BMC Research Notes最新文献

{"title":"A pilot study on the relationship between thermal habits, chronic inflammation, and arterial stiffness in young adults.","authors":"Masayo Nagai, Akiko Tanaka","doi":"10.1186/s13104-025-07236-w","DOIUrl":"https://doi.org/10.1186/s13104-025-07236-w","url":null,"abstract":"<p><strong>Objective: </strong>Atherosclerotic cardiovascular disease (ASCVD) progresses silently, highlighting the importance of early prevention. This pilot study aimed to examine the relationship between thermal habits-specifically hot-tub bathing-and biomarkers of chronic inflammation, as well as arterial stiffness in young adults.</p><p><strong>Results: </strong>Twenty-five participants were included: 9 males (mean age: 21.78 ± 2.05 years) and 16 females (mean age: 21.0 ± 0.97 years). We assessed hot bathing habits and measured plasma interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP), heat shock protein 70 (HSP70), and brachial-ankle pulse wave velocity (baPWV). IL-6 levels were significantly lower among habitual hot-tub bathers (p = 0.04 overall; p = 0.018 in females). In females, hsCRP tended to be lower with immersion bathing (p = 0.08). No significant differences were observed in hsCRP, HSP70, or baPWV in the overall, male, or female groups. In females, IL-6 negatively correlated with ABI (ρ = -0.543, p = 0.03), and baPWV negatively correlated with bathing duration (ρ = -0.562, p = 0.045). These findings suggest that habitual hot-tub bathing, a culturally embedded and easily implemented habit in Japan, may serve as a lifestyle intervention to reduce inflammation and support ASCVD prevention in young adults.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"166"},"PeriodicalIF":1.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue-specific changes in expression of Vegfr2 in tumor and normal tissues of lymphoma-bearing BALB/c mice under chronic restraint stress.","authors":"Alonso A Orozco-Flores, Gloria Romero-Beltrán, Diana Caballero-Hernández, Deyanira Quistián-Martínez, Ricardo Gomez-Flores, Patricia Tamez-Guerra, Cristina Rodríguez-Padilla","doi":"10.1186/s13104-025-07219-x","DOIUrl":"https://doi.org/10.1186/s13104-025-07219-x","url":null,"abstract":"<p><strong>Objective: </strong>Alteration of the expression of vascular endothelial growth factor (VEGF) and its receptors, VEGFR-1 and VEGFR-2, leads to aberrant angiogenesis in cancer; this is exacerbated by chronic stress. Our main aim was to determine the effect of chronic restraint stress on the expression of Vegfr2, the gene encoding VEGFR-2, in tumor, fat, skeletal muscle and brain in a murine model of lymphoma.</p><p><strong>Results: </strong>We found that both chronic stress and tumor burden alter Vegfr2 expression. Under chronic stress, Vegfr2 is differentially expressed in inguinal adipose tissue, decreasing in tumor-free, and increasing in tumor-bearing animals. In skeletal muscle, brain, and tumor, Vegfr2 expression was upregulated by chronic stress. Adipose tissue, brain and skeletal muscle of tumor-bearing animals also showed changes in Vegfr2 expression during tumor progression. We also found that for skeletal muscle the combination of chronic stress and tumor burden enhances Vegfr2 expression (23-folds).</p><p><strong>Conclusion: </strong>Chronic stress and tumor burden influence Vegfr2 expression in normal and tumoral tissues and their co-occurrence enhances its effect on skeletal muscle.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"168"},"PeriodicalIF":1.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of immunomodulatory celecoxsib on the gene expression of inhibitory receptors in dendritic cells generated from monocyte cells.","authors":"Vida Hashemi, Behzad Baradaran, Bahar Naseri, Javad Masoumi, Elham Baghbani, Nazila Alizadeh, Reza Shiri Haris, Arezoo Hosseini","doi":"10.1186/s13104-025-07226-y","DOIUrl":"https://doi.org/10.1186/s13104-025-07226-y","url":null,"abstract":"<p><p>Autoimmune diseases are characterized by irregular immune responses that disrupt self-tolerance. This research explores the effects of the immunomodulatory drug celecoxib on the expression of immune checkpoint receptors in monocyte-derived dendritic cells (DCs). Key receptors, including CTLA-4, VISTA, BTLA, PDL-1, B7H7, and LAG3, play critical roles in initiating and regulating immune responses and maintaining self-tolerance. Previous studies have highlighted the significance of immune checkpoints in preventing autoimmune conditions, with animal research supporting their effectiveness in immunotherapy. Our findings demonstrate that the upregulation of immune checkpoint receptors can enhance the inhibitory functions of DCs, thereby promoting self-tolerance. As a result, tolerogenic DCs present a promising therapeutic avenue for treating autoimmune diseases. Although these results are promising, further trials are required to validate this approach before it can be applied clinically. This study underscores the potential of targeting immune checkpoint receptors as a therapeutic strategy for autoimmune disorders.