British Journal of Dermatology最新文献

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Artificial daylight photodynamic therapy using methyl aminolevulinate in a real-world setting in Germany - Results from the non-interventional study ArtLight. 在德国实际环境中使用氨基乙酰丙酸甲酯的人工日光光动力疗法--非干预性研究 ArtLight 的结果。
IF 11 1区 医学
British Journal of Dermatology Pub Date : 2024-11-07 DOI: 10.1093/bjd/ljae437
Wolfgang G Philipp-Dormston, Matthias Brückner, Matthias Hoffmann, Melvin Baé, Jörg Fränken, Bernd Großmann, Uwe Paasch, Sven Quist, Berenice M Lang, Rajeev Chavda, Rolf-Markus Szeimies
{"title":"Artificial daylight photodynamic therapy using methyl aminolevulinate in a real-world setting in Germany - Results from the non-interventional study ArtLight.","authors":"Wolfgang G Philipp-Dormston, Matthias Brückner, Matthias Hoffmann, Melvin Baé, Jörg Fränken, Bernd Großmann, Uwe Paasch, Sven Quist, Berenice M Lang, Rajeev Chavda, Rolf-Markus Szeimies","doi":"10.1093/bjd/ljae437","DOIUrl":"https://doi.org/10.1093/bjd/ljae437","url":null,"abstract":"<p><strong>Background: </strong>Artificial daylight photodynamic therapy (ADL-PDT) is an alternative, all-year applicable, nearly painless treatment approach for actinic keratoses (AK) with comparable effectiveness to daylight or conventional PDT. At the time this study was initiated, methyl aminolevulinate (MAL) was the only photosensitizer approved for ADL-PDT in Germany.</p><p><strong>Objective: </strong>To gain comprehensive insights into the practicability of MAL-ADL-PDT in patients with AK using different artificial daylight sources under real-world conditions.</p><p><strong>Methods: </strong>This prospective, non-interventional, multicenter study (ArtLight, NCT05725213) enrolled patients with Olsen grade 1 or 2 AK on the face and scalp in Germany. Patients were treated with MAL-ADL-PDT (160mg/g MAL cream). The primary outcome measure was the practicability of MAL-ADL-PDT assessed as rate of resolved AK lesions in the focus area (10x10 cm area within the treatment area). Secondary outcomes included treatment-associated pain (numeric rating scale, NRS-11), Actinic Keratosis Area and Severity Index (AKASI), total lesion count over time, skin preparation, safety, overall assessment of effectiveness, tolerability, adherence, and patient satisfaction.</p><p><strong>Results: </strong>In total, 224 patients (median age: 75.0 years (range 50-91), 85.3% male, 62.5% AK Olsen grade 2, 55.4% treatment-naïve) were included and treated with MAL-ADL-PDT. Three months after treatment, lesion counts were reduced in the focus area by 71% (p<0.001) indicating practicability of the treatment. Nearly all patients (93.3%) experienced none or mild pain during PDT (NRS score 0-3). Median AKASI decreased from 6.2 at baseline to 3.4 at month 3 (95% CI 2.4-3.0; p<0.001). The majority of investigators (82.8%) and patients (80.0%) were satisfied with the treatment. No new safety signals were reported.</p><p><strong>Conclusions: </strong>The clinical practicability of MAL-ADL-PDT was demonstrated under real-world conditions by effective lesion reduction and predominantly none to mild procedural pain. Thus, MAL-ADL-PDT is a convenient way for healthcare professionals to deliver PDT treatment to patients with AK located on the face and scalp.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The perceived quality of life in adult patients with inherited ichthyosis: a qualitative interview study. 遗传性鱼鳞病成年患者的生活质量感知:定性访谈研究。
IF 11 1区 医学
British Journal of Dermatology Pub Date : 2024-11-07 DOI: 10.1093/bjd/ljae436
Fauve C A P van Veen, S Vanya J Rossel, Peter M Steijlen, Albine Moser, Karin Veldman, Michel van Geel, Julia M K Clabbers, Jolien van der Geugten, Antoni H Gostyński
