British Journal of Dermatology最新文献

{"title":"Incidence and patterns of newly developed pigmented lesions in adults at high risk for melanoma.","authors":"Anna K Wolber, Dilki Jayasinghe, Brigid Betz-Stablein, Monika Janda, H Peter Soyer, Harald Kittler","doi":"10.1093/bjd/ljae467","DOIUrl":"https://doi.org/10.1093/bjd/ljae467","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of PCSK9 inhibitors with risk of nonmelanoma skin cancer: a retrospective cohort study.","authors":"Cheng-Yuan Li, Wei-Ting Wang, Sheng-Hsiang Ma, Li-Wei Lo, Chen-Yi Wu, Wei-Chuan Chang, Yi-Ju Chen, Tai-Li Chen","doi":"10.1093/bjd/ljae438","DOIUrl":"10.1093/bjd/ljae438","url":null,"abstract":"<p><strong>Background: </strong>Growing evidence has shown that cholesterol metabolism abnormalities involve carcinogenesis. Proprotein convertase subtilisin/kexin type-9 (PCSK9) inhibitors have been reported to inhibit tumor progression and prevent ultraviolet-related skin damage.</p><p><strong>Objective: </strong>To investigate the association of PCSK9 inhibitors with the risk of nonmelanoma skin cancer (NMSC).</p><p><strong>Methods: </strong>This retrospective cohort study analyzed data from the US Collaborative Network in the TriNetX database. Adults aged ≥40 years with atherosclerotic cardiovascular disease (ASCVD) under statin therapy between 2016 and 2022 were identified. A target trial design was used to compare the risk of NMSC, including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), among patients additionally treated with PCSK9 inhibitors or continuing statin therapy (the control group). Each head-to-head comparison involved propensity score matching. Hazard ratios (HRs) were estimated using Cox proportional hazard models. Stratified analyses based on age, sex, Fitzpatrick skin type, and immune status were also performed.</p><p><strong>Results: </strong>A total of 73,636 patients with ASCVD were analyzed. Compared with the control group, the ASCVD patients initiating PCSK9 inhibitors were associated with lower risks of NMSC (HR: 0.78; 95%CI: 0.71-0.87), BCC (HR: 0.78; 95%CI: 0.69-0.89), and cSCC (HR: 0.79; 95%CI: 0.67-0.93). Subanalyses revealed the reduced risk of NMSC observed with each PCSK9 inhibitor, namely, evolocumab and alirocumab. Stratified analyses showed similar results among patients aged 65-79 years, those more than 80 years, and male patients.</p><p><strong>Conclusions: </strong>Our study indicated ASCVD patients with PCSK9 inhibitors have a lower risk of incident NMSC than those without PCSK9 inhibitors.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A reassuringly routine trial.","authors":"Joerg Albrecht","doi":"10.1093/bjd/ljae468","DOIUrl":"https://doi.org/10.1093/bjd/ljae468","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caffeine-induced fixed drug eruption (FDE): Evidence from a positive patch-test.","authors":"Bouraoui Ouni, Ferdaous Chahed, Bahaeddine Dridi, Raoudha Slim, Nedia Ghariani, Nesrine Bensayed, Neila Fathallah","doi":"10.1093/bjd/ljae463","DOIUrl":"https://doi.org/10.1093/bjd/ljae463","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome sequencing reveals novel IKBKG structural variants associated with incontinentia pigmenti.","authors":"Neta Pipko, Rachel Youjin Oh, Aiyana Kaplan, Andrea Shugar, Anna Szuto, Miriam Weinstein, Grace Yoon, Roberto Mendoza-Londono, Elena Pope, Ted Young, Christian R Marshall, Gregory Costain, Irene Lara-Corrales, Yiming Wang","doi":"10.1093/bjd/ljae462","DOIUrl":"https://doi.org/10.1093/bjd/ljae462","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Typical Eschar in Scrub Typhus.","authors":"Kang An, Chaoyao Guo, Shunqiang Luo","doi":"10.1093/bjd/ljae461","DOIUrl":"https://doi.org/10.1093/bjd/ljae461","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin microbiome dynamics in patients with polymorphic light eruption in response to UV radiations.","authors":"Yacine Amar, Sebastian Niedermeier, Rafaela Silva, Susanne Kublik, Michael Schloter, Tilo Biedermann, Martin Köberle, Bernadette Eberlein","doi":"10.1093/bjd/ljae464","DOIUrl":"https://doi.org/10.1093/bjd/ljae464","url":null,"abstract":"<p><strong>Background: </strong>Polymorphic light eruption (PLE) is the most frequent photodermatosis in Europe with an estimated prevalence of 10 to 20%, particularly in temperate climates. Itching or burning lesions appear only in sun-exposed areas, predominantly on the chest, the arms and forearms within a few hours following exposure. The disease's cause is still unknown, yet studies have suggested that skin microbial elements may play a role in its pathogenesis.</p><p><strong>Objectives: </strong>We investigated in this cohort the skin microbiome of PLE patients upon exposure to ultraviolet radiation (UVR), to assess its role in the onset of PLE lesions.</p><p><strong>Methods: </strong>Forty-one skin swabs have been collected from eleven PLE patients at baseline and following a three-day exposure to UVR and from healthy controls. The collected swabs were analyzed for their microbial composition using a 16S amplicon sequencing approach.</p><p><strong>Results: </strong>The PLE skin showed a dysbalanced microbiome, already at baseline, with significantly reduced microbial diversity and noticeable colonization by bacterial pathogens as Staphylococcus aureus. Upon UVR exposure, the PLE microbiome exhibited a further loss of diversity and decline of beneficial skin commensals. In line with this, we observed that UVR exerted strong antimicrobial effects in vitro against representative skin residents.