BMC Cardiovascular Disorders最新文献

{"title":"Cardio-renal dysfunction in prediabetes and early type 2 diabetes: insights from myocardial strain and renal Doppler assessment.","authors":"Ahmed Atef, Ahmed Fayed, Hemmat El-Haddad, Moataz Fathy, Heba El Deeb","doi":"10.1186/s12872-026-06661-4","DOIUrl":"https://doi.org/10.1186/s12872-026-06661-4","url":null,"abstract":"<p><strong>Background: </strong>Prediabetes and early type 2 diabetes mellitus (T2DM) may be accompanied by subclinical cardiac and renal injury before overt disease appears. This study evaluated early cardio-renal dysfunction in prediabetes and early T2DM using myocardial strain imaging and renal Doppler assessment.</p><p><strong>Methods: </strong>This cross-sectional study included 180 participants: 60 with prediabetes, 60 with newly diagnosed T2DM (≤ 2 years), and 60 age- and sex-matched healthy controls. Conventional echocardiography and two-dimensional speckle-tracking echocardiography were used to assess left ventricular (LV) function and left atrial (LA) mechanics. Renal vascular resistance was assessed using the Doppler-derived renal resistive index (RRI) and pulsatility index (PI). Glycemic status and albuminuria were evaluated using fasting glucose, oral glucose tolerance testing, HbA1c, and urine albumin-to-creatinine ratio.</p><p><strong>Results: </strong>Compared with controls, participants with prediabetes and T2DM showed early alterations in LV relaxation/filling indices and reduced LA strain. LV ejection fraction was modestly lower, while GLS became progressively less negative across the dysglycemic groups (p < 0.001), consistent with reduced longitudinal myocardial deformation. Renal resistive index (RRI) and pulsatility index (PI) were significantly increased in the dysglycemic groups. RRI correlated positively with E/e', linking higher renal vascular resistance with higher estimated LV filling pressure (r = 0.440, p < 0.001).</p><p><strong>Conclusions: </strong>Prediabetes and early T2DM were associated with subclinical abnormalities in myocardial mechanics and renal vascular indices despite preserved conventional cardiac and renal function. Myocardial strain and renal Doppler measures may provide complementary phenotypic information, but prospective validation is required before routine clinical application.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"26 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Discriminating established cardiovascular disease using a novel multiterritory ultrasound plaque burden measure (wTPT): findings from the P-SONAR study.","authors":"Gunnar Austad, Jonn Terje Geitung, Owen Thomas, Serena Tonstad","doi":"10.1186/s12872-026-06711-x","DOIUrl":"https://doi.org/10.1186/s12872-026-06711-x","url":null,"abstract":"","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"26 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149103976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The p.Arg52Leu variant in GNB2 causes a gain-of-function due to an increase of I_{K, ACh} in stimulated hiPSC-CMs.","authors":"Arie O Verkerk, Anne Kayser, Jassin Hamidi, Sven Dittmann, Eric Schulze-Bahr","doi":"10.1186/s12872-026-06735-3","DOIUrl":"10.1186/s12872-026-06735-3","url":null,"abstract":"<p><strong>Background: </strong>Initially discovered and published in 2017, the heterozygous mutation (p.Arg52Leu) in the GNB2 gene is associated with sinus node dysfunction (SND) and atrioventricular block (AVB). Electrophysiological characterization using heterologous expression systems has demonstrated that this R52L GNB2 variant results in a larger G-protein-activated K⁺ (GIRK/I_{K, ACh}) current. So far, this has not been functionally validated in patient-derived disease modelling using human induced pluripotent stem cell-derived cardiomyocytes (CM).</p><p><strong>Methods: </strong>Here, we differentiated CMs derived from human induced pluripotent stem cells (hiPSC-CMs) of a patient carrying the pathogenic p.Arg52Leu GNB2 variant (hiPSC^R52L-CMs) and compared electrophysiological properties with those of two unrelated healthy hiPSC-CMs control lines. Retinoic acid (RA) treatment during the differentiation was used to generate hiPSC-CMs with robust acetylcholine-activated K⁺ currents (I_{K, ACh}).