British Journal of Dermatology最新文献

{"title":"Fine particulate matter exposure and incident atopic dermatitis: a birth cohort study.","authors":"Lih-Hwa Lin, Chung-Chin Lee, Meng-Min Hwang, Chau-Ren Jung, I Hsiu Lai, Wei-Ting Chen, Bing-Fang Hwang","doi":"10.1093/bjd/ljaf075","DOIUrl":"10.1093/bjd/ljaf075","url":null,"abstract":"<p><strong>Background: </strong>The association between exposure to fine particulate matter (PM2.5) from conception to 1 year after birth and the later development of atopic dermatitis (AD) has not been completely elucidated.</p><p><strong>Objectives: </strong>To investigate the effects of PM2.5 exposure during pregnancy and infancy on the later development of AD, and to explore vulnerable time periods to identify biologic pathways that may result in AD after exposure to PM2.5.</p><p><strong>Methods: </strong>We conducted a birth cohort study comprising 564 869 term births born between 2004 and 2013. The infants were followed-up until 5 years after birth. A satellite-based model was used to calculate PM2.5 exposure for each child. A Cox proportional hazards model combined with a distributed lag nonlinear model was created to examine the associations of AD with PM2.5, as well as the dose-response relationship.</p><p><strong>Results: </strong>The birth cohort comprised 76 944 infants diagnosed with AD. Increased cumulative exposure to PM2.5 from 34 weeks' gestation until birth, as well as from 33 weeks after birth, was significantly associated with a higher incidence of AD. With regard to the dose-response relationship, exposure to > 65 μg m-3 PM2.5 sharply increased the risk of AD.</p><p><strong>Conclusions: </strong>Prenatal and postnatal exposure to PM2.5 was related to later development of AD. The sensitive time periods may be late gestation and early life after birth.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1038-1046"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haematological cancers and skin cancer: statistics from the Netherlands.","authors":"Lena A von Schuckmann, Kiarash Khosrotehrani","doi":"10.1093/bjd/ljaf081","DOIUrl":"10.1093/bjd/ljaf081","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"966-967"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'Incidence of noninfectious uveitis among patients with hidradenitis suppurativa'.","authors":"Alan Y Hsu, Chun-Ju Lin, Ning-Yi Hsia, Chun-Ting Lai, Yi-Yu Tsai","doi":"10.1093/bjd/ljaf083","DOIUrl":"10.1093/bjd/ljaf083","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1145"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial burden and the impact of illness perceptions and stigma on quality of life, anxiety and depression in alopecia areata: results from the Alopecia+Me study.","authors":"Evangelos Christou, Nikolina Lalagianni, Sheila M McSweeney, Chantal Cotter, Chuin Ying Ung, Jessica Walburn, Paul McCrone, Mark A Turner, John A McGrath, John Weinman, Christos Tziotzios","doi":"10.1093/bjd/ljaf189","DOIUrl":"https://doi.org/10.1093/bjd/ljaf189","url":null,"abstract":"<p><strong>Background: </strong>Alopecia areata (AA) can significantly impact patients' quality of life (QoL) and mental health, with increased levels of anxiety and depression. It is unclear whether this impact is more strongly associated with disease severity or patients' disease perception, and which patients are more likely to have a greater psychological burden.</p><p><strong>Objectives: </strong>Examine AA's psychosocial impact, whilst focusing on illness perceptions and stigma, aiming to identify high-risk subgroups and key perceptions linked to worse QoL, anxiety and depression.</p><p><strong>Methods: </strong>This was a UK cross-sectional online study. It comprised 596 patients with AA who self-reported disease severity and completed the Dermatology Life Quality Index (DLQI), EuroQol 5-dimensional 5-level (EQ-5D-5L), Hospital Anxiety and Depression Scale (HADS), Stigma Scale for Chronic Illnesses 8-Item (SSCI-8), and Brief Illness Perception Questionnaire (BIPQ).</p><p><strong>Results: </strong>Patients with AA perceived their condition as chronic and life-impacting, with limited personal or treatment control, significant emotional effects, and high concern. Many reported high levels of anxiety, depression, stigma and impaired QoL, all strongly associated with illness perceptions. Hierarchical regression analyses showed that illness perceptions and stigma explained a higher proportion of variance in QoL, anxiety and depression than disease severity. Cluster analysis identified two distinct patient groups based on illness perceptions, with different levels of QoL, anxiety, depression, and stigma.</p><p><strong>Conclusions: </strong>AA has a severe psychosocial impact, more strongly linked to patients' illness perceptions and stigma than disease severity. The identification of two distinct patient profiles based on illness perceptions reveals differences in psychosocial burden, highlighting those at risk of worse outcomes and underscoring the value of evaluating illness perceptions along with stigma in clinical practice to improve patient outcomes.