British Journal of Dermatology最新文献

{"title":"High prevalence of chronic hand eczema in Europe and Canada.","authors":"Anna Sophie Quaade","doi":"10.1093/bjd/ljaf066","DOIUrl":"10.1093/bjd/ljaf066","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"967-968"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ipilimumab + nivolumab in combination vs. nivolumab monotherapy as first-line treatment in patients with metastatic melanoma: conclusions from a real-world French national cohort.","authors":"Charlée Nardin, Dewi Vernerey, François Aubin","doi":"10.1093/bjd/ljaf080","DOIUrl":"10.1093/bjd/ljaf080","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"971-972"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'Incidence of noninfectious uveitis among patients with hidradenitis suppurativa': reply from authors.","authors":"Andrew Strunk, Amit Garg","doi":"10.1093/bjd/ljaf084","DOIUrl":"10.1093/bjd/ljaf084","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1146-1147"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting the melanoma research agenda for all end-users: the need to include patient, clinician and policy perspectives.","authors":"Deonna M Ackermann, Katy J L Bell","doi":"10.1093/bjd/ljaf082","DOIUrl":"10.1093/bjd/ljaf082","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"968-969"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-throughput proteomics identifies inflammatory proteins associated with disease severity and genetic ancestry in patients with hidradenitis suppurativa.","authors":"Peter M Dimitrion, Rachel Krevh, Jesse Veenstra, James Ge, Aamir Siddiqui, Deangelo Ferguson, Aakash Hans, Bobby Zuniga, Kermanjot Sidhu, Steven Daveluy, Iltefat Hamzavi, Li Zhou, Indra Adrianto, Qing-Sheng Mi","doi":"10.1093/bjd/ljaf012","DOIUrl":"10.1093/bjd/ljaf012","url":null,"abstract":"<p><strong>Background: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition with a greater prevalence and disease burden in patients who identify as African American and those with a family history of HS, suggesting a strong genetic component to its pathogenesis.</p><p><strong>Objectives: </strong>To evaluate the relationship between plasma inflammatory protein expression, HS disease severity and genetic ancestry in a diverse cohort of patients with HS.</p><p><strong>Methods: </strong>We performed a case-control, single-centre study of patients with HS and age-, sex- and ethnicity-matched healthy control participants. We profiled circulating inflammatory proteins using Olink® high-throughput proteomics and determined genetic ancestry from whole-genome sequencing data.</p><p><strong>Results: </strong>Using linear regression, we identified novel proteins associated with HS, after adjusting for age, sex and ethnicity. Our analysis also revealed differences in the inflammatory proteome linked to disease severity. Specifically, we found that plasma levels of interleukin (IL)-6 can distinguish between different Hurley stages, indicating that IL-6 may serve as a marker of disease severity. Additionally, we found variations in inflammatory protein levels based on genetic ancestry: patients with predominantly African ancestry exhibited higher levels of inflammatory proteins associated with neutrophilic inflammation, while those with predominantly European ancestry showed increased levels of T helper 1-related inflammatory proteins.</p><p><strong>Conclusions: </strong>Although we were unable to account for treatment status or comorbidities that may influence the level of inflammatory cytokines, genetic ancestry and disease severity may influence the plasma inflammatory profile in patients with HS.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1063-1071"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and pathogenic activity of anti-desmocollin-3 antibodies in patients with pemphigus vulgaris and pemphigus foliaceus.","authors":"Maud Maho-Vaillant, Alexandre Lemieux, Christophe Arnoult, Léopoldine Lebourgeois, Vivien Hébert, Thara Jaworski, Billal Tedbirt, Fabienne Jouen, Olivier Boyer, Sébastien Calbo, Pascal Joly, Marie-Laure Golinski","doi":"10.1093/bjd/ljaf021","DOIUrl":"10.1093/bjd/ljaf021","url":null,"abstract":"<p><strong>Background: </strong>Desmocollin-3 (DSC3) is a calcium-dependent desmosomal cadherin that plays an essential role in cell-cell adhesion. IgG antibodies (Abs) directed against the extracellular (EC) domain of DSC3 have occasionally been detected in rare types of pemphigus. Investigations into the prevalence of anti-EC-DSC3 IgG Abs and those targeting the intracellular (IC) domain of DSC3 in pemphigus vulgaris and pemphigus foliaceus sera, and their potential pathogenic activity, have yielded conflicting results.</p><p><strong>Objectives: </strong>To assess the prevalence and pathogenicity of Abs directed against the EC and IC domains of DSC3 in patients with pemphigus.</p><p><strong>Methods: </strong>Anti-DSC3 IgG and IgA directed against the EC and IC domains of DSC3 were assayed in 146 patients with pemphigus using a newly developed addressable laser bead immunoassay. The pathogenicity of these autoAbs was first tested in vitro using a keratinocyte dissociation assay with patients' sera or from C57BL/6 mice immunized with recombinant IC-DSC3. In vivo pathogenicity was tested by passive transfer of an anti-IC-DSC3 monoclonal Ab (mAb) derived from a hybridoma (A9) into neonatal mice.