Brazilian oral research最新文献

{"title":"Comparative efficacy of violet light, bleaching gel, or their combination, in in-office bleaching: a systematic review and network meta-analysis.","authors":"Michael Willian Favoreto, Renata Maria Oleniki Terra, Camila Mendes Camargo, Bianca Maran, Vanessa Cavalli, Ana Cláudia Chibinski, Alessandro Dourado Loguercio, Alessandra Reis","doi":"10.1590/1807-3107bor-2026.vol40.056","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2026.vol40.056","url":null,"abstract":"<p><p>This systematic review and network meta-analysis aimed to determine whether the use of violet light alone (VIOL) or its combination with bleaching gels (BGVIOL) results in superior bleaching efficacy compared to bleaching gel alone (BG). Randomized clinical trials (RCTs) were identified through searches in PubMed, Cochrane Central, LILACS/BBO, SCOPUS, Web of Science, EMBASE, and gray literature sources in March, 2025. Eligible RCTs compared in-office bleaching using BG, or VIOL, or BGVIOL. The Cochrane risk of bias tool was used to evaluate the risk of bias (RoB 2.0) of the eligible RCTs. A random-effects Bayesian mixed treatment comparison model evaluated color change (ΔE*ab and ΔSGU/final SGU), and risk and intensity of tooth sensitivity (TS). Ranking probabilities were evaluated using the surface under the cumulative ranking curve, and the certainty of evidence was appraised following the Grading of Recommendations Assessment, Development, and Evaluation approach. Out of 4,963 records, 17 RCTs were included, 11 of which had a high RoB. Analysis of ΔE*ab revealed significant mean differences (MD) and 95% credibility interval (95%Crl) for the full dataset for BGVIOL vs. BG (MD = 3.13; 95%CrI: 1.33 to 4.97), but not with the subset of data that excluded studies with high RoB (MD = 2.36; 95%CrI: -0.74 to 5.34). Color change in ΔSGU did not differ among groups. VIOL showed the lowest risk and intensity of TS. Color change achieved with BG and BGVIOL was higher than that obtained with VIOL. VIOL yielded lower risk and intensity of TS. The certainty of the evidence supporting these findings is low or very low.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e056"},"PeriodicalIF":1.4,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13475733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial proteomic profile of early colonizers on the acquired pellicle of patients with head and neck cancer.","authors":"Talita Mendes Oliveira Ventura, Júlia Thomazini Pereira, Ramilli Maria de Oliveira, Larissa Tercília Grizzo Thomassian, Nathalia Regina Ribeiro, Even Akemi Taira, Vinícius Taioqui Pelá, Aline Dionizio Valle, Cássia Maria Fisher Rubira, Paulo Sérgio da Silva Santos, Marília Afonso Rabelo Buzalaf","doi":"10.1590/1807-3107bor-2026.vol40.055","DOIUrl":"10.1590/1807-3107bor-2026.vol40.055","url":null,"abstract":"<p><p>Radiotherapy is the cornerstone of head and neck cancer (HNC) treatment, but it has been frequently associated with changes in the acquired enamel pellicle (AEP), potentially affecting the early stages of dental biofilm formation. Thus, this study aimed to characterize the bacterial proteomic profiles of early colonizers adhering to the AEP in patients with HNC undergoing radiotherapy, with emphasis on radiation-induced changes that may influence oral biofilm development and oral health outcomes. AEP samples were collected from nine patients with HNC before radiotherapy (BRT), during radiotherapy (DRT), and after radiotherapy (ART), as well as from nine orally healthy individuals. Pellicles were obtained 120 min after formation and analyzed by shotgun label-free proteomics using nanoLC-ESI-MS/MS. Protein expression levels were compared between groups using the t test (p < 0.05). AEP showed elevated levels of bacterial proteins predominantly attributed to Actinomyces, mainly associated with DNA binding, chromatin organization, and glucose metabolism. The bacterial proteomic profile shifted markedly DRT, with exclusive detection of proteins involved in carbohydrate transport and metabolism, oxidative stress response, and protein folding, including several ATP-binding cassette transporters and glycolytic enzymes. Proteins related to stress tolerance, transcriptional regulation, and secretion systems were detected ART, many of them associated with bacterial species commonly linked to periodontal diseases, such as Tannerella and Oribacterium. Notably, Cysteine synthase was identified exclusively BRT in all comparisons, suggesting its potential as a biomarker. These findings indicate that radiotherapy induces dynamic changes in the AEP bacterial proteome, potentially favoring dysbiotic biofilm development and increasing susceptibility to oral diseases in patients with HNC.