</p><p><strong>Results: </strong>Patch-clamp experiments demonstrated that without GIRK channel stimulation the maximal diastolic potential (MDP) and spontaneous pacing rate did not differ between mutant and control cell lines and, moreover, a constitutively active I_{K, ACh} was not observed. Upon stimulation of GIRK channels with carbachol (CCh), hiPSC^R52L-CMs displayed an increased I_{K, ACh} density, a more hyperpolarized MDP and a slower spontaneous activity as compared to both control hiPSC-CMs cell lines, thus explaining the bradycardia reported from patients carrying the R52L GNB2 variant. Application of the specific I_{K, ACh} blocker XAF-1407 rescued the phenotype.</p><p><strong>Conclusion: </strong>The reported, mutant GNB2 in patient-derived CMs is associated with a gain-of function upon GIRK channel stimulation and thereby a larger I_{K, ACh}, which could be potentially targeted and rescued by I_{K, ACh} blockers.</p><p><strong>Clinical trial number: </strong>not applicable.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"26 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The merits of the prognostic nutritional index and neutrophil-to-lymphocyte ratio in predicting outcomes of coronary artery bypass grafting: a retrospective cohort study.","authors":"Mohammed Ahmed Elgazzar, Basma Mohamed Hani, Abdelhamid Fathi Ali, Mahmoud Ahmed Elshafie, Ashraf Moustafa Elnahas","doi":"10.1186/s12872-026-06634-7","DOIUrl":"10.1186/s12872-026-06634-7","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery bypass grafting (CABG) carries a risk for serious adverse events. The Prognostic Nutritional Index (PNI) and Neutrophil-to-Lymphocyte Ratio (NLR), are simple measures of nutritional and inflammatory statuses, have been proposed as a potential predictor of postoperative outcomes. This study aimed to assess the predictive performance of preoperative PNI and NLR and their dynamic changes for post-CABG outcomes.</p><p><strong>Methods and materials: </strong>The study investigated the medical records of 327 patients who underwent CABG between February 20, 2020, and February 19, 2025.</p><p><strong>Results: </strong>The overall complication and mortality rates were 15%, and 3.36% respectively. The preoperative PNI decreased significantly (P1 < 0.001) at 24-h postoperative and at the time of discharge. At the time of discharge, the mean PNI value increased significantly (P2 < 0.001) compared to that determined at 24-h postoperative. The magnitude of ∆PNI at discharge was significantly smaller than that at 24-h postoperatively (P3 < 0.001). Multivariate binary logistic regression identified preoperative PNI as an independent predictor of 1-month mortality, while ΔPNI at 24 h was independently associated with 1-month mortality.</p><p><strong>Conclusion and recommendations: </strong>PNI is a simple and inexpensive marker that may serve as a potential predictor of short-term outcomes after CABG. Lower preoperative PNI and greater early postoperative PNI decline were associated with adverse short-term outcomes after CABG, whereas preoperative NLR did not retain independent significance after multivariable adjustment; however, further prospective multicenter studies are required to confirm these findings.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"26 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-omics profiling reveals coordinated metabolic and immuno-inflammatory remodeling in a high-fat diet and single-dose streptozotocin-induced mouse model of diabetic cardiomyopathy.","authors":"Feng Zhang, Chunbo Ai, Hao Zhang, Xiaoqiang Sun, Li Wang, Chao Li, Wei Cai, Xuemei Yin, Yanxin Wang, Yanwei Li, Chengzhi Lu, Zhuqing Li","doi":"10.1186/s12872-026-06682-z","DOIUrl":"10.1186/s12872-026-06682-z","url":null,"abstract":"<p><strong>Background: </strong>Diabetic cardiomyopathy (DCM) is a major myocardial complication of type 2 diabetes and a contributor to heart failure. However, coordinated remodeling across the cardiac transcriptome, proteome and metabolome in DCM remains incompletely defined.</p><p><strong>Methods: </strong>Type 2 diabetes was induced in mice by a high-fat diet combined with single-dose streptozotocin. DCM was characterized by echocardiography, histology, transmission electron microscopy, and systemic metabolic and inflammatory assessments. Left ventricular myocardium underwent RNA sequencing, quantitative proteomics and untargeted metabolomics, followed by integrated pathway and network analyses. Selected pathways were further examined by biochemical assays, with additional evaluation of mitochondrial injury and cGAS-STING signaling.