British Journal of Dermatology最新文献

{"title":"Linking levels of polyunsaturated fatty acids to acne risk.","authors":"Luba Milena Pardo","doi":"10.1093/bjd/ljaf094","DOIUrl":"https://doi.org/10.1093/bjd/ljaf094","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Granulomas: Mechanisms, Cellular Interactions, and Therapeutic Insights.","authors":"Satoshi Nakamizo, Kenji Kabashima","doi":"10.1093/bjd/ljaf096","DOIUrl":"https://doi.org/10.1093/bjd/ljaf096","url":null,"abstract":"<p><p>Granulomas are specialized biological defense mechanisms that form in response to infections with pathogens, foreign bodies, or specific stimuli such as antimicrobials or fungi. These structures function to isolate foreign materials and pathogens that cannot be eliminated by immune cells, primarily through macrophage activity. In the skin, granulomas are a hallmark of several conditions, including sarcoidosis, granuloma annulare, tuberculosis and leprosy, each exhibiting distinct pathological and immunological features. Granulomas can also arise from lipid accumulation, as observed in xanthogranuloma, or be triggered by inflammatory processes associated with unidentified antigens. Among their cellular components, Langhans-type multinucleated giant cells play a pivotal role in granuloma structure and function, contributing to pathogen containment and tissue remodeling, though their precise mechanisms of action remain an area of active investigation. In addition to these giant cells, recent studies have identified TREM2-positive macrophages as key contributors to granuloma formation and maintenance. These macrophages are involved in extracellular degradation of foreign substances and play a role in adapting to the hypoxic and nutrient-poor microenvironment of granulomas through metabolic reprogramming, including the pentose phosphate pathway. Recent advances in molecular biology, such as single-cell RNA sequencing, have provided unprecedented insights into the cellular heterogeneity and molecular pathways involved in granuloma formation. These techniques have revealed disease-specific differences in immune cell profiles and activation states, offering new perspectives on the underlying mechanisms of granulomatous diseases. Despite these advances, the precise processes driving granuloma formation and their functional significance remain largely unclear. This review addresses the central question, \"What is a granuloma? \" by synthesizing recent findings, with a particular focus on cutaneous granulomas, and presenting interpretations grounded in the current body of literature. Furthermore, we discuss the implications of these findings for the development of novel therapeutic strategies, including targeted immunomodulation and cytokine blockade, which hold promise for treating granulomatous diseases while preserving host defense.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"St Andrews Referral Delay in Skin Cancer (StARDISC): A study of keratinocyte skin cancer time to treatment, growth, invasiveness, British Association of Dermatologists risk factors and excision adequacy.","authors":"Ben H Miranda, Shahab Shahid, Anna Correiro, Jufen Zhang, Sebastian Kosasih, Naguib El-Muttardi","doi":"10.1093/bjd/ljaf097","DOIUrl":"https://doi.org/10.1093/bjd/ljaf097","url":null,"abstract":"<p><strong>Background: </strong>British Association of Dermatologists (BAD) guidelines for basal (BCC) and squamous (SCC) cell skin carcinomas are distinct; there is however a paucity of evidence relating to their histopathological behaviour over time, with management guidelines.</p><p><strong>Objectives: </strong>To investigate the effect of lesion time on keratinocyte skin cancer (KSC) growth, development of high-risk factors according to BAD guidelines, and excision margin adequacy. Further aims included investigating the impact of the presence of high or very-high-risk histological parameters on excision rates and clearance margins.</p><p><strong>Methods: </strong>A cohort study was undertaken on a random sample of patients referred to our Plastic Surgery Skin Cancer Centre with BCC and SCC from January to June 2019 inclusive. Data collected included patient demographics, referral source, lesion time (first appearance to treatment), histological data, excision margins and skin cancer risk as defined by BAD guidelines.</p><p><strong>Results: </strong>There were 728 patients included (397 male, 331 female, median age=77 years), who underwent 872 KSC excisions (BCC=454, SCC=418). Longer lesion time was associated with increased BCC (p<0.001, p=0.001) and SCC (p<0.001, p<0.001) surface area and thickness at multivariable regression. The likelihood of developing very-high-risk histological parameters increased with SCC lesion time, including diameter >40mm (p<0.001), thickness >6mm (p<0.001) and total number of very-high-risk factors (p<0.001). SCCs with lesion durations >3 months had greater median surface areas (706.9mm2 vs. 295.3mm2; p<0.001), and thicknesses (3.5mm vs. 3mm; p<0.001), than those with durations ≤3 months); the same was found for median BCC surface area (263.9mm2 vs. 131.9mm2; p<0.001). A general trend in decreasing BCC and SCC adequate excision rates was observed with increasing numbers of high or very-high-risk parameters.</p><p><strong>Conclusions: </strong>Increasing lesion time resulted in increased KSC thickness and surface area, and increased presence of BAD high-risk factors, in SCC far more than BCC; this had a negative impact on surgical excision margins. Crucially, lesion time was significantly associated with increased SCC thickness (but not BCC) at 3 months. Our results support BAD guidance on KSC, which identifies the highest risk lesions and informs the practice of skin cancer units.