British journal of medicine and medical research最新文献

{"title":"Evaluation of Periodontal Tissues and Abdominal Aorta of Rats with Induced Obesity by Monosodium Glutamate and Experimental Periodontitis","authors":"K. Costa, M. Bonfleur, Viviane Pontillo, Stefany Pedrotti, Paula Bernardon, Rose Brancalão, C. Beu, P. Nassar, C. Nassar","doi":"10.9734/BJMMR/2017/30165","DOIUrl":"https://doi.org/10.9734/BJMMR/2017/30165","url":null,"abstract":"Introduction and Aim: The aim of this study was to evaluate the behavior of experimentally-provoked-periodontitis tissues and the abdominal aorta in rats with acquired induced hypothalamic obesity. Methods: Initially in the first 5 days of life, a cohort of twenty-eight male Wistar rats were divided into 2 groups; the first group [n=14] were given intradermal injections of 4 G/kg of solution of Monosodium glutamate (MSG); the second group [n=14] was given 1,25 G/kg/day of saline solution (group CTL) in the cervical region. At 70 days, each of the two groups were further divided into another 2 subgroups, and periodontitis was induced with ligature placing as the experimental variable, on the 1st lower molars, except in group 1 and 3. This created 4 groups: (1) control group without ligature (CTL n=7); (2) control group with ligature (CTLLIG n=7); (3) group MSG without ligature (MSG n=7); (4) and group MSG with ligature (MSGLIG n=7). Total n=28. After 100 days the rats were sacrificed and gingival tissue, abdominal aorta samples, and a hemi-mandible were dissected out for immunological, morphological and radiographic analysis. Results: Both Radiography and histopathology showed significant lower alveolar bone loss when the MSGLIG, group was compared to the CTLLIG group (p< 0.05). In the abdominal aorta morphometric analysis there was statistically significant difference in the measurement of the thickness of the aortic wall, being the largest thickness observed in the MSGLIG group (p< 0.05). Conclusion: Therefore, this study suggests that the periodontitis in association with the hypothalamic obesity may contribute to the increase of the width of the abdominal aorta walls, as well as the hypothalamic obesity may exert a protective effect on alveolar bone loss.","PeriodicalId":9249,"journal":{"name":"British journal of medicine and medical research","volume":"113 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80205401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gemcitabine and Carboplatin in Inoperable, Loco-Regionally Advanced and Metastatic Gallbladder Cancer- A Study from Northern Indian Cancer Institute","authors":"V. Talwar, S. Raina, Varun Goel, D. Doval","doi":"10.9734/bjmmr/2017/30843","DOIUrl":"https://doi.org/10.9734/bjmmr/2017/30843","url":null,"abstract":"Aims: The primary objective of this study was to determine the response rates of the gemcitabine and carboplatin combination chemotherapy in treatment naïve patients with inoperable gall bladder cancer. The secondary objectives were to evaluate the toxicity, progression free survival (PFS), and overall survival (OS). Methodology: Treatment naïve patients with histologically proven inoperable gall bladder cancer treated with gemcitabine and carboplatin chemotherapy between February 2011 and December 2014 were included in this study. The dose of gemcitabine was 1 gm/m on day 1 and 8, and carboplatin [target AUC (area under the concentration versus time curve in mg/ml) of 5] on day 1, in a 21 day cycle. CT scan was used for response assessment. Original Research Article Talwar et al.; BJMMR, 19(12): 1-7, 2017; Article no.BJMMR.30843 2 Results: There were 32 men and 92 women with a median age of 59 years (range 26-75 years). Of the 124 patients, 9 (7.3%) patients achieved a complete response and 54 (43.5%) patients achieved a partial response for an overall response rate of 50.8%. The median PFS was 4.6 months [95% confidence interval (CI) 4–5.5 months], with 1-year survival rate of 20.2%. Common toxicity criteria (CTC) grade 3 anaemia was seen in 6 (4.8%) patients. Grade 3 and 4 neutropenia was observed in 11 (8.9%) and 4 (3.2%) patients respectively, whereas 9 (7.3%) patients experienced Grade 3 thrombocytopenia. Conclusion: The combination of gemcitabine and carboplatin is active in advanced gall