Biomedical research and clinical practice最新文献_第2页

Characteristics and determinants of breastfeeding in mothers of infants who come to healthy child control 接受健康儿童控制的婴儿母亲母乳喂养的特点和决定因素

Biomedical research and clinical practice Pub Date : 2020-01-01 DOI: 10.15761/brcp.1000201

Javier E Castañeda-Juárez, I. Rodríguez-Balderrama, M. O-Cavazos, Dariela Errisuris-Olvera, Carolina Aispuro-Barrantes, P. L. Zamora-Martinez, Ana P Asbun-Morales

{"title":"Characteristics and determinants of breastfeeding in mothers of infants who come to healthy child control","authors":"Javier E Castañeda-Juárez, I. Rodríguez-Balderrama, M. O-Cavazos, Dariela Errisuris-Olvera, Carolina Aispuro-Barrantes, P. L. Zamora-Martinez, Ana P Asbun-Morales","doi":"10.15761/brcp.1000201","DOIUrl":"https://doi.org/10.15761/brcp.1000201","url":null,"abstract":"Introduction: The current recommendation of the World Health Organization is that babies be fed exclusively with breast milk from the first hour of birth until 6 months of age, when the complementary feeding to breastfeeding begins until approximately 24 months old Children who are not breastfed have six times the risk of dying from infectious diseases during the first two months of life. Materials and methods: Observational, cross-sectional, descriptive and analytical study. Women over 18 years old were biological mothers of children 1 to 24 months of age who attended the control consultation of the healthy child, and the mothers were grouped according to the child’s age group: under 1 month, 1 to 6 months, 7 to 12 months and >12 months. Results: Two hundred mothers were included in total, 50 for each age group of the child, 54.4% between 18 and 25 years. The children were born at term, 52.5% were women. The prevalence of women feeding with breast milk was 94.5%, and the overall prevalence of exclusive breastfeeding was 45.5%. The main reasons associated with the abandonment of exclusive breastfeeding were feelings of lack of satiety of the child (30.3%), poor milk production (23.9%) and occupation or work (14.7%). Conclusion: The knowledge of breastfeeding plays an important role in the population of women in our hospital and it is possible that the quality of the information provided plays a role in the decisions that women would make about feeding their children. *Correspondence to: Javier Eduardo Castañeda-Juárez, Pediatrics Department, University Hospital “Dr. José Eleuterio González”, Universidad Autonoma de Nuevo Leon (U.A.N.L.), Monterrey, Nuevo Leon, Mexico, Tel: (+52) 8116543224; E-mail: rmoralav91@alumnes.ub.edu","PeriodicalId":92336,"journal":{"name":"Biomedical research and clinical practice","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67431669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angiosarcoma of the breast and familial aggregation of cancer: Case series of 12 patients and literature review 乳腺血管肉瘤与家族聚集性肿瘤:12例病例及文献复习

Biomedical research and clinical practice Pub Date : 2020-01-01 DOI: 10.15761/BRCP.1000215

Vanesa Rodríguez-Fernández, L. Cameselle-Cortizo, Alba García-Mallo, J. Valdés-Pons, A. Novo-Domínguez, J. Cameselle-Teijeiro, F. Schmitt

引用次数: 0

Association of 25 (OH) vitamin D levels with carotid intima media thickness in elderly north Indians 25 (OH)维生素D水平与老年北印度人颈动脉内膜中层厚度的关系

Biomedical research and clinical practice Pub Date : 2020-01-01 DOI: 10.15761/brcp.1000200

