BMC Cardiovascular Disorders最新文献

{"title":"Association between hemoglobin glycation index and myocardial infarction in critically ill patients with diabetes mellitus: a retrospective study based on MIMIC-IV.","authors":"Dongmei Gao, Aiping Wang","doi":"10.1186/s12872-025-04742-4","DOIUrl":"10.1186/s12872-025-04742-4","url":null,"abstract":"<p><strong>Background: </strong>The hemoglobin glycation index (HGI), which quantifies the difference between observed and predicted hemoglobin A1c (HbA1c) levels, has been linked to adverse outcomes. However, its relationship with myocardial infarction (MI) in patients with diabetes mellitus (DM) remains unexplored. This study aimed to investigate the association between HGI and MI incidence in critically ill patients with diabetes mellitus (DM) using data from the MIMIC-IV database.</p><p><strong>Methods: </strong>Linear regression analysis of HbA1c and fasting blood glucose levels was conducted to calculate HGI. Subsequently, differences in MI incidence across HGI quartiles were assessed using the Kaplan-Meier survival analysis, with the log-rank test applied. Cox proportional hazards models and restricted cubic spline (RCS) analyses were conducted to estimate hazard ratios (HRs) for MI risk across HGI quartiles, with Q1 as the reference.</p><p><strong>Results: </strong>A total of 8,055 DM patients with an initial ICU admission exceeding 24 h were included, with 21.5% of them presenting MI. Compared to HGI Q1 (-3.81, -1.236), the risk of MI increased by 1.26 times in Q2 (HR: 1.26, 95% confidence interval [CI]: 1.10-1.45), 1.48 times in Q3 (HR: 1.48, 95% CI: 1.29-1.69), and 1.39 times in Q4 (HR: 1.39, 95% CI: 1.21-1.60). RCS analysis showed a nonlinear positive association between HGI and outcome events that remained consistent across different subgroups as the stratified analysis suggested.</p><p><strong>Conclusion: </strong>A significant correlation was revealed between HGI and the risk of MI in patients with DM, especially among those with elevated HGI levels, suggesting that HGI may serve as a potential biomarker for assessing MI risk in this population.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"368"},"PeriodicalIF":2.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early detection of left atrial dysfunction in young hypertensive patients with a normal left atrial size: a comprehensive analysis using four-dimensional auto left atrial quantification echocardiography.","authors":"Luyi Ping, Yulin Huang, Gufeng Sun, Lin Jin, Xu Huang, Chunquan Zhang, Jiwei Wang","doi":"10.1186/s12872-025-04825-2","DOIUrl":"10.1186/s12872-025-04825-2","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to detect early left atrial (LA) function abnormalities in young hypertensive patients with a normal two-dimensional LA volume index (2D-LAVI) using four-dimensional auto LA quantification technology (4D Auto LAQ) and to analyse correlations between LA strain parameters and clinical metabolic indicators.</p><p><strong>Methods: </strong>This study enrolled 70 young patients who underwent standard hypertension treatment or diagnosis at the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, from October 2023 to July 2024 and 41 control volunteers enrolled during the same period. LA volume and strain parameters were evaluated with a 4D Auto LAQ. A correlation analysis was conducted between the clinical and strain parameters.</p><p><strong>Results: </strong>Compared with the control group, young hypertensive patients presented significantly greater LA minimum volume (LAVmin), LA minimum volume index (LAVImin) and LA pre-atrial volume (LAVpreA) values (all p < 0.001). The LA ejection fraction (LAEF) was reduced in young hypertensive patients (57.85%±4.47% vs. 50.44%±5.96%, p < 0.001), along with LA reservoir longitudinal strain (25.00% [20.50-29.50%] vs. 20.00% [16.00-24.25%], p < 0.001), LA conduit longitudinal strain (-16.32%±4.19% vs. -11.37%±4.65%, p < 0.001), LA contraction longitudinal strain (-12.27%±2.85% vs. -9.60 ± 4.12, p < 0.001), LA reservoir circumferential strain (34.32%±6.90% vs. 28.41%±6.95%, p < 0.001), LA conduit circumferential strain (-17.90%±4.84% vs. -11.46%±4.96%, p < 0.001), and LA contraction circumferential strain (-18.54%±4.85% vs. -16.23%±6.11%, p < 0.05). Multivariate linear regression analysis revealed that body mass index (BMI), triglyceride (TG), and uric acid (UA) were negatively and independently correlated with LA longitudinal strain.</p><p><strong>Conclusions: </strong>In young hypertensive patients with normal 2D-LAVI, while LAVmin, LAVImin and LAVpreA are elevated, the LAEF and LA reservoir, conduit, and contraction strain are notably reduced. The application of 4D Auto LAQ technology may highlight altered values in young hypertensive patients with normal 2D-LAVI. 4D Auto LAQ may serve as a valuable tool for clinicians in the early detection and assessment of LA dysfunction in young hypertensive patients.