BMC Research Notes最新文献_第9页

Economic burden of sarcopenia-related disability in the elderly population: a study in Iran. 老年人因肌肉疏松症而致残的经济负担：伊朗的一项研究。

IF 1.6

BMC Research Notes Pub Date : 2024-10-24 DOI: 10.1186/s13104-024-06975-6

Ali Darvishi, Adeleh Nikkhah, Gita Shafiee, Rajabali Daroudi, Ramin Heshmat

{"title":"Economic burden of sarcopenia-related disability in the elderly population: a study in Iran.","authors":"Ali Darvishi, Adeleh Nikkhah, Gita Shafiee, Rajabali Daroudi, Ramin Heshmat","doi":"10.1186/s13104-024-06975-6","DOIUrl":"10.1186/s13104-024-06975-6","url":null,"abstract":"Objective: Sarcopenia is linked to escalating health costs, heightened risk of physical disability, diminished quality of life and an increased demand for care services. This study aimed to assess the economic impact of sarcopenia-related disability in Iran. A prevalence-based economic burden study was conducted utilizing the Population Attributable Risk (PAR) method, based on 2022 price index. Prevalence data for sarcopenia, categorized by gender and disease severity, were extracted from recent comprehensive studies. The relative risk of sarcopenia disability was determined from the most robust available evidence. Subsequently, direct medical costs, direct non-medical costs, and indirect costs for each individual with sarcopenia were computed and adjusted to 2022 values to estimate disability costs.Results: Taking into account the prevalence of sarcopenia and the Iranian population across various age groups, 2,192,168 adults aged ≥ 60 years with sarcopenia in Iran were included. The total PAR of sarcopenia for men and women was estimated at 49% and 28%, respectively. The cumulative direct medical costs, direct non-medical costs, and indirect costs amounted to $215.1 million, $7.76 million, and $34.1 million, respectively. Additionally, the average total economic burden of sarcopenia-related disability in Iranian population aged ≥ 60 years was estimated at $257.1 million.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"17 1","pages":"319"},"PeriodicalIF":1.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lack of Candida africana in Ugandan pregnant women: results from a pilot study using MALDI-ToF. 乌干达孕妇体内缺乏非洲念珠菌：使用 MALDI-ToF 进行试点研究的结果。

IF 1.6

BMC Research Notes Pub Date : 2024-10-24 DOI: 10.1186/s13104-024-06973-8

Bwambale Jonani, Herman Roman Bwire, Charles Emmanuel Kasule, Gerald Mboowa

{"title":"Lack of Candida africana in Ugandan pregnant women: results from a pilot study using MALDI-ToF.","authors":"Bwambale Jonani, Herman Roman Bwire, Charles Emmanuel Kasule, Gerald Mboowa","doi":"10.1186/s13104-024-06973-8","DOIUrl":"https://doi.org/10.1186/s13104-024-06973-8","url":null,"abstract":"Background: Candida africana is an emergent variant that has been listed as a new species or variety within the Candida albicans complex since 2001. It has a worldwide intra-albicans complex pooled prevalence of 1.67% and varies between 0 and 8% depending on geographical region. We present the results of a pilot study on its prevalence in Uganda.Methodology: We conducted a cross-sectional study between March and June 2023. We recruited 4 pregnant women from Mulago Specialized Women and Neonatal Hospital, 102 from Kawempe National Referral Hospital, and 48 from Sebbi Hospital. Vaginal swabs were tested using microscopy, culture and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF).Results: The prevalence of C. africana was zero. Out of the 103 isolates, the majority (81.553%) were identified as Candida albicans, followed by Nakeseomyces glabrata (13.592%) and Pichia kudriavzevii (1.942%). Cyberlindnera jadinii, Candida tropicalis, and Candida parapsilosis each accounted for 0.971% of the isolates.Conclusion: The prevalence of C. africana in Uganda is zero. However, large-scale cross-sectional studies, including studies involving the collection of vaginal samples from both urban and rural settings in Uganda and the use of both MALDI-TOF- and PCR-based laboratory methods, are needed to fully describe the public health burden of C. africana infections.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"17 1","pages":"321"},"PeriodicalIF":1.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11506244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between dietary patterns and cardiovascular disease risk factors in Iranian adults: a cross-sectional study. 伊朗成年人饮食模式与心血管疾病风险因素之间的关系：一项横断面研究。