Shikha Sharma, P. Dabla, Amit Gupta

{"title":"Association of 25 (OH) vitamin D levels with carotid intima media thickness in elderly north Indians","authors":"Shikha Sharma, P. Dabla, Amit Gupta","doi":"10.15761/brcp.1000200","DOIUrl":"https://doi.org/10.15761/brcp.1000200","url":null,"abstract":"Background: Atherosclerosis is a major factor for cerebrovascular disease development and involves complex interplay between different cell types of the immune system with cells of the vessel wall. It can be measured by assessing the carotid intima media thickness (CIMT). A number of studies have shown variable results on the relationship between 25 (OH) D deficiency and subclinical atherosclerosis. The objectives of the present study were therefore to investigate the relationship between CIMT and Vitamin D status in the North Indian population ≥ 60 years. Methods: Patients aged ≥ 60 years who visited hospital for health check-up were enrolled and analyzed in present study. Results: 61.2 % of the subjects under study were Vitamin D deficient with mean Vitamin D level of 25.1 ± 15.6 ng/mL. The average C-IMT was 0.81 ± 0.27 mm. A significant inverse relationship was found between 25(OH) D concentration and CIMT with p = 0.003. Conclusion: Our data shows an inverse association of 25 (OH) Vitamin D concentration with CIMT in elderly subjects ≥ 60 years. These findings suggest a potential role Vitamin D deficiency in the development of subclinical atherosclerosis.","PeriodicalId":92336,"journal":{"name":"Biomedical research and clinical practice","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67431137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The hormones involved and the prevention of fecal and urinary urge incontinence 所涉及的激素和预防大便和尿失禁

Biomedical research and clinical practice Pub Date : 2020-01-01 DOI: 10.15761/BRCP.1000211

W. G. Roper

引用次数: 0

Gestational musculoskeletal disorders and corelated discomforts 妊娠期肌肉骨骼疾病及相关不适

Biomedical research and clinical practice Pub Date : 2020-01-01 DOI: 10.15761/brcp.1000198

Sabrina Santos Firmino, Cássio Marcelo Cortez Fagá, Vanessa Penha Basqueroto, A. Benitez, J. Ferreira, Jessica Fernanda Barros Romano, Catarina Villares Stoppe, Gabriel Poi Junqueira de Oliveira, J. Gomes, K. Bresciani

{"title":"Gestational musculoskeletal disorders and corelated discomforts","authors":"Sabrina Santos Firmino, Cássio Marcelo Cortez Fagá, Vanessa Penha Basqueroto, A. Benitez, J. Ferreira, Jessica Fernanda Barros Romano, Catarina Villares Stoppe, Gabriel Poi Junqueira de Oliveira, J. Gomes, K. Bresciani","doi":"10.15761/brcp.1000198","DOIUrl":"https://doi.org/10.15761/brcp.1000198","url":null,"abstract":"The morphological and physiological transformations that occur during pregnancy involve hemodynamic, hormonal and biomechanical adaptations that can generate musculoskeletal disorders and reflect in various physical discomforts. Thus, in this research, the objective was to verify the main musculoskeletal alterations associated with the discomforts of pregnancy through a systematic review of the literature. The study was conducted from November of 2018 to February of 2019, by the PICO strategy, with indexes “Physiotherapy” OR “Posture” AND “Discomfort” AND “Biomechanics” OR “Pregnancy” in PubMed, Scielo and Lilacs databases. After exclusion and inclusion criteria, 25/87 localized articles were selected for data extraction. The hemodynamic, hormonal and biomechanical changes of the pregnant woman reflect in the presence of oedema, increased body weight, ligament laxity and postural changes such as head and shoulder anteriority, hyperlordosis, pelvic anteversion, knee hyperextension, base enlargement, difficulty in the gait that lead to the appearance of musculoskeletal disorders, such as neck pain, thoracic duct syndrome, lower back pain, sacroiliac pain, plantar pressure and also the compromise of postural balance. The study of these disorders provides an indication of persistent pain symptoms during pregnancy and postpartum and knowledge of these changes helps to explain why they occur and the reason for the persistence of this sometimes even limiting pain in the pregnant woman. *Correspondence to: Aline do Nascimento Benitez, School of Medical Sciences and Institute of Computing, University of Campinas, Campinas, São Paulo, Brazil, Tel: + +55 (18) 981993849; E-mail: benitez.alinenascimento@gmail.com","PeriodicalId":92336,"journal":{"name":"Biomedical research and clinical practice","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67431240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, synthesis, and in vitro evaluation of novel dipeptidyl peptidase IV inhibitors 新型二肽基肽酶IV抑制剂的设计、合成和体外评价

Biomedical research and clinical practice Pub Date : 2020-01-01 DOI: 10.15761/BRCP.1000212

