British Journal of Dermatology最新文献

{"title":"Age and biologic survival in patients with moderate-to-severe psoriasis: A cohort study from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR).","authors":"Oras A Alabas, Kayleigh J Mason, Zenas Z N Yiu, Catherine H Smith, Richard B Warren, Christopher E M Griffiths","doi":"10.1093/bjd/ljaf017","DOIUrl":"https://doi.org/10.1093/bjd/ljaf017","url":null,"abstract":"<p><strong>Background: </strong>The current management of psoriasis does not differentiate between young and old patients in selecting the safest and/or most effective biologic.</p><p><strong>Objectives: </strong>To explore the effect of age at treatment initiation in response to biologics in patients with moderate-to-severe psoriasis in the UK and Eire.</p><p><strong>Methods: </strong>Data from patients registering to the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR) from 2007-2024 on first course of Tumour Necrosis Factor (TNF), interleukin (IL) 12/13, IL-17 and IL-23 inhibitors (i) with at least 6 months' follow-up were included. Patients aged ≥16 years at registration were grouped into 16-24, 25-34, 35-44, 45-54, 55-64, 65-74, and ≥75 year cohorts with 45-54 years as the Reference Cohort. Biologic survival was defined as the time between treatment initiation to its discontinuation associated with ineffectiveness or occurrence of adverse events (AEs). Adjusted hazard ratio (aHR) with 95% confidence interval (CI) was estimated using a flexible parametric model to compare discontinuing therapy between age groups. Each model included exposure (biologic class), effect modifier (age groups), interaction terms, baseline demographic, clinical, and disease severity covariates.</p><p><strong>Results: </strong>There were 14,294 patients included; 847 (6%) 16-24; 2,502 (18%) 25-34; 3,575 (25%) 35-44; 3,863 (27%) 45-54; 2,338 (16%) 55-64; 954 (7%) 65-74; and 215 (2%) ≥75 years. The interaction effects model showed individuals aged 16-24 years were more likely to discontinue TNFi due to ineffectiveness compared with the Reference Cohort (45-54 years) [aHR (95% CI) 1.30 (1.10, 1.55)]. For survival associated with AEs, individuals aged 55-64 years were at higher risk of discontinuing TNFi and IL12/23i [1.33 (1.13, 1.56) and 1.34 (1.03, 1.75), respectively], those aged 65-74 years were more likely to discontinue TNFi, IL-12/23i and IL-17i [1.89 (1.54, 2.31), 2.00 (1.47, 2.73) and 1.69 (1.08, 2.64), respectively] whereas individuals aged ≥75 years were at higher risk of discontinuing the four biologic classes.</p><p><strong>Conclusions: </strong>Psoriasis patients aged 16-24 years are more likely to stop TNFi due to ineffectiveness whereas those aged ≥55 years are more likely to stop biologics due to AEs. These large real-world findings provide important information for clinicians treating people with moderate-to-severe psoriasis across all age groups.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic insights into ruxolitinib cream for mild hidradenitis suppurativa.","authors":"John R Ingram","doi":"10.1093/bjd/ljaf019","DOIUrl":"https://doi.org/10.1093/bjd/ljaf019","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-throughput proteomics identifies inflammatory proteins associated with disease severity and genetic ancestry in patients with hidradenitis suppurativa.","authors":"Peter M Dimitrion, Rachel Krevh, Jesse Veenstra, James Ge, Aamir Siddiqui, Deangelo Ferguson, Aakash Hans, Bobby Zuniga, Kermanjot Sidhu, Steven Daveluy, Iltefat Hamzavi, Li Zhou, Indra Adrianto, Qing-Sheng Mi","doi":"10.1093/bjd/ljaf012","DOIUrl":"https://doi.org/10.1093/bjd/ljaf012","url":null,"abstract":"<p><strong>Background: </strong>Hidradenitis Suppurativa (HS) is a chronic inflammatory skin condition with a greater prevalence and disease burden in patients who identify as African American and those with a family history of HS, suggesting a strong genetic component to its pathogenesis.</p><p><strong>Objective: </strong>To evaluate the relationship between plasma inflammatory protein expression, HS disease severity, and genetic ancestry in a diverse cohort of patients with Hidradenitis Suppurativa.</p><p><strong>Methods: </strong>We performed a case-control study of patients with HS compared to age-, sex-, and ethnicity-matched healthy controls. We profiled circulating inflammatory proteins using Olink High-throughput proteomics and determined genetic ancestry from whole-genome sequencing data.</p><p><strong>Results: </strong>Using linear regression, we identified novel proteins associated with HS after adjusting for age, sex, and ethnicity. Our analysis also revealed differences in the inflammatory proteome linked to disease severity. Specifically, we found that plasma IL6 levels can distinguish between different Hurley stages, indicating that IL6 may serve as a marker of disease severity. Additionally, we observed variations in inflammatory protein levels based on genetic ancestry: patients with predominantly African ancestry exhibited higher levels of inflammatory proteins associated with neutrophilic inflammation, while those with predominantly European ancestry showed increased levels of Th1-related inflammatory proteins.