British Journal of Dermatology最新文献

{"title":"Blueberry muffin rash in neonatal leukemia.","authors":"Zeqiao Zhang, Zhimiao Lin","doi":"10.1093/bjd/ljaf116","DOIUrl":"https://doi.org/10.1093/bjd/ljaf116","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the proportions of allele frequencies for SERPINA12 pathogenic variants in Japanese patients with Nagashima-type palmoplantar keratosis/keratoderma.","authors":"Aoi Ebata, Takuya Takeichi, Kazuki Nishida, Basile Chretien, Akira Miyazaki, Takenori Yoshikawa, Yuika Suzuki, Kana Tanahashi, Ryo Fukaura, Mariko Seishima, Yasushi Suga, Yoshinao Muro, Yuka Nakazawa, Tomoo Ogi, Masashi Akiyama","doi":"10.1093/bjd/ljaf111","DOIUrl":"https://doi.org/10.1093/bjd/ljaf111","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adding arginine to the list of single amino acids important in epidermal barrier function.","authors":"Ryan F L O'Shaughnessy","doi":"10.1093/bjd/ljaf110","DOIUrl":"https://doi.org/10.1093/bjd/ljaf110","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air Pollution and Atopic Dermatitis: Critical Windows of Risk in Early Life.","authors":"Christian Vestergaard","doi":"10.1093/bjd/ljaf109","DOIUrl":"https://doi.org/10.1093/bjd/ljaf109","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rescue Therapy in Malignant Atrophic Papulosis: A New Era of Promising Treatments Targeting Interferon and Complement Pathways.","authors":"Yasmine El Maamar, Clément Pruvot, Meryem-Maud Farhat, Barbara Noiret, Constance Laroye, Alexandre Barbe, Lila Ghannem, Pierre Labalette, Delphine Staumont-Salle, David Launay, Éric Hachulla, Emmanuel Ledoult","doi":"10.1093/bjd/ljaf106","DOIUrl":"https://doi.org/10.1093/bjd/ljaf106","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic advances for Cutaneous T Cell Lymphoma.","authors":"Martine Bagot","doi":"10.1093/bjd/ljaf105","DOIUrl":"https://doi.org/10.1093/bjd/ljaf105","url":null,"abstract":"<p><p>Cutaneous T cell lymphomas (CTCL) are a group of rare and heterogenous diseases. There is currently no curative treatment for patients with advanced mycosis fungoides (MF) and Sézary syndrome (SS). EORTC consensus recommendations for the treatment of MF/SS have been updated and focused on recently available treatments. Peginterferon, a new form of interferon, has a favorable risk-benefit profile for CTCL patients treatment. Recently approved monoclonal antibodies have completely modified the treatment algorithm of advanced CTCL treatment. Brentuximab vedotin is very efficient for tumor and transformed MF. Mogamulizumab can induce long term remission in patients with SS. Lacutamab has recently completed an international trial, both in SS and MF. Numerous novel targets have been identified, and several new monoclonal antibodies have been shown able to enhance specific immune responses and to induce targeted antibody dependent cytotoxicity and cytophagocytosis. These new antibodies warrant further evaluation in controlled trials. Kinase inhibitors and Chimeric Antigen Receptor (CAR)-T Therapy are promising new treatments. Finally, recent studies have demonstrated that allogeneic hematopoietic stem-cell transplantation can increase survival and quality of life in patients with advanced CTCL.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroid acne: fluorescence under ultraviolet light.","authors":"Lin Wang, Cheng Tan","doi":"10.1093/bjd/ljaf107","DOIUrl":"https://doi.org/10.1093/bjd/ljaf107","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term (68 weeks) administration of nemolizumab and topical corticosteroids for prurigo nodularis in patients aged ≥13 years: efficacy and safety data from a phase II/III study.","authors":"Hiroo Yokozeki, Hiroyuki Murota, Takayo Matsumura","doi":"10.1093/bjd/ljaf045","DOIUrl":"https://doi.org/10.1093/bjd/ljaf045","url":null,"abstract":"<p><strong>Background: </strong>The biological therapy nemolizumab has been shown to improve the signs and symptoms of prurigo nodularis (PN) to a significantly greater extent than placebo over 16 weeks of treatment. We now report efficacy and safety data over 68 weeks.</p><p><strong>Objectives: </strong>To evaluate the long-term impact of nemolizumab on pruritus, disease severity, quality of life, and topical corticosteroid usage in patients with PN in Japan, and to confirm the safety profile.