bladder carcinoma with mild toxicity.","PeriodicalId":9249,"journal":{"name":"British journal of medicine and medical research","volume":"11 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78335555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic Gastric Plication: Appropriate Option in Times of Crisis?","authors":"Abdul Rahman Hammadieh, M. F. Safadi, Osama Shaheen","doi":"10.9734/bjmmr/2017/30714","DOIUrl":"https://doi.org/10.9734/bjmmr/2017/30714","url":null,"abstract":"Objective: The aim of this study is to investigate the practice of laparoscopic gastric plication (LGP) in Syria with particular emphasis on efficacy and complications, and to explore the concept of bariatric surgery in times of crisis with its related issues and concerns. Materials and Methods: A prospective cohort study included all patients who underwent LGP between February 2011 and September 2014. The main outcome was the percentage of excess weight loss (%EWL). Secondary outcomes included operative time, hospital stay, postoperative complications, and improvement of related comorbidities. Results: Of the 129 patients who underwent LGP in the study period, 96 patients were included in the final analysis. The mean body mass index was 39.5 kg/m (32–49 kg/m). No cases of conversion to laparotomy, leak, intraabdominal infection, or mortality were seen. Vomiting was the most common postoperative complaint, which was encountered in 91.6% of patients. Two patients required operation reversal because of protracted vomiting. Mean %EWL was 60%, 65%, 70%, 67%, 66% and 65% at 6, 12, 18, 24, 30 and 36 months respectively. Obesity-related comorbidities were present in 33 patients (34.4%), and they showed considerable improvement or complete Original Research Article Hammadieh et al.; BJMMR, 19(3): 1-9, 2017; Article no.BJMMR.30714 2 resolution in 57-100% of cases. Weight regain was seen in 7 patients (7.3%) after 36 months, three of whom (3.1%) requested reoperation. Conclusions: LGP is a feasible and safe operation for the treatment of morbid obesity, and it is comparable to other restrictive bariatric operations with fewer rates of serious complications. It is an appropriate technique in times of crisis due to low cost and ease of follow-up.","PeriodicalId":9249,"journal":{"name":"British journal of medicine and medical research","volume":"19 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87247104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalized Gingival Pyogenic Granuloma in a 11 Years Old Female – A Diagnostic Challenge","authors":"J. Leelavathy, S. Ramesh, A. Christy","doi":"10.9734/BJMMR/2017/33309","DOIUrl":"https://doi.org/10.9734/BJMMR/2017/33309","url":null,"abstract":"Aims: To include pyogenic granuloma","PeriodicalId":9249,"journal":{"name":"British journal of medicine and medical research","volume":"88 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87460012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Cause of Upper Gastrointestinal Bleeding in Clinical Practice; A Case Report of Locally Invasive Colon Cancer with Superimposed Actinomycosis","authors":"Y. Awuku, Y. Nartey, J. Lovi, M. Nortey, T. Morna, P. Akakpo","doi":"10.9734/bjmmr/2017/32202","DOIUrl":"https://doi.org/10.9734/bjmmr/2017/32202","url":null,"abstract":"Background: Colon cancer commonly presents with lower gastrointestinal bleeding in symptomatic patients. Upper gastrointestinal bleeding as a symptom of colon cancer is unusual. This case highlights the diagnostic and management challenges of colon cancer masquerading as gastric ulcer with a bleeding complication. Case Presentation: We report the case of a 45-year-old man who presented with passage of melaena stools with associated epigastric pain. Endoscopy revealed gastric ulcer in the greater curvature. Histopathology identified a diffuse adenocarcinoma with superimposed actinomycosis. Intra-operatively the patient was found to have a carcinoma of the transverse colon diffusely infiltrating and ulcerating the stomach in its greater curvature . Patient died from bilateral pulmonary thromboembolism 10 weeks after the surgery. Conclusion: Although rare, colon cancer can present with upper gastrointestinal bleeding. It must be considered as a differential in the work up for a