BMC Cardiovascular Disorders最新文献

{"title":"Associations of patient knowledge with drug-modifiable cardiovascular risk factor control in coronary artery disease patients with and without diabetes mellitus: results from the cross-sectional KNOW-ABC study.","authors":"Maximilian Brockmeyer, Michaela Fell, Claudio Parco, Alexander Hoss, Kris G Vargas, Emilia Wies, Yingfeng Lin, Yvonne Heinen, Nadja Chernyak, Andrea Icks, Christian Jung, Malte Kelm, Georg Wolff","doi":"10.1186/s12872-025-04599-7","DOIUrl":"10.1186/s12872-025-04599-7","url":null,"abstract":"<p><strong>Background: </strong>Control of major drug-modifiable risk factors for glycated hemoglobin (HbA1c), blood pressure (BP), and low-density lipoprotein cholesterol (LDL-C) remains unsatisfactory in the secondary prevention of coronary artery disease (CAD). We aimed to analyze patient knowledge and attainment of LDL-C, BP, and HbA1c treatment goals and associated factors in German CAD patients with and without diabetes mellitus (DM).</p><p><strong>Methods/results: </strong>A total of 204 CAD patients (68 ± 8 years; 75.0% male; 84 with DM (41.2%)) completed a questionnaire assessing their knowledge of LDL-C (< 55 mg/dL), BP (age-adapted), and HbA1c (< 7.0%) treatment goals and levels of information on predefined CAD topics as well as associated factors, including CAD duration, adherence to pharmacotherapy, and physician monitoring of secondary prevention. LDL-C, BP, and HbA1c were measured. The mean duration of CAD was 9.8 ± 8 years. A total of 98.5% reported good adherence to pharmacotherapy. Measurements of LDL-C (81.4%) and HbA1c (71.4%) were predominantly performed by general practitioners. LDL-C goals were attained significantly better in patients with DM (39.3% with vs. 16.7% without DM, p < 0.01). The attainment of BP goals did not differ between patients with and without DM (71.4% vs. 72.5%, p = 0.87). HbA1c goals were attained by 48.8% of DM patients. LDL-C goals were known by 6.0% of patients with vs. 9.2% without DM (p = 0.44), and BP goals were known by 36.9% with vs. 30.0% without DM (p = 0.36). Knowledge of HbA1c goals was prevalent in 53.6% of DM patients. Subjective levels of information on CAD topics did not differ between patients with and without DM. Logistic regression revealed that DM (odds ratio (OR) 3.73, 95% confidence interval (CI) 1.82-7.63) and knowledge of treatment goals were associated with LDL-C goal attainment (OR 3.84, CI 1.19-12.41); no such associations were identified for BP or HbA1c.</p><p><strong>Conclusions: </strong>In German CAD patients with and without DM, a remarkable lack of knowledge and attainment of LDL-C treatment goals exists compared with BP and HbA1c. DM and knowledge of treatment goals were significantly associated with LDL-C treatment goal attainment. General practitioners rather than cardiologists or other specialties currently manage risk factor control.</p><p><strong>Trial registration: </strong>German Clinical Trials Register studyID DRKS00030703.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"148"},"PeriodicalIF":2.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biochemical differences based on sex and clusters of biomarkers in patients with COVID-19: analysis from the CARDIO COVID 19-20 registry.","authors":"Frank Cañón-Estrada, Juan Andrés Muñoz-Ordoñez, Manuela Escalante-Forero, Yorlany Rodas, Andrea Alejandra Arteaga-Tobar, Valeria Azcarate-Rodriguez, Eduardo Perna, Iván Mendoza, Fernando Wyss, José Luis Barisani, Mario Speranza, Walter Alarco, Juan Carlos Ortega, Andrés Ulate, Jessica Mercedes, Daniel Quesada Chaves, Paola Oliver, Andrea Valencia-Orozco, Mario Miguel Barbosa, Hoover León-Giraldo, Noel Alberto Flórez, Juan Esteban Gómez-Mesa","doi":"10.1186/s12872-025-04565-3","DOIUrl":"10.1186/s12872-025-04565-3","url":null,"abstract":"<p><strong>Background: </strong>The inflammatory response associated with COVID-19 varies with sex, potentially affecting disease outcomes. Males have a higher risk of complications compared to females, requiring an evaluation of differences in inflammatory response severity based on sex.