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of hospitalizations due to bacterial skin and soft tissue infections: a retrospective observational study from a Portuguese national registry.","authors":"Gilberto P da Rosa, João V Santos, André Cerejeira, Pedro Matos, Filomena Azevedo, Alberto Freitas, Carmen Lisboa","doi":"10.1093/bjd/ljaf157","DOIUrl":"https://doi.org/10.1093/bjd/ljaf157","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposing an Immune-Inclusive Lens to the New Epidermal Differentiation Disorders Classification.","authors":"Rahul Mahajan, Hitaishi Mehta, Dipankar De, Sanjeev Handa","doi":"10.1093/bjd/ljaf187","DOIUrl":"https://doi.org/10.1093/bjd/ljaf187","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do we avoid over-treating skin cancer in people with severe frailty and limited life expectancy?","authors":"James B Powell, Jugdeep K Dhesi, Catherine A Harwood, Emily J McGrath, Zoe C Venables, Ser-Ling Chua, Stephen G Keohane, Raj Mallipeddi, Jerry R Marsden, Rubeta N Matin, Ashish Sharma, M Firouz Mohd Mustapa","doi":"10.1093/bjd/ljaf174","DOIUrl":"10.1093/bjd/ljaf174","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of the selective TYK2/JAK1 inhibitor TLL-018 in moderate-to-severe plaque psoriasis: A phase 1b, randomized, double-blind, placebo-controlled study.","authors":"Jia-Qi Chen, Min Zheng, Wen-Hao Yin, Ping Wang, Xiao-Wei Shi, Tie-Chi Lei, Zhi-Ming Li, Meng Pan, Yu-Ling Shi, Yu-Zhen Li, Congxin Liang, Xiao-Yong Man","doi":"10.1093/bjd/ljaf185","DOIUrl":"https://doi.org/10.1093/bjd/ljaf185","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis treatments that provide rapid and extensive itch relief, lesion clearance are inadequate.</p><p><strong>Objective: </strong>To evaluate the efficacy and safety of the tyrosine kinase 2/Janus kinase 1 inhibitor TLL-018 in patients with moderate-to-severe psoriasis.</p><p><strong>Methods: </strong>This phase 1b, double-blind, placebo-controlled study randomized participants to receive TLL-018 (2:2:2:1) 10:20:30 mg:placebo (12 weeks) twice daily (BID) orally (NCT05342428). The study included 73 patients with moderate-to-severe psoriasis. Eligible patients were aged 18-75 years and were diagnosed with moderate-to-severe psoriasis at least 6 months prior to screening, as defined by a psoriasis area and severity index (PASI) of ≥12, a body surface area (BSA) ≥10%, and a physician's global assessment (PGA) of ≥3. The primary endpoint was safety of TLL-018. The efficacy endpoints were proportions of patients achieving a PASI 75, PGA of 0 or 1, and DLQI 0/1 at week 12.</p><p><strong>Results: </strong>A total of 73 participants were treated. TLL-018 was well tolerated, and most treatment-emergent adverse events were mild/moderate. At week 12, 40.0% (8 of 20 patients) of the patients achieved PASI 75 with TLL-018 10 mg BID; 47.6% (10 of 21 patients), with 20 mg BID; 61.9% (13 of 21 patients), with 30 mg BID; and 9.1% (1 of 11 patients), with placebo. The PGA 0/1 were 35%, 42.9%, 71.4% and 0%, respectively. 10 of 21 patients (47.6%) in TLL-018 30 mg BID group achieved PASI 90.</p><p><strong>Conclusions: </strong>TLL-018 was well tolerated and showed promising efficacy at week 12 comparing placebo in patients with moderate-to-severe plaque psoriasis.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Added value of pathology consultations in cutaneous lymphomas: a 2-year review from the Dutch national referral and expertise centre.","authors":"Thom Doeleman, Elise S M Beljaards, Rosanne Ottevanger, Patty Jansen, Maarten H Vermeer, Koen D Quint, Rein Willemze, Anne M R Schrader","doi":"10.1093/bjd/ljaf184","DOIUrl":"https://doi.org/10.1093/bjd/ljaf184","url":null,"abstract":"<p><strong>Background: </strong>The accurate diagnosis of cutaneous lymphomas (CLs) and lymphoproliferative disorders presents significant challenges due to their rarity, the diversity of clinicopathological entities, and the necessity of integrating clinical, immunophenotypic, and molecular analyses with histopathology. Misdiagnosis and diagnostic delays are common, potentially leading to inappropriate treatments. The contribution of an expertise centre specifically for the pathology of CL has not been previously investigated.</p><p><strong>Objectives: </strong>To evaluate the value of pathology consultations at the Dutch national referral centre for CLs focusing on diagnostic agreement and identifying common diagnostic pitfalls.</p><p><strong>Methods: </strong>We retrospectively reviewed all pathology consultations concerning CLs received at the Leiden University Medical Centre during 2020 and 2021. Cases were categorized into informative and ambiguous conclusions. Diagnostic agreement between submitting and expert pathologists was assessed and categorized as essential agreement, more specific conclusion, minor disagreement, or major disagreement.</p><p><strong>Results: </strong>A total of 239 consultations from 230 patients, were analysed. The submitted conclusion was categorized as informative in 64% of the consultations and as ambiguous in 36%. Most (59%) consultations in our study exhibited essential agreement with the submitting pathologist. The expert centre reduced ambiguous conclusions from 36% to 13%, primarily by resolving differential diagnostic considerations between lymphoma and pseudolymphomatous infiltrates. However, major diagnostic disagreements, with a potentially significant impact on treatment or prognosis, were found in 12% of consultations mostly involving reclassification from benign dermatoses to lymphomas. Mycosis fungoides, primary cutaneous follicle centre lymphoma, CD30-positive lymphoproliferative disorders, and pseudolymphomas were delineated as specific areas of diagnostic difficulty.</p><p><strong>Conclusions: </strong>The findings indicate that a national referral and expertise centre for CL pathology contributes to ensuring accurate diagnoses and appropriate patient management. Our data encourage low-threshold consultation in an expert centre for all patients with clinical and/or histological suspicion of CL.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cinacalcet-Induced Hypocalcemia in Refractory Darier Disease.","authors":"Luis Alonso-Mtz de Salinas, Jorge Naharro-Rodriguez, Raquel Dominguez-Lopez, Blanca Santos-Latasa, Alba Lecumberri-Indart, Montserrat Fernandez-Guarino, Bibiana Perez-Garcia","doi":"10.1093/bjd/ljaf176","DOIUrl":"https://doi.org/10.1093/bjd/ljaf176","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}