BMC Cardiovascular Disorders最新文献

{"title":"Determinants of readmission amongst hospitalized patients with heart failure in Ghana and Nigeria: a prospective cohort study.","authors":"Dzifa Ahadzi, Amudalat Issa, Odalys Rivera Hernandez, Olutobi Adekunle Sanuade, Mohammed Baba Abdulkadir, Ernest Yorke, Bamidele Tayo","doi":"10.1186/s12872-025-04858-7","DOIUrl":"https://doi.org/10.1186/s12872-025-04858-7","url":null,"abstract":"<p><strong>Background: </strong>Readmission following hospitalization for acute heart failure (HF) is an adverse prognostic event. Readmission rates for HF in African countries are variable, ranging from 1.53 to 25% in the first 30 days, and 12.2% to over 50% at 180 days. Few studies done in the African region have identified several determinants of HF readmission including New York Heart Association functional class, heart failure phenotype, older age, amongst others. This study sought to explore determinants of readmission amongst a contemporary cohort of adult patients hospitalized with HF in Ghana and Nigeria.</p><p><strong>Methods: </strong>This was a multicenter prospective cohort study, with 30- and 90-day follow-up after recruitment, conducted from June 2021 to April 2022, in two tertiary teaching hospitals in Ghana and Nigeria. A total of 201 adult patients who presented with acute heart failure at the two study sites were consecutively enrolled.</p><p><strong>Results: </strong>In this cohort of 201 patients (mean age (SD) 58.8 (15.6) years, 44.3% women), 8.0% and 13.9% were readmitted at 30- and 90-days, respectively. The odds of readmission at 30-days were higher in participants from Nigeria (OR = 4.3, 95% CI - 0.02-0.75, p = 0.039) and those with duration of heart failure diagnosis of 1 month to < 1 year (sub-acute HF) (OR = 4.0, 95% CI - -0.00-0.27, p = 0.045). Every unit increase in pulse rate was associated with almost 5-fold higher odds of readmission at 30-days (OR = 4.7, 95% CI - 0.00-0.01, p = 0.031). The odds of 90-day readmission were higher in participants with New York Heart Association functional class III-IV at discharge (OR = 5.1, 95% CI - -0.03-0.42, p = 0.025).</p><p><strong>Conclusion: </strong>Heart failure patients with sub-acute HF, higher pulse rates at baseline and higher NYHA functional class at discharge, may represent a vulnerable group at high risk of readmission in Ghana and Nigeria. Future studies should explore the mechanisms underlying this observation and consider interventions to reduce the risk of readmission amongst this unique patient population.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"406"},"PeriodicalIF":2.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The important role of preoperative ultrasound in the efficacy and safety of coronary intervention via distal transradial access.","authors":"Tao Chen, Lamei Li, Anni Yang, Xinyu Fan, Ganwei Shi, Feng Li, Gaojun Cai","doi":"10.1186/s12872-025-04861-y","DOIUrl":"https://doi.org/10.1186/s12872-025-04861-y","url":null,"abstract":"<p><strong>Background: </strong>The optimal inner diameter for enhancing the success rate of distal radial artery (DRA) puncture has not been documented. The aim of this study was to explore the appropriate inner diameter of DRA to increase the success rate of puncture and reduce vascular complications.</p><p><strong>Methods: </strong>This is a retrospective study. A receiver operating characteristic (ROC) curve was plotted to predict the DRA inner diameter for puncture success. The operative efficacy and safety were compared between groups with different DRA inner diameters, grouped according to the cut-off value.</p><p><strong>Results: </strong>A total of 670 patients were included in the study. The DRA inner diameter had a significant predictive value (AUC = 0.718) for puncture success, with a cut-off value of 1.95 mm. The puncture success rate was significantly lower in the DRA inner diameter < 2.0 mm group than in the DRA inner diameter ≥ 2.0 mm group (93.1% vs. 98.2%, P = 0.001). Twenty-five (3.7%) developed distal radial artery occlusion (dRAO) after the operation, including 15 dRAO without proximal radial artery occlusion (pRAO) and 10 dRAO with pRAO. The incidence of dRAO with pRAO was significantly greater in the DRA inner diameter < 2.0 mm subgroup than in the DRA inner diameter ≥ 2.0 mm subgroup (2.8% vs. 0.5%, P = 0.041).</p><p><strong>Conclusions: </strong>The success rate of puncture was lower in patients with DRA inner diameter < 2.0 mm, whereas the incidence of dRAO with pRAO was higher.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"404"},"PeriodicalIF":2.