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"363"},"PeriodicalIF":2.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretable artificial intelligence model for predicting heart failure severity after acute myocardial infarction.","authors":"Chenglong Guo, Binyu Gao, Xuexue Han, Tianxing Zhang, Tianqi Tao, Jinggang Xia, Honglei Liu","doi":"10.1186/s12872-025-04818-1","DOIUrl":"10.1186/s12872-025-04818-1","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) after acute myocardial infarction (AMI) is a leading cause of mortality and morbidity worldwide. Accurate prediction and early identification of HF severity are crucial for initiating preventive measures and optimizing treatment strategies. This study aimed to develop an interpretable artificial intelligence (AI) model for HF severity prediction using multidimensional clinical data.</p><p><strong>Methods: </strong>This study included data from 1574 AMI patients, including medical history, clinical features, physiological parameters, laboratory test, coronary angiography and echocardiography results. Both deep learning (TabNet, Multi-Layer Perceptron) and machine learning (Random Forest, XGboost) models were employed in constructing model. Additionally, the Shapley Additive Explanation (SHAP) method was used to elucidate clinical factors importance and enhance model interpretability. A web platform ( https://prediction-killip-gby.streamlit.app/ ) was also developed to facilitate clinical application.</p><p><strong>Results: </strong>Among the models, TabNet demonstrated the best performance, achieving an AUROC of 0.827 for KILLIP four-class classification and 0.831 for KILLIP binary classification. Key clinical factors such as GRACE score, NT-pro BNP, and TIMI score were highly correlated with KILLIP classification, aligning with established clinical knowledge.</p><p><strong>Conclusions: </strong>By leveraging easily accessible multidimensional data, this model enables accurate early prediction and personalized diagnosis of HF risk and severity following AMI. It supports early clinical intervention and improves patient outcomes, offering significant clinical application value.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"362"},"PeriodicalIF":2.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and predictive models for post-operative moderate-to-severe mitral regurgitation following transcatheter aortic valve replacement: a machine learning approach.","authors":"Zhenzhen Li, Jianing Fan, Jiajun Fan, Jiaxin Miao, Dawei Lin, Jingyan Zhao, Xiaochun Zhang, Wenzhi Pan, Daxin Zhou, Junbo Ge","doi":"10.1186/s12872-025-04759-9","DOIUrl":"https://doi.org/10.1186/s12872-025-04759-9","url":null,"abstract":"<p><strong>Background: </strong>Post-operative moderate-to-severe mitral regurgitation (MR) following transcatheter aortic valve replacement (TAVR) is associated with poor outcomes, yet the factors contributing to this complication are not well understood. This study aimed to identify risk factors and develop predictive models for post-operative MR following TAVR using machine learning (ML) techniques to enhance early detection and intervention.</p><p><strong>Methods: </strong>We retrospectively analyzed data from patients who underwent TAVR at our center between August 2014 and August 2023. Patients were classified into post-operative and nonpost-operative MR groups based on postprocedural MR severity. Various ML models were evaluated for predictive performance using metrics such as accuracy, precision, recall, F1 score, and area under the receiver operating characteristic curve (AUC). Shapley Additive Explanation (SHAP) values were used to interpret predictive patterns and develop a clinically relevant model.</p><p><strong>Results: </strong>Among the evaluated models, the random forest model exhibited the highest predictive performance for post-operative moderate-to-severe MR after TAVR. Key predictors, which were confirmed by the SHAP analysis as important in the predictive framework, included echocardiographic parameters, blood test results, patient age, and body mass index.</p><p><strong>Conclusions: </strong>ML models show promise in predicting post-operative moderate-to-severe MR after TAVR by integrating clinical indicators to enhance predictive accuracy.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"361"},"PeriodicalIF":2.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between triglyceride-glucose body mass index and all-cause mortality in ICU patients with sepsis and acute heart failure.","authors":"Heping Xu, Jinyuan Xie, Huan Niu, Xiongwei Cai, Ping He","doi":"10.1186/s12872-025-04804-7","DOIUrl":"10.1186/s12872-025-04804-7","url":null,"abstract":"<p><strong>Background: </strong>The triglyceride‒glucose body mass index (TyG-BMI) has been recognized as a significant predictor of cardiovascular disease risk and plays a crucial role in assessing insulin resistance. However, the correlation between the TyG-BMI and clinical outcomes in patients with sepsis and acute heart failure (AHF) has not been sufficiently explored. This study aimed to investigate the associations between TyG-BMI and clinical outcomes in patients with sepsis and AHF.