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e055"},"PeriodicalIF":1.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148721046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro and in vivo biocompatibility and bioactivity of bioceramic repair materials.","authors":"Lara Cancella de Arantes, Alexandre Henrique Dos Reis-Prado, Karina Sampaio Caiaffa, Pedro Augusto Monteiro Delgado, Sabrina de Castro Oliveira, Francielen Oliveira Fonseca, Warley Luciano Fonseca Tavares, Cristiane Duque, Luciano Tavares Angelo Cintra, Carlos Roberto Emerenciano Bueno, Ricardo Alves de Mesquita, Gustavo Batista de Menezes, Antônio Paulino Ribeiro-Sobrinho, Francine Benetti","doi":"10.1590/1807-3107bor-2026.vol40.053","DOIUrl":"10.1590/1807-3107bor-2026.vol40.053","url":null,"abstract":"<p><p>This study aimed to evaluate the in vitro cytotoxicity and bioactivity, and the in vivo biocompatibility, collagen maturation, and bioactivity, of PBS Cimmo HP and Bio-C Repair Ion+ in comparison with white MTA-Angelus. Osteoblast-like cell viability was assessed using the Alamar Blue assay, while bioactivity was assessed by alkaline phosphatase (ALP) activity and Alizarin Red staining. For the in vivo analysis, polyethylene tubes containing the materials or empty tubes (control) were implanted in the dorsum of mice. After 7 and 30 days (n = 8), the animals were euthanised and the specimens were processed for haematoxylin-eosin, Picrosirius Red, von Kossa (VK), and polarised light (PL) analyses. Data were statistically analysed (p < 0.05). Most materials extracts were cytocompatible (P > 0.05), except for the PBS Cimmo HP 1:4 extract at 48-h (p < 0.05). All materials showed increased ALP activity (p < 0.05). Mineralized nodules were significantly present in most material extracts (p < 0.05), except in the undiluted PBS Cimmo HP extract and in the white MTA-Angelus 1:4 extract. At 7 days, PBS Cimmo HP induced moderate-to-severe inflammation, whereas the other groups induced moderate inflammation (p > 0.05). At 30 days, all groups showed reduced inflammation (p > 0.05). Overall, the fibrous capsule was thick at 7 days and thin at 30 days. At 7 days, the control and PBS Cimmo HP groups showed a greater presence of immature collagen (p < 0.05); at 30 days, more mature collagen was observed in all groups (p > 0.05). The materials exhibited positivity for VK or PL in both periods. In conclusion, PBS Cimmo HP and Bio-C Repair Ion+ were cytocompatible and biocompatible, and demonstrated bioactivity and collagen maturation similar to those of white MTA-Angelus.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e053"},"PeriodicalIF":1.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148720177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is bruxism associated with the use of screen devices in children and adolescents? A systematic review.","authors":"Ayah Qassem Shqair, Matheus Dos Santos Fernandez, Cacilda Castelo Branco Lima, Marília Leão Goettems, Francisco Wilker Mustafa Gomes Muniz","doi":"10.1590/1807-3107bor-2026.vol40.054","DOIUrl":"10.1590/1807-3107bor-2026.vol40.054","url":null,"abstract":"<p><p>This systematic review summarized findings on the association between screen time and bruxism in children and adolescents (PROSPERO- CRD42023429775). Two researchers conducted the search and selection of studies, extracted the data, and analyzed the risk of bias. The quality of the evidence was assessed using the GRADE tool. Five databases were screened on September 25th, 2025. Studies exploring the association between bruxism and the use of screen devices in individuals aged 0-18 were included, considering different and valid study designs, screen devices, and methods of detection of bruxism behavior with or without circadian distinction. Qualitative data synthesis was performed. Eleven cross-sectional and two cohort studies were included. Eight studies found an association between bruxism and the use of screen devices in children and adolescents, while five studies did not find a significant association. In conclusion, an association between screen use or duration and bruxism in children and adolescents cannot be established. Although some studies reported positive associations for awake, sleep, and unspecified bruxism, particularly in research evaluating longer daily screen time or indicators of problematic digital use, the certainty of the evidence was very low. Further well-designed longitudinal studies should be conducted to broaden the overview of this association.