BMC Cardiovascular Disorders最新文献_第10页

Coronary Artery Disease Empowerment Scale (CADES): Persian translation and psychometric properties.

IF 2 3区医学

BMC Cardiovascular Disorders Pub Date : 2024-11-30 DOI: 10.1186/s12872-024-04369-x

Amir Jalali, Amirhossein Naghibzadeh, Mojgan Rostami, Yasin Ahmadi, Mahbod Khodamorovati, Salam Vatandost, Niloufar Darvishi, Khalil Moradi

{"title":"Coronary Artery Disease Empowerment Scale (CADES): Persian translation and psychometric properties.","authors":"Amir Jalali, Amirhossein Naghibzadeh, Mojgan Rostami, Yasin Ahmadi, Mahbod Khodamorovati, Salam Vatandost, Niloufar Darvishi, Khalil Moradi","doi":"10.1186/s12872-024-04369-x","DOIUrl":"https://doi.org/10.1186/s12872-024-04369-x","url":null,"abstract":"Introduction: Coronary artery disease (CAD) is a leading cause of global mortality and a prevalent health issue in Iran. Assessing the empowerment of CAD patients during treatment and care is essential. However, no scale is available to measure empowerment in CAD patients in Iran. Therefore, this study aimed to evaluate the validity and reliability of the Persian version of the \"Coronary Artery Disease Empowerment Scale\" (CADES).Method: This methodological and cross-sectional study was conducted on patients with CAD from June 2022 to April 2023 in Kermanshah City, Iran. The scale was translated using the forward-backward translation method. Construct validity was examined using Exploratory Factor Analysis (EFA) with 190 samples and Confirmatory Factor Analysis (CFA) with 344 samples, both selected through convenience sampling. Internal consistency was assessed using Cronbach's alpha coefficient, and reliability was evaluated using the test-retest method. SPSS version 27 and LISREL version 8 software were utilized for data analysis.Results: The EFA and CFA results confirmed the instrument with three factors and 25 items. The model's main indicators in factor analysis were all above 0.9, indicating a good fit for the model. The Pearson correlation coefficient between the items and subscales with the main scale showed a direct and significant relationship. Additionally, Cronbach's alpha coefficient (0.813) and test-retest reliability (0.763) confirmed the reliability of the Persian version of the CADES.Discussion: The study's results suggest that the Persian version of CADES is both practical and acceptable for evaluating the empowerment of CAD patients. This tool can be relied upon as a valid and reliable method for assessing these patients' empowerment.","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"24 1","pages":"693"},"PeriodicalIF":2.0,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soluble suppression of tumorigenicity 2 associated with microvascular obstruction in patients with ST-segment elevation myocardial infarction.

IF 2 3区医学

BMC Cardiovascular Disorders Pub Date : 2024-11-30 DOI: 10.1186/s12872-024-04364-2

Xinjia Du, Jiahua Liu, Jingfang Zhou, Yanfei Ren, Nauman Gul, Lei Chen, Yuan Lu

{"title":"Soluble suppression of tumorigenicity 2 associated with microvascular obstruction in patients with ST-segment elevation myocardial infarction.","authors":"Xinjia Du, Jiahua Liu, Jingfang Zhou, Yanfei Ren, Nauman Gul, Lei Chen, Yuan Lu","doi":"10.1186/s12872-024-04364-2","DOIUrl":"10.1186/s12872-024-04364-2","url":null,"abstract":"Background: Microvascular obstruction (MVO) develops in approximately 50% of patients with ST-segment elevation myocardial infarction (STEMI) after undergoing percutaneous coronary intervention (PCI). MVO is strongly linked to inflammation, myocardial fibrosis, and adverse clinical outcomes. Soluble suppression of tumorigenicity 2 (sST2) serves as a biomarker for inflammation and myocardial fibrosis. Yet, the correlation between sST2 and MVO in STEMI patients has not been fully elucidated. This study attempts to evaluate the association between sST2 levels and MVO in STEMI patients following pPCI.Methods: In this retrospective study, 315 STEMI patients who underwent pPCI at the Affiliated Hospital of Xuzhou Medical University between June 2018 and August 2023 were included. Cardiac magnetic resonance imaging (CMR) was used to assess the characteristics of myocardial infarction and microvascular obstruction (MVO), while sST2 levels were measured upon admission.Results: The median time for completion of CMR after hospitalization was 5 (4, 6) days. Multivariate regression analysis showed that sST2 (OR 1.01, 95% CI 1.01-1.02, p < 0.001), peak high-sensitivity troponin T (OR 2.40, 95% CI 1.66-3.47, p < 0.001), peak high-C-reactive protein (OR 1.01, 95% CI 1.01-1.02, p < 0.001), left ventricular ejection fraction (OR 0.93, 95% CI 0.89- 0.98, p = 0.009) and age (OR 1.03, 95% CI 1.01- 1.05, p = 0.042)were independently associated with MVO.Conclusion: sST2 is associated with MVO after pPCI in STEMI patients. Incorporating soluble ST2 (sST2) into the risk model for MVO leads to significant improvement.","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"24 1","pages":"691"},"PeriodicalIF":2.0,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inverse association between serum klotho levels and C-reactive protein levels in the US population: a cross-sectional study.