{"title":"The perceived quality of life in adult patients with inherited ichthyosis: a qualitative interview study.","authors":"Fauve C A P van Veen, S Vanya J Rossel, Peter M Steijlen, Albine Moser, Karin Veldman, Michel van Geel, Julia M K Clabbers, Jolien van der Geugten, Antoni H Gostyński","doi":"10.1093/bjd/ljae436","DOIUrl":"10.1093/bjd/ljae436","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploration of the mutational landscape of cutaneous leiomyoma confirms FH as a driver gene and identifies targeting purine metabolism as a potential therapeutic strategy. 对皮肤良性肌瘤突变情况的研究证实,FH 是一种驱动基因,并确定了以嘌呤代谢为靶点的潜在治疗策略。
IF 11 1区 医学
British Journal of Dermatology Pub Date : 2024-11-07 DOI: 10.1093/bjd/ljae432
Louise van der Weyden, Martin Del Castillo Velasco-Herrera, Saamin Cheema, Kim Wong, Jacqueline M Boccacino, Ian Vermes, Victoria Offord, Alastair Droop, David R A Jones, Elizabeth Anderson, Claire Hardy, Nicolas de Saint Aubain, Peter M Ferguson, Carolin Mogler, Neil Rajan, Derek Frew, Paul W Harms, Steven D Billings, Désirée Schatton, Marc Segarra-Mondejar, Mark J Arends, Ingrid Ferreira, Thomas Brenn, Christian Frezza, David J Adams
{"title":"Exploration of the mutational landscape of cutaneous leiomyoma confirms FH as a driver gene and identifies targeting purine metabolism as a potential therapeutic strategy.","authors":"Louise van der Weyden, Martin Del Castillo Velasco-Herrera, Saamin Cheema, Kim Wong, Jacqueline M Boccacino, Ian Vermes, Victoria Offord, Alastair Droop, David R A Jones, Elizabeth Anderson, Claire Hardy, Nicolas de Saint Aubain, Peter M Ferguson, Carolin Mogler, Neil Rajan, Derek Frew, Paul W Harms, Steven D Billings, Désirée Schatton, Marc Segarra-Mondejar, Mark J Arends, Ingrid Ferreira, Thomas Brenn, Christian Frezza, David J Adams","doi":"10.1093/bjd/ljae432","DOIUrl":"10.1093/bjd/ljae432","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethical implications of artificial intelligence in skin cancer diagnostics: use-case analyses. 人工智能在皮肤癌诊断中的伦理意义:用例分析。
IF 11 1区 医学
British Journal of Dermatology Pub Date : 2024-11-06 DOI: 10.1093/bjd/ljae434
Syed F H Shah, Daniel Arecco, Heather Draper, Simona Tiribelli, Eli Harriss, Rubeta N Matin
{"title":"Ethical implications of artificial intelligence in skin cancer diagnostics: use-case analyses.","authors":"Syed F H Shah, Daniel Arecco, Heather Draper, Simona Tiribelli, Eli Harriss, Rubeta N Matin","doi":"10.1093/bjd/ljae434","DOIUrl":"10.1093/bjd/ljae434","url":null,"abstract":"<p><strong>Background: </strong>Skin cancer is the most common cancer worldwide. Early diagnosis is crucial for improving patient survival and morbidity. Artificial intelligence (AI)-assisted smartphone applications (apps) for skin cancer potentially offer accessible, early risk assessment of suspicious skin lesions. However, the integration of novel technologies into dermatology pathways raises ethical concerns. Although ethical principles for AI governance are well known, how these principles should be applied to real-life AI apps readily available for public use is less well understood.</p><p><strong>Objectives: </strong>We conducted an ethical use-case analysis of commercially available skin cancer apps to better understand the ethical issues arising from their development and use in a real-world context.</p><p><strong>Methods: </strong>Established methods for ethical analysis of clinical AI applications were applied to two popular skin cancer apps in the UK: SkinVision and Scanoma. Systematic searches of published literature, regulatory documents, and websites were conducted to review the evidence regarding app development, effectiveness, and use. Screening for inclusion was undertaken by two researchers independently. Ethical concerns were identified with reference to previously described ethical concerns and principles for AI-assisted healthcare.