":"10.1016/j.bja.2026.03.042","DOIUrl":"https://doi.org/10.1016/j.bja.2026.03.042","url":null,"abstract":"<p><strong>Background: </strong>General anaesthesia contributes to healthcare-related environmental impacts through anaesthetics with high global warming potential and ecotoxicity. Inhalational anaesthetics have high global warming potential, whereas propofol-based total i.v. anaesthesia (TIVA) has potential for aquatic toxicity. However, the lowest global warming potential fluorinated anaesthetics used, such as sevoflurane, degrade to trifluoroacetic acid (TFA), which is accumulating irreversibly in the environment. We compared the water contamination potential across three anaesthetic strategies: TIVA with propofol, target-controlled inhalational anaesthesia (TCIA) with sevoflurane, and manually optimised low-flow sevoflurane anaesthesia.</p><p><strong>Methods: </strong>This retrospective observational modelling study included adult general anaesthesia procedures from three French university hospitals, each using one strategy (TIVA, TCIA, or manual sevoflurane). Anaesthetic consumption was obtained from pharmacy records. Using published physicochemical data and established regulatory concentration thresholds, we calculated estimated instantaneous and long-term water contamination potential for propofol and sevoflurane-derived TFA.</p><p><strong>Results: </strong>TIVA, TCIA, and manually optimised sevoflurane strategies were used in 10 717, 7207, and 15 461 cases, respectively. In a 10-yr simulation assuming 1000 h of general anaesthesia per year, TFA accumulated linearly to 29-35 million m³ in halogenated strategies, whereas propofol contamination reached a steady plateau after ∼5 yr in the TIVA strategy to 2.6-2.9 million m³ depending on waste management.</p><p><strong>Conclusions: </strong>TIVA with propofol generated less water contamination and avoided TFA release while producing locally biodegradable residues. Conversely, sevoflurane-derived TCIA and manual methods led to higher TFA emissions, contributing to its global irreversible accumulation. These findings warrant consideration when minimising the environmental impacts of anaesthetic practises.</p>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TET1 downregulation in the dorsal root ganglion and spinal cord is required for short-term sleep disturbance to delay surgical pain recovery.","authors":"Jing Cao, Po-Kai Wang, Bo Xu, Xiyao Gu, Zhiqiang Pan, Weihua Cai, Songxue Su, Zhixiao Li, Julia Delorenzo, Alex Bekker, Huijuan Hu, Yuan-Xiang Tao","doi":"10.1016/j.bja.2026.02.025","DOIUrl":"https://doi.org/10.1016/j.bja.2026.02.025","url":null,"abstract":"<p><strong>Background: </strong>Sleep disturbance delays surgical pain recovery. This impact is associated with gene dysregulation in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH). However, the mechanisms underlying this dysregulation remain unclear.</p><p><strong>Methods: </strong>Expression of ten-eleven translocation methylcytosine dioxygenase 1 (TET1) was examined in the DRG and SDH following plantar incision in rats subjected to short-term rapid eye movement sleep disturbance. A herpes simplex virus expressing Tet1 mRNA (HSV-TET1) was microinjected into the ipsilateral L4 and L5 DRGs or SDH, and its effects on μ-opioid receptor (MOR) expression, TET1 binding to the Oprm1 promoter, and promoter-associated 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) levels in microinjected regions were assessed. Pain behaviours were evaluated, and the effect of Tet1 siRNA microinjection, with or without a lentivirus expressing Oprm1 mRNA (LV-MOR), on MOR expression in microinjected DRGs and SDH and nociceptive threshold in naïve rats was assessed.</p><p><strong>Results: </strong>Short-term rapid eye movement sleep disturbance downregulated TET1 in the ipsilateral L4 and L5 DRGs and SDH and prolonged incisional pain. HSV-TET1 microinjection restored MOR expression, TET1 binding activity to the Oprm1 promoter, and 5hmC levels at the promoter, while reducing 5mC accumulation, in microinjected L4 and L5 DRGs or SDH and prevented short-term rapid eye movement sleep disturbance-induced prolongation of incisional pain. Conversely, Tet1 siRNA microinjection reduced MOR expression in microinjected L4 and L5 DRGs or SDH and induced nociceptive hypersensitivity, effects abolished by LV-MOR co-microinjection.