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous balloon pulmonary valvuloplasty in children: a 10-Year retrospective follow-up study in resource-limited settings.","authors":"Mohammed Nasir, Kefelegn Dejene, Mohammed Bedru, Sura Markos","doi":"10.1186/s12872-025-04881-8","DOIUrl":"https://doi.org/10.1186/s12872-025-04881-8","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous balloon pulmonary valvuloplasty (BPV) is the preferred treatment for pulmonary valve stenosis owing to its effectiveness and safety in patients with appropriate valves. However, there is a lack of research on the immediate and midterm results in developing nations. Thus, this study aimed to evaluate the immediate and midterm outcomes of patients who underwent BPV at the Cardiac Center of Ethiopia.</p><p><strong>Methodology: </strong>A follow-up study was conducted from April 2023 to August 2023 using retrospective chart reviews and phone interviews involving 138 patients aged ≤ 18 years who underwent balloon BPV for moderate to severe pulmonary stenosis (defined as peak pulmonary valvular gradient ≥ 50 mmHg) at the Cardiac Center of Ethiopia between January 2012 and March 2023. The study's primary objective was to assess the procedure's immediate success and mid-term outcomes. The study employed various statistical tests, including a multivariable logistic regression model, to identify predictors of the development of moderate to severe pulmonary regurgitation and restenosis.</p><p><strong>Results: </strong>The patients' median age was 3.95 years (1.5-13 years), with a female to male ratio 1.6. Following BPV, there was a significant decrease in the median peak pulmonary trans-valvular gradient from 106 mmHg to 40 mmHg (p < 0.001). The immediate success rate was 71%, with post-procedural complications at 4.3%. In a median follow-up of 114 months (IQR 72-132 months), 34.1% developed moderate to severe PR, and restenosis occurred in 24.4%. High balloon annulus ratio predicted moderate to severe PR, while dysplastic or complex pulmonary valve, high pre-procedural and immediate post-procedural peak gradients, and high pre-procedural left ventricular systolic pressure predicted restenosis.</p><p><strong>Conclusion: </strong>Most patients typically achieve initial success following BPV at our center. However, it is not unusual for moderate to severe pulmonary regurgitation and restenosis to develop during follow-up. As such, this study underscores the significance of thorough follow-up care for patients who underwent BPV to promptly detect and address potential complications.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"402"},"PeriodicalIF":2.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between triglyceride glucose-waist to height ratio (TyG-WHtR) and hypertension in adults aged 18-60: a cross-sectional study.","authors":"Junwei Huang, Jinzao Chen, Guoyan Pan, Liping Zheng, Jinri Weng, Chunfa Weng, Jianbin Chen, Bin Lin, Zhiwei Wu, Lixian Lin","doi":"10.1186/s12872-025-04853-y","DOIUrl":"https://doi.org/10.1186/s12872-025-04853-y","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to explore the association between TyG and the prevalence of hypertension in US adults aged 18-60.</p><p><strong>Method: </strong>Data was obtained from the National Health and Nutrition Examination Survey (NHANES) covering the circles from 2009 to 2018, involving 12,309 adults aged 18 to 60. The biomarkers studied in this article included weight, body mass index (BMI), waist circumference (WC), weight-adjusted waist index (WWI), waist-to-height ratio (WHtR), triglyceride-glucose index (TyG), triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist circumference (TyG-WC), triglyceride glucose-weight (TyG-Weight), and triglyceride glucose-waist to height ratio (TyG-WHtR). Participants were categorized into a non-Hypertension group (n = 7,076) and a Hypertension group (n = 5,233). A weighted multiple logistic regression model was employed to evaluate the association between biomarkers and hypertension. Restricted cubic splines (RCS) were utilized to examine the non-linear association between biomarkers and the risk of developing hypertension. Threshold effect analysis was used to determine the inflection point. Receiver operating characteristic (ROC) curves were generated to assess the predictive performance of biomarkers for hypertension. Additionally, subgroup and interaction analyses were conducted to confirm the reliability of the associations observed.</p><p><strong>Result: </strong>Our analysis revealed that after adjusting for multiple variables, the risk of hypertension increased by 12% for each unit increase in TyG-WHtR (P < 0.001). The RCS results showed a positive nonlinear association between TyG-WHtR and hypertension, with an inflection point of 5.79. Similar associations were also observed with WWI, WHtR, and TyG. The ROC curve analysis demonstrated that TyG-WHtR had the best predictive performance for hypertension (AUC: 0.6946, 95% CI: 0.6853-0.7039, Cut-off Value: 4.831, all P for comparison < 0.001). Subgroup analysis revealed that the association between TyG-WHtR and hypertension remains robust (all P for interaction > 0.05).