{"title":"严重小儿心力衰竭中身材矮小:生长激素替代的有害作用","authors":"R. Buchhorn","doi":"10.15761/brcp.1000195","DOIUrl":null,"url":null,"abstract":"Growth failure secondary to heart failure in childhood is well documented, but not well understood. A current analysis of 640 children from Chile who require cardiac surgery for congenital heart defects showed short stature in 24.1% [1]. The highest percentage of short stature are related to heart failure of cause complete atrioventricular canal (66.7%), ventricular septal defect (33%) and after Norwood 1 repair of the hyperplastic left heart syndrome (33.3%). Low serum insulin-like growth factor -1 level (IGF-1) indicates heart failure in children with left to right shunt due to congenital heart defects [1] that increase after corrective surgery [3,4]. Impaired linear growth in infants with single ventricle physiology seems to be an indicator of worse neurodevelopmental outcome [5].","PeriodicalId":92336,"journal":{"name":"Biomedical research and clinical practice","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Short stature in severe paediatric heart failure: The deleterious role of growth hormone replacement\",\"authors\":\"R. Buchhorn\",\"doi\":\"10.15761/brcp.1000195\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Growth failure secondary to heart failure in childhood is well documented, but not well understood. A current analysis of 640 children from Chile who require cardiac surgery for congenital heart defects showed short stature in 24.1% [1]. The highest percentage of short stature are related to heart failure of cause complete atrioventricular canal (66.7%), ventricular septal defect (33%) and after Norwood 1 repair of the hyperplastic left heart syndrome (33.3%). Low serum insulin-like growth factor -1 level (IGF-1) indicates heart failure in children with left to right shunt due to congenital heart defects [1] that increase after corrective surgery [3,4]. Impaired linear growth in infants with single ventricle physiology seems to be an indicator of worse neurodevelopmental outcome [5].\",\"PeriodicalId\":92336,\"journal\":{\"name\":\"Biomedical research and clinical practice\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical research and clinical practice\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15761/brcp.1000195\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical research and clinical practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15761/brcp.1000195","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Short stature in severe paediatric heart failure: The deleterious role of growth hormone replacement
Growth failure secondary to heart failure in childhood is well documented, but not well understood. A current analysis of 640 children from Chile who require cardiac surgery for congenital heart defects showed short stature in 24.1% [1]. The highest percentage of short stature are related to heart failure of cause complete atrioventricular canal (66.7%), ventricular septal defect (33%) and after Norwood 1 repair of the hyperplastic left heart syndrome (33.3%). Low serum insulin-like growth factor -1 level (IGF-1) indicates heart failure in children with left to right shunt due to congenital heart defects [1] that increase after corrective surgery [3,4]. Impaired linear growth in infants with single ventricle physiology seems to be an indicator of worse neurodevelopmental outcome [5].
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