</p><p><strong>Results: </strong>Anti-EC-DSC3 or anti-IC-DSC3 IgG and/or IgA Abs were detected in 21.2% of sera from patients with pemphigus vs. 4.0% (P < 0.001) and 5.0% (P < 0.001) of sera from healthy donors, respectively. Most anti-DSC3 Abs corresponded to IgA. Anti-IC-DSC3 Abs were detected in 44% of patients with pemphigus whose serum anti-desmoglein (DSG) 1-3 Ab profile was inconsistent with their clinical and histological features, according to compensation theory. Anti-IC-DSC3 IgG and IgA Abs induced a dissociation of the keratinocyte monolayer in vitro, which was abolished by preadsorption of these IgG or IgA fractions with recombinant IC-DSC3. In addition, IgG from mice immunized with recombinant IC-DSC3 induced acantholysis in vitro. Finally, in neonatal mice, the passive transfer of an anti-IC-DSC3 mAb in combination with anti-DSG1-3 Abs exacerbated blister formation.</p><p><strong>Conclusions: </strong>Our findings suggest that anti-IC-DSC3 Abs are pathogenic and explain the discordance seen in some patients with regard to their clinical phenotype and their anti-DSG1-3 Ab profile.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1072-1082"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-line treatment patterns and overall survival in patients diagnosed with metastatic Merkel cell carcinoma in England from 2013 to 2020: results of a nationwide observational cohort study.","authors":"Seyed Hamidreza Mahmoudpour, Craig Knott, Jenny Nobes, Mairead Kearney, Emmanuelle Boutmy, Patrice Verpillat, Zoe C Venables","doi":"10.1093/bjd/ljaf063","DOIUrl":"10.1093/bjd/ljaf063","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1134-1136"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of noninfectious uveitis among patients with hidradenitis suppurativa.","authors":"Temitope Ayodele, Bria Midgette, Andrew Strunk, Robert Sabat, Kerstin Wolk, Amit Garg","doi":"10.1093/bjd/ljaf004","DOIUrl":"10.1093/bjd/ljaf004","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1120-1122"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin cancer risk in more than 200 000 patients with haematological malignancies over 30 years: a nationwide population-based study in the Netherlands.","authors":"Celeste J Eggermont, Andrya Hollatz, Marlies Wakkee, Marieke Louwman, Avinash G Dinmohamed, Eduardus F M Posthuma, Tamar Nijsten, Loes Hollestein","doi":"10.1093/bjd/ljaf027","DOIUrl":"10.1093/bjd/ljaf027","url":null,"abstract":"<p><strong>Background: </strong>Patients with haematological malignancies are at increased risk of developing skin cancer and often experience worse skin cancer-related outcomes. However, there is a lack of nationwide, population-based data with long-term follow-up on the incidence and risks of different skin cancer types across all haematological malignancies.</p><p><strong>Objectives: </strong>To assess population-based risk estimates for cutaneous squamous cell carcinoma (cSCC), malignant melanoma (MM), Merkel cell carcinoma (MCC) and basal cell carcinoma (BCC) among patients with haematological malignancies, stratified by skin cancer type and haematological malignancy subgroup. These estimates can serve as a base for surveillance guidelines and patient education.</p><p><strong>Methods: </strong>This nationwide population-based epidemiological cohort study used data from 210 794 patients diagnosed with a haematological malignancy between 1989 and 2020 from the Netherlands Cancer Registry (NCR). In addition, data on each type of histopathologically confirmed skin cancer per patient after haematological malignancy diagnosis were retrieved from the NCR. Patients with a history of skin cancer prior to their haematological malignancy were excluded. Cumulative incidences, standardized incidence ratios (SIRs) and absolute excess risks for each of the four skin cancers were calculated and stratified by haematological malignancy subgroup, age, sex, follow-up and primary treatment.</p><p><strong>Results: </strong>The overall 10-year cumulative incidence of developing a first skin cancer was 2.6% for cSCC, 0.5% for MM, 0.05% for MCC and 4.8% for BCC. Compared with the general population, nearly all haematological malignancy subgroups showed more than a twofold increased risk of cSCC, MM, MCC and BCC. Patients with chronic lymphocytic leukaemia (CLL) showed the highest risks for each of the four skin cancers, with SIRs of 4.4 for cSCC, 2.7 for MM, 9.3 for MCC, and 2.6 for BCC. These elevated risks persisted for > 30 years after haematological malignancy diagnosis.</p><p><strong>Conclusions: </strong>Patients with all types of haematological malignancies, and especially those with CLL, have a lifetime increased risk of developing different types of skin cancer. These findings highlight the importance of creating awareness among patients and care providers about this increased risk and promoting sun-protective measures and regular skin self-examinations in this high-risk population.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1029-1037"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyalohyphomycosis caused by antifungal-resistant Scopulariopsis brevicaulis in a patient with CARD9 deficiency.","authors":"Yanyang Guo, Tianshuo Zhao, Chunying Xiao, Dong Yan, Luming Hai, Yubo Ma, Meng Fu","doi":"10.1093/bjd/ljaf051","DOIUrl":"10.1093/bjd/ljaf051","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1131-1132"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}