BMC Cardiovascular Disorders最新文献

{"title":"Dual residual risk of lipid and inflammation: a prospective analysis of RCII on hypertension incidence and cardiovascular prognosis in Chinese and UK populations.","authors":"Lerui Wang, Siyuan Wen, Zhiyi Ma, Boda Zhou","doi":"10.1186/s12872-026-06322-6","DOIUrl":"10.1186/s12872-026-06322-6","url":null,"abstract":"<p><strong>Background: </strong>Residual cardiovascular risk remains a significant clinical challenge despite the intensive management of conventional risk factors. This study aimed to evaluate the impact of the Remnant Cholesterol-Inflammation Index (RCII)-a novel metric integrating dyslipidemia and systemic inflammation-on the incidence of hypertension and its subsequent cardiovascular sequelae.</p><p><strong>Methods: </strong>We leveraged data from two large-scale prospective cohorts. The China Health and Retirement Longitudinal Study (CHARLS) included a cross-sectional cohort for prevalent hypertension (N = 8,650) and a longitudinal incident-hypertension cohort (N = 5,022). The UK Biobank (UKB) included 273,122 participants with hypertension at baseline. Multivariable logistic regression and Cox proportional hazards models were used to assess incident hypertension and long-term adverse outcomes (all-cause mortality, major adverse cardiovascular events [MACE], and cardiovascular death), respectively.</p><p><strong>Results: </strong>In the CHARLS cohort, high RCII was associated with a higher risk of incident hypertension in the fully adjusted model (OR, 1.346; 95% CI, 1.192-1.519). In quartile analysis, the highest RCII quartile was also associated with incident hypertension compared with the lowest quartile (OR, 1.364; 95% CI, 1.150-1.618; P for trend < 0.001). In the UKB cohort, compared with participants in the lowest RCII quartile, those in the highest quartile had higher risks of MACE (HR, 1.273; 95% CI, 1.232-1.315), all-cause mortality (HR, 1.214; 95% CI, 1.169-1.261), and cardiovascular death (HR, 1.284; 95% CI, 1.205-1.368) in fully adjusted complete-case models. Joint-effect analysis showed that concurrent elevation of remnant cholesterol and systemic inflammation was associated with the highest risk of MACE in UKB (HR, 1.16; 95% CI, 1.12-1.20). Exploratory mediation analyses suggested possible indirect pathways involving insulin resistance and oxidative stress.</p><p><strong>Conclusions: </strong>RCII was associated with both incident hypertension and adverse prognosis among hypertensive participants. These findings support RCII as a complementary lipid-inflammatory residual-risk marker; however, external validation and decision-utility studies are needed before clinical implementation.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory analysis of a Phase I cardiac rehabilitation pathway on anxiety and autonomy in patients undergoing PCI: a narrative nursing and transactional stress-coping perspective.","authors":"Yanna Wang, Yongyin Guan, Jinling Chen, Fengyi Wu, Mei Chen, Xiaoyan Chen, Yingyi Lei, Xiaodong Zhu","doi":"10.1186/s12872-026-06302-w","DOIUrl":"10.1186/s12872-026-06302-w","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Aims and objectives: &lt;/strong&gt;This exploratory secondary analysis of a randomized controlled trial - originally powered for medication adherence - investigated associations of a nurse-led Phase I cardiac rehabilitation pathway, integrated with narrative nursing, with anxiety and autonomy following percutaneous coronary intervention (PCI). All psychological analyses are exploratory and intended for hypothesis generation, not causal inference. Findings were interpreted within the transactional model of stress and coping, complemented by narrative nursing theory, focusing on how narrative engagement may help patients reconstruct a sense of control, confidence, and active participation during recovery-addressing narrative foreclosure and supporting autonomy beyond symptom alleviation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Phase I cardiac rehabilitation is essential for percutaneous coronary intervention patient, yet standardized nurse-led protocols are lacking and psychological effects remain incompletely understood. Routine care typically delivers didactic education without attending to patients' fears and self-doubt, potentially trapping them in narrative foreclosure. Narrative medicine suggests that providers acting as story witnesses may help transform stagnant trauma narratives into open recovery narratives, reducing threat perception and fostering engagement.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;A 6-month, parallel-group, assessor-blinded randomized controlled trial.