British journal of anaesthesia最新文献_第2页

Preoperative SGLT-2 inhibitor use and risk of adverse postoperative events: a single-centre retrospective observational study.

IF 9.1 1区医学

British journal of anaesthesia Pub Date : 2025-01-24 DOI: 10.1016/j.bja.2024.12.024

Theresa Tenge, Sebastian Roth, Elena Ahrens, Luca J Wachtendorf, Béla-Simon Paschold, Guanqing Chen, René M'Pembele, Detlef Kindgen-Milles, Anastasia Katsiampoura, Peter Kienbaum, Giovanna Lurati Buse, Maximilian S Schaefer

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Utilising electronic anaesthesia records to audit nitrous oxide consumption and waste, and implementation of a loss monitoring system.

IF 9.1 1区医学

British journal of anaesthesia Pub Date : 2025-01-23 DOI: 10.1016/j.bja.2024.12.018

Michelle Bee Hua Tan, William Gagnon, Huae Min Tham, Li Wen Ong, Bernard Tiang Guan Koh, Srinath Sridharan, Xuan Han Koh, Jo-Anne Yeo

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A clinical decision support tool for acute pain within an electronic health record to improve analgesic prescribing practice.

IF 9.1 1区医学

British journal of anaesthesia Pub Date : 2025-01-23 DOI: 10.1016/j.bja.2024.12.029

Matthew O'Hagan, Daniel Johnson, Dileep N Lobo, Nicholas Levy

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CRISPR: fundamental principles and implications for anaesthesia.

IF 9.1 1区医学

British journal of anaesthesia Pub Date : 2025-01-23 DOI: 10.1016/j.bja.2024.11.040

Alexendar R Perez, Orestes Mavrothalassitis, Janice S Chen, Judith Hellman, Michael A Gropper

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Effect of cannabinoid consumption on propofol dosage: a systematic review and meta-analysis.

IF 9.1 1区医学

British journal of anaesthesia Pub Date : 2025-01-23 DOI: 10.1016/j.bja.2024.12.015

Helmar Bornemann-Cimenti, Kordula Lang-Illievich, Stefan Neuwersch-Sommeregger, Johanna Lang, Thomas Danninger, Sascha Hammer, Istvan-Szilard Szilagyi, Christoph Klivinyi

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Role of heart rate variability in predicting tracheal extubation failure: a systematic review and meta-analysis.

IF 9.1 1区医学

British journal of anaesthesia Pub Date : 2025-01-23 DOI: 10.1016/j.bja.2024.12.030

Terry Cho, Triven Kannan, Krisha Patel, Tumul Chowdhury

引用次数: 0

Qnox index for quantification of intraoperative nociception and analgesia: a prospective single-centre validation study.

IF 9.1 1区医学

British journal of anaesthesia Pub Date : 2025-01-23 DOI: 10.1016/j.bja.2024.10.051

Hao Kong, Dan-Dan Ma, Jia-Hui Ma, Yu-Xiu Zhang, Hong Zhang, Dong-Xin Wang

{"title":"Qnox index for quantification of intraoperative nociception and analgesia: a prospective single-centre validation study.","authors":"Hao Kong, Dan-Dan Ma, Jia-Hui Ma, Yu-Xiu Zhang, Hong Zhang, Dong-Xin Wang","doi":"10.1016/j.bja.2024.10.051","DOIUrl":"https://doi.org/10.1016/j.bja.2024.10.051","url":null,"abstract":"Background: The Qnox index is a novel monitor to quantify intraoperative nociception based on an electroencephalographic algorithm. We evaluated the ability of the Qnox index to discriminate noxious from non-noxious stimuli, respond to stimuli, and discriminate different levels of analgesia in patients under propofol anaesthesia with neuromuscular block.Methods: Qnox was compared with heart rate and mean arterial pressure with five designated stimuli: tetanic stimulations without (tetanic 1) and with sufentanil (tetanic 2), skin incision, tracheal intubation, and a non-noxious period. The response around the skin incision was also evaluated at two target remifentanil concentrations.Results: In 83 adult patients scheduled for elective surgery, Qnox performed worse than heart rate and mean arterial pressure in discriminating tetanic 2, tetanic 1, skin incision, and tracheal intubation noxious stimuli from the non-noxious period, with an area under curve of 0.52 (95% confidence interval 0.43-0.61), 0.54 (0.45-0.62), 0.67 (0.58-0.75), and 0.65 (0.57-0.73), respectively. The post-stimulus values of Qnox increased significantly after tracheal intubation and skin incision, but not after tetanic 1 or tetanic 2. Qnox values after skin incision were similar between the low- and high-remifentanil-concentration groups.Conclusions: Qnox had a poor ability to discriminate noxious stimuli from non-noxious stimuli. Although Qnox responded to tracheal intubation and skin incision, it did not respond to tetanic stimulations and failed to discriminate different levels of analgesia. The Qnox index was not superior to heart rate or mean arterial pressure in assessing nociception during general anaesthesia.Clinical trial registration: Chinese Clinical Trial Registry (ChiCTR2100046063).","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory impact of local anaesthetic volume after an interscalene brachial plexus block with an extrafascial injection: a randomised controlled double-blinded trial.