</p><p><strong>Limitations: </strong>Single-center study. Limited sample size. Unable to account for treatment status or comorbidities that may influence the level of inflammatory cytokines.</p><p><strong>Conclusion: </strong>Genetic ancestry and disease severity influence the plasma inflammatory profile in patients with HS.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythema Variation in Dermatomyositis across Subtypes and Racial Groups: Importance of Outcome Measure for Dermatomyositis Clinical Trials.","authors":"Catherine Shen, Ari Zeidi, Lilian Xie, Lais Lopes Almedia Gomes, Rui Feng, Victoria Werth","doi":"10.1093/bjd/ljaf013","DOIUrl":"https://doi.org/10.1093/bjd/ljaf013","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of non-infectious uveitis among patients with hidradenitis suppurativa.","authors":"Temitope Ayodele, Bria Midgette, Andrew Strunk, Robert Sabat, Kerstin Wolk, Amit Garg","doi":"10.1093/bjd/ljaf004","DOIUrl":"https://doi.org/10.1093/bjd/ljaf004","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grover disease shows Type 2 immune activation and improves with dupilumab.","authors":"Michael J Murphy, Muhammad H Junejo, Okeroghene Rufin, Jeffrey M Cohen, Caroline A Nelson, William Damsky","doi":"10.1093/bjd/ljaf005","DOIUrl":"https://doi.org/10.1093/bjd/ljaf005","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial proteomics reveals sirtuin 1 to be a determinant of T-cell infiltration in human melanoma.","authors":"Jan-Malte Placke, Jenny Bottek, Renata Váraljai, Batool Shannan, Sarah Scharfenberg, Christoph Krisp, Philippa Spangenberg, Camille Soun, Devon Siemes, Lars Borgards, Franziska Hoffmann, Fang Zhao, Anette Paschen, Hartmut Schlueter, Ferdinand von Eggeling, Iris Helfrich, Florian Rambow, Selma Ugurel, Alpaslan Tasdogan, Dirk Schadendorf, Daniel R Engel, Alexander Roesch","doi":"10.1093/bjd/ljae433","DOIUrl":"https://doi.org/10.1093/bjd/ljae433","url":null,"abstract":"<p><strong>Background: </strong>The tumour microenvironment significantly influences the clinical response of patients to therapeutic immune checkpoint inhibition (ICI), but a comprehensive understanding of the underlying immune-regulatory proteome is still lacking.</p><p><strong>Objectives: </strong>To decipher targetable biologic processes that determine tumour-infiltrating lymphocytes (TiLs) as a cellular equivalent of clinical response to ICI.</p><p><strong>Methods: </strong>We mapped the spatial distribution of proteins in TiL-enriched vs. TiL-low compartments in melanoma by combining microscopy, matrix-assisted laser desorption mass spectrometry imaging and liquid chromatography-mass spectrometry, as well as computational data mining. Pharmacological modulation of sirtuin 1 (SIRT1) activity in syngeneic mouse models was used to evaluate the efficacy of pharmacological SIRT1 activation in two syngeneic melanoma mouse models, one known to be α-programmed cell death protein 1 (PD-1) sensitive and the other α-PD-1 resistant.</p><p><strong>Results: </strong>Spatial proteomics and gene ontology-based enrichment analysis identified > 145 proteins enriched in CD8high tumour compartments, including negative regulators of mammalian target of rapamycin signalling such as SIRT1. Multiplexed immunohistochemistry confirmed that SIRT1 protein was expressed more in CD8high than in CD8low compartments. Further analysis of bulk and single-cell RNA sequencing data from melanoma tissue samples suggested the expression of SIRT1 by different lymphocyte subpopulations (CD8+ T cells, CD4+ T cells and B cells). Furthermore, we showed in vivo that pharmacological SIRT1 activation increased the immunological effect of α-PD-1 ICI against melanoma cells in mice, which was accompanied by an increase in T-cell infiltration and T-cell-related cytokines, including interferon (IFN)-γ, CCL4, CXCL9, CXCL10 and tumour necrosis factor-α. In silico analysis of large transcriptional data cohorts showed that SIRT1 was positively associated with the proinflammatory T-cell chemokines CXCL9, CXCL10 and IFN-γ, and prolonged overall survival of patients with melanoma.</p><p><strong>Conclusions: </strong>Our study deciphers the proteomics landscape in human melanoma, providing important information on the tumour microenvironment and identifying SIRT1 as having important prognostic and therapeutic implications.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serpiginous Pustules and Erythematous Plaques on the Soles.","authors":"Tian Chen, Dong-Lai Ma","doi":"10.1093/bjd/ljae497","DOIUrl":"https://doi.org/10.1093/bjd/ljae497","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin microbiome and polymorphous light eruption.","authors":"Vijaykumar Patra, Peter Wolf","doi":"10.1093/bjd/ljae513","DOIUrl":"https://doi.org/10.1093/bjd/ljae513","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tinea corporis at the injection site of interleukin-17 inhibitor in psoriasis vulgaris.","authors":"Keigo Takase, Takayoshi Komatsu-Fujii, Toshiaki Kogame, Atsushi Otsuka, Kenji Kabashima","doi":"10.1093/bjd/ljae511","DOIUrl":"https://doi.org/10.1093/bjd/ljae511","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}