Brazilian oral research最新文献

{"title":"Comparative analysis of clinicopathological characteristics in young and elderly patients with oral squamous cell carcinoma: a retrospective study in Northeastern Brazil.","authors":"Pedro Augusto Bulhões Curioso, Ivan José Correia Neto, Lucas Lacerda de Souza, Edilmar de Moura Santos, Alan Roger Santos-Silva, Pablo Agustin Vargas, Marcio Ajudarte Lopes","doi":"10.1590/1807-3107bor-2024.vol38.0138","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2024.vol38.0138","url":null,"abstract":"<p><p>The aim of this study was to perform a clinicopathological analysis of oral squamous cell carcinoma (OSCC) in young patients from the northeast of Brazil and compare with elderly individuals. This retrospective study reviewed 104 OSCC cases from 2000 to 2015, focusing on patients under 40 and over 60 at diagnosis. Forty-two patients under 40 years old (40.38%) and 62 patients over 60 years old (59.62%) were analyzed using descriptive statistics, chi-square, and Fisher's exact tests for clinicopathological factors, and Kaplan-Meier and Cox models for survival and prognostics. Most of the patients were male, with younger patients having lower rates of smoking (45.24%) and alcohol use (28.57%) compared to older patients (82.30% and 40.32%, respectively). Younger patients had a higher prevalence of tongue cancer and smaller tumors but faced more compromised surgical margins, perineural invasion, local recurrence, regional metastasis, distant metastasis, and second primary tumors. Statistical findings highlighted age-related differences in clinicopathological features and indicated that despite similar overall survival rates, younger patients had a poorer prognosis related to local recurrences, regional recurrences, and second tumors. Perineural invasion emerged as an independent prognostic factor. The study suggests that younger OSCC patients require personalized management strategies to address their higher risk of adverse outcomes, with an emphasis on the prognostic significance of perineural invasion.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e138"},"PeriodicalIF":1.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental appointments in the primary health care setting for users with toothache: a longitudinal analysis.","authors":"Fabiano Costa Diniz, Maria Inês Barreiros Senna, Érika Talita Silva, Lígia de Assis Silva, Gizelton Pereira Alencar, Elisa Lopes Pinheiro, Loliza Luiz Figueiredo Houri Chalub, Raquel Conceição Ferreira","doi":"10.1590/1807-3107bor-2024.vol38.0134","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2024.vol38.0134","url":null,"abstract":"<p><p>This study aimed to estimate the morbidity associated with toothache treated in the primary health care (PHC) setting, stratified by the population size of Brazilian municipalities, from 2018 to 2022. This longitudinal ecological study was based on public national data from routine public dental service utilization records within the Health Information System for Primary Care. These data were employed to compute the rate of dental appointments for users with toothache (per 1,000 users) within each municipality throughout 15 four-month periods (P1-2018 to P3-2022), classified by population size. We integrated the databases for population size, denominator, and numerators. A longitudinal data regression model was used to estimate the four-monthly variation before and after P2-2020. Records from 5,332 municipalities (95.72%) were analyzed. The average rate of dental appointments for users with toothache (per 1,000 users) ranged from 9.65 (P2-2020) to 27.24 (P1-2018). Throughout the period, larger municipalities showed the lowest rates. Before P2-2020, the average rate in municipalities with >100,000 inhabitants fell by an average of 20.56% every four months, higher than the 7.25% variation in municipalities with < 5,000 inhabitants. After P2-2020, the rate in municipalities with < 5,000 inhabitants rose by 2.27%, a value lower than the variation in larger municipalities. The rates of dental appointments for users with toothache in the PHC setting indicate the persistent severity of dental conditions among public health service users, with variations across different regions of the country. The COVID-19 pandemic has affected the rate of dental appointments for users with toothache, underscoring the need for dental services to enhance their adaptability and responsiveness to such crises.