</p><p><strong>Objective: </strong>To compare clinical data, biochemical biomarkers, and outcomes among hospitalized COVID-19 patients in Latin America and the Caribbean (LA&C) based on sex and to perform a cluster analysis of biomarker profiles for both sexes.</p><p><strong>Methods: </strong>This prospective, multicenter observational registry made by the Inter-American Council of Heart Failure and Pulmonary Hypertension of the Inter-American Society of Cardiology included hospitalized COVID-19 patients from 44 hospitals in 14 countries in LA&C between May 1, 2020, and June 30, 2021.</p><p><strong>Results: </strong>Of 3,260 patients (1,201 females and 2,059 males), males had higher C-reactive protein and ferritin levels, while females had higher natriuretic peptides and d-dimer levels. Males had more cardiovascular complications (acute coronary syndrome [3.3% vs. 2.2%], decompensated heart failure [8.9% vs. 7.8%], pulmonary embolism [4.4% vs. 2.9%]), intensive care unit (ICU) admissions (56.9% vs. 47.7%), and overall mortality (27.5% vs. 22.1%). Cluster analysis identified three groups: one with normal-range biomarkers but elevated ferritin, one with coagulation abnormalities, and one with an inflammatory profile linked to renal injury and increased non-cardiovascular mortality.</p><p><strong>Conclusions: </strong>In the LA&C population hospitalized with COVID-19, males had higher inflammatory biomarker levels, correlating with increased cardiovascular complications and mortality. The cluster with an inflammatory profile showed higher non-cardiovascular mortality, while clusters with elevated ferritin levels were associated with increased ICU admissions.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"147"},"PeriodicalIF":2.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The features of distinctive bipolar intracardiac electrograms for ventricular arrhythmias in the DGCV system origin.","authors":"Weiqian Lin, Jiasheng Yu, Cheng Zheng, Jiafeng Lin, Guojuan Xu","doi":"10.1186/s12872-025-04606-x","DOIUrl":"10.1186/s12872-025-04606-x","url":null,"abstract":"<p><strong>Aims: </strong>To investigate the characteristics of bipolar intracardiac electrograms (bi-EGMs) in target sites of ventricular arrhythmias (VAs) originating from the distal great vein system (DGCVs).</p><p><strong>Methods: </strong>169 patients undergoing first-time ablation for VAs originated from DGCVs were enrolled in present study. Successful ablation was achieved in 146 patients. Bi-EGMs on successful sites were recorded and analyzed.</p><p><strong>Results: </strong>In the 146 cases, the DGCVs was subdivided into DGCV (100 cases), AIV (28cases), and summit-CV (18 cases) subgroup based on anatomic location of final target site. An A and V wave were consistently recorded in Bi-EGM of target sites. A total of 59 cases showed A/V ≥ 1 while 87 patients were < 1. The incidence of A/V ≥ 1 recorded in target sites was higher in the DGCV subgroup (52%, 52/100) compared to the AIV (10.71%, 3/28) and summit-CV (22.22%, 4/18) subgroups (all p < 0.05). In A/V > 1 cases, pacing-induced ventricle capture, atrium capture or alternate atrium and ventricle capture, and no chamber capture were 83.05%(49/59), 6.78%(4/59),10.19%(6/59), respectively, and they were 90.80%(79/87), 1.15%(1/87), 8.05%(7/87) (p > 0.05) in 87 cases of A/V < 1. A presystolic multicomponent fractionated potential was frequently observed in target sites of DGCVs VAs(102/146, 69.86%), with the DGCV subgroup being more frequent than the AIV and summit-CV subgroups (74/100, 74% vs. 19/28, 67.86% vs. 9/18, 50%).</p><p><strong>Conclusion: </strong>Catheter ablation of VAs arising from DGCV system is challenging. Different from traditional concept of atrioventricular annulus VAs, whose AV ratio of target sites should be less than 1, A/V ≥ 1 could be observed in VAs arising from DGCVs. In this region, target site identification should not be restrained by AV ratio. In addition, the presence of specific potentials in Bi-EGMs, can serve as an indicator for identifying target sites.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"150"},"PeriodicalIF":2.