IF 1.6

BMC Research Notes Pub Date : 2024-10-24 DOI: 10.1186/s13104-024-06976-5

Mostafa Lotfi, Seyyed Mostafa Jalali, Kimia Leilami, Moein Askarpour, Zainab Shateri, Abbas Rezaianzadeh, Masoumeh Ghoddusi Johari, Mehran Nouri, Shiva Faghih

{"title":"The association between dietary patterns and cardiovascular disease risk factors in Iranian adults: a cross-sectional study.","authors":"Mostafa Lotfi, Seyyed Mostafa Jalali, Kimia Leilami, Moein Askarpour, Zainab Shateri, Abbas Rezaianzadeh, Masoumeh Ghoddusi Johari, Mehran Nouri, Shiva Faghih","doi":"10.1186/s13104-024-06976-5","DOIUrl":"10.1186/s13104-024-06976-5","url":null,"abstract":"Background: Dietary patterns are important factors associated with cardiovascular diseases (CVDs). We examined the association between dietary patterns derived from factor analysis and CVD risk factors.Methods: In the present cross-sectional study, a total of 3,687 adults (aged 40 to 70 years) with one or more types of CVDs were enrolled as participants. A validated semi-quantitative food-frequency questionnaire was utilized to assess food intakes, and then dietary patterns were extracted by factor analysis. Fasting blood sugar (FBS), lipid profile, anthropometric indices, and blood pressure (BP) were measured. Multivariable-adjusted logistic regression analysis was employed to ascertain the odds ratio (OR) of CVD risk factors associated with posteriori dietary patterns. In this study, healthy and unhealthy dietary patterns were identified.Results: Adherence to a healthy dietary pattern was associated with a decrease in systolic BP (SBP) (OR = 0.78; 95% confidence interval (CI): 0.62-0.99) and high-density lipoprotein cholesterol (HDL-C) levels (OR = 1.32; 95% CI: 1.06-1.64). Additionally, greater adherence to the unhealthy dietary pattern was positively associated with SBP (OR = 1.43; 95% CI: 1.13-1.80) and diastolic BP (DBP) (OR = 1.33; 95% CI: 1.01-1.76).Conclusions: We concluded that greater adherence to an unhealthy dietary pattern was associated with an increase in SBP and DBP. On the other hand, greater adherence to a healthy dietary pattern could be effective in reducing SBP. Further investigation is recommended to validate these findings.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"17 1","pages":"322"},"PeriodicalIF":1.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting symptomatic kidney stones using machine learning algorithms: insights from the Fasa adults cohort study (FACS). 利用机器学习算法预测无症状肾结石：法萨成人队列研究（FACS）的启示。

IF 1.6

BMC Research Notes Pub Date : 2024-10-24 DOI: 10.1186/s13104-024-06979-2

Fatemeh Mahmoodi, Aref Andishgar, Eisa Mahmoudi, Alireza Monsef, Sina Bazmi, Reza Tabrizi

{"title":"Predicting symptomatic kidney stones using machine learning algorithms: insights from the Fasa adults cohort study (FACS).","authors":"Fatemeh Mahmoodi, Aref Andishgar, Eisa Mahmoudi, Alireza Monsef, Sina Bazmi, Reza Tabrizi","doi":"10.1186/s13104-024-06979-2","DOIUrl":"10.1186/s13104-024-06979-2","url":null,"abstract":"Objectives: To enhance the identification of individuals at risk of developing clinically significant kidney stones.Methods: In this study, data from the Fasa Adults Cohort Study were analyzed to explore factors linked to symptomatic and clinically significant kidney stone disease. After cleaning, 10,128 participants with 103 variables were studied. One outcome variable (presence of symptomatic kidney stones) and 102 predictor variables from surveys and tests were assessed. Five Machine learning (ML) algorithms (SVM, RF, KNN, GBM, XGB) were applied to examine kidney stone factors, with performance comparisons made. Data balancing was done using SMOTE, and metrics like accuracy, precision, sensitivity, specificity, F1 score, and AUC were evaluated for each algorithm.Results: The XGB model outperformed others with AUC of 0.60, while RF, GBM, SVC, and KNN had AUC values of 0.58, 0.57, 0.54, and 0.52. RF, GBM, and XGB showed good accuracy at 0.81, 0.81, and 0.77. Top predictors for kidney stones were serum creatinine, salt intake, hospitalization history, sleep duration, and BUN levels.Conclusions: ML models show promise in evaluating an individual's risk of developing painful kidney stones and recommending early lifestyle changes to reduce this risk. Further research can enhance predictive accuracy and tailor interventions for better prevention/management.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"17 1","pages":"318"},"PeriodicalIF":1.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the correlation between body mass index and lung function test parameters: a cross-sectional analytical study. 探索体重指数与肺功能测试参数之间的相关性：一项横断面分析研究。