IF 2 3区医学

BMC Cardiovascular Disorders Pub Date : 2024-11-29 DOI: 10.1186/s12872-024-04375-z

Xuelan Peng, Yingjie Hu, Jiarong Xu, Ling Chen, Wei Ren, Wenzhi Cai

{"title":"Inverse association between serum klotho levels and C-reactive protein levels in the US population: a cross-sectional study.","authors":"Xuelan Peng, Yingjie Hu, Jiarong Xu, Ling Chen, Wei Ren, Wenzhi Cai","doi":"10.1186/s12872-024-04375-z","DOIUrl":"10.1186/s12872-024-04375-z","url":null,"abstract":"Background: The inverse relationship between serum Klotho levels and systemic inflammation, particularly C-reactive protein (CRP), has been suggested in limited studies. However, the association within a large and diverse population remains underexplored.Methods: We conducted a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) to investigate the association between serum Klotho levels and CRP among a nationally representative sample of the US population. Multiple linear regression analyses were performed to assess this relationship while adjusting for relevant covariates. Stratified analysis with interaction, restricted cubic splines (RCS) were employed to support the research objectives.Results: A total of 5901 participants had a mean age of 57.9 ± 11.0 years, with 49.4% of them being male and 50.6% of them being female. A negative association between serum Klotho and CRP was revealed in the fully adjusted model (β -0.26; 95% CI -0.41∼-0.11). When serum Klotho was taken as quartiles with Q1 as reference, the adjusted β that were lowest in Q4 were - 0.1 (95% CI -0.16∼-0.04, p-value = 0.002) in model 4, respectively. These statistics were robust in stratified analyses.Conclusion: While our study demonstrates an inverse association between serum Klotho levels and CRP, suggesting a potential cardioprotective role of Klotho, it is important to note that our cross-sectional design does not permit the establishment of causality. Therefore, we cannot definitively conclude that increasing Klotho levels will directly reduce cardiovascular risk. Our findings do, however, highlight the need for further research to explore the potential of Klotho as a therapeutic target for cardiovascular health.","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"24 1","pages":"687"},"PeriodicalIF":2.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11606063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel retrieving device for coronary stent dislodgement.

IF 2 3区医学

BMC Cardiovascular Disorders Pub Date : 2024-11-29 DOI: 10.1186/s12872-024-04377-x

Zhan-Ying Han, Yong-Jian Zhu, Wen-Jie Lu, Zhi-Fang Wang, Jian-Feng Yang, Wen-Cai Zhang, Chun-Guang Qiu, Jian-Zeng Dong

{"title":"Novel retrieving device for coronary stent dislodgement.","authors":"Zhan-Ying Han, Yong-Jian Zhu, Wen-Jie Lu, Zhi-Fang Wang, Jian-Feng Yang, Wen-Cai Zhang, Chun-Guang Qiu, Jian-Zeng Dong","doi":"10.1186/s12872-024-04377-x","DOIUrl":"10.1186/s12872-024-04377-x","url":null,"abstract":"Background: Stent dislodgement is a rare but particularly challenging complication. However, current treatment strategies are suboptimal.Objective: This study sought to preliminarily assess the feasibility of a novel self-expanding basket (SEB) catheter to successfully retrieve dislodged stent during percutaneous coronary intervention (PCI).Method: The novel SEB catheter is designed as a self-expanding basket tip made of superelastic shape nitinol memory alloy, which could automatically expand to tightly wrap and flatten the deformed struts regardless of whether the stent come off the guidewire. Consecutive patients with coronary artery disease who experienced stent dislodgement during PCI were included. The primary outcome was procedure success defined as completely removing the stent without surgical incision of blood vessels, or hemostatic forceps, or injury of access vessels.Results: From May 2020 to May 2023, a total of 6 patients encountering stent dislodgment were enrolled. Five presented as stent dislodgment with the guidewire in situ and the rest one as total stent and guidewire loss. Successful retrieving of dislodged stent with SEB catheter was achieved in 100% (6 of 6) subjects. After retracting lost stent, 5 of 6 patients received new stent implantation, and one only underwent balloon angioplasty with acceptable imaging results. No safety events were observed.Conclusions: This preliminary report of the novel stent retrieving device presents favorable efficacy and safety profile. Further multicenter study is required to confirm these findings.Clinical trial number: Not applicable.","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"24 1","pages":"690"},"PeriodicalIF":2.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wellen's syndrome caused by severe ostial stenosis of the left main coronary artery: a case report.