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of ICU-admitted patients via data from the MIMIC-IV database. Multivariable logistic regression, sensitivity analysis, and restricted cubic spline (RCS) models were used to assess the relationship between TyG-BMI and all-cause mortality. K‒M survival analysis and Boruta analysis were employed to evaluate the predictive value of the TyG-BMI. Subgroup analyses considered the effects of age, sex, ethnicity, and comorbidities.</p><p><strong>Results: </strong>Among the 1,729 patients, a higher TyG-BMI was associated with lower all-cause mortality at 90 and 180 days. Each standard deviation increase in the TyG-BMI was linked to 0.2% and 0.3% reductions in 90-day and 180-day all-cause mortality, respectively. Kaplan‒Meier analysis revealed significantly lower all-cause mortality in patients with higher TyG-BMIs (P < 0.0001). The RCS model revealed a nonlinear relationship between the TyG-BMI and mortality. Boruta analysis identified the TyG-BMI as an important clinical feature. Sensitivity analyses revealed that the association remained significant after patients with myocardial infarction, malignancies, or missing data were excluded. The subgroup analysis revealed that for the 90-day and 180-day mortality rates, significant interactions were found only in the subgroup of patients with kidney diseases (P < 0.05).</p><p><strong>Conclusion: </strong>The TyG-BMI may have potential value in predicting mortality in ICU patients with sepsis and AHF, supporting early risk assessment and clinical intervention. This study provides critical insights into patient prognosis.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"359"},"PeriodicalIF":2.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and predictions of the global burden of ischemic heart disease in women of childbearing age attribute to high body mass index and hypertension,1990-2021: a systematic analysis for the Global Burden of Disease Study.","authors":"Qi Gu, Shuxiong Nong, Chenang Liu, Yongfeng Chen, Meng Wu, Chilin Liao, Cong Hu","doi":"10.1186/s12872-025-04741-5","DOIUrl":"https://doi.org/10.1186/s12872-025-04741-5","url":null,"abstract":"<p><strong>Background: </strong>High body mass index (BMI) and hypertension are quite prevalent in women of childbearing age (WCBA) and are also common risk factors for ischemic heart disease (IHD). However, there are few studies globally evaluating the burden of IHD of WCBA attribute to high BMI and hypertension.</p><p><strong>Methods: </strong>The DALYs (Disability-adjusted life years), Deaths, YLDs (Year lived with disabilitys), YLLs (Year of life losts) of IHD in WCBA attributable to high BMI and hypertension were analyzed by age, sex, year, and geographical location and Socio-demographic Index (SDI). To assess the contribution of epidemiological changes, population growth, and population ageing, a decomposition analysis was used. Exponential Smoothing (ES) modeling and the Autoregressive Integrated Moving Average (ARIMA) model were used to predict the global ASDR (age-standardized DALYs rate), ASMR (age-standardized mortality rate) attributed to the 2 risk factors from 2022 to 2050. The cluster analysis was used to evaluate the changing pattern of burden across GBD regions.</p><p><strong>Results: </strong>In 2021, the number of global deaths attribution to high BMI was 9,865,138 (95% UI: 3,845,800-15,976,196), and the corresponding ASMR was 216.05 (95% UI: 84.26-349.49) per 100000 population. In various age groups, the largest increase occurred in 20-24 years group (EAPC = 1.26 (95% CI:1.13-1.39)). The number of DALYs of IHD in WCBA attribution to hypertension is 2,158,633 (95% UI:1,725,994-2,538,752) with a corresponding ASMR 46.05 (95% UI: 36.87-54.15) per 100,000 population. The number of DALYs of IHD in WCBA attribution to hypertension is 37,920,567 (95% UI: 30,389,745-44,641,339), and the corresponding ASDR is 817.79 (95% UI: 655.74-962.67) per 100000 population. The largest number of Deaths and DALYs of IHD in WCBA was found between 45-49 years. From 1990 to 2021, ASMR and ASDR attributable to high BMI and hypertension led to a sustained upward trend in Low and Low-medium SDI regions. In addition, the ASMR and ASDR for high BMI and hypertension are highest in the Low-middle SDI regions. Globally, from 1990 to 2021, the overall changes in ASMR and ASDR indicate a relatively stable trend in IHD in WCNA attribute to high BMI. Meanwhile, ASMR and ASDR showed an overall downward trend for hypertension. The number of DALYs, deaths, YLLs, and YLDs of IHD in WCBA attribution to high BMI and hypertension based on the ES and ASMIR models are all increasing from 2022 to 2050.