</p><p><strong>Conclusion: </strong>There is a significant association between WWI, WHtR, TyG, and TyG-WHtR with hypertension in American adults aged 18 to 60, with TyG-WHtR demonstrating the best predicted performance.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"403"},"PeriodicalIF":2.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global cardiovascular disease burden attributable to particulate matter pollution, 1990-2021: an analysis of the global burden of disease study 2021 and forecast to 2045.","authors":"Yangyu Zhao, Xinyue Yang, Yanyan Du, Lei Chen, Jiayang Dong, Tenglong Hu, Na Sun, Qiang Sun, Wenyan Liang, Xiqing Wei, Zhiqiang Zhang","doi":"10.1186/s12872-025-04724-6","DOIUrl":"10.1186/s12872-025-04724-6","url":null,"abstract":"<p><strong>Aims: </strong>This study aims to analyze the global trends and projected burden of cardiovascular diseases (CVD) attributable to particulate matter (PM) pollution. The objectives are to assess spatiotemporal trends, socio-demographic variations, and gender differences and to forecast the future burden using data from the Global Burden of Disease (GBD) 2021 study.</p><p><strong>Methods: </strong>We utilized data from GBD 2021 to evaluate age-standardized mortality rates (ASMR) and disability-adjusted life years (DALYs) of CVD attributable to PM from 1990 to 2021. Age-period-cohort models and Joinpoint regression analysis were employed to evaluate temporal trends. The Bayesian age-period-cohort (BAPC) model, which incorporates prior information to improve prediction stability, was selected to project the future burden up to 2045 due to its robustness in handling long-term epidemiological trends.</p><p><strong>Results: </strong>Between 1990 and 2021, global number of deaths and DALYs for CVD attributed to PM increased by 91.68% and 78.89%, respectively. Despite these increases, ASMR and age-standardized DALYs rates declined significantly, especially among females. The burden disproportionately affected low- and middle- Socio-demographic Index (SDI) regions, with significant gender and age differences. The elderly population and regions with lower SDI will bear the greater burden. Predictions indicate that by 2045, the number of deaths and DALYs will increase by approximately three times, with females experiencing a more pronounced rise.</p><p><strong>Conclusion: </strong>The study emphasizes that despite improvements in age-standardized rates, the global burden of CVD attributable to PM has significantly increased. Due to population aging, uneven regional progress, and persistent exposure to PM, targeted intervention measures and enhanced air quality regulations are needed to reduce future health impacts. These findings provide critical insights for global health policies and strategies.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"401"},"PeriodicalIF":2.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical factors associated with severe coronary stenosis in patients undergoing cardiac surgery.","authors":"Rui Wang, Wei Gao, Xinyu Che, Ruopei Shen, Chunfeng Dai, Yan Xia, Ao Chen, Danbo Lu, Jiaqi Ma, Hungju Chen, Chenguang Li, Zhangwei Chen, Juying Qian, Junbo Ge","doi":"10.1186/s12872-025-04835-0","DOIUrl":"10.1186/s12872-025-04835-0","url":null,"abstract":"<p><strong>Background: </strong>Many cardiovascular patients undergoing valve surgeries require coronary angiography (CAG). Positive results may lead to bypass surgery, while negative results require no treatment. Although informative, CAG is costly and exposes patients to significant radiation. This study aimed to develop a model to reduce unnecessary procedures.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on 5,086 patients who underwent valve repair/replacement or other cardiac surgeries at Zhongshan Hospital between 2016 and 2021 and received CAG. Patients treated between 2016 and 2020 formed the training set, while those treated in 2021 constituted the validation set. Severe coronary stenosis was defined as a ≥ 50% reduction in luminal diameter. Logistic regression analysis identified independent predictors in the training set, and a scoring system (Coronary Angiography Positivity Prediction Score) was constructed based on the β-coefficients of each variable. The model was evaluated for discrimination and calibration.