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This exploratory analysis enrolled 162 post-PCI patients, who were randomized to an intervention group (n = 81) or a control group (n = 81). The intervention group received a nurse-led, structured Phase I cardiac rehabilitation pathway developed from evidence-based principles and adapted to local practice, supplemented with narrative nursing modules targeting the relief of narrative foreclosure. The control group received conventional care. Outcomes were assessed using the Cardiac Rehabilitation Inventory at baseline, 7 days post-discharge, and at 1, 3, and 6 months, and were analyzed using repeated-measures analysis of variance (ANOVA), with ANCOVA applied for outcomes with baseline imbalances. All analyses of psychological outcomes were exploratory.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;After baseline adjustment, the intervention group showed significantly lower process anxiety at all follow-ups (F = 7.323, P = 0.008). For outcome anxiety, neither the group main effect (F = 2.088, P = 0.151) nor group × time interaction (F = 0.439, P = 0.725) reached significance, though the intervention group maintained numerically lower scores. For autonomy, significant main effects of time (F = 90.900, P &lt; 0.001) and group (F = 36.843, P &lt; 0.001), and a significant time × group interaction (F = 27.814, P &lt; 0.001) were observed, with between-group differences widening over six months.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;In this exploratory analysis, a nurse-led pathw","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic versus open radial artery harvesting for coronary artery bypass grafting: an updated systematic review, meta-analysis, and GRADE assessment.","authors":"Tayyaba Ikram Qazi, Aleena Amir Malik, Mariya Khan, Muhammad Yahya, Yashfa Asad, Sarah Idrees, Muhammad Uzair Gull, Abbas Khan, Faiza Munir, Abdul Saboor Khan, Atiqullah Sadaqat, Muhammad Maaz Amjad, Pari Kotak, Muhammad Ahmad Akif Rauf, Sajid Rehman, Muhammad Yasir, Muhammad Huzaifa Khattak, Hamza Wazir Khan, Asia Batool, Haris Wazir Khan, Bilal Wazir Khan","doi":"10.1186/s12872-026-06326-2","DOIUrl":"10.1186/s12872-026-06326-2","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic radial artery harvesting (ERAH) is a minimally invasive alternative to open radial artery harvesting (ORAH) for coronary artery bypass grafting (CABG), though concerns persist regarding graft patency and neurological outcomes.</p><p><strong>Methods: </strong>PubMed, Embase, Cochrane Library, and ClinicalTrials.gov were searched through February 21, 2026. Randomized controlled trials and propensity-matched observational studies were included. Risk of bias was assessed using ROB 2 and the Newcastle-Ottawa Scale; certainty of evidence was evaluated using GRADE. Pooled risk ratios and mean differences with 95% confidence intervals were calculated using a random-effects model.</p><p><strong>Results: </strong>ERAH significantly reduced wound complications (RR = 0.61, 95% CI: 0.39-0.96) and wound infections (RR = 0.57, 95% CI: 0.35-0.93), though this benefit did not persist in RCT-only analysis. Neurological complications were reduced after sensitivity analysis (RR = 0.44, 95% CI: 0.34-0.57). Graft patency was comparable (RR = 1.01, 95% CI: 0.90-1.14), with no significant differences in mortality, MACCE, or myocardial infarction. Observational data showed modest reductions in cardiopulmonary bypass time and hospital stay.</p><p><strong>Conclusions: </strong>ERAH demonstrates comparable graft patency and major clinical outcomes to ORAH. Donor-site benefits suggested by observational studies are not consistently supported by randomized evidence. Large trials with standardized outcomes and long-term follow-up are needed.</p><p><strong>Trial registration: </strong>PROSPERO, CRD420261334767.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vericiguat for heart failure with reduced ejection fraction on quadruple therapy without recent worsening heart failure: an exploratory real-world cohort study.","authors":"Peng Han, Yuan Ning, Bohui Zhang, Xi Zhang, Che Wang, Tiantong Yu, Yan Chen, Boda Zhu, Youhu Chen, Genrui Chen, Shuai Zhao, Chengxiang Li, Yan Chen, Kun Lian","doi":"10.1186/s12872-026-06319-1","DOIUrl":"10.1186/s12872-026-06319-1","url":null,"abstract":"<p><strong>Background: </strong>Heart failure with reduced ejection fraction (HFrEF) patients remain at substantial risk despite quadruple guideline-directed medical therapy (GDMT [ARNI + SGLT2 inhibitor + β-blocker + MRA]). Data on vericiguat in stable HFrEF patients without recent worsening heart failure receiving contemporary quadruple GDMT are limited. This observational study aimed to explore the efficacy and safety of vericiguat in this population.</p><p><strong>Methods: </strong>A total of 450 adult patients with LVEF < 45% were enrolled (200 received quadruple GDMT plus vericiguat, 250 received quadruple GDMT alone). After 1:1 propensity score matching (PSM), 144 well-matched pairs were identified. The primary outcome was the composite of cardiovascular death or first HF hospitalization within 12 months. Secondary outcomes included changes in NYHA functional class, KCCQ-12 scores, and occurrence of hypotension. Due to the non-randomized design, all efficacy findings except the primary composite endpoint are considered exploratory.