</p><p><strong>Conclusions: </strong>Over the past 30 years, the ASMR and ASDR of IHD in WCBA has continued to rise. Countries need to remain vigilant about the increasing burden of IHD in WCBA attribute to high BMI and hypertension. It requires proactive prevention strategies, strict control of risk factors, and increased medical coverage to alleviate the burden of IHD. Each region should develop more proactive and effective strategic measures.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"360"},"PeriodicalIF":2.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microcirculatory resistance based on a single angiographic view in ST-segment elevation myocardial infarction patients.","authors":"Zhe Zhang, Qing Dai, Xinlin Zhang, Shiyang Qiao, Xue Bao, Kun Wang, Peng Xue, Yuan Gao, Xuemei Guo, Yanan Xue, Zhonghai Wei, Biao Xu, Lina Kang","doi":"10.1186/s12872-025-04796-4","DOIUrl":"https://doi.org/10.1186/s12872-025-04796-4","url":null,"abstract":"<p><strong>Background: </strong>Angio-based microvascular resistance (AMR) was proposed as a tool to quantitatively assess coronary microvascular based on single angiographic projection. The aims of this study are to assess the diagnostic accuracy and prognostic significance of AMR in ST-segment elevation myocardial infarction (STEMI) patients.</p><p><strong>Methods: </strong>AMR was measured (Of these, 22 patients measured index of microvascular resistance (IMR)) in 70 STEMI patients after primary percutaneous coronary intervention (pPCI). ST-segment resolution (STR) was assessed 2 h after pPCI simultaneously. Transthoracic echocardiography was performed within 1 day and approximately 1 year after pPCI. STEMI patients underwent pPCI were followed up for 7.3 years and the primary endpoint was the major adverse cardiac and cerebral events (MACCEs).</p><p><strong>Results: </strong>AMR showed significant correlations with IMR (R = 0.334, P = 0.005). AMR has good predictive power for STR after pPCI (area under the curve: 0.889, sensitivity: 94.59%, specificity: 75.76%) in receiver operating characteristic (ROC) curve. Low-AMR patients showed markedly improved left ventricular ejection fraction (LVEF) 1 year after pPCI (42(40-49) vs. 41(39-44), P = 0.041). High-AMR patients showed higher risk for MACCEs than those with Low-AMR (HR = 3.90, P = 0.02). In multivariate cox regression analysis, AMR was considered an independent predictor of MACCEs (HR: 1.153, P = 0.020).</p><p><strong>Conclusions: </strong>AMR is a reliable tool for the estimation of microvascular resistance and prognosis in the absence of intracoronary pressure-temperature sensor wire and adenosine based on single angiographic projection.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"357"},"PeriodicalIF":2.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vena contracta area measurement by three-dimensional echocardiography for assessing mitral regurgitation severity using a novel, fast, and reliable method.","authors":"Mehrnoush Toufan, Dina Ashouri, Sina Hamzehzadeh, Behnam Atashi Jahromi, Maryam Chenaghlou","doi":"10.1186/s12872-025-04822-5","DOIUrl":"https://doi.org/10.1186/s12872-025-04822-5","url":null,"abstract":"<p><strong>Background: </strong>Echocardiography is the standard tool for the evaluation of mitral regurgitation (MR). Although Two-dimensional echocardiography is the most recommended tool, it has some limitations. Three-dimensional echocardiography (3DE) is suggested to overcome these limitations, however, it is more time-consuming. Introducing a simplified and accurate 3-D method could be helpful in this regard.</p><p><strong>Methods: </strong>Patients diagnosed with significant MR who were referred to Shahid Madani heart center, Tabriz, Iran for evaluation of MR severity were entered in this study. Patients with prior MR surgery, poor image quality, and without self-consent for participation in the study were excluded. Two-dimensional transthoracic echocardiography (TTE) and 3D transesophageal echocardiography (TEE) were performed in all patients. MR severity was compared between these two methods and between direct planimetry (DP) of the vena contracta area (VCA) and 3D directed multiplanar reconstruction (MPR).</p><p><strong>Results: </strong>A total of 53 patients were studied. Thirty-six (69.7%) of the patients were female. The mean age of patients was 66.21 ± 11.91 years. 3DVCA using DP was significantly correlated with the 2D method in terms of MR severity (p = 0.006). There was a significant correlation between the results of 3DE DP and 2DE magnetic resonance voiding cystography (MRVC) diameter (r = 0.503 and p = 0.0001). A significant correlation was also found between the result of DP and MPR-derived VCA using 3D (r = 0.97 and p = 0.0001).