A. Mehanna, M. Kelada

{"title":"Design, synthesis, and in vitro evaluation of novel dipeptidyl peptidase IV inhibitors","authors":"A. Mehanna, M. Kelada","doi":"10.15761/BRCP.1000212","DOIUrl":"https://doi.org/10.15761/BRCP.1000212","url":null,"abstract":"The current research describes the design, synthesis, and in vitro evaluate as DPPIV inhibitors for four new compounds. The design of the new compounds aimed to study the effect of replacing the 2-benzyl-piperazine ring system of a reported potent DPP IV inhibitor, IC 50 of 19 nM, with piperidine and pyrrolidine heterocyclic ring systems. The newly synthesized compounds, along with the lead compound, were studied for docking affinities and mode of interactions with the DPP active site using molecular modelling approach in an attempt to correlate between the binding parameters and the observed in vitro inhibitory activities. Compound (1), a 4-benzylpiperidine derivative, possessed a ΔG value of -8.9 Kcal/mol, and an IC 50 of 1.6 ± 0.04 µM. Compound (2), a 2-benzylpyrrolidine derivative, showed a ΔG value of -9.0 Kcal/mol, and an IC 50 of 0.3 ± 0.03 µM. Compound (3), a phenethyl-piperazine derivative, exhibited a ΔG value of -8.9 Kcal/mol, and an IC 50 of 1.2 ± 0.04 µM. Compound (4), a 4-amino-1-benzylpiperidine derivative, showed a ΔG value of -8.9 Kcal/mol, and an IC 50 of 4 ± 0.08 µM. The study revealed that compound (2), with reduced ring size into pyrrolidine in place of the lead compound piperazine ring, while retaining the benzyl substitution at the 2-position, resulted in the most active inhibitor among the four newly designed compounds; however, with less inhibitory activity in comparison to the reported 2-benzyl-piperazine","PeriodicalId":92336,"journal":{"name":"Biomedical research and clinical practice","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67431509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased risk of anxiety and depression associated with chronic pain and fibromyalgia in Pakistani population 巴基斯坦人群慢性疼痛和纤维肌痛相关的焦虑和抑郁风险增加

Biomedical research and clinical practice Pub Date : 2019-01-01 DOI: 10.15761/brcp.1000178

J. Muhammad, M. Ishaq

{"title":"Increased risk of anxiety and depression associated with chronic pain and fibromyalgia in Pakistani population","authors":"J. Muhammad, M. Ishaq","doi":"10.15761/brcp.1000178","DOIUrl":"https://doi.org/10.15761/brcp.1000178","url":null,"abstract":"Objective: Fibromyalgia (FM) is reported to be strongly linked with anxiety and depression and is accompanied with the chronic antidepressant treatment. The aim of our study was to assess the frequency of fibromyalgia in patients presenting with chronic pain. Also, we assessed the prevalence of anxiety and depression in patients suffering from chronic pain compared to fibromyalgia. Material and methods: A cross-sectional survey was conducted on 502 patients who presented at the rheumatology outpatient clinic of a tertiary-care hospital. Diagnosis of FM was based upon the defined criteria of American College of Rheumatology. Demographic data was collected using a pre-designed questionnaire. Whereas anxiety and depression were assessed using a preformed and previously validated Hospital-based Anxiety and Depression Scale (HADS). Results: Results showed that a higher level of perceived pain (both chronic widespread pain or fibromyalgia pain) was significantly associated with a higher incidence of anxiety and depression in such patients. Furthermore, patients suffering from both chronic pain and high levels of anxiety and depression were at a higher increased risk of developing FM syndrome. Conclusion: It was concluded that anxiety and depressive symptoms are significantly associated with increased pain perception, therefore anxiety and depression should be diagnosed and properly treated in order to improve FM symptoms for better quality of life.","PeriodicalId":92336,"journal":{"name":"Biomedical research and clinical practice","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67430668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Towards artificial cells for biomedical applications 迈向生物医学用途的人造细胞

Biomedical research and clinical practice Pub Date : 2019-01-01 DOI: 10.15761/brcp.1000189

