British Journal of Dermatology最新文献

{"title":"Air pollution and atopic dermatitis: critical windows of risk in early life.","authors":"Christian Vestergaard","doi":"10.1093/bjd/ljaf109","DOIUrl":"10.1093/bjd/ljaf109","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"967"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of skin and subcutaneous diseases: an update from the Global Burden of Disease Study 2021.","authors":"Pengcheng Huai, Peiye Xing, Yilin Yang, Yaoyao Kong, Furen Zhang","doi":"10.1093/bjd/ljaf071","DOIUrl":"10.1093/bjd/ljaf071","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1136-1138"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term safety and efficacy of Oleogel-S10 (birch bark extract) in epidermolysis bullosa: 24-month results from the phase III EASE study.","authors":"Dédée F Murrell, Christine Bodemer, Anna L Bruckner, Tracy Cunningham, Charles Davis, Mariá Florencia Fernández, Dimitra Kiritsi, Laura Maher, Eli Sprecher, Mauricio Torres-Pradilla, Johannes S Kern","doi":"10.1093/bjd/ljaf022","DOIUrl":"10.1093/bjd/ljaf022","url":null,"abstract":"<p><strong>Background: </strong>Epidermolysis bullosa (EB) is a group of rare and severe genetic disorders characterized by persistent skin fragility and open wounds. EB manifests as cutaneous and mucosal blistering, erosions and impaired wound healing.</p><p><strong>Objectives: </strong>To determine the long-term efficacy, tolerability and safety of Oleogel-S10 (birch bark extract) in dystrophic EB (DEB) and junctional EB (JEB) in the 24-month open-label phase (OLP) of the EASE study.</p><p><strong>Methods: </strong>EASE was a double-blind randomized controlled phase III study consisting of two phases: a 90-day double-blind phase (DBP) and a 24-month OLP. Patients from both former treatment groups in the DBP entered the single-arm OLP (n = 205). Patients received Oleogel-S10 on all partial-thickness EB wounds. OLP endpoints included the incidence and severity/relatedness of adverse events (AEs), maximum wound infection severity, changes in body surface area percentage (BSAP) of wounds, EB Disease Activity and Scarring Index (EBDASI), pain, itch, disease severity and quality-of-life outcomes.</p><p><strong>Results: </strong>The OLP data demonstrated that Oleogel-S10 target wound treatment adherence was > 99% and mean (SD) treatment duration was 584.7 (246.1 days). Seventy-two per cent of patients in the OLP were aged < 18 years and 86.8% had DEB; recessive DEB predominated (78.0%). AEs were reported in 77.1% of patients and were typically mild-to-moderate in severity. Severe and serious AEs were seen in 18.0% and 24.4% of patients, respectively. AEs resulted in the withdrawal of 7.8% of patients (n = 16), including three with treatment-related AEs. Nine deaths were reported; none were attributable to the treatment. The incidence of target wound infections was low (n = 7); five were mild-to-moderate in severity and two were severe. In patients treated with Oleogel-S10 throughout, mean (SD) BSAP changes from DBP baseline at 3, 12 and 24 months were -4.3% (8.1) (P < 0.001), -5.9% (8.6) (P < 0.001) and -3.7% (9.0) (P = 0.003), respectively. Similarly, significant changes in EBDASI skin activity score from DBP baseline were observed: -3.9 (8.3) (P < 0.001), -5.1 (8.2) (P < 0.001) and -3.0 (8.3) (P = 0.007) at 3, 12 and 24 months, respectively.</p><p><strong>Conclusions: </strong>These data support an encouraging long-term safety profile of Oleogel-S10 and a sustained reduction in wound burden over at least 24 months of Oleogel-S10 treatment.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1007-1017"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatological care in Muslim patients: a perspective on gender and cultural considerations.","authors":"Hibo Rijal, Shaimaa Helal, Morvarid Hessami-Booshehri, Erin Dahlke","doi":"10.1093/bjd/ljaf068","DOIUrl":"10.1093/bjd/ljaf068","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1117-1119"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient research priorities in melanoma: a national qualitative interview study.","authors":"Khaylen Mistry, Omsin Srimudkul, Mitesh Patel, John Ragan, Dimitrios Karponis, Zoe C Venables, Nick J Levell","doi":"10.1093/bjd/ljaf048","DOIUrl":"10.1093/bjd/ljaf048","url":null,"abstract":"<p><strong>Background: </strong>Outcomes for advanced melanoma have improved following the advent of immunotherapy and targeted therapy. This heralds a need for reconsideration of future research agendas. Patients can - and are keen to - help identify and prioritize research topics to ensure future research benefits patients. No previous peer-reviewed research has reported patient research priorities for melanoma.