IF 9.1 1区医学

British journal of anaesthesia Pub Date : 2025-01-23 DOI: 10.1016/j.bja.2024.12.010

Yves Renard, Sina Grape, Erin Gonvers, Jean-Benoit Rossel, Patrick Goetti, Eric Albrecht

{"title":"Respiratory impact of local anaesthetic volume after an interscalene brachial plexus block with an extrafascial injection: a randomised controlled double-blinded trial.","authors":"Yves Renard, Sina Grape, Erin Gonvers, Jean-Benoit Rossel, Patrick Goetti, Eric Albrecht","doi":"10.1016/j.bja.2024.12.010","DOIUrl":"https://doi.org/10.1016/j.bja.2024.12.010","url":null,"abstract":"Background: We have previously demonstrated that an extrafascial injection of 20 ml of local anaesthetic for interscalene brachial plexus block (ISB) reduces the rate of hemidiaphragmatic paralysis by 70% compared with an intrafascial injection, with similar efficacy. In this double-blind trial, we tested the hypothesis that a local anaesthetic volume of 10 ml injected extrafascially would reduce the rate of hemidiaphragmatic paralysis vs a volume of 20 ml, while providing similar analgesia.Methods: Sixty ASA physical status 1-3 patients scheduled for elective shoulder surgery under general anaesthesia were randomised to receive ultrasound-guided extrafascial ISB using ropivacaine 0.75% 20 ml (control group) or 10 ml (low-volume group) injected lateral to the brachial plexus sheath. The primary outcome was incidence of hemidiaphragmatic paralysis (diaphragmatic excursion reduction of >75%), measured by M-mode ultrasonography, at 30 min after the procedure. Secondary outcomes included duration of analgesia and i.v. morphine consumption at 24 h after surgery.Results: The 30-min hemidiaphragmatic paralysis rate was 80% (95% confidence interval [CI] 61-91%) in the control group and 19% (95% CI 8-40%) in the low-volume group (P<0.001). Participants in the low-volume vs control group had a shorter duration of analgesia (550 vs 873 min; P<0.01) and higher i.v. morphine consumption (20 vs 12 mg; P=0.03).Conclusions: A low volume of local anaesthetic injected extrafascially reduced the rate of hemidiaphragmatic paralysis, but at the expense of a shorter duration of analgesia compared with standard-dose extrafascial anaesthetic injection.Clinical trial registration: NCT04726280.","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hologram-assisted thoracic epidural insertion in the Thiel soft embalmed cadaver: proof of concept simulation study.

IF 9.1 1区医学

British journal of anaesthesia Pub Date : 2025-01-22 DOI: 10.1016/j.bja.2024.11.039

Graeme McLeod, Mel McKendrick, Rony Portelli, Zsolt Husz, Gareth James, Gary McKendrick

引用次数: 0

Sprouting sympathetic fibres release CXCL16 and norepinephrine to synergistically mediate sensory neuronal hyperexcitability in a rodent model of neuropathic pain.

IF 9.1 1区医学

British journal of anaesthesia Pub Date : 2025-01-22 DOI: 10.1016/j.bja.2024.10.019

Chen Wang, Anjie Di, Yan Wu, Meng Liu, Ming Wei, Zhengkai Liang, Feng Liu, Haiting Fan, Bo Dong, Changlin Li, Ting Xu, Wenjun Xin, Xia Feng

{"title":"Sprouting sympathetic fibres release CXCL16 and norepinephrine to synergistically mediate sensory neuronal hyperexcitability in a rodent model of neuropathic pain.","authors":"Chen Wang, Anjie Di, Yan Wu, Meng Liu, Ming Wei, Zhengkai Liang, Feng Liu, Haiting Fan, Bo Dong, Changlin Li, Ting Xu, Wenjun Xin, Xia Feng","doi":"10.1016/j.bja.2024.10.019","DOIUrl":"https://doi.org/10.1016/j.bja.2024.10.019","url":null,"abstract":"Background: Chronic neuropathic pain generally has a poor response to treatment with conventional drugs. Sympathectomy can alleviate neuropathic pain in some patients, suggesting that abnormal sympathetic-somatosensory signaling interactions might underlie some forms of neuropathic pain. The molecular mechanisms underlying sympathetic-somatosensory interactions in neuropathic pain remain obscure.Methods: Lumbar sympathectomy was performed in spared nerve injury (SNI) mice or rats, and the up-down method was used to measure the mechanical paw withdrawal threshold. Dorsal root ganglia (DRG) injection and perfusion were used to deliver virus or drugs. Methylated RNA immunoprecipitation sequencing, RNA-sequencing, and immunoelectron microscopy were used to identify neurotransmitters.Results: We found that sprouting tyrosine hydroxylase-positive sympathetic fibres in DRG mediated the maintenance of mechanical allodynia after SNI (day 28, P<0.001). We further found that SNI significantly increased the N6-methyladenosine level of CXCL16 messenger RNA (day 28, P<0.001), which was attributable to the reduced N6-methyladenosine demethylase fat mass and obesity-associated protein (P=0.002) and increased interaction with YTHDF1 (P=0.013) in the sympathetic ganglion. Enhanced expression of CXCL16 in the sympathetic ganglia can lead to increases release into the DRG and act synergistically with norepinephrine from sympathetic terminals to enhance DRG neuronal excitability.Conclusions: Norepinephrine and CXCL16 co-released from sympathetic nerve terminals in the DRG synergistically contribute to maintenance of neuropathic pain in a rodent model.","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0