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e054"},"PeriodicalIF":1.4,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148720566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of remote diagnosis of oral mucositis in children and adolescents with cancer using a mobile App: a pilot study.","authors":"Thayana Maria Navarro Ribeiro de Lima Martins, Paula Maria Maracajá Bezerra, Fábio Gomes Dos Santos, Eliane Batista de Medeiros Serpa, Ana Maria Gondim Valença, Simone Alves de Sousa","doi":"10.1590/1807-3107bor-2026.vol40.044","DOIUrl":"10.1590/1807-3107bor-2026.vol40.044","url":null,"abstract":"<p><p>Remote examinations have become increasingly common in Dentistry, especially with the use of applications. This preliminary cross-sectional study evaluated the accuracy of remote examination of oral mucositis (OM) and severe oral mucositis (SOM) using photos obtained through the Telepediatric Dentistry in Oncology (TON) application, comparing its results with the in-person clinical examination (gold standard). A total of 21 pediatric patients (13 boys, 8 girls; mean age 9.05 ± 3.46 years) undergoing chemotherapy were examined, totaling 28 in-person examinations and 224 photographic images assessed remotely by four calibrated dentists (Kappa > 0.7). The photos covered eight oral cavity sites (lips, right and left buccal mucosa, tongue dorsum, lateral tongue, palate, and floor of the mouth) and were analyzed for the presence or absence of OM and SOM. Among the 28 examinations, 11 presented OM and 3 presented SOM. The remote examination identified all positive cases (sensitivity 100%; 95%CI: 0.741-1), while specificity was 59% for OM, reflecting the occurrence of false positives, especially in the lips and buccal mucosa. Agreement between remote examiners and the gold standard ranged from 0.17 to 1.0, depending on the region and evaluator, being higher in the tongue dorsum, lateral tongue, and floor of the mouth. The results indicate that remote examination via TON may be feasible and has the ability to detect OM and SOM, potentially serving as a complementary tool in dental monitoring of children and adolescents undergoing oncology treatment, particularly when in-person examination is not possible.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e044"},"PeriodicalIF":1.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13426465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of academic year on dental student's knowledge about syphilis and its oral manifestations.","authors":"Antonio Carlos Pacheco Filho, Karina Tonini Dos Santos Pacheco, Ana Carla Layber Porto, Clea Adas Saliba Garbin","doi":"10.1590/1807-3107bor-2026.vol40.043","DOIUrl":"10.1590/1807-3107bor-2026.vol40.043","url":null,"abstract":"<p><p>This study aimed to investigate the influence of the year in the course on dental students' knowledge about syphilis and its oral manifestations. A cross-sectional study was conducted with dental students at the Federal University of Espírito Santo, Brazil, who were divided into two groups: earlier years of the Dentistry program (second and third years) and later years (fourth and fifth years). Data were collected using a questionnaire with 16 questions addressing knowledge of the main characteristics of syphilis. The Chi-square test (or Fisher's exact test with Yates correction) was used to assess the association between variables, with a significance level of 5%. The prevalence ratio (PR) and the 95% confidence interval (95% CI) were used as measures of effect size. Overall, 171 students were invited, and 169 participated in the study. Only 40 (23.7%) students answered correctly about the stages of the disease. Nearly all participants answered that syphilis presents oral manifestations; however, only 44 (26%) answered the question correctly. Regarding differential diagnoses, only 63 (37.3%) reported knowledge of the subject. The direction of the bivariate analysis was inverse to the year of study, indicating a possible association between students enrolled in the early years of the Dentistry program and better knowledge about etiologic agents (p < 0.001), clinical manifestations (p < 0.001), disease stages (p < 0.001), oral manifestations (p < 0.001), differential diagnosis (p = 0.019), and drugs (p = 0.001) related to the disease compared with students enrolled in the later years.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e043"},"PeriodicalIF":1.