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e134"},"PeriodicalIF":1.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fiberglass posts reduced fractures in endodontically treated teeth restored with veneers: a case-control study.","authors":"Fábio Herrmann Coelho-DE-Souza, Andréa de Azevedo Brito Conceição, Maria Carolina Guilherme Erhardt, Luciano de Souza Gonçalves","doi":"10.1590/1807-3107bor-2024.vol38.0137","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2024.vol38.0137","url":null,"abstract":"<p><p>This study aimed to evaluate the effects of fiberglass posts on fracture behavior in endodontically treated teeth (ETT) restored with composite veneers. Adult patients who had endodontically treated anterior teeth restored with composite veneers, with or without fiberglass posts, were divided into the case (with fractured teeth) and control (without fractured teeth) groups. All fracture patterns were sorted by a 6-point scoring system: 0, no fracture; 1, veneer buccal fracture; 2, incisal edge fracture; 3, coronal middle-third fracture; 4, coronal cervical fracture; 5, coronal and root fracture; and 6, root fracture. The odds ratio was calculated concerning the outcome (fracture) and exposed factor (post presence). Fracture patterns were analyzed by the Mann-Whitney and Fisher exact tests, with a significance level of 95%. Of the 89 ETT restored with composite veneers (31 with posts; 58 without posts), 30 were fractured. The odds ratio revealed a reduction in fracture risk to 34% compared with ETT without posts. Teeth without posts fractured more frequently, showing more complex fracture patterns. In conclusion, fiberglass posts decreased the risk of fractures in ETT restored with composite veneers.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e137"},"PeriodicalIF":1.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral cancer immunology: state of the art and future perspectives.","authors":"Fábio Muradás Girardi, Lauren Frenzel Schuch, Manoela Domingues Martins","doi":"10.1590/1807-3107bor-2024.vol38.0129","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2024.vol38.0129","url":null,"abstract":"<p><p>Oral cancer is a multifactorial disease involving genetic, epigenetic, and environmental factors. The literature indicates that inflammatory cells at the advancing front of the tumor induce a host immune response, preventing the spread of the tumor. However, cancer cells adopt various continued strategies to circumvent this immune surveillance. The complexity of immune mechanisms suggests that there must be virtually individual patterns of anti-tumor immune responses. Due to this important interaction of cancer with the immune system, the objective of the present study was to provide an up-to-date overview of immuno-oncology focused on oral cancer, summarizing the basic immunology, the classic risk factors, immunotherapy, and future treatment and prognostic perspectives.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e129"},"PeriodicalIF":1.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermogenic preworkout supplement induces alveolar bone loss in a rat model of tooth movement via RANK/RANKL/OPG pathway.","authors":"Gurgiane Rodrigues Gurgel Cavalcante, Mariana Cabral Moreno, Flavia Queiroz Pirih, Vanessa de Paula Soares, Éricka Janine Dantas da Silveira, José Sandro Pereira da Silva, Hallissa Simplício Gomes Pereira, Katherine Pennington Klein, Maria Luiza Diniz de Sousa Lopes, Aurigena Antunes de Araujo, Agnes Andrade Martins, Ruthinéia Diógenes Alves Uchôa Lins","doi":"10.1590/1807-3107bor-2024.vol38.0131","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2024.vol38.0131","url":null,"abstract":"<p><p>The aim of this study was to investigate the effect of thermogenic supplementation on the bone tissue of rats subjected to orthodontic movement. A total of 38 male Wistar rats underwent orthodontic movement of the