patient passing melaena stool.","PeriodicalId":9249,"journal":{"name":"British journal of medicine and medical research","volume":"32 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72814795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Human Resources for Eye Health in Ogun State of Nigeria: Progress towards Vision 2020","authors":"T. Bogunjoko, Ao Hassan, T. Akanbi, A. Ashaye, A. Akinye","doi":"10.9734/BJMMR/2017/31702","DOIUrl":"https://doi.org/10.9734/BJMMR/2017/31702","url":null,"abstract":"Aims: To conduct a situational analysis of human resources for eye health (HReH) and assess its progress towards vision 2020 goals in Ogun state of Nigeria. Study Design: A descriptive cross-sectional study. Place and Duration of Study: 21 eye care facilities in Ogun state between November and December 2014. Methodology: Data was collected with an adapted questionnaire developed by WHO and IAPB. The questionnaire was filled by telephone interview to key officials of registration boards for ophthalmologists, optometrists and ophthalmic nurses and public and private institutions employing these professionals in the state. Sources of population data was from census, state website and estimated rate of annual population. Each of these targets graded to show if vision 2020 target was met in 2014. Results: There were 21 eye care facilities in Ogun state. 7 (33%) are government owned, 2 (9.5%) Original Research Article Bogunjoko et al.; BJMMR, 19(10): 1-9, 2017; Article no.BJMMR.31702 2 are non-governmental organization (NGO)/mission owned and 12 (57.2%) are private for profit. There were 77 eye care workers in active service made up of 27 ophthalmologists, 31 ophthalmic nurses and 19 optometrists in 2014. Most eye care workers in Ogun state work in government establishments (66%), 26% in private for profit and 7.8% in NGO/mission. Vision 2020 targets had only been achieved for ophthalmologists in 2014. The Ogun state ratio for ophthalmologist was 5.4 per million populations, 3.8 for optometrists and 6.3 for ophthalmic nurses. The percentage of each of the eye care workers average 25% in the capital city and 75% outside capital. Practitioner per million population specific for capital and outside capital is worse outside capital city. Conclusion: The HReH was above the vision 2020 target for ophthalmologists. The ophthalmic nurses are above average and optometrists very low. There is need for a targeted investment for these two categories of practitioners and the need to address maldistribution of eye care workers.","PeriodicalId":9249,"journal":{"name":"British journal of medicine and medical research","volume":"5 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82022568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystic Partially Differentiated Nephroblastoma, A Hyperfavourable Variant of Nephroblatoma: A Case Report with Review of the Literature","authors":"B. Ojo, W. Yongo, C. Soo, I. Annongu, R. Vhriterhire, H. Mohammed, E. Ogwuche, O. Shorun, I. Ugwu, E. Umobong, B. Eke, D. Omeh, M. Ogiator, P. Abayol","doi":"10.9734/BJMMR/2017/24956","DOIUrl":"https://doi.org/10.9734/BJMMR/2017/24956","url":null,"abstract":"Cystic partially differentiated nephroblastoma is a rare variant of Wilm’s tumor and it represents the hyperfavourable end of the Wilm’s spectrum affecting young children. We described the first documented case from the northern part of Nigeria. The index patient presented with left flank mass. He had unilateral nephrectomy and surgical pathology established its diagnosis. It is a lower risk but malignant tumor that comes as the differential diagnosis of pediatric cystic renal lesions and need to be differentiated from benign lesions such as cystic nephroma and mixed epithelial and stroma tumor of kidney. It should always be considered as a differential diagnosis of childhood abdominal mass with appropriate investigations and management since it is curable by nephrectomy alone.","PeriodicalId":9249,"journal":{"name":"British journal of medicine and medical research","volume":"1 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90377867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Achilles Tendon Pathology: Ultrasonography Versus Plain X-ray","authors":"M. Khasru, Farzana