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upadacitinib outperforms dupilumab in restoring the fungal microbiome in atopic dermatitis.","authors":"Tingting Li, Rong Tao, Li Yang, Zhe Wan, Ruoyu Li, Ruojun Wang","doi":"10.1093/bjd/ljaf095","DOIUrl":"https://doi.org/10.1093/bjd/ljaf095","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear hypermelanosis in narrow bands, a mosaic pattern manifestation of dyskeratosis congenita?","authors":"Ran Mo, Mingming Xu, Zhiming Chen, Ruiyu Xiang, Xiaofang Li, Hongyang Li, Guoyi Zhang, Jianfang Sun, Wei Zhang, Yong Yang","doi":"10.1093/bjd/ljaf091","DOIUrl":"https://doi.org/10.1093/bjd/ljaf091","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid improvements in Kaposi sarcoma with metformin: a report of two cases.","authors":"Ting Su, Yongkai Yu, Zhonglan Su, Yan Lu","doi":"10.1093/bjd/ljaf090","DOIUrl":"https://doi.org/10.1093/bjd/ljaf090","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the Itch Cycle: Long-Term effects of Nemolizumab in Prurigo Nodularis.","authors":"Kamila Kędra, Adam Reich","doi":"10.1093/bjd/ljaf093","DOIUrl":"https://doi.org/10.1093/bjd/ljaf093","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global shifts in submissions to the BJD: a decade of change.","authors":"John A McGrath","doi":"10.1093/bjd/ljaf089","DOIUrl":"https://doi.org/10.1093/bjd/ljaf089","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Landscape of m6A RNA Methylation in Skin Diseases.","authors":"Qi Zhang, Guozhen Liu, Li Jing, Sis Aghayants, Fangjing Xu, Yucheng Fan","doi":"10.1093/bjd/ljaf087","DOIUrl":"https://doi.org/10.1093/bjd/ljaf087","url":null,"abstract":"<p><p>Skin diseases encompass a diverse range of conditions with significant psychological and physiological impacts. N6-methyladenosine (m6A) RNA methylation is a key epitranscriptomic modification that regulates gene expression by influencing RNA stability, splicing, translation, export, and degradation. Recent studies have highlighted the crucial role of m6A modification in the pathogenesis and progression of various skin diseases. M6A modification affects critical biological processes of the skin, such as inflammation, immune response, and cellular aging. This review systematically explores the landscape of m6A modification in non-tumor skin diseases, elucidating its regulatory roles and therapeutic implications, including wound healing, scar and keloid, skin aging, psoriasis, systemic lupus erythematosus, acne vulgaris, rosacea, chronic actinic dermatitis, and scleroderma. The intricate mechanisms of m6A modification can lead to the development of novel diagnostic biomarkers and therapeutic strategies, ultimately improving patient outcomes.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium-glucose Cotransporter 2 Inhibitors and Inverse Risk of New-onset Atopic Dermatitis in Diabetic Population: a Nationwide, Active-comparator Study.","authors":"Yuan-Liang Wen, Wan-Ting Hsu, Yi-Hsien Chen, Hui-Han Kao, Chun-Cheng Liao, Sheng-Yin To, Hui-Wen Yang, Li-Ting Kao","doi":"10.1093/bjd/ljaf086","DOIUrl":"https://doi.org/10.1093/bjd/ljaf086","url":null,"abstract":"<p><strong>Background: </strong>Sodium-glucose cotransporter-2 inhibitors (SGLT2i), a novel class of antidiabetic medications, have emerged as a key treatment option for diabetes management. Notably, SGLT2i promote glucose and sodium excretion through urine, a mechanism that may be implicated in the potential association between SGLT2i use and atopic dermatitis (AD) risk.</p><p><strong>Objectives: </strong>This study investigated the relationship between SGLT2i use and new-onset AD in diabetic patients.</p><p><strong>Methods: </strong>This nationwide active-comparator cohort study utilized data from the Taiwan National Health Insurance Database to investigate the association between SGLT2i use and AD risk. The study included adult patients with type 2 diabetes who initiated SGLT2i or DPP4i between May 2016 and December 2018, with no prescriptions for other SGLT2i or DPP4i in the 12 months prior to cohort entry. A total of 148,354 SGLT2i users were identified as the study group, while 322,703 DPP4i users were designated as the active comparator group. The primary outcome was the incidence of AD. To minimize potential confounding, inverse probability of treatment weighting (IPTW) was applied to balance baseline characteristics, medical history, and ever having medication use between the two groups. Additionally, sensitivity analyses, subgroup analyses, and gender-specific assessments were conducted to further validate the findings. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the risk of developing AD.</p><p><strong>Results: </strong>In the full cohort, SGLT2i users had a lower AD incidence (9.742 vs. 12.070 per 1,000 person-years) than DPP4i users. SGLT2i users had a significantly lower risk of AD compared to DPP4i users (HR = 0.847) after IPTW adjustment. Different SGLT2i types also showed a consistent protective effect for AD. Notably, the highest SGLT2i dosage was associated with the lowest AD risk (IPTW-adjusted HR = 0.647), consistent across sensitivity analyses. Additionally, male SGLT2i users exhibit a much lower risk of AD (IPTW-adjusted HR=0.750) than female SGLT2i users.</p><p><strong>Conclusions: </strong>SGLT2i show a significant protective effect against AD in diabetic patients compared to DPP4i. This robust finding, consistent across weighting and sensitivity analyses, supports SGLT2i use, with a strong protective effect also observed in the dose-response analysis.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}