left permanent maxillary first molars for 21 days. The rats were assigned to three groups: Control group: water; Thermogenic 1: C4 Beta Pump thermogenic; or Thermogenic 2: PRE-HD/Pre-workout. Micro-computed tomography (micro-CT) was used to investigate the dynamic changes in the microstructure of alveolar bone during orthodontic tooth movement in rats. Histopathologic analysis was performed by hematoxylin and eosin (H&E) staining, whereas tartrate-resistant acid phosphatase (TRAP) was employed for osteoclast count. Maxillary tissue was collected and evaluated by immunohistochemistry for receptor activator of NF-κB (RANK), receptor activator of NF-κB ligand (RANKL), and osteoprotegerin (OPG). The Thermogenic 2 group exhibited a significantly lower percentage of bone volume fraction (BV/TV) (68.21% ± 17.70%) compared to the control (86.84% + 12.91%) and Thermogenic 1 groups (86.84% + 15.94%) (p < 0.05). The control group had a significantly higher mean orthodontic movement in the mesial direction (0.2143 mm + 0.1513 mm) than the Thermogenic 2 group (0.0420 mm + 0.05215 mm) (p < 0.05). The Thermogenic 2 and Thermogenic 1 groups showed a stronger immunostaining for RANKL when compared to the control group (p < 0.05). The supplementation used in the Thermogenic 2 group (PRE-HD/Pre-workout) induced alveolar bone loss in rats subjected to orthodontic movement, which can be related to the regulation of the RANK/RANKL/OPG signaling pathway. This suggests the influence of thermogenic supplements on bone metabolism seems to depend on their composition.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e131"},"PeriodicalIF":1.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal epidemiological profile of oral potentially malignant disorders in southern Brazil.","authors":"Natália Souza Dos Santos, Amanda Zimmer Rodrigues, Camila Alves Ferri, Taiane Berguemaier de Lima, Natalia Koerich Laureano, Pantelis Varvaki Rados, Vinícius Coelho Carrard, Laura de Campos Hildebrand, Fernanda Visioli","doi":"10.1590/1807-3107bor-2024.vol38.0132","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2024.vol38.0132","url":null,"abstract":"<p><p>The study aimed to investigate oral potentially malignant disorders (OPMDs) diagnosed in an Oral Pathology service in southern Brazil over a span of 56 years and to assess the factors influencing their severity and outcomes. A retrospective analysis of histopathological records from 1965 to 2021 was performed. Lesions diagnosed as leukoplakia, erythroplakia, leukoerythroplakia, or actinic cheilitis were included. Data on age, sex, race, tobacco smoking, alcohol drinking, clinical characteristics, biopsy type, and histopathological diagnosis were collected. Among 32.698 histopathological reports, 2.10% were classified as OPMD. The study included 689 specimens from 602 patients, with a predominance of cases affecting men aged over 51 years, particularly in anatomical sites considered of low risk. White lesions, with leukoplakia as the most common clinical diagnosis were observed. Over time, there was an increase in the incidence of OPMDs among females and in high-risk anatomical sites. The mean follow-up period was 30.28 ± 29.86 months, during which 9.6% of cases exhibited malignant transformation. Lesions diagnosed as leukoerythroplakia and those presenting epithelial dysplasia exhibited a higher risk of malignant transformation, particularly when located in high-risk sites. This underscores the importance of identifying clinical and microscopic features, as well as lesion's anatomical location, as crucial factors in determining the risk of malignant transformation. These findings provide valuable insights for clinicians managing OPMDs and contribute to the improvement of oral cancer prevention.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e132"},"PeriodicalIF":1.