IF 2 3区医学

BMC Cardiovascular Disorders Pub Date : 2024-11-29 DOI: 10.1186/s12872-024-04365-1

Jie Tan, Xiaoxian Liao, Tao Tan, Xingyu Li, Huilong Tan

引用次数: 0

Clinical profile of dilated cardiomyopathy in children enrolled in chronic cardiac care: a decade review in a sub-Saharan African tertiary center.

IF 2 3区医学

BMC Cardiovascular Disorders Pub Date : 2024-11-29 DOI: 10.1186/s12872-024-04356-2

Henock Gashaw, Henok Tadele

{"title":"Clinical profile of dilated cardiomyopathy in children enrolled in chronic cardiac care: a decade review in a sub-Saharan African tertiary center.","authors":"Henock Gashaw, Henok Tadele","doi":"10.1186/s12872-024-04356-2","DOIUrl":"10.1186/s12872-024-04356-2","url":null,"abstract":"Background: Dilated cardiomyopathy (DCM) is a myocardial disease characterized by a dilated left ventricle (LV) and reduced LV systolic function. The clinical profile of DCM is not well studied in Africa with no reports from Ethiopia. This study aimed to describe the clinical profile of DCM and the factors associated with its clinical outcome in a tertiary center.Results: This study included 75 DCM patients, males 52%. The median age at DCM diagnosis was 18 months (Interquartile range/IQR: 7-46). The major DCM clinical presentations were cough, 84%, fast breathing, 64% and shortness of breath, 56%. The median left ventricular systolic ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) at diagnosis were 30% (IQR: 24-36) and 14% (IQR: 11-18), respectively. The majority don't have a cause labeled or documented, 81.3% while HIV and anthracycline-related DCM accounted for 6.7% each. Concerning outcomes, the majority didn't show any clinical status change or were static, 62.7% while one-third, 32%, showed improvement. The case fatality rate in this series was 5.3% [4] (95% CI: 1.47-13.1). The presence of severe acute malnutrition (wasting) at presentation, p 0.017; the latest LV systolic function (LVEF, p 0.000 and LVFS, p 0.000) and the use of enalapril, p 0.017, were associated with DCM clinical outcome.Conclusion: Boys in their second birth year were most affected by DCM. The major DCM presentations were a mix of respiratory and cardiac symptoms with severely depressed LV systolic function. Nutritional status at presentation, recent LV systolic function and enalapril use were associated with DCM clinical outcome. Timely nutritional assessment, treatment and support, and enhanced HF medical treatment are recommended to improve DCM clinical outcomes.","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"24 1","pages":"689"},"PeriodicalIF":2.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of mortality and cardiovascular complications due to COVID-19, RSV, and influenza in hospitalized children and young adults.

IF 2 3区医学

BMC Cardiovascular Disorders Pub Date : 2024-11-28 DOI: 10.1186/s12872-024-04366-0