</p><p><strong>Objectives: </strong>To determine the prioritized research topics of patients with melanoma in England.</p><p><strong>Methods: </strong>Patients aged ≥ 18 years, diagnosed with melanoma in the past 10 years, were recruited across England by skin cancer charities. Preinterview questionnaires obtained demographic, tumour and treatment information. Semi-structured interviews were conducted where patients were asked what they thought were important topics to research in melanoma. Using a grounded theory approach, transcripts were analysed in an iterative process to identify themes for patient research priorities.</p><p><strong>Results: </strong>Twenty patients were individually interviewed from eight of nine English regions. Five key themes were identified: (1) 'Risk factors and prevention of melanoma' - patients voiced a desire for research into modifiable risk factors and public campaigns to prevent melanoma; (2) 'Diagnostic delay and misdiagnosis of melanoma' - patients felt diagnostic delays could be reduced through research to support nonspecialists and integrating technology such as teledermatology or artificial intelligence'; (3) 'Indications, outcomes, side-effects and interactions of treatments for melanoma' - novel treatments inspired patients to encourage future research into the indications, outcomes and side-effects of therapeutic options; (4) 'Optimizing follow-up for melanoma' - with increased survivorship, research to support the delivery of a personalized approach to follow-up was valued; and (5) 'Factors that influence survival from melanoma' - patients prioritized research to accurately predict recurrence and survival based on patient-specific factors.</p><p><strong>Conclusions: </strong>This is the first peer-reviewed study to report patient research priorities in melanoma. Many of the themes identified align with National Institute for Health and Care Excellence research recommendations. Additionally, novel themes were identified that provide a rationale to develop a James Lind Alliance Priority Setting Partnership for melanoma. If research addresses topics relevant to patients, decision-makers will be equipped to deliver services that meet patient needs.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1055-1062"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geospatial analyses demonstrate variation of cutaneous T-cell lymphomas across Australia, providing insights into possible causes.","authors":"Belinda A Campbell, Peter D Baade, Paramita Dasgupta, Jessica K Cameron, Sandro V Porceddu, H Miles Prince, Karin Thursky","doi":"10.1093/bjd/ljae476","DOIUrl":"10.1093/bjd/ljae476","url":null,"abstract":"<p><strong>Background: </strong>Cutaneous T-cell lymphomas (CTCLs) are rare with distinct diagnostic challenges. Equitable access to cancer care is a recognized priority, internationally. To date, the geospatial distribution of CTCL has not been definitively studied. Understanding the incidence and geographical distribution of patients with CTCL are critical first steps towards the ultimate goal of equity of care. Geospatial analyses also allow the opportunity to explore environmental causative factors: for CTCL, the contribution of solar ultraviolet (UV) radiation on causation remains unclear.</p><p><strong>Objectives: </strong>We investigate geospatial patterns of CTCL incidence across Australia, compare with all rare cancers, and consider solar UV exposure on causality and diagnosis rates.</p><p><strong>Methods: </strong>All CTCL diagnoses (1 January 2000 to 31 December 2019) were obtained from the nationwide dataset. Areas of residence were collected according to nationally approved definitions. Bayesian spatial incidence models were applied. Geospatial distributions were visually analysed.</p><p><strong>Results: </strong>The CTCL age-standardised incidence rate was 7.7 (95% confidence interval 7.4-7.9) per million people per year in Australia. Diagnostic disparity was seen between Australian states/territories, with lower diagnosis rates in rural/remote and socioeconomically disadvantaged areas. Incidence exceeded the national average within more densely populated capital cities. Visual comparisons of the geospatial distribution of CTCL revealed marked discordances with the geospatial patterns of all rare cancers and solar UV in Australia.