</p><p><strong>Results: </strong>Among 4,049 patients, 536 (13.2%) had severe coronary stenosis. Independent predictors included age ≥ 60 years, male sex, hypertension, diabetes, hyperlipidemia, and left ventricular ejection fraction ≤ 58%. The scoring system ranged from 0 to 11 points and demonstrated good discrimination, with an area under the receiver operating characteristic curve of 0.715 (95% confidence interval: 0.694-0.740) in the training set. In the high-risk group (≥ 6 points), the probability of severe coronary stenosis was 23.1%, compared to 8% in the low-risk group (< 6 points). The scoring system also performed well in the validation set with the curve of 0.740 (95% CI, 0.695-0.784).</p><p><strong>Conclusion: </strong>We developed and validated a scoring system based on six clinical variables to predict severe coronary stenosis in patients undergoing valve surgeries. This tool may help optimize individual treatment strategies and reduce unnecessary CAG procedures.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"395"},"PeriodicalIF":2.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of hemoglobin to serum creatinine ratio in ST-elevation myocardial infarction: a secondary analysis based on a cohort study.","authors":"Weibiao Ji, Yangbo Chen, Haoyue Zhou, Weipeng Huang, Shangbo Xu","doi":"10.1186/s12872-025-04856-9","DOIUrl":"10.1186/s12872-025-04856-9","url":null,"abstract":"<p><strong>Introduction: </strong>The long-term relationship between hemoglobin to serum creatinine (HB/SCr) ratio and clinical outcomes in ST-elevation myocardial infarction (STEMI) remains uncertain. This study aimed to determine the predictive value of the HB/SCr ratio for long-term major adverse cardiovascular events (MACE) in patients with STEMI.</p><p><strong>Methods: </strong>This study was based on a prospective cohort conducted in China, which included 460 STEMI patients who successfully underwent primary percutaneous coronary intervention. Cox proportional hazards models were utilized to explore the relationship between the HB/SCr ratio and MACE in STEMI patients over a 30-month follow-up period. The predictive value of the HB/SCr ratio for MACE was assessed using the receiver operating characteristic curve.</p><p><strong>Results: </strong>A total of 118 patients (26%) developed MACE during the follow-up period. After adjusting for confounding factors, a lower HB/SCr ratio emerged as a significant predictor of MACE in STEMI patients. Subgroup analyses indicated that the HB/SCr ratio was inversely associated with MACE in patients aged ≥ 60 years, males, those with a history of hypertension, individuals experiencing anterior wall myocardial infarction, patients classified as Killip grade I, and those receiving single stent implantation. Sensitivity analysis revealed that the inverse association between the HB/SCr ratio and MACE occurrence persisted in patients with normal hemoglobin levels. The area under the curve for the HB/SCr ratio in predicting MACE was 0.611.</p><p><strong>Conclusions: </strong>The baseline HB/SCr ratio was inversely associated with MACE, suggesting that it may serve as a useful biomarker for identifying high-risk STEMI patients at an early stage.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"394"},"PeriodicalIF":2.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of cardiometabolic risk in pre- and post-menopausal women.","authors":"İlksen Orhan, Hatice Serap Koçak, Emine Kaplan","doi":"10.1186/s12872-025-04850-1","DOIUrl":"10.1186/s12872-025-04850-1","url":null,"abstract":"<p><strong>Objective: </strong>The study was designed to determine and compare the cardiometabolic risk in premenopausal and postmenopausal women.</p><p><strong>Methods: </strong>Data were collected using cross-sectional and correlational study. In this study, the sociodemographic characteristics, anthropometric measurements, and biochemical parameters of menopausal women were examined.</p><p><strong>Results: </strong>The average age of menopausal women is higher compared to premenopausal women. Menopausal duration, number of children, daily cigarette consumption, body weight, body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio, systolic and diastolic blood pressure, fasting blood glucose, hemoglobin, AST (aspartate aminotransferase), and Framingham risk score are higher in menopausal women compared to premenopausal women. Conversely, height, HDL (high-density lipoprotein) level, LDL (low-density lipoprotein) level, TSH (thyroid-stimulating hormone), ALT (alanine aminotransferase), HbA1c (glycated hemoglobin), serum albumin, and visceral adiposity index (VAI) values are lower in menopausal women compared to premenopausal women.</p><p><strong>Conclusion: </strong>These findings indicate changes in the metabolic profiles of menopausal women. This study could serve as an important resource for assessing the health status of menopausal women and for implementing appropriate measures.</p><p><strong>Clinical trial number: </strong>not applicable.