</p><p><strong>Conclusions: </strong>TET1 downregulation is required for short-term sleep disturbance to delay surgical pain recovery, likely by reducing μ-opioid receptor expression in the dorsal root ganglion and spinal dorsal horn.</p>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of postoperative delirium with haemodynamic determinants of cerebral perfusion pressure during cardiac surgery: a retrospective cohort study.","authors":"Lee A Goeddel, Jonathan Gomez, Marina Hernandez, Lily Koffman, Zachary Murphy, Grace Wayson, Glenn Whitman, Karen Bandeen-Roche, John Muschelli, Ciprian M Crainiceanu, Nauder Faraday, Charles H Brown","doi":"10.1016/j.bja.2026.03.018","DOIUrl":"https://doi.org/10.1016/j.bja.2026.03.018","url":null,"abstract":"<p><strong>Background: </strong>Delirium is common after cardiac surgery, and an important factor could be cerebral perfusion. As cerebral perfusion pressure (CPP) is determined by the difference between mean arterial pressure (MAP) and central venous pressure (CVP), which are modifiable factors, understanding their relationship with delirium is essential.</p><p><strong>Methods: </strong>In a retrospective cohort study, patients undergoing cardiac surgery were assessed for delirium using the Confusion Assessment Method for the ICU. Haemodynamic exposures were calculated as time spent in narrow ranges: 14 MAP ranges in increments of 5 mm Hg (45-115), 10 CVP ranges in increments of 2 mm Hg (0-20), and 70 joint MAP/CVP ranges. Separate regression models estimated odds ratios for each range (or predefined zones of adjacent ranges), adjusted for covariates and multiple comparisons. Simulations estimated the effect of redistributing MAP/CVP exposures.</p><p><strong>Results: </strong>In 1759 patients, 345 (19.6%) developed delirium. In predefined zones that grouped MAP and CVP ranges, delirium was associated with time spent in the cerebral hypoperfusion zone (adjusted odds ratio 1.02, 95% confidence interval 1.00-1.03, P=0.04). Simulated reductions of time in zones of cerebral hypoperfusion and hyperperfusion reduced delirium, particularly in patients with prolonged exposures to these zones. There were also associations between delirium and time in individual haemodynamic ranges of high CVP/low MAP (hypoperfusion) and high MAP/low CVP (hyperperfusion).</p><p><strong>Conclusions: </strong>Delirium was associated with a zone of low cerebral perfusion pressure in adjusted models and individual ranges of low and high cerebral perfusion pressures. Trials to assess whether optimising cerebral perfusion reduces delirium are needed but may require large enrolment or prognostic enrichment.</p>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microglial activation disrupts hippocampal CA1 sharp-wave ripples via the CA3-CA1 neural circuit that contributes to postoperative memory consolidation deficits in aged mice.","authors":"Jiangnan Wu, Xu Wang, Wei Li, Wei Sun, Hao Feng, Zunsai Feng, Ziqing Xu, Zhun Wang, Gongming Wang, Mengyuan Zhang","doi":"10.1016/j.bja.2026.03.019","DOIUrl":"https://doi.org/10.1016/j.bja.2026.03.019","url":null,"abstract":"<p><strong>Background: </strong>Memory impairment is a common postoperative neurological complication among elderly patients. Sharp-wave ripples (SPW-Rs) in the CA1 region of the hippocampus play a critical role in memory consolidation. However, the extent to which disruptions in CA1 SPW-Rs contribute to postoperative memory impairment remains poorly understood.</p><p><strong>Methods: </strong>An 18-month-old male C57BL/6J mice were exposed to 3 vol% sevoflurane combined with laparotomy. Various methodologies, including context fear conditioning, local field potential monitoring, immunofluorescence staining, viral tracing, optogenetics, and chemogenetics, were used to elucidate the involvement of SPW-Rs in the CA1 region in postoperative memory impairment in aged mice.