British journal of anaesthesia最新文献

{"title":"Associate Editorial Board","authors":"","doi":"10.1016/S0007-0912(24)00513-0","DOIUrl":"10.1016/S0007-0912(24)00513-0","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"133 4","pages":"Page ii"},"PeriodicalIF":9.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0007091224005130/pdfft?md5=20cd50c3cb79064cac60ad6154c0653b&pid=1-s2.0-S0007091224005130-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided suprainguinal fascia iliaca compartment block and early postoperative analgesia after total hip arthroplasty. Comment on Br J Anaesth 2024; 133: 146–51","authors":"Guanyu Yang, Qinjun Chu","doi":"10.1016/j.bja.2024.08.025","DOIUrl":"10.1016/j.bja.2024.08.025","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"133 6","pages":"Pages 1328-1329"},"PeriodicalIF":9.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Troponin clearance via continuous renal replacement therapies in the ICU","authors":"Boyd Sean , Sabina Mason , Sean Griffin , Colm Keane , Eoin Begley , Evelyn Deasy , Maria Donnelly , Julio Chevarria , Deirdre M. D’Arcy , Yvelynne P. Kelly","doi":"10.1016/j.bja.2024.07.004","DOIUrl":"10.1016/j.bja.2024.07.004","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"133 4","pages":"Page 921"},"PeriodicalIF":9.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrochloric acid ingestion in adults: presentation and outcomes in a 10-year retrospective cohort study","authors":"Amélie Sabzé , Maxime Coutrot , Emmanuel Dudoignon , Hélène Corte , Benoit Plaud , François Dépret , Benjamin Deniau","doi":"10.1016/j.bja.2024.07.032","DOIUrl":"10.1016/j.bja.2024.07.032","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"133 6","pages":"Pages 1344-1346"},"PeriodicalIF":9.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Readability of patient information in paediatric anaesthesia","authors":"Connor Haugh, Rachael Horan","doi":"10.1016/j.bja.2024.07.002","DOIUrl":"10.1016/j.bja.2024.07.002","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"133 4","pages":"Page 920"},"PeriodicalIF":9.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propofol binds and inhibits skeletal muscle ryanodine receptor 1","authors":"Thomas T. Joseph ,&nbsp;Weiming Bu ,&nbsp;Omid Haji-Ghassemi ,&nbsp;Yu S. Chen ,&nbsp;Kellie Woll ,&nbsp;Paul D. Allen ,&nbsp;Grace Brannigan ,&nbsp;Filip van Petegem ,&nbsp;Roderic G. Eckenhoff","doi":"10.1016/j.bja.2024.06.048","DOIUrl":"10.1016/j.bja.2024.06.048","url":null,"abstract":"<div><h3>Background</h3><div>As the primary Ca²⁺ release channel in skeletal muscle sarcoplasmic reticulum (SR), mutations in type 1 ryanodine receptor (RyR1) or its binding partners underlie a constellation of muscle disorders, including malignant hyperthermia (MH). In patients with MH mutations, triggering agents including halogenated volatile anaesthetics bias RyR1 to an open state resulting in uncontrolled Ca²⁺ release, increased sarcomere tension, and heat production. Propofol does not trigger MH and is commonly used for patients at risk of MH. The atomic-level interactions of any anaesthetic with RyR1 are unknown.</div></div><div><h3>Methods</h3><div>RyR1 opening was measured by [³H]ryanodine binding in heavy SR vesicles (wild type) and single-channel recordings of MH mutant R615C RyR1 in planar lipid bilayers, each exposed to propofol or the photoaffinity ligand analogue <em>m</em>-azipropofol (AziP<em>m</em>). Activator-mediated wild-type RyR1 opening as a function of propofol concentration was measured by Fura-2 Ca²⁺ imaging of human skeletal myotubes. AziP<em>m</em> binding sites, reflecting propofol binding, were identified on RyR1 using photoaffinity labelling. Propofol binding affinity to a photoadducted site was predicted using molecular dynamics (MD) simulation.</div></div><div><h3>Results</h3><div>Both propofol and AziP<em>m</em> decreased RyR1 opening in planar lipid bilayers (<em>P</em>&lt;0.01) and heavy SR vesicles, and inhibited activator-induced Ca²⁺ release from human skeletal myotube SR. Several putative propofol binding sites on RyR1 were photoadducted by AziP<em>m</em>. MD simulation predicted propofol <em>K</em>_D values of 55.8 μM and 1.4 μM in the V4828 pocket in open and closed RyR1, respectively.</div></div><div><h3>Conclusions</h3><div>Propofol demonstrated direct binding and inhibition of RyR1 at clinically plausible concentrations, consistent with the hypothesis that propofol partially mitigates malignant hyperthermia by inhibition of induced Ca²⁺ flux through RyR1.