Michael R Mathis,Kamrouz Ghadimi,Andrew Benner,Elizabeth S Jewell,Allison M Janda,Hyeon Joo,Michael D Maile,Jessica R Golbus,Keith D Aaronson,Milo C Engoren,
{"title":"Corrigendum to 'Heart failure diagnostic accuracy, intraoperative fluid management, and postoperative acute kidney injury: a single-centre prospective observational study' [Br J Anaesth 2025; 134: 32-44].","authors":"Michael R Mathis,Kamrouz Ghadimi,Andrew Benner,Elizabeth S Jewell,Allison M Janda,Hyeon Joo,Michael D Maile,Jessica R Golbus,Keith D Aaronson,Milo C Engoren, ","doi":"10.1016/j.bja.2025.06.012","DOIUrl":"https://doi.org/10.1016/j.bja.2025.06.012","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"23 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew F. Cumpstey, Jaideep J. Pandit, Eoin M. Kelleher
{"title":"M.A.GropperL.I.ErikssonL.A.FleisherN.H.CohenK.LeslieO.Johnson-AkejuMiller's Anesthesia10th edn2025Published by Elsevier3016 pp, 2 volumes. Price $389.99. ISBN 9780323935920","authors":"Andrew F. Cumpstey, Jaideep J. Pandit, Eoin M. Kelleher","doi":"10.1016/j.bja.2025.06.017","DOIUrl":"https://doi.org/10.1016/j.bja.2025.06.017","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"37 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hannah R Pollock,Rachel Outterson,Nirvik Pal,Bryant W Tran
{"title":"The carbon footprint of general anaesthesia in adult patients: total intravenous anaesthesia as an environmentally friendly alternative. Comment on Br J Anaesth 2025; 134: 1620-7.","authors":"Hannah R Pollock,Rachel Outterson,Nirvik Pal,Bryant W Tran","doi":"10.1016/j.bja.2025.06.020","DOIUrl":"https://doi.org/10.1016/j.bja.2025.06.020","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"109 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Amaral,Natalia Marques,Vanessa Tapioca,Eduardo Pereira,Adivânio Americo,Jeff Gadsden
{"title":"Suzetrigine for acute postoperative pain: a systematic review and meta-analysis of current evidence.","authors":"Sara Amaral,Natalia Marques,Vanessa Tapioca,Eduardo Pereira,Adivânio Americo,Jeff Gadsden","doi":"10.1016/j.bja.2025.06.014","DOIUrl":"https://doi.org/10.1016/j.bja.2025.06.014","url":null,"abstract":"","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"193 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Coding of post-surgical pain in ICD-11: between conceptual richness and practical constraints.","authors":"Valeria Martinez,Annachiara Spagna,Nadine Attal","doi":"10.1016/j.bja.2025.05.028","DOIUrl":"https://doi.org/10.1016/j.bja.2025.05.028","url":null,"abstract":"The 11th revision of the International Classification of Diseases (ICD-11) marks a decisive step forward in recognising chronic postsurgical pain as a distinct clinical entity. Yet, significant gaps remain between its conceptual framework, coding tools, and real-world clinical practice. Here we highlight these inconsistencies and call for stronger integration of the diagnostic criteria, along with improved visibility of neuropathic pain mechanisms as well as the psychosocial dimensions of pain.","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"13 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of superficial and deep parasternal blocks on recovery after cardiac surgery with sternotomy: a randomised controlled trial.","authors":"Achille Demarquette,Audrey Jeanneteau,Aymeric Blanchard-Daguet,Olivier Fouquet,Elsa Parot-Schinkel,Sigismond Lasocki,Emmanuel Rineau,Maxime Léger","doi":"10.1016/j.bja.2025.05.043","DOIUrl":"https://doi.org/10.1016/j.bja.2025.05.043","url":null,"abstract":"BACKGROUNDPain is common after cardiac surgery and can impair recovery. Regional anaesthesia has been proposed to limit pain, but its impact on recovery is unknown. This study compared the impact of superficial or deep parasternal intercostal plane blocks (SPIP or DPIP) in addition to standard care vs standard care alone on postoperative quality of recovery (QoR) after cardiac surgery with sternotomy.METHODSIn this single-centre, randomised, single-blind, controlled trial, adult patients undergoing cardiac surgery with sternotomy were randomly assigned to one of