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"164"},"PeriodicalIF":1.6,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of an online cardiotocography course tailored to LMIC settings: a feasibility study conducted in a tertiary care hospital in Sri Lanka.","authors":"M Rishard, I Weerasundara, R Fonseka, A de Abrew, M S D Wijesinghe, H Senanayake, M Lazzerini","doi":"10.1186/s13104-025-07239-7","DOIUrl":"https://doi.org/10.1186/s13104-025-07239-7","url":null,"abstract":"<p><strong>Objective: </strong>Effective cardiotocography (CTG) training is crucial for accurate interpretation and timely interventions in low-resource settings. This mixed-method study in Sri Lanka developed and assessed an online CTG course to address training gaps and improve neonatal outcomes. The study involved a clinical audit, course development, implementation, and evaluation via the Kirkpatrick model.</p><p><strong>Results: </strong>The audit revealed lapses in CTG documentation, interpretation, and interventions. The posttest scores improved by 40.6% (152.8%), but some participants did not complete the course because of a lack of motivation, time constraints, and inadequate facilities. Postimplementation audits revealed improvements in practices, although uterine contraction documentation and overall impression recording declined. The findings suggest the feasibility and effectiveness of online self-learning courses in improving CTG knowledge and practices in Sri Lanka. However, motivation, incentives, and reinforcement measures are needed for better outcomes.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"163"},"PeriodicalIF":1.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early dysphagia following anterior cervical discectomy and fusion: a centre experience.","authors":"Hani Aljohani, Abdulrahman H Alashkar, Mohamed Abdulazim, Yasser Alsequab, Eid Algaman, Almunthir Alyahya, Sultan Alhujilan, Faisal Ahmad Alaboodi","doi":"10.1186/s13104-025-07215-1","DOIUrl":"https://doi.org/10.1186/s13104-025-07215-1","url":null,"abstract":"<p><strong>Objective: </strong>Anterior cervical discectomy and fusion (ACDF) is a commonly performed surgical procedure in patients with cervical spine radiculopathy and/or myelopathy. It's considered safe, but one of its most common complications is postoperative dysphagia, which can negatively impact the patient's quality of life, and increase health costs. In this study, we discuss our experience with post-ACDF dysphagia (PAD) in terms of incidence, risk factors and approach to management.</p><p><strong>Results: </strong>In total, 196 eligible patients were included with a mean age of 50.38 years (SD = 11.18); 107 patients (54.6%) were males, and 89 (45.4%) were females. The incidence of PAD was 5.6% (11/196 patients). No significant association could be found between the development of PAD and the assessed patient-related factors (age, gender, body mass index, and comorbidities) nor surgical factors (number of operated levels, use of anterior plate, operative time).</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"162"},"PeriodicalIF":1.6,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of knowledge, attitudes, and practices of antibiotic resistance among university students in Saudi Arabia.","authors":"Rana K Albadrani, Aysha H Alyenbawi, Mody Albalawi, Amnah Obidan, Hayam A Alwabsi, Sahar Khateeb, Ahmed S Aly, Mervat S Mohamed","doi":"10.1186/s13104-025-07241-z","DOIUrl":"https://doi.org/10.1186/s13104-025-07241-z","url":null,"abstract":"<p><strong>Objective: </strong>Antibiotic resistance is a global health threat, driven by widespread misconceptions and the misuse of antibiotics. This study aims to assess the knowledge, attitudes, and practices of undergraduate students at the University of Tabuk, Saudi Arabia, regarding antibiotic use and resistance, identifying key misconceptions and behaviours contributing to antibiotic resistance.</p><p><strong>Results: </strong>The analysis revealed misconceptions about antibiotic use and resistance among 800 undergraduate students at the University of Tabuk. Approximately 46% of respondents incorrectly believed that antibiotics could treat viral infections, while 23% were uncertain about their effectiveness against bacterial infections. Although 56% acknowledged that antibiotics might lose effectiveness over time, 24% were unsure about the reason. Additionally, 53% mistakenly believed that viruses could develop antibiotic resistance. These findings highlight persistent gaps in understanding among students. Strengthening awareness through workshops and structured interventions could improve knowledge and promote responsible antibiotic use. Addressing these misconceptions is essential to reducing inappropriate antibiotic practices and mitigating the risks associated with antibiotic resistance.