</p><p><strong>Conclusions: </strong>Taken together, UVR can lead to profound skin microbiome changes, allowing the proliferation of dysbiotic members that can release a variety of elements able to trigger PLE lesions. This is the first study investigating the cutaneous microbiome changes in PLE patients upon UVR, offering new insights into disease pathogenesis, so far unexplored.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial daylight - the future for PDT in an uncertain climate?","authors":"Terence H Wong, Colin A Morton","doi":"10.1093/bjd/ljae466","DOIUrl":"https://doi.org/10.1093/bjd/ljae466","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multitranscriptome analysis revealed that stromal cells in the papillary dermis promote angiogenesis in psoriasis vulgaris.","authors":"Bo Zhang, Junpu Mei, Qijun Liao, Shan Zhou, He Huang, Hui Liu, Xiaoli Xu, Yafen Yu, Chao Wu, Wenjun Wang, Weining Hu, Tingting Zhu, Yin Zhang, Mengyun Chen, Caihong Zhu, Mengjun Yu, Jinping Gao, Xianfa Tang, Xiawei Liu, Ze Guo, Xiaodong Zheng, Wen Zhuang, Gang Chen, Lili Tang, Xiaoyan Ding, Hui Cheng, Yang Li, Hongyan Wang, Hui Li, Yangrui Zhang, Xing Fan, Rouxi Chen, Zherou Rong, Ping Liu, Shengxiu Liu, Zhen Yue, Peiguang Wang, Zhiming Cai, Min Gao, Zaixing Wang, Xiaodong Fang, Fusheng Zhou, Huayang Tang","doi":"10.1093/bjd/ljae459","DOIUrl":"https://doi.org/10.1093/bjd/ljae459","url":null,"abstract":"<p><strong>Background: </strong>The pathogenesis of psoriasis, an inflammatory skin disease, is incompletely understood. Growing evidence substantiates the involvement of stromal cells in the inflammatory process.</p><p><strong>Objectives: </strong>To investigate the roles of stromal cells, including fibroblasts, vascular endothelial cells (VECs) and smooth muscle cells (VSMCs), in the psoriatic inflammatory microenvironment and the possible underlying mechanisms involved.</p><p><strong>Methods: </strong>This study employed combination of single-cell, spatial transcriptome and bulk RNA sequencing using lesional and nonlesional skin samples from patients with psoriasis vulgaris (PV) and healthy skin samples from unaffected individuals.</p><p><strong>Results: </strong>Through the analysis of transcriptome from 364,098 single cells, we uncovered WNT5A+ fibroblasts, ITIH5+ VECs and VCAN+ VSMCs with the significantly increased cell proportions in the papillary dermis of lesional skin. We defined eight unique subclusters of fibroblasts in the skin and observed a shift of WIF1+ fibroblasts towards WNT5A+ fibroblasts, with abnormal activation of the non-canonical Wnt signaling pathway and increased capabilities of angiogenesis and pro-inflammatory. For the microvascular cells, VSMCs could undergo phenotypic transformation from a contractile phenotype to a synthetic phenotype in the development of psoriatic inflammation. ITIH5+ VECs and VCAN+ VSMCs were identified with an essential role in regulating angiogenesis and vascular remodeling involved in the mechanism of psoriatic pathological changes. Ligand receptor analyses demonstrated WNT5A+ fibroblasts were extensively implicated in interactions with various cell types in skin, especially with ITIH5+ VECs and VCAN+ VSMCs within the papillary dermis.</p><p><strong>Conclusions: </strong>Interactions of stromal cells in the papillary dermis were identified as possible pathogenic elements in psoriasis vulgaris. Improving the inflammatory microenvironment by targeting stromal cells might be a potential treatment strategy for psoriasis.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailored Bioengineering and Nanomedicine Strategies for Sex-Specific Healing of Chronic Wounds.","authors":"Negar Mahmoudi, Shahriar Sharifi, Dmitry Leshchiner, Sachi Horibata, Zijin Lin, Noor Ghazali, Mohammad-Ali Shahbazi, Ayushi Priyam, Richard J Williams, Irena Pastar, Lisa Gould, Simon Matoori, David Nisbet, Morteza Mahmoudi","doi":"10.1093/bjd/ljae457","DOIUrl":"https://doi.org/10.1093/bjd/ljae457","url":null,"abstract":"<p><p>Chronic wounds, defined by their prolonged healing process, significantly impair patient quality of life and impose a hefty financial burden on healthcare systems worldwide. Sex/gender-specific mechanisms regulate inflammation and infection, angiogenesis, matrix synthesis, and cell recruitment contribute to cutaneous wound healing, but remain largely understudied. This review is aimed to spotlight the innovative realm of bioengineering and nanomedicine, which is at the helm of revolutionizing complex chronic wound care. It underscores the significance of integrating patient sex into the development and (pre)clinical testing of these avant-garde treatment modalities, in order to enhance healing prospects for both women and men. Moreover, we explore the representation of both sexes in clinical trials of bioengineered and nanomedicine products. Finally, we examine the primary reasons for the historical neglect in translating sex-specific wound healing research into clinical practice and propose strategic solutions. By tackling these issues, the article advocates for advanced treatment frameworks that could significantly improve healing outcomes for individuals of all sexes, thereby optimizing both efficacy and inclusivity in chronic wound management.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}