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender disparities in hypertension prevalence, awareness and healthcare seeking behaviour among young adults in Nigeria.","authors":"Rabiu Ibrahim Jalo, Eniola Adetola Bamgboye, Mobolaji Modinat Salawu, Joshua Odunayo Akinyemi, Uzoamaka Uja, Okechukwu Samuel Ogah, Oyediran Emmanuel Oyewole, Oluwadolapo Salisu, Mahmoud Umar Sani, IkeOluwapo Oyeneye Ajayi","doi":"10.1186/s12872-025-04603-0","DOIUrl":"10.1186/s12872-025-04603-0","url":null,"abstract":"<p><strong>Background: </strong>The burden of hypertension and healthcare seeking behaviour can be driven by gender-related inequalities in access to care. Low hypertension awareness often originates in early adulthood, determining gender patterns in hypertension. The factors that contribute to these patterns in this life stage are critical for improving hypertension control and reducing cardiovascular disease risk. This study was conducted to assess the gender disparities in hypertension prevalence, awareness and healthcare seeking behaviour among young adults in three selected states in Nigeria.</p><p><strong>Methods: </strong>Using a cross-sectional design, we assessed gender differences in prevalence, awareness and healthcare seeking behaviour for hypertension among 924 young adults aged 18 - 40 years in three states of Nigeria (Abia, Oyo and Kano States). Pearson's Chi-square was used to test associations between variables. Predictors of gender disparities were assessed with binary logistic regression at 5% level of statistical significance.</p><p><strong>Results: </strong>Of these, 416 (45.0%) were less than 30 years old while 508 (55.0%) of the respondents were ≥ 30 years of age with a mean age ± SD of 29.6 ± 6.8 and 29.8 ± 6.8 for male and female respondents respectively. Overall, the prevalence of hypertension among young adults in the three states was 169 (18.2%); higher among females 107 (19.2%) compared to males 61 (16.7%). Awareness of high blood pressure (BP) was higher among female respondents 333 (59.7%) compared to their male counterparts 192 (52.5%) and the difference was statistically significant (p = 0.03). Visits to a health care provider was higher among females (16.0%) than males (8.7%). Age, marital status, ethnicity, education and occupation were significantly associated (p < 0.005) with elevated BP among female hypertensives while age, marital status and ethnicity were significantly associated with elevated BP among male hypertensives.</p><p><strong>Conclusions: </strong>The study showed gender specific differences with regards to the burden, awareness and health seeking behaviour for hypertension among young adults in Nigeria. There is need for gender specific interventions to control the increasing burden of hypertension in Nigeria.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"151"},"PeriodicalIF":2.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound assessment of the association between left atrial remodeling and fibrosis in patients with valvular atrial fibrillation: a clinical investigation.","authors":"Tao Xu, Haotian Hu, Runyu Zhu, Wenshu Hu, Xinyi Li, Dian Shen, Aoyi Zhang, Chang Zhou","doi":"10.1186/s12872-025-04580-4","DOIUrl":"10.1186/s12872-025-04580-4","url":null,"abstract":"<p><strong>Background: </strong>Advanced heart failure in patients with valvular atrial fibrillation (VAF) poses a significant threat to human health. Noninvasive assessment of left atrial remodeling in various pathological conditions is instrumental in guiding clinical treatment decisions, evaluating efficacy, and predicting prognosis.</p><p><strong>Methods: </strong>The study enrolled 63 patients diagnosed with mitral stenosis (MS), among whom 44 presented concomitant atrial fibrillation (AF) and 19 had sinus rhythm. Left atrial volume and functional parameters were evaluated using real-time three-dimensional echocardiography (RT-3DE) and two-dimensional speckle tracking imaging (2D-STI) techniques, while left atrial stiffness index (LASI) was calculated accordingly. During surgery, left atrial myocardial specimens were obtained to determine the CVF through histopathological evaluation, reflecting the extent of left atrial myocardial fibrosis. Comparative analysis was conducted between the AF group and the control group regarding left atrial volume, functional parameters, LASI, as well as their correlation with CVF.