IF 1.6

BMC Research Notes Pub Date : 2024-10-24 DOI: 10.1186/s13104-024-06967-6

Waheed Hussein Elsaidy, Sultan Abdullah Alzahrani, Sami Mohammed Boodai

{"title":"Exploring the correlation between body mass index and lung function test parameters: a cross-sectional analytical study.","authors":"Waheed Hussein Elsaidy, Sultan Abdullah Alzahrani, Sami Mohammed Boodai","doi":"10.1186/s13104-024-06967-6","DOIUrl":"10.1186/s13104-024-06967-6","url":null,"abstract":"Purpose: The correlation between body weight and health is a significant public health concern. While the adverse effects of obesity on pulmonary function are well-known, the impact of being underweight remains debated due to limited research. This study aimed to investigate the correlation between Body Mass Index (BMI) categories and lung function parameters.Results: A study of 3077 participants found significant differences in gender, age, height, and weight across various Body Mass Index (BMI) categories. The study found non-significant variations in forced expiratory flow (FVC) across BMI categories, with underweight individuals showing lower FVC compared to normal and overweight individuals. BMI significantly impacted mean forced expiratory flow during the middle half of FVC. A significant negative correlation was observed between age and FVC, FEV1, FEV1/FVC ratio, and FEF25-75. A significant positive correlation was observed between weight, height, and lung function parameters. Multiple regression analysis revealed a decrease in lung function with advancing age, while height showed significant positive associations. The study concluded that age, sex, smoking, height, and weight collectively explained 41.0% of the variance in FVC, FEV, and FEF25-75.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"17 1","pages":"320"},"PeriodicalIF":1.6,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early adoption of triamcinolone acetonide suprachoroidal injection for uveitic macular edema: a physician survey. 医生调查：早期采用曲安奈德类药物脉络膜上注射治疗葡萄膜炎性黄斑水肿。

IF 1.6

BMC Research Notes Pub Date : 2024-10-23 DOI: 10.1186/s13104-024-06969-4

Christopher R Henry, Scott D Walter, Peter Y Chang, David J Warrow, Parisa Emami Naeini, Kevin J Blinder, Teresa Brevetti, Mohamed Yassine, Mark S Dacey, David S Chu, Veena R Raiji, Lana M Rifkin, Milan Shah, Michael A Singer

{"title":"Early adoption of triamcinolone acetonide suprachoroidal injection for uveitic macular edema: a physician survey.","authors":"Christopher R Henry, Scott D Walter, Peter Y Chang, David J Warrow, Parisa Emami Naeini, Kevin J Blinder, Teresa Brevetti, Mohamed Yassine, Mark S Dacey, David S Chu, Veena R Raiji, Lana M Rifkin, Milan Shah, Michael A Singer","doi":"10.1186/s13104-024-06969-4","DOIUrl":"10.1186/s13104-024-06969-4","url":null,"abstract":"Objective: To obtain physicians' \"real-world\" perspectives on early experiences with triamcinolone acetonide suprachoroidal injection (SCS-TA) for treatment of patients with uveitic macular edema (UME).Results: Twelve retina/uveitis specialists in the United States were surveyed about SCS-TA injection procedure and patient outcomes. Survey participants administered ≥ 291 SCS-TA injections to 243 patients with UME with various disease characteristics (etiologies, chronicity, and anatomical subtypes). Commonly reported reasons for SCS-TA adoption included potential for lowering the risk of steroid-associated intraocular pressure elevations versus intravitreal injections or implants (100%), potential for longer duration of action versus intravitreal steroid injections or implants (92%), and desire to use a new delivery modality (83%). Nearly all participants (92%) found injection procedure relatively easy post-training, with most (75%) procedurally comfortable after completing 2-5 injections. 58% of participants indicated that their patients gained 2-3 lines of vision by first follow-up visit, and 92% reported having patients who experienced 100-150 μm or greater reduction in central subfield thickness. Overall, 92% of participants were satisfied with SCS-TA treatment outcomes. Findings from this survey of early adopters of SCS-TA indicate that the suprachoroidal injection technique was easy to learn and resulted in favorable patient outcomes consistent with clinical trial data.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"17 1","pages":"317"},"PeriodicalIF":1.6,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV and hepatitis C Virus in internally displaced people with and without injection drug use experience in the region of Shida Kartli, Georgia. 格鲁吉亚 Shida Kartli 地区有注射吸毒经历和无注射吸毒经历的境内流离失所者中的艾滋病毒和丙型肝炎病毒。