</p><p><strong>Results: </strong>Postoperative memory impairment in aged mice was associated with deficits in memory consolidation, characterised by a reduced SPW-R frequency and duration in the CA1 region. Induction of SPW-Rs had the potential to improve memory consolidation (from 34.3 [9.4] to 53.1 [18.7]%, P=0.016). Additionally, we observed a decrease in the number of c-Fos-positive pyramidal neurones in the CA3 region following surgery, which contributed to diminished excitatory transmission to the CA1 region. Activating CA3 pyramidal neurones through chemogenetic approaches restored activity in CA1 pyramidal neurones, ameliorating SPW-R disruption (frequency from 0.20 [0.05] to 0.25 [0.15] events s^-1, P=0.018; duration from 0.034 [0.0028] to 0.039 [0.0033] s, P=0.014) and memory impairment. Microglial activation was associated with SPW-R disruption and postoperative memory deficits.</p><p><strong>Conclusions: </strong>Surgery triggers microglial activation, leading to the release of neuroinflammatory factors that inhibit hippocampal CA3 pyramidal neurone activation, ultimately disrupting SPW-R dynamics and impairing memory consolidation.</p>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147833898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effectiveness of perioperative oxygen therapy strategies in children. Comment on Br J Anaesth 2026; 136: 1307-18.","authors":"Tuhin Mistry, Abhijit Sukumaran Nair","doi":"10.1016/j.bja.2026.03.039","DOIUrl":"https://doi.org/10.1016/j.bja.2026.03.039","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of individualised versus routine intraoperative blood pressure management on acute kidney injury in noncardiac surgery: a GRADE-assessed meta-analysis of randomised controlled trials.","authors":"Laila Shalabi, Ahmed Ibrahim, Shrouk Ramadan, Shahed Shalabi, Karim Kouz, Bernd Saugel, Matthieu Legrand","doi":"10.1016/j.bja.2026.03.028","DOIUrl":"https://doi.org/10.1016/j.bja.2026.03.028","url":null,"abstract":"<p><strong>Background: </strong>We performed a systematic review and meta-analysis of randomised controlled trials (RCTs) to determine whether individualised intraoperative blood pressure (BP) management improves postoperative outcomes in patients having noncardiac surgery compared with routine BP management.</p><p><strong>Methods: </strong>A comprehensive literature search was performed across PubMed, Scopus, Web of Science, and Embase for relevant RCTs. The primary outcome was the incidence of postoperative acute kidney injury (AKI). We performed frequentist (random-effects model with Knapp-Hartung adjustment) and Bayesian meta-analyses.</p><p><strong>Results: </strong>Ten RCTs (n=5842 patients) were included. Although individualised, compared with routine, intraoperative BP management resulted in significantly higher intraoperative BP (reflected by a reduction in the area under a mean arterial pressure (MAP) of 65 mm Hg; mean difference -44.5 mm Hg × min, 95% confidence interval [CI] -58.5 to -30.4, P=0.0005), it did not reduce the incidence of AKI (risk ratio [RR] 0.83, 95% CI 0.65-1.07, P=0.13), 30-day mortality (RR 0.78, 95% CI 0.35-1.75, P=0.44), or myocardial injury (RR 1.11, 95% CI 0.92-1.35, P=0.14). A significant reduction in postoperative delirium was observed (RR 0.46, 95% CI 0.25-0.83, P=0.02). Bayesian analysis indicated a 91% probability of any degree of AKI protection (RR<1); however, the probability of this benefit reaching a clinically meaningful threshold (RR<0.8) was low (39%).</p><p><strong>Conclusions: </strong>Compared with routine intraoperative BP management (typically targeting MAP ≥60-65 mm Hg), individualised intraoperative BP management resulted in higher intraoperative BP but did not significantly reduce postoperative AKI. Individualised intraoperative BP management might decrease the risk of postoperative delirium.</p><p><strong>Systematic review protocol: </strong>CRD420251186093.</p>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphine requirements and chronic beta-blocker use in lower limb surgery: a propensity score matched cohort study.","authors":"Bernard V Delvaux, Yoann Elmaleh, Karim Guessous, Philippe Marchal, Patrice Forget","doi":"10.1016/j.bja.2026.03.054","DOIUrl":"https://doi.org/10.1016/j.bja.2026.03.054","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}