</p><p><strong>Results: </strong>(1) Patients with MS combined with AF exhibit larger left atrial volume, decreased strain at all stages, reduced function, and increased stiffness of the left atrium compared to patients in sinus rhythm. (2) LASI was positively correlated with CVF in both the control and AF groups, exhibiting the highest correlation coefficient (p < 0.05).</p><p><strong>Conclusion: </strong>The application of RT-3DE, 2D-STI, and LASI enables effective evaluation of left atrial structure and function changes in patients with VAF. LASI provides a more accurate indication of the extent of myocardial fibrosis.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"149"},"PeriodicalIF":2.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of red cell distribution width/albumin ratio and 28-day mortality in chronic obstructive pulmonary disease patients with atrial fibrillation: a medical information mart for intensive care IV study.","authors":"Jian-Min Qu, Xia-Hong Tang, Wen-Juan Tang, Li-Ya Pan","doi":"10.1186/s12872-025-04537-7","DOIUrl":"10.1186/s12872-025-04537-7","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) complicated by atrial fibrillation (AF) in ICU patients is associated with higher risks of adverse outcomes. The red cell distribution width to albumin ratio (RAR), may predict mortality in critical illness, yet its link to 28-day mortality in ICU patients with COPD and AF remains unclear.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 693 ICU patients with COPD and AF from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, grouped by RAR tertiles. The primary endpoint was 28-day mortality, with secondary endpoints including 90-day, 365-day, and ICU mortality. Multivariate cox models estimated hazard ratios (HRs) for mortality, while restricted cubic spline regression assessed the linearity of the RAR-mortality relationship. Kaplan-Meier curves compared survival across tertiles, and subgroup analyses explored RAR's impact across age, gender, race, and comorbidities.</p><p><strong>Results: </strong>Our study included 693 ICU patients with both COPD and AF, with an average age of 74.9 years. The 28-day mortality was 30.7%. Patients in the highest RAR tertile had significantly worse 28-day survival (p < 0.0001). Higher RAR was linearly associated with increased 28-day mortality (p for non-linearity > 0.05), with each 1-unit increase in RAR linked to an 18% rise in mortality risk (95% CI: 1.08-1.29). Sensitivity analyses confirmed RAR's relevance for 90-day, 365-day, and ICU mortality.</p><p><strong>Conclusions: </strong>RAR is independently associated with 28-day mortality in COPD patients with AF. Elevated RAR levels correlate with higher 28-day mortality rates in this population.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"146"},"PeriodicalIF":2.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The link between adherence to antihypertensive medications and mortality rates in patients with hypertension: a systematic review and meta-analysis of cohort studies.","authors":"Xuemei Peng, Lihong Wan, Benkai Yu, Jianhui Zhang","doi":"10.1186/s12872-025-04538-6","DOIUrl":"10.1186/s12872-025-04538-6","url":null,"abstract":"<p><strong>Background: </strong>Hypertension (HTN) significantly contributes to cardiovascular disease (CVD) and mortality. This systematic review and meta-analysis specifically investigates how different levels of adherence to antihypertensive therapy (AHT) affect mortality rates in HTN patients. By synthesizing cohort studies, it aims to enhance understanding and inform clinical practices to improve outcomes in hypertensive populations.</p><p><strong>Methods: </strong>Our meta-analysis employed a comprehensive search strategy using keywords related to hypertension, medical adherence, and mortality across PubMed, Scopus, and Web of Science, up to July 2024. The eligibility criteria focused on cohort studies linking AHT adherence to mortality. The Newcastle-Ottawa Scale (NOS) was used to assess the risk of bias (ROB). Quantitative analyses involved hazard ratios (HR) and confidence intervals (CI), with an 80% adherence threshold. Subgroup and meta-regression analyses were also conducted using STATA-17 to explore various outcome factors.