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"161"},"PeriodicalIF":1.6,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lesionia: a digital data management system to enhance collaborative management of epidemiological and clinical data of cutaneous leishmaniases patients.","authors":"Emna Harigua-Souiai, Youssef Ben Salem, Maaoui Hariga, Yusr Saadi, Hejer Souguir, Hamed Chouaieb, Olufemi Adedokun, Imen Mkada, Zeineb Moussa, Akila Fathallah-Mili, Meryem Lemrani, Nabil Haddad, Ayoade Oduola, Oussama Souiai, Insaf Bel Hadj Ali, Ikram Guizani","doi":"10.1186/s13104-025-07208-0","DOIUrl":"https://doi.org/10.1186/s13104-025-07208-0","url":null,"abstract":"<p><p>Digital Systems for Data Management (DSDM) have become a critical cornerstone in collaborative biomedical research and clinical trials involving multiple investigators, institutions, and populations. DSDM provide unique features that ensure that data meet the standards of FAIR (Findability, Accessibility, Interoperability and Reusability). We herein present Lesionia, a DSDM designed to support the PEER518 consortium that aimed at developing new cutaneous leishmaniases (CL) diagnostics using samples and data collected from patients suspected of having CL in countries in the MENA region and West Africa. The consortium involved nine institutions across five countries: Tunisia, Morocco, Lebanon, Mali, and the USA, and informally Scientists from Algeria and Nigeria. The guidelines on the data to be collected by the clinicians and biologists during the project were used for the development of a Questionnaire that served as a basis for the implementation of a dedicated web-based DSDM.Lesionia was developed and validated for the management and the analysis of clinical and epidemiological data in the diagnosis of CL. It consists of a relational database, a web-based user interface (WUI) and a tool for experimental data handling and analysis of clinical and epidemiological data of CL cases. The platform was deployed and validated during the PEER518 project using data collected across the involved teams. Lesionia is expandable to include further collaborators, partners, and projects. It is designed for data handling from the consented patient interview and sample collection to the samples' storage and investigation. The WUI permits data entry, fetching, visualization and analysis. Rigorous controls on data entry were implemented to reduce discrepancies. It also offers a set of analysis tools that range from descriptive statistics to variable correlation analysis. Lesionia is accessible in a secure manner to all users of the consortium through a web browser.Lesionia will be a valuable tool for collaborative and integrative management of clinical and epidemiological data. It is an open-source software that can broadly serve the scientific community interested in studying, controlling, reporting, and diagnosing CL and similar cutaneous diseases.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"160"},"PeriodicalIF":1.6,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The spiritual needs of surgical patients in Iranian hospital settings: a qualitative study.","authors":"Fahimeh Alsadat Hosseini, Marzieh Momennasab, Shahrzad Yektatalab, Armin Zareiyan","doi":"10.1186/s13104-025-07228-w","DOIUrl":"https://doi.org/10.1186/s13104-025-07228-w","url":null,"abstract":"<p><strong>Background and aim: </strong>Surgical patients seek spiritual support because they feel threatened by their physical integrity and sense of self. Delivering spiritual care to surgical patients requires recognizing their spiritual needs. These needs can take on various forms in different cultures and religions. Thus, the present study aimed to investigate the spiritual needs of surgical patients in Iranian hospital setting.</p><p><strong>Method: </strong>This qualitative content analysis study research was conducted on 16 surgical hospitalized patients in Shiraz, Iran. The data was collected through in-depth and semi-structured interviews. The qualitative content analysis method of Graneheim and Lundman was used for analyzing the data, and Guba and Lincoln criteria were used to ensure the trustworthiness of the research data.</p><p><strong>Results: </strong>The findings of this study were presented in the form of four key categories: \"Divine Resilience,\" which highlights the need for a divine relationship to achieve spiritual strength; \"Supportive Bonds in the Healing Process,\" emphasizing the importance of interpersonal connections and support networks; \"Peaceful Environment,\" reflecting the necessity of a tranquil and supportive setting; and \"Transcendence Beyond Difficulties,\" which underscores the patients' quest for meaning and purpose amidst their challenges.