Causal association between polyunsaturated fatty acids and acne: a two-sample Mendelian randomization study.

IF 11 1区 医学 Q1 DERMATOLOGY
Bo Ri Kim, Gahyun Kim, Seon-Pil Jin, Chong Won Choi, Jinho Kim, Hyunsun Park
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引用次数: 0

Abstract

Background: Observational studies have demonstrated a close association between polyunsaturated fatty acids (PUFAs) and acne. However, the findings of clinical trials have been inconsistent, leaving the causal relationship between PUFAs and acne unclear.

Objectives: To investigate the causal association between genetically proxied PUFAs and acne risk.

Methods: Mendelian randomization (MR) was performed using single nucleotide polymorphisms associated with PUFAs as instrumental variables. The causal associations between PUFAs and acne were estimated among 115 006 UK Biobank participants and 363 927 participants of Finnish descent.

Results: Genetically predicted docosahexaenoic acid (DHA) levels [β = -0.303, 95% confidence interval (CI) -0.480 to -0.126; P = 7.74 × 10-4] and its percentage to total fatty acids (β = -0.402, 95% CI -0.651 to -0.258; P = 5.91 × 10-6) showed a significant causal association with a decreased risk of acne. Conversely, genetically predicted percentages of linoleic acid (LA) in total fatty acids (β = 0.768, 95% CI 0.411-0.126; P = 2.87 × 10-4) and omega-6 : omega-3 ratio (β = 0.373, 95% CI 0.142-0.604; P = 4.48 × 10-3) were robustly associated with an increased risk of acne. These effects were attenuated after excluding a genetic variant of rs174528 located upstream of FADS1, highlighting the biologic link between FADS1 and delta-5 desaturase activity. Multivariable MR analysis indicated that PUFAs were causally associated with acne, independent of body mass index.

Conclusions: Our study indicates that high DHA levels and their ratios to total fatty acids have causal protective effects against acne, while high LA levels and omega-6 : omega-3 ratio are associated with increased acne risk. This association was largely attributable to the influence of genetic variants related to FADS1.

多不饱和脂肪酸与痤疮之间的因果关系:一项双样本孟德尔随机研究。
背景:观察性研究已经证明了多不饱和脂肪酸(PUFAs)和痤疮之间的密切联系。然而,临床试验的结果并不一致,使得PUFAs和痤疮之间的因果关系尚不清楚。目的:探讨基因介导的PUFAs与痤疮风险之间的因果关系。方法:使用与PUFAs相关的单核苷酸多态性作为工具变量进行孟德尔随机化(MR)。在115,006名英国生物银行参与者和363,927名芬兰血统参与者中,估计了PUFAs和痤疮之间的因果关系。结果:基因预测二十二碳六烯酸(DHA)水平(Beta= -0.303;95% CI: -0.480 ~ -0.126;p = 7.74E-04)及其占总脂肪酸的百分比(β = -0.402;95% CI: -0.651 ~ -0.258;p = 5.91E-06)显示与痤疮风险降低有显著的因果关系。相反,亚油酸(LA)在总脂肪酸中的遗传预测百分比(β =0.768;95% ci: 0.411-0.126;p = 2.87E-04)和omega-6: omega-3 (Beta=0.373;95% ci: 0.142-0.604;p = 4.48E-03)与痤疮风险增加密切相关。在排除了位于脂肪酸去饱和酶1 (FADS1)上游的rs174528遗传变异后,这些影响减弱,突出了FADS1与δ -5去饱和酶活性之间的生物学联系。多变量磁共振分析表明,PUFAs与痤疮有因果关系,与体重指数无关。结论:我们的研究表明,高DHA水平及其与总脂肪酸的比例对痤疮有因果保护作用,而高LA水平和omega-6: omega-3比例与痤疮风险增加有关。这种关联很大程度上归因于与FADS1相关的遗传变异的影响。
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来源期刊
British Journal of Dermatology
British Journal of Dermatology 医学-皮肤病学
CiteScore
16.30
自引率
3.90%
发文量
1062
审稿时长
2-4 weeks
期刊介绍: The British Journal of Dermatology (BJD) is committed to publishing the highest quality dermatological research. Through its publications, the journal seeks to advance the understanding, management, and treatment of skin diseases, ultimately aiming to improve patient outcomes.
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