</p><p><strong>Conclusion: </strong>TEE is an invaluable method to decide the severity and mechanism of patients with MR, especially if TTE does not give adequate information. The method proposed in this study for evaluation of MR severity and mechanism using 3D TEE could be a helpful option, especially in the above-mentioned conditions. In this study, 3D direct planimetry had an acceptable correlation with 2DE MRVC and also with 3D MPR-derived VCA.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"358"},"PeriodicalIF":2.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate variability in children and adolescents with incidentally found early repolarization pattern.","authors":"Ahmet F Arinc, Sule Arici, Figen Akalin","doi":"10.1186/s12872-025-04824-3","DOIUrl":"https://doi.org/10.1186/s12872-025-04824-3","url":null,"abstract":"<p><strong>Background: </strong>Early repolarization pattern (ERP) on electrocardiogram (ECG) was long considered benign, but recent data suggest a potential association with fatal arrhythmia and sudden cardiac death. Its relevance in pediatric populations remains unclear. This study investigated the risk of premature death and arrhythmia in children with incidentally found early repolarization using ECG and heart rate variability parameters.</p><p><strong>Methods: </strong>This cross-sectional study included healthy children aged 6-18 years with incidentally detected ERP (study group) and age- and sex-matched controls without ERP. All participants underwent medical history evaluation, physical examination, 12-lead ECG, transthoracic echocardiography, and 24-h Holter monitoring. ECG parameters (P wave, QTc, JT, Tp-e, and their dispersions), time-domain (SDNN, SDANN, SDNN-i, r-MSSD, pNN50), and frequency-domain (HF, LF, LF/HF) HRV parameters were analyzed.-i, r-MSSD, pNN50 and \"Frequency-domain\" parameters HF, LF, LF/HF were obtained.</p><p><strong>Results: </strong>The study group had lower heart rates (p = 0.020) and increased JT dispersion (p = 0.025). Interventricular septal thickness was significantly greater in the ERP group (p = 0.030). LF/HF ratio (p = 0.045), awake HF (p = 0.046), and awake LF/HF (p = 0.036) were significantly higher in ERP patients. Parasympathetic activity predominance was more evident in males. ERP localized in inferolateral leads was associated with higher heart rate and lower SDNN and VLF during sleep (p = 0.049, p = 0.040, p = 0.040, respectively).</p><p><strong>Conclusion: </strong>Incidental ERP in children was not associated with arrhythmic events but correlated with increased parasympathetic tone. Inferolateral ERP may indicate a relatively higher autonomic imbalance risk.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"356"},"PeriodicalIF":2.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilic myocarditis in dilated cardiomyopathy: a case report.","authors":"Mengxuan Li, Hong Chen","doi":"10.1186/s12872-025-04826-1","DOIUrl":"https://doi.org/10.1186/s12872-025-04826-1","url":null,"abstract":"<p><strong>Background: </strong>Eosinophilic myocarditis (EM) is a rare cardiac condition that is often difficult to diagnose. Although endocardial myocardial biopsy is considered the gold standard for diagnosis, sampling errors can lead to false-negative results. This case report discusses the diagnosis and treatment of dilated cardiomyopathy in a patient with EM.</p><p><strong>Case presentation: </strong>In this article, we report a case of a 32-year-old female patient diagnosed with dilated cardiomyopathy. EM was strongly suspected based on a progressive increase in eosinophil count, the absence of known allergens or common etiological factors, elevated eosinophil levels in alveolar lavage fluid, and a diagnosis of eosinophilic pneumonia. However, endocardial myocardial biopsy results failed to show definite evidence of myocarditis. Despite the implementation of various therapeutic interventions including pharmacological treatments, electrical defibrillation, endotracheal intubation, and ventilator-assisted breathing, the patient's condition showed minimal improvement. Subsequent initiation of extracorporeal membrane oxygenation and intra-aortic balloon pump support also failed to achieve the anticipated recovery. The patient subsequently underwent heart transplantation, and cardiac tissue samples were sent for pathology examination. The diagnostic report revealed a large number of eosinophils, confirming the diagnosis of EM. After heart transplantation, the patient's vital signs gradually stabilized, and she was discharged in good condition.</p><p><strong>Conclusions: </strong>Endocardial myocardial biopsy plays an important role in diagnosing EM but may yield false-negative results. In this case, heart transplantation provided critical diagnostic information, with the pathology report confirming the presence of eosinophils and supporting the diagnosis of EM.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"355"},"PeriodicalIF":2.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}