</p><p><strong>Results: </strong>From initial 1,999 studies 12 cohort studies included in our analysis. All included studies had low ROB score. A meta-analysis of 12 studies involving 2,198,311 patient with HTN revealed that poor adherence to treatment significantly increased all-cause mortality (HR: 1.32 [1.14, 1.51], p < 0.001) with high heterogeneity (I²: 98.73%). Additionally, an analysis of four studies with 1,695,872 patients indicated that low adherence was linked to elevated cardiovascular mortality (HR: 1.61 [1.43, 1.78], p < 0.001), showing moderate heterogeneity (I²: 49.51%).</p><p><strong>Conclusions: </strong>The study found that poor adherence to AHT significantly increases overall and cardiovascular mortality risk, underscoring the need for improved compliance strategies. Limitations like inconsistent definitions, observational biases, and varying follow-up durations necessitate further research to validate these findings.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"145"},"PeriodicalIF":2.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of the C-reactive protein-albumin-lymphocyte index with all-cause and cardiovascular mortality among individuals with cardiovascular disease: evidence from the NHANES 2001-2010.","authors":"Dunzheng Han, Lanlan Wu, Haobin Zhou, Yuting Xue, Shangfei He, Zhuang Ma, Shuwen Su, Peixin Li, Shenrong Liu, Zheng Huang","doi":"10.1186/s12872-025-04596-w","DOIUrl":"10.1186/s12872-025-04596-w","url":null,"abstract":"<p><strong>Background: </strong>Evidence regarding the C-reactive protein‒albumin‒lymphocyte (CALLY) index and mortality risk in individuals with cardiovascular disease (CVD) is scarce. This study investigated the relationships of the CALLY index with all-cause and cardiovascular mortality risk in CVD patients among American adults.</p><p><strong>Methods: </strong>This study enrolled 2183 CVD individuals from five NHANES cycles (2001-2010), and mortality outcomes were determined by linking the data to National Death Index (NDI) records up to December 31, 2019. Weighted multivariate Cox regression models and subgroup analyses were performed to assess the associations of the CALLY index with all-cause and cardiovascular mortality. A restricted cubic spline (RCS) was used to visualize the association of the CALLY index with mortality risk.</p><p><strong>Results: </strong>During a median follow-up of 122 months (interquartile range, 71-157 months), 1208 (weighted percentage, 49.62%) of the 2183 CVD individuals died, including 398 (weighted percentage, 24.85%) with cardiovascular deaths and 810 (weighted percentage, 75.15%) with noncardiovascular deaths. Cox regression revealed an inverse correlation between the CALLY index and the risk of all-cause and cardiovascular mortality after adjusting for covariates. Compared with individuals with a lower CALLY index, those with a higher CALLY index had a significantly lower risk of both all-cause (HR 0.58, 95% CI: 0.48, 0.71, p < 0.001) and cardiovascular mortality (HR 0.54, 95% CI: 0.38, 0.76, p < 0.001). The RCS regression analysis revealed a nonlinear association between the CALLY index and all-cause and cardiovascular mortality (p < 0.05 for nonlinearity) in CVD patients. The associations were consistent in the subgroup analyses regardless of age, sex, income, education level, race, smoking status, diabetes, and hypertension (all p values for interactions > 0.05).</p><p><strong>Conclusion: </strong>An increased CALLY index is independently associated with decreased all-cause and cardiovascular mortality in CVD patients.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"144"},"PeriodicalIF":2.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA): a comprehensive meta-analysis of clinical characteristics, management, and prognosis compared to MI with the Obstructive Coronary Artery (MIOCA).","authors":"Nahid Khorasani, Yaser Mohammadi, Mahdiye Sarpoli, Toba Kazemi, Seyed Mohammad Riahi","doi":"10.1186/s12872-025-04504-2","DOIUrl":"10.1186/s12872-025-04504-2","url":null,"abstract":"<p><strong>Background: </strong>MINOCA (Myocardial Infarction with Non-Obstructive Coronary Arteries) represents a unique subset of acute coronary syndrome, distinct from MIOCA (Myocardial Infarction with Obstructive Coronary Arteries) and a control group. This study systematically compares their prevalence, clinical characteristics, management strategies, and outcomes to improve understanding and treatment approaches.