</p><p><strong>Results: </strong>Diabetic mice developed systolic and diastolic dysfunction with ventricular remodeling, interstitial fibrosis, mitochondrial ultrastructural damage, insulin resistance, and heightened systemic and myocardial inflammation. Transcriptomic and proteomic profiling revealed concordant suppression of sarcomeric organization, calcium handling, and mitochondrial oxidative metabolism, indicating downregulation of a contraction-calcium-mitochondrial energetics axis. Metabolomics showed reduced pyruvate-linked intermediates and enrichment of pentose phosphate, nucleotide and glutathione-related metabolites, consistent with diversion of central carbon flux from mitochondrial oxidation toward redox and biosynthetic programs. Across all three omics layers, phospholipid-choline metabolism emerged as a remodeled hub connecting central carbon pathways with complement, cell adhesion and inflammatory signaling. Increased cGAS-STING activity in DCM myocardium further linked mitochondrial injury to innate immune activation.</p><p><strong>Conclusions: </strong>Integrated multi-omics analysis reveals coordinated remodeling across mitochondrial function, metabolism, inflammation, and fibrosis in experimental DCM. Alterations in phospholipid-choline metabolism, pentose phosphate and central carbon pathways, cGAS-STING signaling, and the contraction-calcium-mitochondrial module were concurrently observed and collectively characterize the molecular landscape of diabetic cardiomyopathy. These findings provide a framework for future mechanistic studies and may help identify candidate biomarkers and potential therapeutic pathways for further investigation.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"26 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in the management of cardiogenic shock complicating acute myocardial infarction: a questionnaire survey in Beijing.","authors":"Yidan Ren, Yuwei Liu, Yaxin Xie, Chenxu Zhao, Xiaqiu Tian, Liangshan Wang, Zhongtao Du, Xing Hao, Chenglong Li, Xiaotong Hou, Hong Wang","doi":"10.1186/s12872-026-06287-6","DOIUrl":"10.1186/s12872-026-06287-6","url":null,"abstract":"<p><strong>Objective: </strong>To investigate disparities in the management of cardiogenic shock complicating acute myocardial infarction (AMI-CS) across different hospital levels in Beijing.</p><p><strong>Methods: </strong>A standardized questionnaire was electronically distributed to 61 hospitals through the Beijing Cardiovascular Internal Medicine Quality Control and Improvement Center and the Beijing Extracorporeal Life Support Quality Control and Improvement Center. A multistage sampling method was also used to survey hospitals in eight Beijing districts that were not included in these quality control networks. Hospitals were categorized as Level 1 hospitals, Level 2 hospitals, or Level 3 hospitals according to international standards and the domestic context.</p><p><strong>Results: </strong>A total of 142 hospitals were analyzed. All participating hospitals were capable of managing cardiovascular diseases. 33.1% of hospitals did not have percutaneous coronary intervention (PCI) capability; 40.8% provided only intra-aortic balloon pump and PCI, whereas 26.0% offered temporary or durable mechanical circulatory support. Level 3 hospitals often lacked established protocols for AMI-CS management. Level 1 hospitals (59.4%) and Level 2 hospitals (56.5%) were more likely to maintain a minimum mean arterial pressure target of 65 mmHg, whereas Level 3 hospitals more commonly accepted a lower target (45.5%). Pulmonary artery catheter monitoring was infrequently used across all hospital levels. Continuous lactate monitoring also differed significantly (Level 3, 39.1% vs. Level 2, 74.6% vs. Level 1, 84.4%; overall p < 0.001). Among the 61 hospitals participating in the quality control network, only 3.6% adopted the Society for Cardiovascular Angiography and Interventions shock stage classification. Shock teams were available in 71.9% of Level 1 hospitals and 44.4% of Level 2 hospitals. Furthermore, only 31.9% of Level 3 hospitals had established referral networks.</p><p><strong>Conclusion: </strong>Significant disparities exist in the diagnosis and management of AMI-CS across different hospital levels in Beijing. There is an urgent need to enhance the understanding and management of AMI-CS, especially in Level 2 and Level 3 hospitals.