British Journal of Dermatology最新文献

{"title":"Tonsillar microbiota alterations contribute to immune responses in psoriasis by skewing aged neutrophils.","authors":"Jiaoling Chen, Xuan Liu, Yaxing Bai, Xin Tang, Ke Xue, Zhenlai Zhu, Wanting Liu, Jiaqi Wang, Caiyu Wang, Hongjiang Qiao, Erle Dang, Wen Yin, Gang Wang, Shuai Shao","doi":"10.1093/bjd/ljaf134","DOIUrl":"10.1093/bjd/ljaf134","url":null,"abstract":"<p><strong>Background: </strong>The interplay between microbiota and the onset of immune-mediated diseases is increasingly coming to light. However, the role of tonsillar microbiota in cutaneous inflammation remains largely unknown.</p><p><strong>Objectives: </strong>To determine how the tonsillar microbiota influences skin inflammation in psoriasis and to uncover the underlying molecular mechanisms.</p><p><strong>Methods: </strong>Tonsillar microbiota samples were collected from 24 healthy control individuals and 28 patients with psoriasis. Microbial community composition was analysed with 16S rRNA and metagenomic sequencing. Serum levels of short-chain fatty acids (SCFAs) were measured via liquid chromatography-mass spectrometry in 10 healthy control participants and 14 patients with psoriasis. Peripheral blood neutrophils from both groups were then exposed to a representative microbial metabolite and key proinflammatory markers evaluated using functional immune assays.</p><p><strong>Results: </strong>We found significant alterations in the diversity and composition of the tonsillar microbial community in patients with psoriasis, with an increased prevalence of Bacteroidales and a decreased prevalence of Burkholderiales, Micrococcales and Pasteurellales relative to healthy control participants. Notably, a marked reduction in Rothia mucilaginosa correlated inversely with systemic inflammation (neutrophil-to-lymphocyte ratio) and disease severity (Psoriasis Area and Severity Index). Metagenomic analysis revealed disruptions in pathways critical to SCFA production, including propanoate, pyruvate and butanoate metabolism, which was supported by the significantly lower serum SCFA levels found in patients with psoriasis. Functional assays demonstrated that SCFAs inhibited neutrophil ageing, proinflammatory cytokine secretion and neutrophil extracellular trap formation.</p><p><strong>Conclusions: </strong>Our findings reveal that changes in tonsillar microbiota and their metabolic outputs contribute to psoriasis by modulating -immune responses, with potential clinical implications.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"310-321"},"PeriodicalIF":9.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magical Goo.","authors":"Krisha Tripathy","doi":"10.1093/bjd/ljaf120","DOIUrl":"10.1093/bjd/ljaf120","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"322"},"PeriodicalIF":11.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orofacial granulomatosis secondary to sodium metabisulfite contact allergy.","authors":"Vanessa Tran, Celestine Wong, Simone Belobrov, Ryan De Cruz, Vanessa Morgan, Laura Scardamaglia","doi":"10.1093/bjd/ljaf132","DOIUrl":"10.1093/bjd/ljaf132","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"330-331"},"PeriodicalIF":11.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isotretinoin and peanut allergy: evidence of safety is staring us in the face.","authors":"Davina Henderson, Paul J Turner, Jonathan O'B Hourihane","doi":"10.1093/bjd/ljaf137","DOIUrl":"10.1093/bjd/ljaf137","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"324-325"},"PeriodicalIF":11.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"P107 Association between the COVID-19 vaccination programme and incidence rates of bullous pemphigoid, herpes zoster and urticaria in the UK: an interrupted time series analysis","authors":"Mikolaj Swiderski, Sarah J. Lewis, Yana Vinogradova, Matthew J Ridd, Zenas Z N Yiu, Antonia Lloyd-Lavery, Vibhore Prasad, Sonia Gran","doi":"10.1093/bjd/ljaf085.135","DOIUrl":"https://doi.org/10.1093/bjd/ljaf085.135","url":null,"abstract":"Abstract Following the introduction of the COVID-19 vaccination programme, there were numerous reports of adverse cutaneous reactions. In particular, several population-based studies reported associations between the COVID-19 vaccines and bullous pemphigoid (BP), herpes zoster (HZ) and urticaria. However, these studies were hospital based and not representative of the UK population. Reliable estimates of the risks of these serious conditions following vaccination may help patients make informed decisions. We aimed to compare monthly incidence rates (IRs) of BP, HZ and urticaria before and after the UK’s COVID-19 programme started. We conducted a population-based cohort study using the Clinical Practice Research Datalink (during 1 January 2019 to 31 May 2023). We estimated monthly IRs (cases per 100 000 person-years) of the examined conditions. We used interrupted time series analysis to compare changes in slopes (i.e. trajectories) of examined IRs before and after intervention (vaccine programme). Sensitivity analyses accounted for COVID-19 national lockdowns and the total number of general practitioner appointments. There were 3506 incident cases of BP, 129 668 of HZ, 63 320 of urticaria and 29 623 of venous leg ulcer during the observation period. The median ages (in years) were 80 (interquartile range 71–86) for patients with BP, 61 (47–72) for HZ and 45 (32–61) for urticaria. The analysis did not detect changes in IRs of BP postintervention. Furthermore, no pre- or postintervention slopes were detected. There was a downward preintervention slope for the IR of HZ [IR −4.44, 95% confidence interval (CI) −5.54 to −3.35; P &amp;lt; 0.005]. The IR for HZ increased postintervention compared with the preintervention period (5.15, 95% CI 3.43–6.88; P &amp;lt; 0.005). However, we could not detect a slope postintervention. Sensitivity analysis results were similar. There was a downward preintervention slope for the IR of urticaria (−3.42, 95% CI −4.13 to −2.70; P &amp;lt; 0.005). The urticaria IR increased postintervention compared with the preintervention period (4.40, 95% CI 