British Journal of Dermatology最新文献

{"title":"Anatomical distribution of acral lentiginous melanoma in the hand and nail among Japanese individuals.","authors":"Yuna Kochi, Yaei Togawa, Yuriko Yamazaki, Yosuke Yamamoto, Keisuke Suehiro, Hiroyuki Matsue, Takashi Inozume","doi":"10.1093/bjd/ljaf070","DOIUrl":"10.1093/bjd/ljaf070","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1128-1130"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global shifts in submissions to the BJD: a decade of change.","authors":"John A McGrath","doi":"10.1093/bjd/ljaf089","DOIUrl":"10.1093/bjd/ljaf089","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"963-964"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orismilast for moderate-to-severe atopic dermatitis: the potential therapeutic value of a new oral pharmacological alternative.","authors":"Carlos Alves","doi":"10.1093/bjd/ljaf042","DOIUrl":"10.1093/bjd/ljaf042","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"965-966"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An evidence-driven classification of nonfiltering ingredients for topical photoprotection.","authors":"Anthony Brown, Thierry Passeron, Corinne Granger, Yolanda Gilaberte, Carles Trullas, Jaime Piquero-Casals, Giovanni Leone, Sergio Schalka, Henry W Lim, Jean Krutmann","doi":"10.1093/bjd/ljaf055","DOIUrl":"10.1093/bjd/ljaf055","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1132-1134"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human scalp hair follicles can 'taste': chemosensory signalling via the bitter taste receptor TAS2R4 inhibits hair growth ex vivo.","authors":"Jennifer Gherardini, Thomas Rouillé, Rivka C Stone, Markus Fehrholz, Wolfgang Funk, Jose Rodríguez-Feliz, Alan J Bauman, Tamás Bíró, Jérémy Chéret, Ralf Paus","doi":"10.1093/bjd/ljaf060","DOIUrl":"10.1093/bjd/ljaf060","url":null,"abstract":"<p><strong>Background: </strong>Taste receptors (TRs) exert many 'nongustatory' chemosensory functions beyond the sensation of taste. Recently, human keratinocytes have been found to express some bitter TRs, whose physiological functions remain unknown. As it has been discovered that human scalp hair follicles (HFs) use olfactory receptors to regulate their growth, we hypothesized that some bitter TRs may exert a similar function.</p><p><strong>Objectives: </strong>To explore whether human scalp HFs express the bitter TR TAS2R4 and whether its stimulation with cognate agonists or its selective knockdown affects key human HF functions and, if yes, how.</p><p><strong>Methods: </strong>TAS2R4 mRNA and protein expression were assessed in situ, and organ-cultured scalp HFs were stimulated with the TAS2R4-agonistic natural sweetener rebaudioside A (Reb A) in the presence or absence of TAS2R4 small interfering RNA. Subsequently, changes in hair growth, growth factor expression and HF gene expression were assessed ex vivo.</p><p><strong>Results: </strong>TAS2R4 mRNA and protein were mainly expressed in the outer root sheath and matrix of human anagen VI scalp HFs. Stimulating these with Reb A ex vivo initially inhibited hair matrix keratinocyte proliferation, followed by enhanced intrafollicular production of catagen-promoting transforming growth factor (TGF)-β2. This led to TGF-β-driven premature catagen entry, which could be antagonized by TGF-β-neutralizing antibodies. Premature catagen induction was also seen with other known TAS2R4 agonists, while TAS2R4 knockdown in the -presence of Reb A promoted hair growth, documenting that the observed effects of Reb A on the HF depend on TAS2R4-mediated signalling. Gene expression profiling (RNA sequencing) revealed differential transcriptional signatures consistent with TAS2R4-mediated changes in cell cycle control and TGF-β pathway signalling.</p><p><strong>Conclusions: </strong>Our study found that human scalp HFs engage in chemosensation via bitter TRs to regulate their growth, matrix keratinocyte proliferation, growth factor production and overall gene expression. Specifically, we demonstrated that a simple tastant like Reb A can promote the anagen-catagen switch of human scalp HFs and their production of TGF-β2, and modulate HF keratinocyte proliferation and intrafollicular gene transcription in a TAS2R4-dependent manner. This expands our understanding of bitter TR-mediated chemosensation in human skin and suggests a novel, drug-free strategy to inhibiting unwanted hair growth (e.g. in hirsutism and hypertrichosis) by targeting TAS2R4 (e.g. via topical Reb A).</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1083-1095"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air pollution and atopic dermatitis: critical windows of risk in early life.","authors":"Christian Vestergaard","doi":"10.1093/bjd/ljaf109","DOIUrl":"10.1093/bjd/ljaf109","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"967"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of skin and subcutaneous diseases: an update from the Global Burden of Disease Study 2021.","authors":"Pengcheng Huai, Peiye Xing, Yilin Yang, Yaoyao Kong, Furen Zhang","doi":"10.1093/bjd/ljaf071","DOIUrl":"10.1093/bjd/ljaf071","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1136-1138"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term safety and efficacy of Oleogel-S10 (birch bark extract) in epidermolysis bullosa: 24-month results from the phase III EASE study.","authors":"Dédée F Murrell, Christine Bodemer, Anna L Bruckner, Tracy Cunningham, Charles Davis, Mariá Florencia Fernández, Dimitra Kiritsi, Laura Maher, Eli Sprecher, Mauricio Torres-Pradilla, Johannes S Kern","doi":"10.1093/bjd/ljaf022","DOIUrl":"10.1093/bjd/ljaf022","url":null,"abstract":"<p><strong>Background: </strong>Epidermolysis bullosa (EB) is a group of rare and severe genetic disorders characterized by persistent skin fragility and open wounds. EB manifests as cutaneous and mucosal blistering, erosions and impaired wound healing.