IF 1.6

BMC Research Notes Pub Date : 2024-10-20 DOI: 10.1186/s13104-024-06891-9

Adrian Trovato, Maka Gogia, Ana Aslanikashvili, Tamuna Kasrashvili, Ganna Kovalenko, Anna Yakovleva, Britt Skaathun, Tetyana I Vasylyeva

{"title":"HIV and hepatitis C Virus in internally displaced people with and without injection drug use experience in the region of Shida Kartli, Georgia.","authors":"Adrian Trovato, Maka Gogia, Ana Aslanikashvili, Tamuna Kasrashvili, Ganna Kovalenko, Anna Yakovleva, Britt Skaathun, Tetyana I Vasylyeva","doi":"10.1186/s13104-024-06891-9","DOIUrl":"10.1186/s13104-024-06891-9","url":null,"abstract":"Objective: Internally displaced persons (IDPs) can have limited access to HIV and hepatitis C Virus (HCV) treatment and prevention. IDPs comprise > 7% of Georgian population but prevalence and levels of HIV and HCV knowledge in this population remain unknown. We tested 100 IDPs in Georgia for HIV and HCV, many of whom had drug injecting experience, and interviewed them about their migration experience, sexual and drug injecting practices, and HIV/HCV transmission knowledge.Results: The average age of participants was 37.5 years (range 18-63); 31% were women. Almost half (N = 48) of participants reported ever injecting drugs; 17% of those (N = 8) started injecting drugs within the last year. Anti-HCV and HIV prevalence was 11% and 0%, respectively. Fewer people without drug use experience compared to people who inject drugs correctly answered all questions on the HIV knowledge test (13% vs. 35%, p = 0.015) or knew where to get tested for HIV (67% vs 98%, p < 0.001). There was no difference in HCV knowledge between the two groups. HIV and HCV prevalence remains low among Georgian IDPs, but levels of HIV knowledge were much lower than levels of HCV knowledge.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"17 1","pages":"315"},"PeriodicalIF":1.6,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of prebiotic supplementation on serum levels of tryptophan and kynurenine in obese women with major depressive disorder: a double-blinded placebo-controlled randomized clinical trial. 补充益生元对患有重度抑郁症的肥胖女性血清中色氨酸和犬尿氨酸水平的影响：一项双盲安慰剂对照随机临床试验。

IF 1.6

BMC Research Notes Pub Date : 2024-10-20 DOI: 10.1186/s13104-024-06963-w

Fatemeh Khademi, Helda Tutunchi, Elnaz Vaghef-Mehrabani, Mehrangiz Ebrahimi-Mameghani