</p><p><strong>Trial registration: </strong>ChiCTR, ChiCTR2500095278. Registered 4 January 2025. Retrospectively registered.</p><p><strong>Results: </strong>Over 12 months, the primary composite endpoint occurred in 5.56% of the vericiguat group versus 9.03% of the control group (P = 0.365; HR 0.616, 95% CI 0.255-1.486). No statistically significant differences were observed for cardiovascular death or all-cause mortality. Exploratory analyses showed that the vericiguat group had higher KCCQ-12 Overall Summary Scores (91.61 ± 9.56 vs. 87.93 ± 11.25, P = 0.003) and a greater proportion achieving a ≥ 5-point improvement (94.44% vs. 81.25%, P = 0.001). NYHA functional class distribution also differed between groups (P = 0.029). Hypotension rates were similar between groups.</p><p><strong>Conclusion: </strong>Among HFrEF patients without recent worsening, vericiguat did not significantly reduce the primary composite endpoint at 12 months. Exploratory observations suggest potential associations with improved quality of life and functional class without increased hypotension risk. These hypothesis‑generating findings require confirmation in adequately powered randomized controlled trials.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed presentation of traumatic giant left anterior descending artery pseudoaneurysm as acute coronary syndrome and cardiogenic shock: a case report.","authors":"Mustafa Uçar","doi":"10.1186/s12872-026-06324-4","DOIUrl":"10.1186/s12872-026-06324-4","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery pseudoaneurysms are rare vascular abnormalities that may develop after percutaneous coronary intervention, infection, or trauma. Although many cases remain asymptomatic, pseudoaneurysms may occasionally present with life-threatening complications. Delayed presentation of traumatic coronary pseudoaneurysm as acute coronary syndrome (ACS) complicated by cardiogenic shock is extremely uncommon.</p><p><strong>Case presentation: </strong>A 74-year-old man presented with chest pain, dyspnea, hypotension, and signs of cardiogenic shock. Electrocardiography demonstrated anterior myocardial infarction. Emergency coronary angiography revealed proximal occlusion of the left anterior descending artery (LAD) associated with a giant pseudoaneurysm and severe circumflex artery stenosis. Given the patient's hemodynamic instability and high surgical risk related to multiple comorbidities, percutaneous treatment was selected. Following restoration of coronary flow, a covered stent was implanted to seal the pseudoaneurysm. Subsequently, complex bifurcation intervention using the double kissing crush technique was performed. Residual pseudoaneurysm filling was completely eliminated with prolonged balloon inflation. Further history revealed a motor vehicle accident five months before presentation, suggesting a presumed traumatic etiology. The patient recovered uneventfully and was discharged on the fifth day.</p><p><strong>Conclusions: </strong>This case highlights an unusual delayed presentation of traumatic giant LAD pseudoaneurysm as ACS complicated by cardiogenic shock. Careful clinical history taking may help identify traumatic etiologies. Complex percutaneous coronary intervention with covered stent implantation may represent a feasible treatment option in carefully selected high-risk patients.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced prediction of cardiovascular-kidney-metabolic syndrome using eight machine learning models and 24 composite indices.","authors":"Minghao Li, Junyuan Xiang, Fang Xiao, Qianxiang Wang, Lin Liu, Yujia Huo, Chunyu Zhang, Li Deng, Jian Feng","doi":"10.1186/s12872-026-06318-2","DOIUrl":"10.1186/s12872-026-06318-2","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to construct and validate a machine learning classifier for cross-sectionally stratifying existing cardiovascular-kidney-metabolic (CKM) syndrome stages using routine composite inflammatory, metabolic and anthropometric indices, and to interpret core driving biomarkers via SHAP analysis.</p><p><strong>Methods and results: </strong>We analyzed data from 12,106 participants from the National Health and Nutrition Examination Survey (NHANES). Among 24 initial biomarkers, 10 were selected after addressing multicollinearity and applying feature selection. Several machine learning algorithms were evaluated, with the LightGBM model demonstrating the highest performance (ROC AUC: 0.88). External validation using the China Health and Retirement Longitudinal Study (CHARLS) dataset confirmed the model's generalizability (ROC AUC: 0.84). SHapley Additive exPlanations (SHAP) analysis revealed that metabolic markers-specifically eGDR, METS_VF, TyG, and TyG_BMI-were consistently the strongest predictors across CKM stages, whereas inflammatory indicators showed more limited utility.