Maria Wiesauer, G. Knör

{"title":"Towards artificial cells for biomedical applications","authors":"Maria Wiesauer, G. Knör","doi":"10.15761/brcp.1000189","DOIUrl":"https://doi.org/10.15761/brcp.1000189","url":null,"abstract":"A novel toolbox for future applications in precision nanomedicine and synthetic biology is the development of artificial cell organelles and the creation of cell-like structures operating similar to biological systems with a minimalistic set of building blocks. To achieve this ambitious goal, two major design strategies are followed in the field of synthetic biology. The top-down approach tries to generate a radically trimmed but still intact artificial cell by eliminating all non-essential components from the much more complex native systems. In contrast, bottom-up synthetic biology aims at constructing a functioning minimal cell by combining all essential building blocks step-by-step starting from scratch. In the present contribution, the author ́s ongoing activities to develop artificial reaction centres for novel types of photoautotrophic processes and to provide fully biocompatible synthetic enzyme counterparts and artificial organelles as abiotic building blocks for bottom-up synthetic biology are summarized. This unique approach has the potential to create unprecedented minimal artificial cell-like systems that can be powered and readily controlled by light as an external stimulus, which will provide new perspectives for molecular photomedicine and photopharmacology. *Correspondence to: Günther Knör, Johannes Kepler University Linz, Institute of Inorganic Chemistry, Center for Nanobionics and Photochemical Sciences (CNPS), Altenberger Strasse 69, 4040 Linz, Austria, Tel: +43(0)732-2468-5100; E-mail: guenther.knoer@jku.at","PeriodicalId":92336,"journal":{"name":"Biomedical research and clinical practice","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67430851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short stature in severe paediatric heart failure: The deleterious role of growth hormone replacement 严重小儿心力衰竭中身材矮小:生长激素替代的有害作用

Biomedical research and clinical practice Pub Date : 2019-01-01 DOI: 10.15761/brcp.1000195

R. Buchhorn

引用次数: 0

Oral administration of fructose improves jejunal villous morphology and nutrient digestion and absorption capabilities in a rat model of total parenteral nutrition 在全肠外营养大鼠模型中，口服果糖可改善空肠绒毛形态和营养物质消化吸收能力

Biomedical research and clinical practice Pub Date : 2019-01-01 DOI: 10.15761/brcp.1000179

Takuji Suzuki, Yuki Mayanagi, A. Keta, A. Kasahara, Ayaka Sato, Takumi Takahashi

{"title":"Oral administration of fructose improves jejunal villous morphology and nutrient digestion and absorption capabilities in a rat model of total parenteral nutrition","authors":"Takuji Suzuki, Yuki Mayanagi, A. Keta, A. Kasahara, Ayaka Sato, Takumi Takahashi","doi":"10.15761/brcp.1000179","DOIUrl":"https://doi.org/10.15761/brcp.1000179","url":null,"abstract":"Digestive tract functions decline depending on the period of parenteral nutrition treatment, and a gradual transition to enteral nutrition as soon as possible is being encouraged. Rapid treatment via enteral nutrition is important to prevent the decline of intestinal capabilities following a parenteral nutrition state. However, the ideal nutrients leading to the recovery of intestinal functions remain unknown. We investigated what nutrient types more efficiently recover small intestinal capabilities using a rat model of total parenteral nutrition (TPN). We administered TPN conditions for 7 days with Wistar rats (male, 10 weeks old, each experiment n = 5). Selected nutrients [i.e. long-chain triglycerides, medium-chain triglycerides (MCTs), glucose or fructose] were administered orally for 3 days starting from day 8 of TPN. Morphology of the jejunal villus, mRNA expression levels for the digestion/absorption of nutrient-related genes and disaccharidases activity were markedly recovered following oral administration of all nutrients tested in this study. In particular, MCTs comprehensively and fructose specifically for mRNA expression more efficiently recovered small intestinal capabilities. Our results suggest that the difference in the chemical structure even the same kind of nutrient have an impact on the morphology and functions of the small intestine. Especially, fructose intake after TPN may be useful for the recovery of gastrointestinal functions during the transition phase to normal diet.","PeriodicalId":92336,"journal":{"name":"Biomedical research and clinical practice","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67430673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5