Nazrin, Siddiq, T. Marzen, Nayeem Anwar, F. Haseen, M. Moniruzzaman, I. Jahan, Mohammad Ahsan Ullah, S. Rahman, A. Salek","doi":"10.9734/BJMMR/2017/31501","DOIUrl":"https://doi.org/10.9734/BJMMR/2017/31501","url":null,"abstract":"Aims: The current study aimed to highlight diagnostic usefulness of ultrasonography (USG) in Achilles tendon pathology. Methods: This cross-sectional study was conducted in the department of Physical Medicine and Rehabilitation in co-operation with Orthopedics and Traumatology facility of Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. The study period was 2 years (July 2010 to June 2012); and 61 patients with posterior heel pain selected consecutively. Along with history taking, enrolled subjects examined meticulously. Non-invasive measures such as X-ray, USG (Siemens premium edition, Acuson antares, transducer: VF 10-5, 5.7-10 MHz) also used to acquire further information regarding heel pathology. A semi-structured questionnaire used to preserve primary data. Since, four subjects refused to do USG and X-rays were not available from another seven, we studied over rest fifty. Uni-variate analysis performed. Having been used kappa statistics, sensitivity, specificity, positive predictive value, and negative predictive value of ultrasound and X-ray in several Achilles tendon pathologies performed; p < 0.05 considered statistically significant. Results: Among of all participants, 38.0% belonged to 36-45 age range and maximum (68.0%) were male. Although a substantial 37 (76.0%) had been suffering from localized back heel pain, 13 (26.0%) of them had systemic diseases like diabetes mellitus (76.9%), dyslipidaemia (1, 2.0%), systemic lupus erythematosus (1, 2.0%), and ankylosing spondylitis (1, 2.0%). Achilles tendinitis, Achilles tendon rupture, retrocalcaneal bursitis, tendon xanthoma diagnosed using ultrasonogram in 31 (62.0%), 7 (14%), 3(6%), and 1 (2.0%) patients respectively. Concerning Achilles tendon pathology, USG was 95.0% sensitive, 50.0%, specific, and 92.0% accurate, whereas diagnostic sensitivity, specificity, and accuracy for X-ray was 39.0%, 75.0%, and 42.0% respectively. Conclusion: In diagnosing soft tissue pathologies in and around Achilles tendon ultrasound is far better option than conventional X-ray.","PeriodicalId":9249,"journal":{"name":"British journal of medicine and medical research","volume":"11 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88603829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiotensin-(1-7) Influences Tryptophan Absorption in the Rat and Mouse Intestine","authors":"E. Borges, Patricia Lima, A. Peluso, W. Sampaio, Jamil Oliveira, M. Oliveira, G. Etelvino, R. Ruoccolo, A. Ferreira, Robson Santos","doi":"10.9734/BJMMR/2017/30329","DOIUrl":"https://doi.org/10.9734/BJMMR/2017/30329","url":null,"abstract":"1 Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. 2 Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. 3 Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.","PeriodicalId":9249,"journal":{"name":"British journal of medicine and medical research","volume":"33 4 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85224732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trisomy 21: Genetic Analysis Aided Diagnosis","authors":"Ankit Dhimole, Sreedevi Reddy, A. Nagarajappa, Nalin Saxena","doi":"10.9734/BJMMR/2017/30147","DOIUrl":"https://doi.org/10.9734/BJMMR/2017/30147","url":null,"abstract":"Being the most common yet rare genetic syndrome in the field of dentistry Trisomy 21 also known as the Down’s syndrome named after John Langdon Down has its own importance in dentistry. It has characteristic physical, genetic and mental features which could remain undiagnosed particularly in low socio-economic group areas in countries of southern asia. Dental professionals could be the first ones to diagnose this problem as it shows unique intra-oral and extra-oral features. So we report a classic case of Down’s syndrome which remained undiagnosed throughout his life till he visited a dental professional. Case Study","PeriodicalId":9249,"journal":{"name":"British journal of medicine and medical research","volume":"22 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77769146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}