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"26 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13613741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left-sided 3D totally endoscopic mitral valve repair guided by left atrial appendage orientation in situs inversus totalis with mirror-image dextrocardia: a case report.","authors":"Qiuji Wang, Dagang Li, Gengliang Qin, Yalin Liao, Ping Zhao, Xu Chen, Ruiguo Qiao, Biru Zeng, Yueer Chen, Gangbing Ding, Xiaohua Liu, Hanwei Li, Bobo Shi, Xiaoxuan Lin, Daiqiang Huang, Zhaoxu Gai, Miao Xu, Qijun Zheng, Chunying Meng","doi":"10.1186/s12872-026-06277-8","DOIUrl":"10.1186/s12872-026-06277-8","url":null,"abstract":"<p><strong>Background: </strong>Situs inversus totalis with mirror-image dextrocardia is a rare anatomical condition that creates specific challenges for minimally invasive mitral valve surgery. In totally endoscopic procedures, the reversed cardiac orientation may affect thoracic access, peripheral cannulation, left atrial exposure and accurate identification of mitral valve segments. We report a case of left-sided three-dimensional totally endoscopic mitral valve repair in this setting, with emphasis on operative planning and intraoperative segment orientation.</p><p><strong>Case presentation: </strong>A 39-year-old woman presented with progressive exertional dyspnea and New York Heart Association class II to III symptoms. Echocardiography showed severe mitral regurgitation caused by posterior leaflet prolapse involving P2 and extending toward P3. Computed tomography angiography confirmed situs inversus totalis, mirror-image dextrocardia, a right-sided aortic arch, bilateral superior vena cavae and an uninterrupted inferior vena cava. A left-sided three-dimensional totally endoscopic approach was used with peripheral cardiopulmonary bypass through the left femoral vessels and supplemental left internal jugular venous drainage. Intraoperative segment orientation was deliberately re-established using the left atrial appendage as a fixed landmark to identify the A1/P1 side and distinguish it from A3/P3. Valve repair consisted of neochordal implantation to the prolapsing posterior leaflet and ring annuloplasty. Intraoperative transesophageal echocardiography, predischarge transthoracic echocardiography and 1-month follow-up transthoracic echocardiography showed no residual or recurrent mitral regurgitation, with preserved left ventricular systolic function at follow-up.</p><p><strong>Conclusions: </strong>This case illustrates that valve-preserving, totally endoscopic mitral repair can be feasible in situs inversus totalis with mirror-image dextrocardia when imaging, cannulation, access and segment orientation are planned as a single operative strategy. The main educational message is that, in this case, the left atrial appendage served as a practical anatomical reference for maintaining segmental orientation during mitral repair in mirror-image anatomy.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"26 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13613623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the triglyceride-glucose-body mass index and the risk of early vascular aging in young and middle-aged Chinese adults: a cross-sectional study.","authors":"Chaomin Kong, Caixia Lyu, Wenjin Lu, Xuedong Bai, Hongyang Dong, Feifei Zhang, Lixia Yao, Shuchun Chen","doi":"10.1186/s12872-026-06239-0","DOIUrl":"10.1186/s12872-026-06239-0","url":null,"abstract":"<p><strong>Background: </strong>Early vascular aging (EVA) reflects accelerated arterial aging and is increasingly recognized as an important precursor of cardiovascular disease (CVD). Insulin resistance (IR) has been implicated in the pathogenesis of vascular aging. The triglyceride-glucose-body mass index (TyG-BMI), a surrogate marker of IR, has demonstrated predictive value for several cardiometabolic disorders. However, evidence regarding its association with EVA remains limited.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 1,272 Chinese adults aged 30 ~ 59 years who completed brachial-ankle pulse wave velocity (baPWV) measurement. EVA was defined as a baPWV value above the 90th percentile in the corresponding 10-year age group. Multivariable logistic regression models were applied to assess the association between TyG-BMI and EVA. Restricted cubic spline (RCS) analysis was conducted to explore the potential nonlinear relationship. Additional analyses further examined the associations of TyG-BMI with baPWV and Framingham risk score (FRS)-derived indicators. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive ability of TyG-BMI for EVA.