</p><p><strong>Conclusion: </strong>Key metabolic composite indices exhibit significant associations with CKM staging and may serve as practical, clinically feasible tools for risk stratification. The model's robust performance across distinct populations (U.S. and China) supports its potential clinical utility. Further validation in diverse populations and prospective studies is needed to confirm their predictive value and translational potential.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Individualized nursing intervention enhances health outcomes and quality of life in patients with heart failure.","authors":"Fengli Liu, Jiansi Zhang, Zhi Liu","doi":"10.1186/s12872-026-06190-0","DOIUrl":"10.1186/s12872-026-06190-0","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) is associated with high morbidity, readmissions, and impaired quality of life. Because patient responses vary, tailored, nurse-led strategies, particularly in nutrition, activity, and psychosocial support, may address needs that routine care does not fully meet.</p><p><strong>Objective: </strong>To assess the effectiveness of an individualized, nurse-led intervention integrating nutrition, graded exercise, and psychosocial support in patients with HF.</p><p><strong>Methods: </strong>This prospective, single-center, parallel-group study involved adults with HF (n = 110 per group), who were assigned to groups using an odd-even allocation method. The control group (CG) received routine nursing care. The observation group (OG) received the same routine care plus a 3-month individualized program comprising customized nutritional counseling, staged exercise guidance, and structured psychosocial support with follow-up. Baseline and follow-up assessments consisted of measuring time to symptom resolution, cardiac function, arterial blood gases, nutritional status, psychological status, quality of life, and adverse events between the two groups.</p><p><strong>Results: </strong>Compared with routine nursing care (CG), individualized nurse-led care (OG) had shortened time to symptom improvement (dyspnea 2.05 ± 0.61 vs. 2.57 ± 0.76 days; p < 0.001), improved cardiac function (LVEF, CO ↑; LVEDD, LVESD ↓; 6MWT ↑; all p < 0.05), enhanced gas exchange (PaCO₂ ↓, PaO₂ ↑; both p < 0.05), and better nutritional status (p < 0.05). Additionally, the OG had improved psychological status (p < 0.05), enhanced quality of life (SF-36 75.43 ± 9.03 vs. 66.43 ± 9.09; p < 0.05), and fewer adverse events (6.36% vs. 20.0%; χ²=7.462; p = 0.006).</p><p><strong>Conclusion: </strong>An individualized nurse-led intervention is associated with multidomain benefits in patients with HF, supporting the integration of personalized nursing strategies into routine HF care pathways.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world management and outcomes of myocardial infarction in a transitional country: insights from an 11-year observational study of 13,099 patients.","authors":"Gani Bajraktari, Defrim Morina, Besfort Kryeziu, Albion Luzha, Afrim Poniku, Pranvera Ibrahimi, Arlind Batalli, Edita Pllana-Pruthi, Ardian Nikaj, Artan Bajraktari, Edmond Haliti, Shpend Elezi, Michael Y Henein","doi":"10.1186/s12872-026-06259-w","DOIUrl":"10.1186/s12872-026-06259-w","url":null,"abstract":"<p><strong>Background and aim: </strong>Acute myocardial infarction (AMI) remains a leading cause of death globally, despite substantial advances in prevention, diagnosis and reperfusion therapy. In transitional health systems, in-hospital mortality is higher due to limited reperfusion capacity and infrastructure limitations. Kosovo introduced primary percutaneous coronary intervention (PPCI) in 2014, achieving nationwide 24/7 coverage in 2018. We evaluated 11-year trends in AMI management in Kosovo and identified independent predictors of in-hospital mortality.</p><p><strong>Methods: </strong>We analyzed 13,099 consecutive patients hospitalized with AMI between 2014 and 2024 at Kosovo's main tertiary cardiology center. Patients were classified as ST-elevation MI (STEMI) or non-ST-elevation MI (NSTEMI). Multivariable logistic regression was used to identify independent predictors of in-hospital mortality.</p><p><strong>Results: </strong>Patient's mean age was 63.8 ± 11.5 years, and 29% were women. STEMI accounted for 55% of cases. Overall in-hospital mortality was 9.0%, declining from 19.3% in 2014 to 7.7% in 2024. Mortality was higher in STEMI than NSTEMI (12% vs. 6%, p < 0.001). In multivariable analysis, cardiogenic shock, advanced age, female sex, reduced left ventricular ejection fraction, admission hyperglycaemia, and absence of PPCI were independently associated with higher mortality.