British Journal of Dermatology最新文献

{"title":"Advances.","authors":"Krisha Tripathy","doi":"10.1093/bjd/ljaf121","DOIUrl":"https://doi.org/10.1093/bjd/ljaf121","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Validation and Interpretation Thresholds of the Hidradenitis Suppurativa Quality of Life (HiSQOL©) Questionnaire Using Pooled Data from the Phase 3 BE HEARD I & II Trials of Bimekizumab in Hidradenitis Suppurativa.","authors":"Joslyn S Kirby, Linnea Thorlacius, Jérémy Lambert, Valerie Ciaravino, Robert Rolleri, Ingrid Pansar, Edward Muller, Christopher G Pelligra, John R Ingram","doi":"10.1093/bjd/ljaf067","DOIUrl":"https://doi.org/10.1093/bjd/ljaf067","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magical Goo.","authors":"Krisha Tripathy","doi":"10.1093/bjd/ljaf120","DOIUrl":"https://doi.org/10.1093/bjd/ljaf120","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Furuncular Myiasis in the skin of colour.","authors":"Neerja Saraswat, Durga Madhab Tripathy, Rajesh W Adhau, Anirudh Tripathy, Anil Balki","doi":"10.1093/bjd/ljaf114","DOIUrl":"https://doi.org/10.1093/bjd/ljaf114","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of congenital ichthyoses: Guidelines of care: Part One: 2024 Update.","authors":"Juliette Mazereeuw-Hautier, Amy S Paller, Isabelle Dreyfus, Eli Sprecher, Edel O'Toole, Christine Bodemer, Masashi Akiyama, Andrea Diociaiuti, Maya El Hachem, Judith Fischer, Rogelio Gonzalez-Sarmiento, Carlos Gutiérrez-Cerrajero, Hagen Ott, Cristina Has, Nathalie Jonca, Céline Granier Tournier, Sarah Milesi, Hélène Texier, Ana Martinez, Heiko Traupe, Carmen Maria Salavastru, Matthias Schmuth, Kathrin Giehl, Mandy Aldwin, Ruth Anton Morales, Saturnino Santos, Marie-Anne Morren, Anne Audouze, Raman Malhotra, Karin Veldman, Joanna Narbutt, Kira Süßmuth, Angela Hernandez-Martin, Antoni Gostynski","doi":"10.1093/bjd/ljaf076","DOIUrl":"https://doi.org/10.1093/bjd/ljaf076","url":null,"abstract":"<p><p>In 2019, a group of experts published the first European guidelines for the management of congenital ichthyoses after a multidisciplinary expert meeting held in 2016. An update of these guidelines and literature search was planned every 5 years, given the clinical, molecular and therapeutic advances, including the use of biologic therapies. We present here updated guidelines that have been developed by a reorganized multidisciplinary group of international experts after systematic review of recent literature, discussions, and consensus reached at an expert conference held in June 2023. The guidelines provide summarized evidence and expert-based recommendations that aim to guide clinicians in the management of these rare and often complex diseases. These guidelines consist of two sections. This Part One covers topical and systemic therapies (including oral retinoids, biologics, Janus kinase Inhibitors (JAKI)), future therapeutic approaches, psychosocial management, telemedicine, communicating the diagnosis/genetic counseling, prenatal diagnosis and preimplantation genetic testing.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Proposal for a New Pathogenesis-guided Classification for Inherited Epidermal Differentiation Disorders.","authors":"Ángela Hernández-Martín, Amy S Paller, Eli Sprecher, Masashi Akiyama, Céline Granier Tournier, Mandy Aldwin-Easton, Christine Bodemer, Keith Choate, Judith Fischer, Antoni Gostynski, Alain Hovnanian, Akemi Ishida-Yamamoto, Edel A O'Toole, Matthias Schmuth, Janice Schwartz, Gianluca Tadini, Joyce Teng, Juliette Mazereeuw-Hautier","doi":"10.1093/bjd/ljaf065","DOIUrl":"https://doi.org/10.1093/bjd/ljaf065","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methotrexate and Cyclosporin Improve Skin Biomarkers in Paediatric Atopic Dermatitis: Results from the TREatment of Severe Atopic Eczema Trial.","authors":"Helen Alexander, Saerrah Murryam, Sanja Kezic, Ehsan Motazedi, David