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13426464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathways to oral health-related quality of life in preschool children: a structural model from SB Brasil 2023.","authors":"Laissa Viegas Cardoso de Barros, Jéssica Madeira Bittencourt, Raquel Conceição Ferreira, Saul Martins Paiva, Cristiane Baccin Bendo","doi":"10.1590/1807-3107bor-2026.vol40.045","DOIUrl":"10.1590/1807-3107bor-2026.vol40.045","url":null,"abstract":"<p><p>The aim was to test a structural equation model examining the direct and indirect pathways between early childhood caries (ECC) severity and oral health-related quality of life (OHRQoL) in Brazilian preschool children, incorporating dental pain, treatment urgency, dental visits, anterior open bite (AOB), and maternal schooling into the model. A population-based study was conducted using data on five-year-old children from the 2023 Brazilian National Oral Health Survey (SB Brasil). The Brazilian version of the SOHO-5 was used to measure the impact of oral health conditions on OHRQoL. Calibrated dentists assessed ECC (dmft and pufa indices), AOB (Foster & Hamilton), and urgent oral health care needs. Parents or caregivers answered a questionnaire addressing dental pain, dental visits, and mother's schooling. Structural equation modeling was performed. Children with greater ECC severity (β = 0.674; p < 0.001) and dental pain (β = 0.241; p < 0.019) were more likely to require urgent care. Greater ECC severity was also directly associated with worse OHRQoL by both by the self-report (β = 0.261; p < 0.001) and proxy-report (β = 0.303; p < 0.001), and indirectly mediated by dental pain in both the self-report (β = 0.426; p < 0.001) and proxy report (β=0.401; p<0.001). Dental pain was associated with worse OHRQoL according to both self-report (β = 0.633; p < 0.001) and proxy-report (β = 0.597; p < 0.001). The structural model demonstrated that ECC severity negatively impacts OHRQoL through direct effects and indirect pathways mediated by dental pain. ECC and dental pain were also associated with a higher likelihood of urgent treatment.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e045"},"PeriodicalIF":1.4,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13405635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periostin and TGFβ1 levels in the saliva and gingival fluid of periodontitis patients: a cross-sectional study.","authors":"Mehmet Akif Turkan, Mehmet Oguzhan Ergin, Kamile Erciyas","doi":"10.1590/1807-3107bor-2026.vol40.048","DOIUrl":"10.1590/1807-3107bor-2026.vol40.048","url":null,"abstract":"<p><p>Periodontitis is a chronic infectious disease characterized by the progressive destruction of tooth-supporting tissues. Identifying reliable, noninvasive biomarkers is essential for improving early detection and monitoring. This cross-sectional case‒control study evaluated clinical periodontal parameters and quantified periostin and transforming growth factor-beta 1 (TGF-β1) levels in the saliva and gingival crevicular fluid (GCF) of patients with stage I-II periodontitis and periodontally healthy controls. A total of 60 systemically healthy, nonsmoking participants aged 20-60 years were included (30 periodontitis patients and 30 periodontally healthy controls). Clinical periodontal parameters, including the plaque index, gingival index, probing depth, and clinical attachment level, were recorded. GCF and saliva samples were analyzed using an enzyme-linked immunosorbent assay (ELISA). Compared with periodontally healthy controls, stage I-II periodontitis patients had significantly greater numbers of clinical periodontal parameters (p < 0.001). They also had elevated salivary periostin (1,234.5 ± 505.82 ng/mL vs. 596.32 ± 320.47 ng/mL; p = 0.001), GCF TGF-β1 (10.14 ± 4.44 pg/mL vs. 6.50 ± 3.13 pg/mL; p = 0.003), and salivary TGF-β1 (31.59 ± 7.69 pg/mL vs. 20.25 ± 9.48 pg/mL; p = 0.001) levels. GCF periostin levels did not significantly differ between the periodontitis group (311.3 ± 210.3 ng/mL) and the periodontally healthy control group (208.6 ± 147.6 ng/mL) (p = 0.092). These findings suggest that salivary periostin and TGF-β1, together with GCF TGF-β1, may serve as promising noninvasive biomarkers for the diagnosis and monitoring of early-stage periodontitis. Salivary periostin showed particularly strong discriminatory potential and may hold promise for future chairside diagnostic applications.