Sagya Khanal, Bishes Khanal, Fu-Sheng Chou, Anita J Moon-Grady, Laxmi V Ghimire

{"title":"Comparison of mortality and cardiovascular complications due to COVID-19, RSV, and influenza in hospitalized children and young adults.","authors":"Sagya Khanal, Bishes Khanal, Fu-Sheng Chou, Anita J Moon-Grady, Laxmi V Ghimire","doi":"10.1186/s12872-024-04366-0","DOIUrl":"10.1186/s12872-024-04366-0","url":null,"abstract":"Background: Respiratory viruses are linked to cardiovascular complications. We aim to compare cardiovascular complications due to COVID-19, influenza and RSV.Methods: We analyzed cross-sectional data from hospitalized children and young adults (≤ 20 years) from 2020 and 2021 using National Inpatient Sample (NIS). We included individuals hospitalized for COVID-19, RSV, and influenza, and weighted data were used to compare cardiovascular complications.Results: Of 212,655 respiratory virus admissions, 85,055 were from COVID-19, 103,185 were from RSV, and 24,415 were from influenza. Myocarditis was higher in COVID-19 [0.9%, n = 740] as compared to influenza [0.2%, n = 55] and RSV [0.1%, n = 65]. In the adjusted logistic regression, the odds of myocarditis was 61% lower in influenza [aOR = 0.39 (0.20-0.76), P = 0.006], and 85% lower in RSV [aOR = 0.15 (0.07-0.34) P < 0.001] as compared to COVID-19. Bradyarrhythmias/heart block was higher in COVID-19 [0.8%, n = 690] versus influenza [0.5%, n = 110] and RSV [0.2%, n = 205]. After adjusting for confounders for bradyarrhythmias/heart block, compared to COVID-19, the odds were 49% lower in RSV [aOR = 0.51 (0.33-0.80), P = 0.004] but no statistically significant difference in influenza [aOR = 0.79 (0.48-1.31), P = 0.374] was seen. Tachyarrhythmias, sudden cardiac arrest, and in-hospital mortality showed no differences after adjusting for covariates.Conclusion: Individuals with COVID-19 infection are more likely to develop cardiovascular complications compared to influenza and RSV, highlighting the need for higher index of suspicion and prompt treatment, as well as steps to limit infection and transmission of this virus in children.","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"24 1","pages":"686"},"PeriodicalIF":2.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are socio-economic inequalities related to cardiovascular disease risk? A systematic review and meta-analysis of prospective studies. 社会经济不平等与心血管疾病风险有关吗？前瞻性研究的系统回顾和荟萃分析。

IF 2 3区医学

BMC Cardiovascular Disorders Pub Date : 2024-11-27 DOI: 10.1186/s12872-024-04248-5

Ololade J Baruwa, Federica Alberti, Sunday Onagbiye, Annalisa Guddemi, Anna Odone, Hannah Ricci, Maddalena Gaeta, Schmid Daniela, Cristian Ricci

{"title":"Are socio-economic inequalities related to cardiovascular disease risk? A systematic review and meta-analysis of prospective studies.","authors":"Ololade J Baruwa, Federica Alberti, Sunday Onagbiye, Annalisa Guddemi, Anna Odone, Hannah Ricci, Maddalena Gaeta, Schmid Daniela, Cristian Ricci","doi":"10.1186/s12872-024-04248-5","DOIUrl":"10.1186/s12872-024-04248-5","url":null,"abstract":"Purpose: The aim of this research was to investigate the relationship between socio-economic inequalities and fatal and non-fatal cardiovascular events.Methods: A systematic review of recently published cohort studies and a meta-analysis of relative risk (RR) of low compared with high socio-economic status (SES) in relation to cardiovascular incidence and mortality was conducted. Supplementary evaluations were conducted considering different proxies of SES in relation to different types of cardiovascular disease (CVD).Results: We identified 17 studies including approximately 26.5 million of participants with more than 900,000 CVD events. We estimated a 50% increased CVD risk for low SES with respect to high SES (RR = 1.49 [95% confidence interval: 1.26, 1.78]). For sex-specific risk, we estimated a 79% increased CVD risk for women of low SES (RR = 1.79 [1.30, 2.46]). In men, the same investigation found a 45% increased CVD risk (RR = 1.45 [1.09, 1.92]). We reported that low education (RR = 1.56 [1.27, 1.91]), increased CVD risk the most, more than low income (RR = 1.38 [1.12, 1.70]).Conclusion: Although not statistically significant, women of low SES were at higher CVD risk than men. CVD risk was more relevant to educational inequality than economic inequality.","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"24 1","pages":"685"},"PeriodicalIF":2.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary patterns and premature coronary artery disease: result from the Iran premature coronary artery disease (IPAD) study. 饮食模式与早发冠状动脉疾病：伊朗早发冠状动脉疾病（IPAD）研究结果。

IF 2 3区医学

BMC Cardiovascular Disorders Pub Date : 2024-11-27 DOI: 10.1186/s12872-024-04333-9

Ghazal Ghasempour Dabaghi, Ehsan Zarepur, Mehrdad Rabiee Rad, Noushin Mohammadifard, Fahimeh Haghighatdoost, Alireza Khosravi, Nahid Azdaki, Nahid Salehi, Masoud Lotfizadeh, Samad Ghaffari, Arsalan Salari, Mostafa Cheraghi, Ahmadreza Assareh, Nizal Sarrafzadegan