</p><p><strong>Results: </strong>After full adjustment, each 10-unit increase in TyG-BMI was associated with a 14.9% increased risk of EVA (odds ratio [OR] 1.149, 95% confidence interval [CI] 1.083~1.231). RCS analysis revealed a nonlinear association between TyG-BMI and EVA, with a turning point at a TyG-BMI value of 210.98. TyG-BMI also showed a nonlinear association with baPWV and FRS-derived indicators (predicted vascular age, age gap, and predicted 10-year CVD risk). In the fully adjusted model incorporating TyG-BMI, the area under the curve (AUC) for identifying EVA was 0.8533.</p><p><strong>Conclusions: </strong>This cross-sectional study demonstrated that TyG-BMI was independently and nonlinearly associated with EVA among young and middle-aged Chinese adults. The observed turning point suggests a potential reference point for this association. These findings suggest that TyG-BMI may serve as a simple, readily accessible indicator for assessing EVA risk in this population, pending external validation.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"26 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13613587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Sjögren's syndrome-associated fulminant myocarditis presenting as cardiogenic shock requiring VA-ECMO: a case report.","authors":"Thanh Hoa Tran, Quoc Thang Le, Thao My Doan Ai, Sinh Hien Nguyen","doi":"10.1186/s12872-026-06700-0","DOIUrl":"10.1186/s12872-026-06700-0","url":null,"abstract":"","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"26 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Native myocardial T1 mapping using rapid 1.5T T1FLASH and T1 MOLLI during breath-hold and free-breathing.","authors":"Lena Maria Röwer, Yara Hussen-Demir, Pablo Emilio Verde, Dirk Voit, Jens Frahm, Gerald Antoch, Dirk Klee, Frank Pillekamp","doi":"10.1186/s12872-026-06687-8","DOIUrl":"10.1186/s12872-026-06687-8","url":null,"abstract":"<p><strong>Background: </strong>Quantitative myocardial T1 mapping is an established technique in cardiovascular magnetic resonance (CMR). However, conventional T1 mapping requires relatively long breath-holds (BH), which may lead to breathing artifacts and reduced image quality in patients with limited BH capacity. The T1 fast low angle shot (T1FLASH) sequence enables myocardial T1 mapping with shorter BH durations.</p><p><strong>Methods: </strong>In this prospective study, 14 healthy adult volunteers (8 female; mean age 27 ± 4 years) underwent myocardial T1 mapping at 1.5 T using modified Look-Locker inversion recovery with motion correction (T1 MOLLI MOCO) and rapid T1FLASH. Both sequences were acquired during BH and free breathing (FB). Global and segmental myocardial T1 values and image quality were assessed. Interrater, intrarater, and interstudy reproducibility were evaluated. Comfort was assessed using a questionnaire. Statistical analysis included the Shapiro-Wilk test, paired t-test, Pearson correlation, Bland-Altman analysis, intraclass correlation coefficient, Wilcoxon signed-rank test, and Spearman rank correlation (p < 0.05).</p><p><strong>Results: </strong>BH duration was significantly shorter with rapid T1FLASH compared with T1 MOLLI MOCO (3-4 s vs. 12-14 s), and participant comfort was higher with rapid T1FLASH (p < 0.05). During BH, global myocardial T1 values were significantly higher with rapid T1FLASH (1030 ± 35 ms) than with T1 MOLLI MOCO (1000 ± 26 ms; p < 0.01). The slightly increased variability observed with rapid T1FLASH remained below diagnostically relevant thresholds (4% error margin). Both techniques showed moderate-to-good correlation for global T1 values (r = 0.63; p < 0.01). Rapid T1FLASH demonstrated good image quality that was comparable for clinical interpretation during BH, although T1 MOLLI MOCO received slightly higher qualitative image scores. During FB, variability of global and segmental T1 measurements increased significantly, with apical segments being more and AHA segments 2 (basal anteroseptal), 5 (basal inferolateral), 8 (mid anteroseptal), 11 (mid inferolateral) less affected by respiratory artifacts. Interrater, intrarater, and interstudy reproducibility were good to excellent.</p><p><strong>Conclusions: </strong>Rapid T1FLASH demonstrated good agreement with conventional T1 MOLLI MOCO and reproducible myocardial T1 measurements, with substantially reduced BH duration while maintaining good image quality. These findings support further evaluation of rapid T1FLASH as an alternative T1 mapping approach in patients with limited BH capacity. Conventional T1 MOLLI MOCO remains the preferred technique when adequate BH can be achieved.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"26 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13613673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}