3.27–5.53; P &amp;lt; 0.005), resulting in an upward slope (0.98, 95% CI 0.43–1.52; P &amp;lt; 0.005). However, we could not detect a slope postintervention after accounting for lockdowns or the number of general practitioner appointments. In conclusion, we did not find a link between vaccinations and BP. There were modest increases in IRs for HZ and urticaria, which could be explained by COVID-19 vaccines. However, for many patients, the benefits of vaccination will likely outweigh the potential risks of HZ and urticaria. Further studies to estimate outcome risk based on individual patient-level data (e.g. case–control and self-controlled case series designs) should be used to determine whether the reported increases in HZ and urticaria IRs were driven by vaccinations or other coincident factors.","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":"193 Supplement_1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://academic.oup.com/bjd/article-pdf/193/Supplement_1/ljaf085.135/63486004/ljaf085.135.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147897434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive single-cell chromatin and transcriptomic profiling of peripheral immune cells in nonsegmental vitiligo.","authors":"Jesus Gay-Mimbrera, Daniel Lozano-Ojalvo, Pedro J Gómez-Arias, Irene Rivera-Ruiz, Macarena Aguilar-Luque, Carmen Mochón-Jiménez, Eloísa Andújar Pulido, Mónica Pérez-Alegre, Emma Guttman-Yassky, Juan Ruano","doi":"10.1093/bjd/ljaf041","DOIUrl":"10.1093/bjd/ljaf041","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Nonsegmental vitiligo (NSV) is an autoimmune condition characterized by melanocyte loss. While skin-specific mechanisms have been well studied, systemic immune dysregulation contributing to NSV pathogenesis remains unclear.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;To use a multi-omic single-cell approach to investigate circulating immune cells in NSV, integrating transcriptional and chromatin accessibility data.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;An integrative single-cell RNA sequencing (scRNAseq)/single-cell assay for transposase-accessible chromatin sequencing (scATACseq) analysis was conducted on peripheral blood mononuclear cells (PBMCs) from people with NSV (n = 11) and healthy control participants (n = 5), identifying transcriptional markers, cell-cell interactions, chromatin accessibility and transcription factor (TF) dynamics. Key findings were validated in an expanded cohort (patients with NSV, n = 16; healthy controls, n = 9) using spectral flow cytometry, with additional stratification by sex, age, disease activity, severity and duration.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Analysis of 59 192 PBMCs identified 8204 gene expression markers and 13 925 ATAC peaks across 25 immune cell subtypes. A broadly activated immune response was observed, characterized by cytotoxicity, antigen presentation, cell exhaustion and stress, predominantly in monocytes, natural killer cells, CD8+ T cells and dendritic cells. Multi-omic integration revealed T helper (Th)1/Th17 polarization and dysfunctional regulatory T cell [Treg/memory Treg (mTreg)] responses. Chromatin accessibility highlighted enriched TF binding sites for forkhead box O3 (FOXO3), Sp1, activator protein 1 (AP-1), signal transducer and activator of transcription (STAT)1/STAT3, interferon regulatory factor (IRF)1 and IRF4, regulating pathways linked to cytotoxicity, antigen processing, nuclear factor-κB, Toll-like receptor and Janus kinase/STAT signalling. Flow cytometry validated these findings, showing that disease activity and shorter duration were associated with heightened immune dysregulation. Robust T-cell receptor activation drove Th1/Th17 polarization and elevated interferon-γ and tumour necrosis factor-α production in CD4+ and CD8+ T cells. Cutaneous lymphocyte-associated antigen (CLA)+ skin-homing Th1/Th17-polarized CD4+ T cells, CD8+ T cells and mTregs exhibited persistent activation, marked by basal programmed cell death protein 1 (PD1)+ expression. OX40/OX40L-mediated interactions between monocytes and effector T cells amplified inflammation. Regulatory dysfunction, including reduced interleukin (IL)-4 and IL-13 production by mTregs, was prominent in moderate-to-severe and active disease.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This is the first multi-omic single-cell study of PBMCs from people with NSV, revealing systemic immune dysregulation driven by cytotoxicity, antigen presentation, exhaustion and regulatory failure. Disease severity, activity and evolutio","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"115-124"},"PeriodicalIF":9.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adding arginine to the list of single amino acids important in epidermal barrier function.","authors":"Ryan F L O'Shaughnessy","doi":"10.1093/bjd/ljaf110","DOIUrl":"10.1093/bjd/ljaf110","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"7-8"},"PeriodicalIF":9.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KLF4 variants in palmoplantar, nonsyndromic and syndromic epidermal differentiation disorder phenotypes.","authors":"Robert W Gruber, Matthias Schmuth","doi":"10.1093/bjd/ljaf117","DOIUrl":"10.1093/bjd/ljaf117","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"8"},"PeriodicalIF":9.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear hypermelanosis in narrow bands: a mosaic pattern manifestation of dyskeratosis congenita?","authors":"Ran Mo, Mingming Xu, Zhiming Chen, Ruiyu Xiang, Xiaofang Li, Hongyang Li, Guoyi Zhang, Jianfang Sun, Wei Zhang, Yong Yang","doi":"10.1093/bjd/ljaf091","DOIUrl":"10.1093/bjd/ljaf091","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"178-180"},"PeriodicalIF":11.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid improvements in Kaposi sarcoma with metformin: a report of two cases.","authors":"Ting Su, Yongkai Yu, Zhonglan Su, Yan Lu","doi":"10.1093/bjd/ljaf090","DOIUrl":"10.1093/bjd/ljaf090","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"175-176"},"PeriodicalIF":11.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}