{"title":"The effect of prebiotic supplementation on serum levels of tryptophan and kynurenine in obese women with major depressive disorder: a double-blinded placebo-controlled randomized clinical trial.","authors":"Fatemeh Khademi, Helda Tutunchi, Elnaz Vaghef-Mehrabani, Mehrangiz Ebrahimi-Mameghani","doi":"10.1186/s13104-024-06963-w","DOIUrl":"10.1186/s13104-024-06963-w","url":null,"abstract":"Objective: The objective of the present study was to examine the effect of calorie restricted diet (CRD) plus inulin supplementation on serum levels of tryptophan (Trp), kynurenine (Kyn) and Trp/Kyn ratio in obese women with major depressive disorder (MDD).Results: In this double-blind placebo-controlled randomized clinical trial, 51 obese women (BMI = 30-40 kg/m2) with mild MDD were assessed for depression level using Hamilton depression rating scale (HDRS). The patients were randomly allocated into either \"Prebiotic group\" (received 10 g/day inulin) or \"Placebo group\" (received 10 g/day maltodextrin). All participants also received individualized CRD. Fasting serum levels of Trp, Kyn, and Trp/Kyn ratio were assessed at baseline and after 8 weeks. Results showed slightly greater increases in serum levels of Trp and Trp/Kyn ratio as well as reductions in serum level of Kyn and HDRS score in prebiotic group than placebo group. However, between group differences in these parameters as well as HDRS score were not statistically significant after adjusting for baseline variables at the end of the trial. Results indicates that CRD accompanied by inulin supplementation (10 g/day) did not influence serum levels of Trp, Kyn and Trp/Kyn ratio as well as HDRS score after 8 weeks.Trial registration: The trial was registered in the Iranian registry of clinical trials at 2018-08-02 ( https://www.irct.ir/ ; registration number: IRCT20100209003320N15).","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"17 1","pages":"316"},"PeriodicalIF":1.6,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recruitment of pregnant and breastfeeding women in pharmacokinetic studies: strategies, opportunities, barriers, and recommendations. 在药代动力学研究中招募孕妇和哺乳期妇女：策略、机会、障碍和建议。

IF 1.6

BMC Research Notes Pub Date : 2024-10-17 DOI: 10.1186/s13104-024-06946-x

Ritah Nakijoba, Aida N Kawuma, Simon Peter Asiimwe, Christine Turyahabwe, Jovia Christine Tabwenda, Jacqueline Kyeyune, Johnson Magoola, Francis Williams Ojara, Catriona Waitt

{"title":"Recruitment of pregnant and breastfeeding women in pharmacokinetic studies: strategies, opportunities, barriers, and recommendations.","authors":"Ritah Nakijoba, Aida N Kawuma, Simon Peter Asiimwe, Christine Turyahabwe, Jovia Christine Tabwenda, Jacqueline Kyeyune, Johnson Magoola, Francis Williams Ojara, Catriona Waitt","doi":"10.1186/s13104-024-06946-x","DOIUrl":"https://doi.org/10.1186/s13104-024-06946-x","url":null,"abstract":"Pregnant and breastfeeding women are often under-represented in clinical research, including pharmacokinetic studies, due to ethical and logistical challenges. This paper examines strategies to improve the recruitment and retention of this demographic in pharmacokinetic research, drawing on experiences from five studies conducted at the Infectious Diseases Institute, Makerere University, Uganda. Key strategies implemented include Community Advisory Board meetings, the involvement of Peer Mothers as Co-Investigators, established recruitment sites, the use of safety protocols, and the utilization of diverse communication platforms, including social media and stakeholder meetings. Despite these efforts, substantial barriers, such as scheduling conflicts and frequent staff turnover at recruitment sites, continue to threaten progress. The paper recommends flexible scheduling, strengthening public engagement, and transparent demonstration of adherence to ethical principles; justice, non-maleficence, respect, and beneficence to ensure the safety and inclusivity of pregnant and breastfeeding women. The inclusion of this population in pharmacokinetic studies is essential for providing evidence-based care that meets their unique health needs.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"17 1","pages":"312"},"PeriodicalIF":1.6,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11488264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment outcome of post-streptococcal acute glomerulonephritis and its associated factors among children less than 15 years at the referral hospital of East Amhara, Ethiopia. 埃塞俄比亚东阿姆哈拉转诊医院 15 岁以下儿童链球菌感染后急性肾小球肾炎的治疗结果及其相关因素。

IF 1.6

BMC Research Notes Pub Date : 2024-10-17 DOI: 10.1186/s13104-024-06971-w

Leweyehu Alemaw Mengstie, Taye Tesfa, Samrawit Addisu, Sisay Shewasinad

引用次数: 0