</p><p><strong>Conclusions: </strong>In-hospital AMI mortality in Kosovo declined substantially over 11 years, coinciding with the expansion of 24/7 PPCI. STEMI remained the highest-risk presentation, and cardiogenic shock was the dominant predictor of death. These findings highlight the critical importance of timely reperfusion and system-level strengthening of acute cardiac care in transitional healthcare settings.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of the serum sodium to log(D-dimer) ratio for the risk of all-cause death in patients with chronic heart failure with different ejection fractions.","authors":"Yujuan Peng, Wei Zhang, Yunhong Yang, Tao Shi, Fazhi Yang, Sirui Yang, Xinuo Ma, Ping Xia, Lixing Chen","doi":"10.1186/s12872-026-05609-y","DOIUrl":"10.1186/s12872-026-05609-y","url":null,"abstract":"<p><strong>Background: </strong>The ratio of serum sodium to log(D-dimer) (log-SDR) in different types of chronic heart failure (CHF) is not well established.</p><p><strong>Methods: </strong>A total of 1,221 hospitalized CHF patients from the First Affiliated Hospital of Kunming Medical University between January 2017 and October 2021 were retrospectively analyzed. Patients were categorized into log-SDR-L group (log-SDR < 47.90) and log-SDR-H group (log-SDR ≥ 47.90).Prognostic assessments included Kaplan-Meier survival analysis, Cox survival analyses and time-dependent Receiver operating characteristic (ROC) curves analysis to evaluate predictive performance.</p><p><strong>Results: </strong>We collected data from 1008 patients with CHF. Kaplan-Meier survival analysis revealed that patients with high log-SDR levels had better overall survival (OS). After multivariate adjustment Cox proportional hazards analysis, the level of log-SDR was still independently related to mortality, regardless of CHF subtype.</p><p><strong>Conclusions: </strong>log-SDR is an important predictor of all-cause mortality in patients with HF, especially female HFrEF plus HFmrEF(HR:0.927, 95%CI:0.898-0.958, p < 0.001). Lower log-SDR levels are associated with an increased risk of all-cause mortality, irrespective of the HF subtype.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"26 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13383445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cholesterol, high-density lipoprotein, and glucose index and modified indices in predicting cardiovascular diseases incidence among population with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study.","authors":"Zhen Zhao, Pengchong Du, Manning Jian, Yuanyuan Liu, Hongyi Pan, Qing Liu","doi":"10.1186/s12872-026-06295-6","DOIUrl":"10.1186/s12872-026-06295-6","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular-kidney-metabolic (CKM) syndrome, characterized by the interplay of metabolic risk factors, chronic kidney disease, and cardiovascular dysfunction, is a key driver of cardiovascular disease (CVD) incidence. The cholesterol, high-density lipoprotein, and glucose (CHG) index, which integrates total cholesterol, high-density lipoprotein, and fasting blood glucose, and its modified indices (combined with obesity indicators) have potential for CVD risk prediction. However, their role across CKM stages 0-3 remains unclear.</p><p><strong>Methods: </strong>A nationwide prospective cohort study included 5,404 participants with CKM stages 0-3, screened from 17,708 individuals screened between 2011 and 2020. CHG index and modified indices (CHG-BMI, CHG-Wc, CHG-WHtR) were calculated. Logistic regression, restricted cubic spline (RCS) analysis, subgroup analysis, and sensitivity analysis were used to evaluate associations with CVD incidence and identify exploratory threshold association.</p><p><strong>Results: </strong>During follow-up, 25.5% of participants developed CVD. CHG and modified indices were independently associated with increased CVD risk (all P < 0.001). In fully adjusted models, CHG as continuous data showed a 28% higher risk (OR = 1.28, 95% CI: 1.06-1.58) of outcome, and CHG-WHtR was 54% higher (OR = 1.28, 95% CI: 1.16-2.04). Meanwhile, the highest quartile (Q4) of CHG-WHtR was associated with a 43% higher risk (OR = 1.43, 95% CI: 1.03-1.98) compared to Q1, while CHG-BMI (OR = 1.68, 95% CI: 1.22-2.31) showed stronger associations. RCS analysis identified exploratory inflection points like CHG ≥ 5.15 and CHG-WHtR ≥ 2.41, above which CVD risk significantly increased (P < 0.005) and validated by bootstrap sampling. Subgroup analysis confirmed consistent associations across age, gender, and CKM stages subpopulations. Multiple sensitivity analysis supported the robustness of these associations across CKM stages.</p><p><strong>Conclusion: </strong>CHG index and its modified indices, particularly CHG-WHtR and CHG-Wc, are valuable indicators associated with reported incident CVD across CKM stages 0-3. Their stage-specific associations and exploratory threshold association support their utility in risk stratification for CKM syndrome.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}