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"399"},"PeriodicalIF":2.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke prediction in elderly patients with atrial fibrillation using machine learning combined clinical and left atrial appendage imaging phenotypic features.","authors":"Hao Huang, Yan Xiong, Yuan Yao, Jie Zeng","doi":"10.1186/s12872-025-04870-x","DOIUrl":"10.1186/s12872-025-04870-x","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) is one of the primary etiologies for ischemic stroke, and it is of paramount importance to delineate the risk phenotypes among elderly AF patients and to investigate more efficacious models for predicting stroke risk.</p><p><strong>Methods: </strong>This single-center prospective cohort study collected clinical data and cardiac computed tomography angiography (CTA) images from elderly AF patients. The clinical phenotypes and left atrial appendage (LAA) radiomic phenotypes of elderly AF patients were identified through K-means clustering. The independent correlations between these phenotypes and stroke risk were subsequently analyzed. Machine learning algorithms-Logistic Regression, Naive Bayes, Support Vector Machine (SVM), Random Forest, and Extreme Gradient Boosting-were selected to develop a predictive model for stroke risk in this patient cohort. The model was assessed using the Area Under the Receiver Operating Characteristic Curve, Hosmer-Lemeshow tests, and Decision Curve Analysis.</p><p><strong>Results: </strong>A total of 419 elderly AF patients (≥ 65 years old) were included. K-means clustering identified three clinical phenotypes: Group A (cardiac enlargement/dysfunction), Group B (normal phenotype), and Group C (metabolic/coagulation abnormalities). Stroke incidence was highest in Group A (19.3%) and Group C (14.5%) versus Group B (3.3%). Similarly, LAA radiomic phenotypes revealed elevated stroke risk in patients with enlarged LAA structure (Group B: 20.0%) and complex LAA morphology (Group C: 14.0%) compared to normal LAA (Group A: 2.9%). Among the five machine learning models, the SVM model achieved superior prediction performance (AUROC: 0.858 [95% CI: 0.830-0.887]).</p><p><strong>Conclusion: </strong>The stroke-risk prediction model for elderly AF patients constructed based on the SVM algorithm has strong predictive efficacy.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"400"},"PeriodicalIF":2.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride-glucose index is associated with silent cerebral infarcts in patients with atrial fibrillation undergoing catheter ablation.","authors":"Bowen Qiu, Zhongxiao Liu, Dandan Zuo, Chenchen Cui, Chuanyi Sang, Chengzong Li, Wensu Chen, Chaoqun Zhang","doi":"10.1186/s12872-025-04803-8","DOIUrl":"10.1186/s12872-025-04803-8","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation catheter ablation (AFCA) is associated with a high risk of silent cerebral infarcts (SCI). Triglyceride-glucose (TyG) index is associated with stroke. However, the relationship between TyG index and SCI is unclear. The aim of this study was to investigate the association of TyG index with SCI after AFCA.</p><p><strong>Methods: </strong>This was a single-center prospective study. We consecutively selected patients who underwent AFCA from October 2019 to March 2024. All patients completed cranial magnetic resonance imaging (MRI) within 24-48 h after AFCA. SCI was defined as new single or multiple brain injuries detectable on MRI without any clinical manifestations or neurolocalization signs.</p><p><strong>Results: </strong>A total of 379 patients were enrolled, including 60 patients (15.8%) with SCI. Compared with patients without SCI, patients with SCI had a higher TyG index (9.03 ± 0.87 vs. 8.65 ± 0.56, p < 0.01). Pearson correlation analysis showed that TyG index correlated with left atrium dimension (LAD) (r = 0.119, p = 0.020), neutrophils (r = 0.176, p < 0.001), lymphocytes (r = 0.107, p = 0.037), and skin sympathetic nerve activity (r = 0.304, p = 0.020). After adjusting for potential confounding factors, multivariate analysis showed that TyG index (OR = 2.426; 95%CI: 1.567 ~ 3.757, p < 0.001) was independent factors for SCI after AFCA. Integrating TyG index could significantly improve ability of the model to recognize SCI after AFCA (NRI 0.164, 95% CI 0.069-0.258, p < 0.001; IDI 0.063, 95% CI 0.026-0.100, p < 0.001).</p><p><strong>Conclusions: </strong>TyG index is associated with SCI after AFCA, and elevated TyG index is an independent risk factor for SCI. Integrating TyG index could significantly improve the risk assessment model regarding SCI.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"398"},"PeriodicalIF":2.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}