</p><p><strong>Methods: </strong>This systematic review and meta-analysis followed PRISMA guidelines across multiple databases up to 2024. STATA 17 was used for statistical analyses, and the Newcastle-Ottawa Scale was employed to assess study quality.</p><p><strong>Results: </strong>One-hundred and twelve studies, including 5,908,768 patients, were analyzed. The pooled prevalence of MINOCA among patients undergoing coronary angiography was 8.92% (95% CI: 8.90-8.94). MINOCA patients were generally younger, predominantly female, and more likely to present with atypical chest pain and dyspnea compared to MIOCA patients. Laboratory findings showed higher levels of CRP, BNP, and fibrinogen in MINOCA patients, suggesting inflammation and microvascular dysfunction as key mechanisms. In contrast, MIOCA patients had higher rates of diabetes and dyslipidemia, highlighting differences in pathophysiological processes. Medication use differed between the groups, with MINOCA patients more likely to be prescribed anticoagulants and β-blockers. Prognostically, MINOCA patients experienced significantly lower rates of adverse short- and long-term outcomes, including major adverse cardiac events (MACE) and cardiovascular death, compared to MIOCA patients.</p><p><strong>Conclusions: </strong>This study demonstrated that patients with MINOCA have a better prognosis compared to those with MIOCA and are at a lower risk of serious cardiac events. Based on the findings of this study, we emphasize that microcirculation and vascular spasm are the main mechanisms involved in MINOCA. Considering these findings, it is suggested that a better management strategy for MINOCA patients can be established by precisely defining diagnostic criteria and focusing on anti-inflammatory treatments and risk factor control.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"143"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphocyte to c-reactive protein ratio predicts the risk of contrast-induced acute kidney injury in STEMI patients undergoing percutaneous coronary intervention.","authors":"Lanqing Xiang, Bowen Qiu, Lei Chen, Chunyue Wang, Wen Zhang, Lu Liu, Guoqing Yin, Fuad A Abdu, Cailin Feng, Xian Lv, Jiasuer Alifu, Yuan Lu, Wenliang Che","doi":"10.1186/s12872-025-04522-0","DOIUrl":"10.1186/s12872-025-04522-0","url":null,"abstract":"<p><strong>Background: </strong>Contrast-induced acute kidney injury (CI-AKI) is a common complication of percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) patients. Our aim was to assess the lymphocyte to C-reactive protein ratio (LCR) to predict CI-AKI in patients with acute STEMI.</p><p><strong>Methods: </strong>A total of 777 patients with STEMI undergoing primary PCI were continuously included in this study. The occurrence of CI-AKI was monitored during the follow-up period for all patients. Logistic regression analysis was employed to assess the relationship between LCR and CI-AKI. Furthermore, ROC analysis was conducted to establish the optimal LCR cut-off value for the prediction of CI-AKI.</p><p><strong>Results: </strong>The incidence of CI-AKI after PCI was 12.2% (95/777). Univariate and multivariate analysis showed that LCR was an independent factor for CI-AKI after PCI. ROC curve analysis of LCR showed the optimal cut-off value of LCR identified for predicting CI-AKI was 7875.94, yielding the area under the curve of 0.626 (95% CI: 0.572-0.679; P < 0.001). The integration of the LCR could significantly improve the ability of the model to identify CI-AKI (IDI = 0.016[P < 0.001], and NRI = 0.137[P = 0.006]).</p><p><strong>Conclusion: </strong>LCR is an independent risk factor for CI-AKI in STEMI patients undergoing primary PCI. Integration of LCR can significantly improve the risk model for CI-AKI.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"140"},"PeriodicalIF":2.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}