</p><p><strong>Results: </strong>By conceptualising ethical principles within the use-context of skin cancer apps, we identified specific ethical issues arising throughout the AI lifecycle of both apps. One company provided extensive detail regarding algorithm development and decision-making, this information was insufficiently reported for the other app. Other concerns identified related to number, quality, and consistency of studies assessing algorithm efficacy. Limited efforts to address potential skin tone biases and exclusion of individuals with darker skin tones as target users by one app risks perpetuating existing inequalities. Inadequate regulatory oversight was identified.</p><p><strong>Conclusions: </strong>Findings from our ethical use-case analysis of two patient-facing AI-assisted skin cancer apps suggest inadequate incorporation of bioethical norms such as justice, responsibility and transparency into the development and deployment of both apps. Improved regulation should increase accountability. Ensuring ethics by design through integration between technology developers, dermatologists, ethicists, and the public is urgently needed to prevent the potential benefits of AI-assisted skin cancer apps being overshadowed by potential ethical harms.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CCR8/CCL1 and CXCR3/CXCL10 axis mediated memory T cell activations in recalcitrant drug-induced hypersensitivity patients. CCR8/CCL1和CXCR3/CXCL10轴介导了顽固性药物过敏症患者记忆T细胞的激活。
IF 11 1区 医学
British Journal of Dermatology Pub Date : 2024-11-06 DOI: 10.1093/bjd/ljae375
Tsu-Man Chiu, Chun-Bing Chen, Chun-Wei Lu, Rosaline Chung-Yee Hui, Min-Hui Chi, Ya-Ching Chang, Jennifer Wu, Kuan-Yu Chen, Yang Yu-Wei Lin, Pei-Chi Lo, Tsai-Ching Hsu, Chuang-Wei Wang, Wen-Hung Chung
{"title":"CCR8/CCL1 and CXCR3/CXCL10 axis mediated memory T cell activations in recalcitrant drug-induced hypersensitivity patients.","authors":"Tsu-Man Chiu, Chun-Bing Chen, Chun-Wei Lu, Rosaline Chung-Yee Hui, Min-Hui Chi, Ya-Ching Chang, Jennifer Wu, Kuan-Yu Chen, Yang Yu-Wei Lin, Pei-Chi Lo, Tsai-Ching Hsu, Chuang-Wei Wang, Wen-Hung Chung","doi":"10.1093/bjd/ljae375","DOIUrl":"10.1093/bjd/ljae375","url":null,"abstract":"<p><strong>Background: </strong>As a drug-induced hypersensitivity syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS) is potentially fatal. Most patients with DRESS recover within a few weeks; however, some patients may suffer from a prolonged disease course and develop autoimmune sequelae.</p><p><strong>Objective: </strong>We investigated the immune mechanism and therapeutic targets of patients with recalcitrant DRESS with a prolonged disease course.</p><p><strong>Methods: </strong>A total of 32 patients with recalcitrant DRESS with a prolonged treatment course ≥8 weeks, 28 patients with short-duration DRESS with a treatment course <2 weeks, and 26 healthy individuals were enrolled in the study for analysis.</p><p><strong>Results: </strong>Bulk transcriptome results demonstrated that mRNA expression levels of CCR8 and CXCR3 were significantly increased in the blood samples from patients in the acute stage of prolonged DRESS (adjusted p-values: CCR8=1.50×10-9 and CXCR3=2.60×10-4, respectively, for comparison of patients with prolonged DRESS to the healthy donor group). Serum and skin lesional concentrations of CCL1 and CXCL10, as the ligands of CCR8 and CXCR3, respectively, were significantly elevated in patients with prolonged DRESS as compared to those patients with short-duration DRESS. The results from high-parameter flow cytometry and autoantibody screening also identified significant escalations of CD8+ GNLY+CXCR3+effector memory T cells, CD8+central memory T cells, CD4+CCR8+Th2 cells, and IgG-anti-HES6 autoantibodies in patients with prolonged DRESS. Furthermore, in vitro blocking assays revealed that JAK inhibitors (mainly tofacitinib and upadacitinib) significantly decreased the release of CCL1 and CXCL10, and some patients with prolonged DRESS were successfully treated with JAK inhibitors.