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic and protective effects of bioactive toothpastes on eroded enamel surfaces.","authors":"Andressa Feitosa Bezerra de Oliveira, Vitória Régia Rolim Nunes, Juliellen Luiz da Cunha, Anderson Gomes Forte, Arthur Felipe de Brito Andrade, Nayanna Lana Soares Fernandes, Ana Maria Barros Chaves Pereira, Paulo Henrique Perlatti D'Alpino, Fábio Correia Sampaio","doi":"10.1590/1807-3107bor-2024.vol38.0139","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2024.vol38.0139","url":null,"abstract":"<p><p>This study aimed to evaluate the effectiveness of bioactive toothpastes in remineralizing eroded enamel surfaces in vitro. Bovine enamel blocks (n = 48) were obtained and classified into untreated, demineralized, and treated areas. Specimens were randomly classified into six groups (n = 8 each): fluoride-free toothpaste (NCT), Colgate Total 12 (PCT), Sensodyne Repair and Protect (SRP), Sensodyne Pronamel (SPE), Regenerador + Sensitive (RGS), and RGS/calcium booster (RCB). The specimens were subjected to erosive pH cycling for 5 days for 4 times/day (90 s) and treated with toothpaste slurries (1:3) for 1 min. The Vickers hardness (50 g/10 s) and percentage surface hardness recovery (%SMHR) were calculated. Furthermore, the topography and roughness (Ra) of the enamel surface were evaluated using a 3D non-contact optical profilometer, along with the tooth surface loss (TSL). Data were statistically analyzed using analysis of variance or Tukey's test (significance: 5%). The %SMHR of the SRP and NCT groups were significantly lower than those of the other groups (p < 0.05). Ra was higher when the eroded area was treated with SRP and SPE (p < 0.05). Treatment with RGS, PCT, and SPE favored the recovery of the enamel surface compared with the NCT group (p < 0.05). The best TSL results were obtained with treatment with RGS, followed by PCT and SPE (p < 0.05). The RCB group showed statistically equivalent results for surface hardness recovery and TSL (p > 0.05). Conclusively, PCT and RGS toothpastes were more effective in remineralizing the enamel surface.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e139"},"PeriodicalIF":1.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143055856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roughness profile and surface roughness after toothbrushing and degree of conversion of bulk-fill resins.","authors":"Raquel Sano Suga Terada, Bruna Marin Fronza, Juliana Jendiroba Faraoni, Lidiane Vizioli de Castro Hoshino, Francielle Sato, Regina Guenka Palma-Dibb, Debora Lopes Salles Scheffel, Marcelo Giannini","doi":"10.1590/1807-3107bor-2024.vol38.0128","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2024.vol38.0128","url":null,"abstract":"<p><p>The aim of this study was to assess roughness profile and surface roughness after simulated toothbrushing cycles, as well as the degree of conversion (DC) of bulk-fill resin composites at different depths. Forty nine composite discs were made from three low-viscosity bulk-fill resins (Filtek Bulk-Fill Flowable/3M Oral Care - FBF, Beautifil-Bulk Flowable/Shofu Inc. - BBF and Surefill SDR Flow/Dentsply Caulk - SDR), three high-viscosity bulk-fill resin composites (Filtek Bulk-Fill Restorative/3M Oral Care - FBR, Beautifil-Bulk Restorative/Shofu Inc. - BBR and Tetric EvoCeram Bulk Fill/Ivoclar Vivadent - TEB) and one conventional composite (Filtek Supreme Ultra/3M Oral Care - FSU) (n=7), using addition silicon molds (2 mm thick x 10 mm diameter). The roughness profile (Rv) and surface roughness (Sa) were analyzed after 30,000 brushing cycles using confocal laser scanning microscopy. Five samples (4 mm thick x 2 mm diameter) were produced per resin composite and light-cured for 20 seconds using a LED-curing unit. After 24 hours at 37oC, DC of samples was evaluated at four depths, using a confocal Raman microscope. The data were analyzed by ANOVA and Tukey post hoc multiple-comparison tests (α = 0.05). The Rv values of FSU were lower than those obtained for BBR and BBF. The toothbrushing significantly decreased the Sa for all composites. The DC was significantly reduced at 4 mm depth. Toothbrushing changed composite surface of all materials, especially for BBR and BBF. Composites were not able to maintain the DC values shown at the top compared with those at the bottom (4 mm depth).</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e128"},"PeriodicalIF":1.