{"title":"Dietary patterns and premature coronary artery disease: result from the Iran premature coronary artery disease (IPAD) study.","authors":"Ghazal Ghasempour Dabaghi, Ehsan Zarepur, Mehrdad Rabiee Rad, Noushin Mohammadifard, Fahimeh Haghighatdoost, Alireza Khosravi, Nahid Azdaki, Nahid Salehi, Masoud Lotfizadeh, Samad Ghaffari, Arsalan Salari, Mostafa Cheraghi, Ahmadreza Assareh, Nizal Sarrafzadegan","doi":"10.1186/s12872-024-04333-9","DOIUrl":"10.1186/s12872-024-04333-9","url":null,"abstract":"Background: Premature coronary artery disease (PCAD) is one of the major health concerns leading to considerable death and disabilities. This study aimed to evaluate the relationship of dietary patterns with risk of PCAD.Methods: Iran premature coronary diseases (IPAD) is a case-control study consists of 3159 participants. Obstructive CAD in ≥ 75% of at least one coronary artery or ≥ 50% in the left main artery based on coronary angiography in women under 70 and men under 60 years old was considered PCAD. The habitual dietary intake of participants was collected using a semi-quantitative validated food frequency questionnaire (SFFQ). Principal Component Analysis (PCA) was used to extract dietary patterns.Results: Three main dietary patterns including healthy, Western and high-fat, high-sugar were identified. Patients categorized in the last tertile of the healthy dietary pattern had a decreased risk of PCAD (OR = 0.77, 95% CI: 0.64-0.93), while those in the top tertile of Western (OR = 2.38, 95 CI:1.97-2.86) and High-fat simple carbohydrate (HFSC) (OR = 3.10, 95% CI:2.57-3.75) diets had increased risk of PCAD.Conclusions: A healthy dietary pattern was significantly related to a decreased risk of PCAD presence, whereas Western and HFSC diets were connected to a higher risk of PCAD.","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"24 1","pages":"683"},"PeriodicalIF":2.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of gene polymorphism in ERG rs2836411 with anemia and susceptibility to aortic dissection. ERG rs2836411 基因多态性与贫血和主动脉夹层易感性的关系

IF 2 3区医学

BMC Cardiovascular Disorders Pub Date : 2024-11-27 DOI: 10.1186/s12872-024-04345-5

Ying Wang, Gaoshan Li, Fangzheng Zeng, Kunyan Li, Wenxu Pan, Mingle Zhang, Hao Yang, Jun Jin

{"title":"Association of gene polymorphism in ERG rs2836411 with anemia and susceptibility to aortic dissection.","authors":"Ying Wang, Gaoshan Li, Fangzheng Zeng, Kunyan Li, Wenxu Pan, Mingle Zhang, Hao Yang, Jun Jin","doi":"10.1186/s12872-024-04345-5","DOIUrl":"10.1186/s12872-024-04345-5","url":null,"abstract":"Background: The erythroblast transformation-specific related gene (ERG) is expressed in hematopoietic stem and progenitor cells and endothelial cells. This study aimed to investigate if ERG rs2836411 is a novel genetic locus associated with anemia and aortic dissection (AD).Method: A case-control trial was conducted to evaluate the association between ERG rs2836411 polymorphism, anemia, and AD risk. The ERG rs2836411 polymorphism was analyzed using Sanger dideoxy chain termination sequencing on genomic DNA extracted from whole blood. Serum erythropoietin (EPO) and interleukin-6 (IL-6) concentrations were measured by enzyme-linked immunosorbent assay (ELISA).Results: 119 preoperative AD patients and 119 healthy controls were enrolled, with age and sex matched. Anemia was found independently associated with AD presence (Odds ratio (OR) 20.82, p < 0.001). Remarkably, T carriers (CT + TT) of ERG rs2836411 were associated with anemia in AD patients (OR 2.81, p = 0.013) but not in controls. After adjusting for conventional risk factors including age, sex, smoking and hypertension status, T carriers (CT + TT) were independently associated with AD presence (OR 2.20, p = 0.015), but were not associated if anemia was further adjusted. While EPO concentration was higher in AD patients and was associated with AD presence (OR 1.09, p = 0.006), no difference in EPO levels was observed between the ERG genotypes of AD patients.Conclusions: T carriers (CT + TT) of ERG rs2836411 are independently associated with anemia and AD presence. The association between ERG rs2836411 polymorphism and susceptibility to AD may be mediated by anemia. Further studies are warranted to validate whether this association is causal.","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"24 1","pages":"682"},"PeriodicalIF":2.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0