</p><p><strong>Objectives: </strong>To determine the long-term efficacy, tolerability and safety of Oleogel-S10 (birch bark extract) in dystrophic EB (DEB) and junctional EB (JEB) in the 24-month open-label phase (OLP) of the EASE study.</p><p><strong>Methods: </strong>EASE was a double-blind randomized controlled phase III study consisting of two phases: a 90-day double-blind phase (DBP) and a 24-month OLP. Patients from both former treatment groups in the DBP entered the single-arm OLP (n = 205). Patients received Oleogel-S10 on all partial-thickness EB wounds. OLP endpoints included the incidence and severity/relatedness of adverse events (AEs), maximum wound infection severity, changes in body surface area percentage (BSAP) of wounds, EB Disease Activity and Scarring Index (EBDASI), pain, itch, disease severity and quality-of-life outcomes.</p><p><strong>Results: </strong>The OLP data demonstrated that Oleogel-S10 target wound treatment adherence was > 99% and mean (SD) treatment duration was 584.7 (246.1 days). Seventy-two per cent of patients in the OLP were aged < 18 years and 86.8% had DEB; recessive DEB predominated (78.0%). AEs were reported in 77.1% of patients and were typically mild-to-moderate in severity. Severe and serious AEs were seen in 18.0% and 24.4% of patients, respectively. AEs resulted in the withdrawal of 7.8% of patients (n = 16), including three with treatment-related AEs. Nine deaths were reported; none were attributable to the treatment. The incidence of target wound infections was low (n = 7); five were mild-to-moderate in severity and two were severe. In patients treated with Oleogel-S10 throughout, mean (SD) BSAP changes from DBP baseline at 3, 12 and 24 months were -4.3% (8.1) (P < 0.001), -5.9% (8.6) (P < 0.001) and -3.7% (9.0) (P = 0.003), respectively. Similarly, significant changes in EBDASI skin activity score from DBP baseline were observed: -3.9 (8.3) (P < 0.001), -5.1 (8.2) (P < 0.001) and -3.0 (8.3) (P = 0.007) at 3, 12 and 24 months, respectively.</p><p><strong>Conclusions: </strong>These data support an encouraging long-term safety profile of Oleogel-S10 and a sustained reduction in wound burden over at least 24 months of Oleogel-S10 treatment.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1007-1017"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatological care in Muslim patients: a perspective on gender and cultural considerations.","authors":"Hibo Rijal, Shaimaa Helal, Morvarid Hessami-Booshehri, Erin Dahlke","doi":"10.1093/bjd/ljaf068","DOIUrl":"10.1093/bjd/ljaf068","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1117-1119"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient research priorities in melanoma: a national qualitative interview study.","authors":"Khaylen Mistry, Omsin Srimudkul, Mitesh Patel, John Ragan, Dimitrios Karponis, Zoe C Venables, Nick J Levell","doi":"10.1093/bjd/ljaf048","DOIUrl":"10.1093/bjd/ljaf048","url":null,"abstract":"<p><strong>Background: </strong>Outcomes for advanced melanoma have improved following the advent of immunotherapy and targeted therapy. This heralds a need for reconsideration of future research agendas. Patients can - and are keen to - help identify and prioritize research topics to ensure future research benefits patients. No previous peer-reviewed research has reported patient research priorities for melanoma.</p><p><strong>Objectives: </strong>To determine the prioritized research topics of patients with melanoma in England.</p><p><strong>Methods: </strong>Patients aged ≥ 18 years, diagnosed with melanoma in the past 10 years, were recruited across England by skin cancer charities. Preinterview questionnaires obtained demographic, tumour and treatment information. Semi-structured interviews were conducted where patients were asked what they thought were important topics to research in melanoma. Using a grounded theory approach, transcripts were analysed in an iterative process to identify themes for patient research priorities.</p><p><strong>Results: </strong>Twenty patients were individually interviewed from eight of nine English regions. Five key themes were identified: (1) 'Risk factors and prevention of melanoma' - patients voiced a desire for research into modifiable risk factors and public campaigns to prevent melanoma; (2) 'Diagnostic delay and misdiagnosis of melanoma' - patients felt diagnostic delays could be reduced through research to support nonspecialists and integrating technology such as teledermatology or artificial intelligence'; (3) 'Indications, outcomes, side-effects and interactions of treatments for melanoma' - novel treatments inspired patients to encourage future research into the indications, outcomes and side-effects of therapeutic options; (4) 'Optimizing follow-up for melanoma' - with increased survivorship, research to support the delivery of a personalized approach to follow-up was valued; and (5) 'Factors that influence survival from melanoma' - patients prioritized research to accurately predict recurrence and survival based on patient-specific factors.</p><p><strong>Conclusions: </strong>This is the first peer-reviewed study to report patient research priorities in melanoma. Many of the themes identified align with National Institute for Health and Care Excellence research recommendations. Additionally, novel themes were identified that provide a rationale to develop a James Lind Alliance Priority Setting Partnership for melanoma. If research addresses topics relevant to patients, decision-makers will be equipped to deliver services that meet patient needs.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1055-1062"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}