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial efficacy of natural-based endodontic solutions: a systematic review with a network meta-analysis.","authors":"Danilo Cassiano Ferraz, Anahi de Paula Melo, Felipe de Souza Matos, Luiz Renato Paranhos, Camilla Christian Gomes Moura, Cauane Blumenberg, Juliane Maria Guerreiro-Tanomaru, Mário Tanomaru-Filho","doi":"10.1590/1807-3107bor-2024.vol38.0093","DOIUrl":"10.1590/1807-3107bor-2024.vol38.0093","url":null,"abstract":"<p><p>This systematic review aims to provide preclinical evidence of the antimicrobial efficacy of natural endodontic solutions (NES) compared to sodium hypochlorite (NaOCl) and chlorhexidine (CHX) against Enterococcus faecalis. The study followed the PRISMA guidelines and had a registered protocol (PROSPERO - CRD42021224022). The inclusion criteria comprised ex vivo studies simulating root canal irrigation to assess the standardized mean difference of colony-forming units (CFUs). Records were systematically identified in PubMed, Scopus, EMBASE, SciELO, Web of Science, LILACS, DANS Easy, and BDTD databases in January 2024. The RoBDEMAT tool helped determine the risk of bias. As for the network meta-analysis, CFU data were collected pre- and post-irrigation protocols as an effect measure. Thirty-five studies met the eligibility criteria and were included in the qualitative analysis, and seven studies were eligible for the network meta-analysis. The total sample consisted of 1,504 root canals. Among the tested solutions, apple cider vinegar combined with 2.5% NaOCl showed the highest probability of reducing CFUs after root canal irrigation (95%CI: -0.76-0.20), followed by 2% CHX and NaOCl (considering the different concentrations [95%CI: -0.32-0.17]). The bias assessment revealed significant omissions in reporting, particularly regarding sample size calculation, sample randomization, and operator blinding. The obtained evidence demonstrated that, even though NES did not overcome NaOCl, they have antimicrobial potential against Enterococcus faecalis.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e093"},"PeriodicalIF":1.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of in vitro antimicrobial intracanal medicaments against C. albicans and E. faecalis in primary teeth.","authors":"Emily Feitosa Rêgo, Yedda Maria Ribeiro Vasconcelos Rosário, Rogerio Gleiser, Antônio Ferreira-Pereira, Maristela Barbosa Portela, Laura Guimarães Primo","doi":"10.1590/1807-3107bor-2024.vol38.0133","DOIUrl":"https://doi.org/10.1590/1807-3107bor-2024.vol38.0133","url":null,"abstract":"<p><p>To exclusively evaluate, in vitro, the efficacy of five intracanal medicaments against Candida albicans and Enterococcus faecalis in infected single-rooted primary teeth. Forty-three teeth were selected, out of which 42 were simultaneously contaminated with C. albicans and E. faecalis, verified by measuring the initial quantification (IQ), whereas one tooth was used as sterile control. Forty-two teeth were then randomly assigned to six groups (n = 7 teeth in each); one was the control group, while the others received calcium hydroxide (CH), camphorated paramonochlorophenol (CMCP), CH/CMCP, chlorhexidine (CHX), or iodoform paste (IP). Two samples from each group were then randomly selected and evaluated under a scanning electron microscope along with the sterile control (n = 1) for qualitative analyses (n = 13). The remaining samples (n = 30) were collected after 7 days of intracanal medicaments (final quantification - FQ) and 7 days after medicament removal (residual quantification - RQ). ANOVA and Tukey's and c2 tests (p £ 0.05) were performed for the statistical analysis. All the medicaments, except CMCP, significantly reduced the levels of C. albicans from IQ to FQ (p = 0.046). Only CHX (p = 0.000) and IP (p = 0.007) showed a significant reduction from IQ to FQ against E. faecalis. The 2% CHX and IP demonstrated a favorable performance as an intracanal medicament, with a good antimicrobial activity against C. albicans and E. faecalis.</p>","PeriodicalId":9240,"journal":{"name":"Brazilian oral research","volume":"38 ","pages":"e133"},"PeriodicalIF":1.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143055857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}