Prieto-Merino, Alan D Irvine, Carsten Flohr","doi":"10.1093/bjd/ljaf115","DOIUrl":"https://doi.org/10.1093/bjd/ljaf115","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The landscape of long non-coding RNA during cSCC progression.","authors":"Max Bone, Daniel Schreyer, Mairi Treanor-Taylor, Charlotte M Proby, Catherine A Harwood, Irene M Leigh, Peter Bailey, Gareth J Inman","doi":"10.1093/bjd/ljaf108","DOIUrl":"https://doi.org/10.1093/bjd/ljaf108","url":null,"abstract":"<p><strong>Background: </strong>Cutaneous squamous cell carcinoma (cSCC) is a common cancer with high morbidity and poor prognosis for metastatic disease. Disease may progress from pre-malignant Actinic Keratosis (AK) to invasive and metastatic cSCC but perhaps is best characterised as a disease continuum progressing from a differentiated to a progenitor like state. The critical molecular mediators of this process remain poorly defined. Long non-coding RNAs (lncRNAs), a relatively unexplored class of RNA molecules over 200 nucleotides long, are likely to have important functional roles in cSCC.</p><p><strong>Objectives: </strong>Here we wished to provide a comprehensive landscape of lncRNA expression during the cSCC continuum and identify potentially functional lncRNA drivers of disease progression.</p><p><strong>Methods: </strong>We interrogated bulk RNA sequencing data from 110 patient samples, encompassing normal sun-exposed skin (n=26), Actinic Keratosis (n=14), primary cSCC (n=66), and metastases (n=4)1 to identify changes in lncRNA expression during disease progression. We developed a bioinformatics pipeline to infer lncRNA function based on co-expression patterns and generated a lncRNA signature score which we validated in head and neck squamous cell carcinoma (HNSC), and pancreatic adenocarcinoma (PAAD). We performed bulk RNA sequencing on 15 patient-derived cell lines and integrated this data to identify tumour cell specific lncRNAs and validated our findings in multiple other cSCC gene expression cohorts. Using in-vitro knockdown approaches we investigated the functional role of LINC00941.</p><p><strong>Results: </strong>We characterised the landscape of lncRNAs during cSCC disease progression and revealed that lncRNA expression alone is sufficient to identify disease states and progression along the disease continuum. Correlation analysis revealed potentially functionally relevant lncRNAs and the processes that they may regulate. We developed a 267 lncRNA signature that correlates with a progenitor like state and predicts poor prognosis in HNSC and PAAD. Bulk RNA sequencing of patient derived cell lines (PDCLs) revealed tumour cell specific lncRNAs and knockdown of LINC00941 indicated that this is required for cell proliferation and colony formation in vitro.</p><p><strong>Conclusions: </strong>Our findings provide a comprehensive description of lncRNA transcriptomic changes in cSCC and demonstrate their functional relevance as both biomarkers and drivers of disease progression in this and potentially other cancers.</p>","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KLF4 variants in palmoplantar, non-syndromic and syndromic epidermal differentiation disorder phenotypes.","authors":"Robert W Gruber, Matthias Schmuth","doi":"10.1093/bjd/ljaf117","DOIUrl":"https://doi.org/10.1093/bjd/ljaf117","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal JAK-Inhibitor Usage Associated with Increased Risk of Aborted Pregnancy: A Systematic Review and Meta-Analysis.","authors":"Ajay S Dulai, Krisha Tripathy, Emi Murase, Anurag Tarmaster, Zill-E-Huma Khan, Mildred Min, Raja Sivamani, Jenny E Murase","doi":"10.1093/bjd/ljaf113","DOIUrl":"https://doi.org/10.1093/bjd/ljaf113","url":null,"abstract":"","PeriodicalId":9238,"journal":{"name":"British Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":11.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}