</p><p><strong>Conclusions: </strong>Geographical heterogeneity in CTCL exists across Australia. Incidence reflects population density. Geospatial patterns of CTCL differ substantially from all rare cancers, with implications for the unique diagnostic challenges and unmet needs of this patient population. The distribution of CTCL across Australia does not support a causative link with UV exposure. Further global evaluation of geospatial patterns is warranted.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1018-1028"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotype-phenotype correlation for skin and neuropsychiatric features in tuberous sclerosis complex.","authors":"Emi Kaneda, Hanako Koguchi-Yoshioka, Keisuke Nimura, Satoshi Hattori, Saki Ishino, Manabu Fujimoto, Mari Wataya-Kaneda","doi":"10.1093/bjd/ljaf038","DOIUrl":"10.1093/bjd/ljaf038","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1122-1124"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental triggers of psoriasis: insights from a UK patient-reported cohort (mySkin).","authors":"Madeline Kroah-Hartman, John Y W Lee, Niamh Dooley, Wei Ren Tan, Maaike F M Mineur, Alexandra Paolino, Jade Pizzato, Freya Jackson-Duffy, Kingsley Powell, Manpreet K Sagoo, Georgia Sewell, Camille Lancelot, Lucy Moorhead, Helen McAteer, Bolaji Coker, John Weinman, Jonathan N Barker, Sarah Chapman, Sam Norton, Catherine H Smith, Satveer K Mahil","doi":"10.1093/bjd/ljaf073","DOIUrl":"10.1093/bjd/ljaf073","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1138-1141"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous granulomas: mechanisms, cellular interactions and therapeutic insights.","authors":"Satoshi Nakamizo, Kenji Kabashima","doi":"10.1093/bjd/ljaf096","DOIUrl":"10.1093/bjd/ljaf096","url":null,"abstract":"<p><p>Granulomas are specialized biologic defence mechanisms that form in response to infections by pathogens, foreign bodies or specific stimuli such as antimicrobials or fungi. These structures function to isolate foreign materials and pathogens that cannot be eliminated by immune cells, primarily through macrophage activity. In the skin, granulomas are a hallmark of several conditions, including sarcoidosis, granuloma annulare, tuberculosis and leprosy, each exhibiting distinct pathological and immunological features. Granulomas can also arise from lipid accumulation, as observed in xanthogranuloma, or be triggered by inflammatory processes associated with unidentified antigens. Among their cellular components, Langhans-type multinucleated giant cells play a pivotal role in granuloma structure and function, contributing to pathogen containment and tissue remodelling, although their precise mechanisms of action remain an area of active investigation. In addition to these giant cells, recent studies have identified triggering receptors expressed on myeloid cells 2 (TREM2)+ macrophages as key contributors to granuloma formation and maintenance. These macrophages are involved in extracellular degradation of foreign substances and play a role in adapting to the hypoxic and nutrient-poor microenvironment of granulomas through metabolic reprogramming, including the pentose phosphate pathway. Recent advances in molecular biology, such as single-cell RNA sequencing, have provided unprecedented insights into the cellular heterogeneity and molecular pathways involved in granuloma formation. These techniques have revealed disease-specific differences in immune cell profiles and activation states, offering new perspectives on the underlying mechanisms of granulomatous diseases. Despite these advances, the precise processes driving granuloma formation and their functional significance remain largely unclear. This review addresses the central question, 'What is a granuloma?', by synthesizing recent findings, with a particular focus on cutaneous granulomas, and presenting interpretations grounded in the current body of literature. We also discuss the implications of these findings for the development of novel therapeutic strategies, including targeted immunomodulation and cytokine blockade, which hold promise for treating granulomatous diseases while preserving host defence.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"974-982"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unseen spaces: inverse psoriasis between the toes.","authors":"Sarah Preis, Tilo Biedermann, Alexander Zink","doi":"10.1093/bjd/ljae500","DOIUrl":"10.1093/bjd/ljae500","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":"1150"},"PeriodicalIF":11.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}