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e048"},"PeriodicalIF":1.4,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13405632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different platform preparation and retrieval techniques on broken file removal and fracture strength.","authors":"Esra Yavas, Selen Kucukkaya Eren","doi":"10.1590/1807-3107bor-2026.vol40.047","DOIUrl":"10.1590/1807-3107bor-2026.vol40.047","url":null,"abstract":"<p><p>The aim was to evaluate the effects of different strategies on broken instrument removal and root fracture strength. After canal preparation of anterior single-rooted teeth, the samples were divided into one control group (n = 10) and six experimental groups (n = 15). A #25/.06 rotary file was broken at a length of 4 mm in the middle-third canal region in the experimental groups, and no instrument fractures were created in the control group. Access to the instrument was achieved with Gates-Glidden (GG) burs or ultrasonic tips. Dentin around the instrument was removed to create partial or full platforms. Finally, the instruments were removed with ultrasonic tips or a BTR Pen. The effectiveness of broken instrument removal, the duration of removal, and any complications that occurred were recorded. All the root canals were obturated. Fracture strength analysis was performed using a universal testing machine. Statistical analysis was performed using the Kruskal-Wallis and Dunn tests (p < 0.05). All broken instruments were successfully removed. The access time to the broken instrument in the groups using GG burs was shorter than that in the groups using ultrasonic tips (p < 0.05), while there was no significant difference between the groups in terms of total removal time (p > 0.05). The fracture strength of the control group was similar to that of the group in which ultrasonic tips were used to access the broken instrument and to create a full platform, and the BTR Pen was used for the removal of the broken instrument (p > 0.05), but showed higher fracture strength than that of the other experimental groups (p < 0.05). Different strategies used in the removal of broken instruments affected access time and root fracture strength.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e047"},"PeriodicalIF":1.4,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13405633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between gastroesophageal reflux and bruxism: a scoping and bibliometric review.","authors":"Vitor Laguardia Guido Faria, Luiz Renato Paranhos, Douglas Teixeira da Silva, Danilo Cassiano Ferraz, Paulo Isaias Seraidarian, Marcelo Bighetti Toniollo, Rafael Rodrigues Lima, Paulo Cézar Simamoto Júnior","doi":"10.1590/1807-3107bor-2026.vol40.046","DOIUrl":"10.1590/1807-3107bor-2026.vol40.046","url":null,"abstract":"<p><p>This review summarizes the literature on association between gastroesophageal reflux disease (GERD) and bruxism. A systematic search was performed in June 2024 and updated in October 2025 across electronic databases (MedLine/PubMed, LILACS/BBO, SciELO, EMBASE, Scopus, and Web of Science) and grey literature (OpenGrey, ProQuest, and LIVIVO). Case reports, clinical trials, and observational studies addressing the GERD-bruxism association in individuals of any age without systemic diseases, syndromes, or neuromotor disorders were included. Study selection and data extraction were independently conducted by two reviewers. Twenty-two articles met inclusion: six case reports, six cross-sectional studies, four case-control studies, and six clinical trials, totaling 15,889 participants (73.4% women; mean age 44.5 years). All but three cross-sectional studies reported an association between GERD and bruxism. Clinical studies have consistently demonstrated that esophageal acidification, whether experimentally induced or present in patients with GERD, increases the hourly frequency of rhythmic masticatory muscle activity (RMMA), short bursts and RMMA with grinding. Two clinical trials that tested proton pump inhibitors observed a reduced RMMA frequency. One clinical study assessed awake bruxism, and two observational studies assessed sleep bruxism. Bibliometric analysis identified 9 author clusters and 17 collaboration networks, with research concentrated in Japan but showing marked global growth from 2018 to 2025. Bruxism and GERD showed a positive association. However, methodological heterogeneity and numerous confounders prevented robust evidence and limited the clinical inference. Bibliometric analysis shows that research remains centered in Japan but is expanding globally, reflecting growing interdisciplinary interest and the need for greater international and methodological integration.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"40 ","pages":"e046"},"PeriodicalIF":1.4,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13405642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148618604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}