</p><p><strong>Conclusion: </strong>Surgical patients experience interconnected spiritual needs, including divine resilience, supportive interpersonal relationships, a peaceful environment, and transcendence beyond difficulties. Addressing these needs by healthcare authorities and policymakers is essential for providing holistic surgical care and enhancing patients' overall well-being.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"155"},"PeriodicalIF":1.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic resistance and virulence patterns of O25 and O16 serogroups in uropathogenic Escherichia coli.","authors":"Seyedamirmehdi Hejazi Dehaghani, Haider Qassim Raheem, Mohammad Latifpour, Mehrdad Hallaji","doi":"10.1186/s13104-025-07192-5","DOIUrl":"https://doi.org/10.1186/s13104-025-07192-5","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates antibiotic resistance patterns, virulence factors, and phylogenetic groups of O25 and O16 serogroups in uropathogenic Escherichia coli (UPEC) isolates from kidney transplant recipients (KTPs) and non-KTPs. The presence of serogroups O25 and O16, resistance genes (e.g., bla_CTX-M, bla_TEM), and virulence factors (e.g., fimH, PAI) were determined using PCR. Phylogenetic groups were identified via quadruplex PCR, and genetic diversity was assessed using ERIC-PCR.</p><p><strong>Results: </strong>A total of 111 E. coli isolates were examined in the present study. The O-serotyping results indicated that 18% and 3.6% of isolates were positive for O25 and O16 serogroup, respectively. In serogroup O25, the highest resistance rates were observed for nalidixic acid and cotrimoxazole, whereas in serogroup O16, the highest resistance rates were against cotrimoxazole and ampicillin-sulbactam. ESBL production was identified in 30% of O25 and 25% of O16 isolates. O25 isolates belonged to phylogenetic group B2, whereas O16 isolates were grouped in B1. ERIC-PCR revealed significant genetic diversity among isolates. The O25 serogroup is prevalent and closely associated with high antibiotic resistance and virulence, suggesting its critical role in UTI pathogenesis in transplant patients. These findings underscore the importance of monitoring resistance patterns and developing targeted therapeutic and preventive strategies for managing UPEC infections.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"157"},"PeriodicalIF":1.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot study on seasonal variability in microbial contamination in the developing tourist region of Mindo, Ecuador: a comparative analysis of the Saguambi, Mindo, and Canchupí Rivers.","authors":"Milena Naomi Martínez-Játiva, Pamela Borja-Serrano, Hugo Valdebenito, António Machado","doi":"10.1186/s13104-025-07205-3","DOIUrl":"https://doi.org/10.1186/s13104-025-07205-3","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the microbial load in the Saguambi, Mindo, and Canchupí Rivers in Mindo (Ecuador) by quantifying bacteriological indicators (Escherichia coli and total coliforms) and identifying pathogenic microorganisms (e.g., Giardia, Cryptosporidium spp., Helicobacter pylori, Mycobacterium tuberculosis, and Mycobacterium leprae) using molecular techniques. This assessment aims to establish the potential risk associated with the consumption and recreational use of these water sources.</p><p><strong>Results: </strong>A total of 36 surface water samples were analyzed in this study, with 12 samples collected per river (Saguambi, Mindo, and Canchupí). Sampling was conducted in duplicate at two collection points per river (before and after the community) across three seasons (dry, rainy, and transitional), resulting in 4 samples per river per season. All samples showed consistently high microbial levels exceeding international guidelines at most collection points across the three rivers. The Canchupí River exhibited the highest E. coli and total coliform counts during the dry season, with values of 1.50 × 10⁷ and 1.79 × 10⁷ CFU/100 mL, respectively. The Saguambi River showed the highest E. coli levels in the transitional season (9.42 × 10⁴ CFU/100 mL). The Mindo River peaked in E. coli (7.15 × 10⁵ CFU/100 mL) and total coliforms (5.85 × 10⁵ CFU/100 mL) after the community. Molecular analysis identified M. tuberculosis in all rivers year-round. M. leprae was found in the Saguambi and Mindo Rivers, and H. pylori was identified in both Mindo and Canchupí Rivers. Giardia and Cryptosporidium parasites' detection varied among rivers and seasons.</p>","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"156"},"PeriodicalIF":1.6,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}