</div></div>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"133 5","pages":"Pages 1093-1100"},"PeriodicalIF":9.1,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Medicare eligibility with access to cardiac surgical care by patients identifying as other than non-Hispanic White: a regression discontinuity analysis","authors":"Monica Arndt,&nbsp;Hung-Mo Lin,&nbsp;Eric D. Strand,&nbsp;Clark Fisher,&nbsp;Robert B. Schonberger","doi":"10.1016/j.bja.2024.07.031","DOIUrl":"10.1016/j.bja.2024.07.031","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"133 6","pages":"Pages 1341-1343"},"PeriodicalIF":9.1,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Kelly E. Michaelsen","doi":"10.1016/j.bja.2024.07.027","DOIUrl":"10.1016/j.bja.2024.07.027","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"133 6","pages":"Page 1357"},"PeriodicalIF":9.1,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of balanced crystalloids versus 0.9% saline on delayed graft function and perioperative outcomes in kidney transplantation: a meta-analysis of randomised controlled trials","authors":"Tzu Chang ,&nbsp;Ming-Chieh Shih ,&nbsp;Yi-Luen Wu ,&nbsp;Tsung-Ta Wu ,&nbsp;Jen-Ting Yang ,&nbsp;Chun-Yu Wu","doi":"10.1016/j.bja.2024.08.008","DOIUrl":"10.1016/j.bja.2024.08.008","url":null,"abstract":"<div><h3>Background</h3><div>Delayed graft function after kidney transplantation is linked to poor graft survival and increased chronic allograft injury. Recent guidelines suggest using balanced crystalloids over 0.9% saline owing to better metabolic profiles, but their impact on DGF remains unclear.</div></div><div><h3>Methods</h3><div>We searched PubMed, Embase, and Cochrane Central Registry of Clinical Trials from inception until February 29, 2024, and included RCTs that randomised adult participants to receive either intravenous balanced fluids or 0.9% saline intraoperatively. We pooled data using a random-effects model and present risk ratios (RRs) or mean differences, with 95% confidence intervals (CIs). We assessed individual study risk of bias using the modified Cochrane tool and certainty of evidence using GRADE. Outcomes analysed were delayed graft function incidence, vasopressor requirements, length of hospital stay, and postoperative metabolic profiles.</div></div><div><h3>Results</h3><div>Of 106 publications identified, we included 11 RCTs (<em>n</em>=1717). Pooled analysis showed that the use of balanced fluids was associated with a lower incidence of delayed graft function compared with 0.9% saline (RR 0.82, 95% CI: 0.69 to 0.98, <em>P</em>=0.01, moderate certainty). Balanced crystalloids were associated with higher postoperative serum pH, higher serum bicarbonate, and lower serum chloride concentration, but effects on vasopressor requirements, length of hospital stay, and serum creatinine were uncertain.</div></div><div><h3>Conclusions</h3><div>Balanced crystalloid intravenous fluid therapy reduced delayed graft function incidence and maintained more favourable serum chemistry profiles compared with 0.9% saline in patients undergoing kidney transplantation. However, crystalloid type did not significantly influence vasopressor requirements and length of hospital stay.</div></div>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"133 6","pages":"Pages 1173-1182"},"PeriodicalIF":9.1,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between inspired oxygen fraction and development of postoperative pulmonary complications in thoracic surgery: a multicentre retrospective cohort study","authors":"Nicholas J. Douville ,&nbsp;Mark E. Smolkin ,&nbsp;Bhiken I. Naik ,&nbsp;Michael R. Mathis ,&nbsp;Douglas A. Colquhoun ,&nbsp;Sachin Kheterpal ,&nbsp;Stephen R. Collins ,&nbsp;Linda W. Martin ,&nbsp;Wanda M. Popescu ,&nbsp;Nathan L. Pace ,&nbsp;Randal S. Blank","doi":"10.1016/j.bja.2024.08.005","DOIUrl":"10.1016/j.bja.2024.08.005","url":null,"abstract":"<div><h3>Background</h3><div>Limited data exist to guide oxygen administration during one-lung ventilation for thoracic surgery. We hypothesised that high intraoperative inspired oxygen fraction during lung resection surgery requiring one-lung ventilation is independently associated with postoperative pulmonary complications (PPCs).</div></div><div><h3>Methods</h3><div>We performed this retrospective multicentre study using two integrated perioperative databases (Multicenter Perioperative Outcomes Group and Society of Thoracic Surgeons General Thoracic Surgery Database) to study adult thoracic surgical procedures using one-lung ventilation. The primary outcome was a composite of PPCs (atelectasis, acute respiratory distress syndrome, pneumonia, respiratory failure, reintubation, and prolonged ventilation &gt;48 h). The exposure of interest was high inspired oxygen fraction (FiO₂), defined by area under the curve of a FiO₂ threshold &gt; 80%. Univariate analysis and logistic regression modelling assessed the association between intraoperative FiO₂ and PPCs.</div></div><div><h3>Results</h3><div>Across four US medical centres, 141/2733 (5.2%) procedures conducted in 2716 patients (55% female; mean age 66 yr) resulted in PPCs. FiO₂ was univariately associated with PPCs (adjusted OR [aOR]: 1.17, 95% confidence interval [CI]: 1.04–1.33, <em>P</em>=0.012). Logistic regression modelling showed that duration of one-lung ventilation (aOR: 1.20, 95% CI: 1.03–1.41, <em>P</em>=0.022), but not the time-weighted average FiO₂ (aOR: 1.01, 95% CI: 1.00–1.02, <em>P</em>=0.165), was associated with PPCs.</div></div><div><h3>Conclusions</h3><div>Our results do not support limiting the inspired oxygen fraction for the purpose of reducing postoperative pulmonary complications in thoracic surgery involving one-lung ventilation.</div></div>","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"133 5","pages":"Pages 1073-1084"},"PeriodicalIF":9.1,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142231347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}