</p><p><strong>Methods: </strong>Asian patients aged ≥13 years were randomly assigned (1:1:1) to receive nemolizumab 30 mg, 60 mg, or placebo, with concomitant medium-potency topical corticosteroids, every 4 weeks for 16 weeks. For the subsequent 52 weeks, nemolizumab treatment was continued, while placebo-treated patients were reallocated to either the 30-mg or 60-mg nemolizumab groups. Efficacy outcome measures included the Peak Pruritus Numerical Rating Scale (PP-NRS), 5-level itch scale, Investigator's Global Assessment (IGA), the number of PN nodules, Insomnia Severity Index, Dermatology Life Quality Index, and use of topical corticosteroids. Safety measures included the frequency of treatment-emergent adverse events (TEAEs).</p><p><strong>Results: </strong>In the modified intention-to-treat population (n=226), nemolizumab provided sustained and continuing improvements in efficacy between weeks 16 and 68. In patients who received nemolizumab 30 mg, the PP-NRS had decreased by 60.5% at week 16 and 78.6% at week 68; respective decreases in the 60-mg group were 55.1% and 76.5%. Across all treatment groups, a large proportion of patients had improvements indicating a reduction from moderate-to-severe to mild pruritus, IGA improvements indicating a reduction in PN severity, a decrease in the number of nodules, and rapid and durable improvements in sleep and daily life activities. Nemolizumab-treated patients were also able to reduce the daily quantity of medium-potency and higher topical corticosteroids used by at least half. There was no indication of relapse in pruritus, PN severity, or quality of life scores following treatment cessation. Most TEAEs were mild and were similar to those reported in prior studies.</p><p><strong>Conclusions: </strong>Nemolizumab elicited continuous and durable improvements across multiple measures of pruritus, PN severity, and quality of life over 68 weeks of treatment, with no new safety concerns. (Funded by Maruho; jRCT number, 2011200017).</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A qualitative interview study exploring patient views and experiences of treatment for hidradenitis suppurativa in the UK.","authors":"Laura Howells, Paul Leighton, Kim S Thomas, Fiona Collier, Angela Gibbons, Ceri Harris, Kerry Hood, Muhammad Riaz, Jeremy Rodrigues, Helen Stanton, Emma Thomas-Jones, John R Ingram","doi":"10.1093/bjd/ljaf046","DOIUrl":"https://doi.org/10.1093/bjd/ljaf046","url":null,"abstract":"<p><strong>Background: </strong>Hidradenitis suppurativa (HS) is a long-term skin condition where evidence for management after first line treatment fails is limited, and practice varies across the UK. Both medical and surgical treatment options are potential avenues for treatment. Furthermore, patient perspectives on HS treatments have received little attention in research to date.</p><p><strong>Aim: </strong>To explore patients' views and experiences of treatment for HS to inform clinical care.</p><p><strong>Methods: </strong>A nested qualitative study within a prospective cohort study. Interviews with 35 participants were completed by telephone. Purposive sampling was undertaken. Framework analysis was used to develop themes.</p><p><strong>Results: </strong>Views on treatments: Past experiences and knowledge informed patient beliefs and whether an individual felt a treatment option was appropriate or a good 'fit' for them at a specific moment in time. Healthcare professional recommendations can be influential on both patient's views and which treatment option they ultimately receive. Experiences of treatments: There were positive experiences across all treatment types used within the study. Negative experiences included side effects of medications, lack of efficacy, delays to procedures, and burden of wound care. However, even when personal experiences were not wholly positive for an individual, participants often believed the same treatment may potentially help others with HS, due to the importance placed on personalisation of treatment.</p><p><strong>Conclusions: </strong>This paper has implications for how healthcare professionals discuss treatment options with people with HS. A 'one size fits all' approach is inappropriate, and shared decision making that elicits patient beliefs and preferences is crucial.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High magnification dermoscopy for in vivo identification of larvae within eggs in active scabies infestation.","authors":"Roberta Giuffrida, Linda Tognetti, Stefania Guida, Claudio Conforti, Elisa Cinotti, Iris Zalaudek, Fabrizio Guarneri","doi":"10.1093/bjd/ljaf104","DOIUrl":"https://doi.org/10.1093/bjd/ljaf104","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}