three groups (with a 1:1:1 allocation ratio): control group (standard care without regional anaesthesia), SPIP group, or DPIP group. The primary endpoint was QoR assessed using a French validated version of the Quality of Recovery-15 questionnaire at 24 h after surgery. Secondary outcomes included postoperative pain scores, analgesic consumption, ICU and hospital length of stay, and adverse events.RESULTSBetween July 1, 2022, and August 30, 2023, we randomised 254 patients (81.1% men, 65.5 [27-85] yr). The French validated version of the Quality of Recovery-15 scores did not significantly differ between any parasternal block group (SPIP or DPIP) and the standard care group (P=0.248). Postoperative pain and analgesic consumption were similar across groups, with low pain scores (median [interquartile range] 24-h numerical rating scale: 2.0 [3.0-0.0]). There were more pneumothoraces in the DPIP group (P=0.032). No significant differences were observed for other complications.CONCLUSIONSRegional anaesthesia by parasternal intercostal plane blocks after sternotomy did not improve QoR at 24 h compared with standard care.CLINICAL TRIAL REGISTRATIONNCT05345639.","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"12 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Harriet E Taylor,Joseph C Salf,Charlotte R Roper-Marchand,Dhaneesha N S Senaratne,Blair H Smith,Lesley A Colvin,Jacob George
{"title":"Are adults with chronic pain more likely to develop hypertension than adults without chronic pain? A systematic review and meta-analysis.","authors":"Harriet E Taylor,Joseph C Salf,Charlotte R Roper-Marchand,Dhaneesha N S Senaratne,Blair H Smith,Lesley A Colvin,Jacob George","doi":"10.1016/j.bja.2025.06.006","DOIUrl":"https://doi.org/10.1016/j.bja.2025.06.006","url":null,"abstract":"BACKGROUNDAn association between persistent pain and blood pressure is increasingly recognised but is not fully understood. In this systematic review, we aimed to establish whether chronic pain (CP) is associated with a diagnosis of hypertension (HTN).METHODSAfter prospective registration (PROSPERO ID: CRD42025629486), we searched six databases from inception until January 8, 2025, for studies investigating the association between CP and HTN. Title and abstract screening, full-text review, data extraction, and risk of bias assessment were performed by two independent reviewers. Study quality assessment used the Risk of Bias In Non-randomised Studies of Exposures (ROBINS-E) tool. Meta-analysis was conducted using a random effects model.RESULTSFrom 7973 records, we identified 23 eligible studies for inclusion, of which 20 provided suitable data for meta-analysis (total participants n=1 594 264). The pooled odds ratio for HTN in people with CP compared with controls was 1.66 (95% confidence interval [CI] 1.28-2.15) with high inter-study heterogeneity (I2=99.8%, Cochran Q=10 132, p<0.001). For specific pain conditions, the pooled odds ratio for HTN was 1.38 (95% CI 1.20-1.58, n = 374 234, heterogeneity: I2=65.1%, Cochran Q=14.34, p=0.014) in people with chronic, widespread pain, and 1.56 (95% CI 1.37-1.79, n=477 681, heterogeneity: I2=0%, Cochran Q=0.17, p=0.92) in people with chronic headache. There was no association between HTN and musculoskeletal pain, lower back pain, or gender.CONCLUSIONSIn line with a growing body of evidence in this field, this systematic review and meta-analysis confirms an association between chest pain and hypertension. Further research is warranted to understand this association and elucidate any mediating factors.SYSTEMATIC REVIEW PROTOCOLPROSPERO (CRD42025629486).","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"194 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Araneda,J C De la Cuadra,Marcia Corvetto,Detlef Balde,René de la Fuente,Mauricio Ibacache,Víctor Contreras,Sandra Solari,Ignacio Cortínez