</p><p><strong>Conclusions: </strong>JAK inhibitors (tofacitinib and upadacitinib) were associated with decreased concentrations of CCL1 and CXCL10, suggesting that they may attenuate CCR8/CCL1- and CXCR3/CXCL10-axis-mediated memory T cell activation, which contribute to disease pathogenesis for patients with recalcitrant DRESS and a long-term treatment course.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
List of Critical Drugs in Dermatology: Results of a Delphi Consensus in France. 皮肤科关键药物清单:法国德尔菲共识的结果。
IF 11 1区 医学
British Journal of Dermatology Pub Date : 2024-11-05 DOI: 10.1093/bjd/ljae427
Guillaume Chaby, Sébastien Barbarot, Florence Corgibet, Jean Noel Dauendorffer, Nicole Jouan, Marc Reverte, Stéphane Honoré, Gaëlle Quereux, Olivier Chosidow
{"title":"List of Critical Drugs in Dermatology: Results of a Delphi Consensus in France.","authors":"Guillaume Chaby, Sébastien Barbarot, Florence Corgibet, Jean Noel Dauendorffer, Nicole Jouan, Marc Reverte, Stéphane Honoré, Gaëlle Quereux, Olivier Chosidow","doi":"10.1093/bjd/ljae427","DOIUrl":"https://doi.org/10.1093/bjd/ljae427","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Biologic-Resistant Hand Dermatitis Demonstrates Dual T2/T17 Transcriptomic Abnormalities and Responds to JAK Inhibition. 一例生物耐药性手部皮炎病例显示出双 T2/T17 转录组异常并对 JAK 抑制剂有反应。
IF 11 1区 医学
British Journal of Dermatology Pub Date : 2024-11-05 DOI: 10.1093/bjd/ljae430
Mark A Taylor, Michelle Yuan, Sijia Wang, Jeffrey P North, Jeffry B Cheng, Raymond J Cho
{"title":"A Case of Biologic-Resistant Hand Dermatitis Demonstrates Dual T2/T17 Transcriptomic Abnormalities and Responds to JAK Inhibition.","authors":"Mark A Taylor, Michelle Yuan, Sijia Wang, Jeffrey P North, Jeffry B Cheng, Raymond J Cho","doi":"10.1093/bjd/ljae430","DOIUrl":"https://doi.org/10.1093/bjd/ljae430","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on 'Failure of scabies treatment: a systemic review and meta-analysis'. 就 "疥疮治疗失败:系统回顾和荟萃分析 "发表评论。
IF 11 1区 医学
British Journal of Dermatology Pub Date : 2024-11-04 DOI: 10.1093/bjd/ljae431
Craig G Burkhart
{"title":"Comment on 'Failure of scabies treatment: a systemic review and meta-analysis'.","authors":"Craig G Burkhart","doi":"10.1093/bjd/ljae431","DOIUrl":"https://doi.org/10.1093/bjd/ljae431","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The future of patient-reported outcome measurement in hyperhidrosis lies in thoughtful, evidence-based implementation. 多汗症患者报告结果测量的未来在于深思熟虑的循证实施。
IF 11 1区 医学
British Journal of Dermatology Pub Date : 2024-11-01 DOI: 10.1093/bjd/ljae428
Liam Jackman, Rakhshan Kamran
{"title":"The future of patient-reported outcome measurement in hyperhidrosis lies in thoughtful, evidence-based implementation.","authors":"Liam Jackman, Rakhshan Kamran","doi":"10.1093/bjd/ljae428","DOIUrl":"https://doi.org/10.1093/bjd/ljae428","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The usefulness of large language models for patient information on melanoma: challenges and opportunities. 大型语言模型对黑色素瘤患者信息的实用性:挑战与机遇。
IF 11 1区 医学
British Journal of Dermatology Pub Date : 2024-11-01 DOI: 10.1093/bjd/ljae429
Tobias E Sangers, Remco van Doorn
{"title":"The usefulness of large language models for patient information on melanoma: challenges and opportunities.","authors":"Tobias E Sangers, Remco van Doorn","doi":"10.1093/bjd/ljae429","DOIUrl":"https://doi.org/10.1093/bjd/ljae429","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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