{"title":"Pharmacokinetic modelling and simulation for prolonged infusion of levobupivacaine with or without epinephrine in transversus abdominis plane and erector spinae plane blocks: a randomised controlled trial and analysis of pooled data.","authors":"Andrea Araneda,J C De la Cuadra,Marcia Corvetto,Detlef Balde,René de la Fuente,Mauricio Ibacache,Víctor Contreras,Sandra Solari,Ignacio Cortínez","doi":"10.1016/j.bja.2025.05.047","DOIUrl":"https://doi.org/10.1016/j.bja.2025.05.047","url":null,"abstract":"BACKGROUNDInterfacial blocks often require large volumes of local anaesthetic, raising concerns about systemic absorption and potential toxicity. This study examined the pharmacokinetics of levobupivacaine with and without epinephrine during thoracic erector spinae plane (ESP) or transversus abdominis plane (TAP) blocks, simulating reported 48-h dosing regimens to evaluate safety.METHODSData from three studies were analysed. Study 1 included 38 patients receiving an ESP block before video-assisted thoracoscopy, whereas Study 2 analysed published data on TAP blocks. Both studies used 20 ml of levobupivacaine 0.25% with or without epinephrine (5 μg ml-1), measuring arterial concentrations over 90 min. Study 3 involved intravenous bupivacaine administration in 10 healthy volunteers. Pharmacokinetic analysis used NONMEM software, with significance set at P<0.05.RESULTSWe analysed 258 ESP samples, 150 TAP samples, and 190 bupivacaine i.v.SAMPLESA one-compartment model described the data, with a mean distribution volume of 41.9 L (coefficient of variation, 47%) and clearance rate of 0.288 L min-1 (coefficient of variation, 38%). Epinephrine reduced bioavailability (54.3% vs 32.8%) and prolonged absorption half-life (0.84 min vs 1.55 min; P<0.05). Simulated doses of 50 mg plus 300 mg per 24 h over 48 h remained below toxic thresholds.CONCLUSIONSSimilar dosing regimens for ESP and TAP blocks are supported by this pharmacokinetic analysis, with epinephrine effectively reducing systemic drug concentrations by prolonging absorption half-life and lowering bioavailability. The findings suggest that extended 300 mg per 24 h dosing for 48 h is likely to be safe. Further studies in broader patient populations are warranted to evaluate safety.CLINICAL TRIAL REGISTRATIONNCT04799184.","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"22 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mark R Edwards,Gudrun Kunst,Lui G Forni,Desirée Chappell,Timothy E Miller,
{"title":"Perioperative Quality Initiative consensus statement on goal-directed haemodynamic therapy.","authors":"Mark R Edwards,Gudrun Kunst,Lui G Forni,Desirée Chappell,Timothy E Miller, ","doi":"10.1016/j.bja.2025.05.033","DOIUrl":"https://doi.org/10.1016/j.bja.2025.05.033","url":null,"abstract":"Perioperative goal-directed haemodynamic therapy (GDHT) includes a variety of protocolised approaches to the assessment and management of the circulatory system and blood flow for patients undergoing surgery. Here we present updated consensus statements on perioperative GDHT developed during the 11th Perioperative Quality Initiative (POQI) consensus conference meeting held in London, UK in June, 2023. Statements relating to the definitions, components, and underlying physiology surrounding GDHT are proposed. We recommend considering use of GDHT in specific settings including during cardiopulmonary bypass (CPB), after cardiac surgery, and during hip fracture surgery. However, the level of evidence is weak in these settings. Clinicians can consider use of GDHT protocols on an individual patient basis for moderate- to high-risk patients undergoing major noncardiac surgery; however, we recommend against use of fixed low-dose inotrope infusions as part of GDHT protocols. We do not recommend routine use of GDHT protocols for patients undergoing major elective abdominal surgery. There is currently insufficient evidence to recommend routine use of GDHT during emergency abdominal surgery. Future research should focus on individualisation of GDHT to individual patients' haemodynamic requirements, newer paradigms such as technology-assisted delivery of GDHT protocols, and the role of predictive models using artificial intelligence.","PeriodicalId":9250,"journal":{"name":"British journal of anaesthesia","volume":"13 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}