BMC Cardiovascular Disorders最新文献

{"title":"Developing and validation of the Sexual Fear Scale in Chinese patients with coronary heart disease.","authors":"Fengpei Zhang, Weihong Yang, Yachai Li, Yingying Fan, Xiaoyun Xiong","doi":"10.1186/s12872-025-04827-0","DOIUrl":"10.1186/s12872-025-04827-0","url":null,"abstract":"<p><strong>Background: </strong>Sexual fear in patients with coronary heart disease (CHD) can negatively affect their sexual life and overall well-being. However, validated tools for assessing this fear are lacking. This study aimed to develop a sexual fear scale for patients with CHD and evaluate its psychometric properties.</p><p><strong>Methods: </strong>A multi-stage cross-sectional study was conducted with 409 patients. The process included item generation (literature review, expert consultation, and patient interviews), item selection (critical ratio, correlation analysis, and internal consistency), and psychometric evaluation (content validity, reliability, criterion validity, and construct validity via exploratory and confirmatory factor analysis).</p><p><strong>Results: </strong>Finally, a 19-item scale including 2 dimensions of perceived risk and fear psychology was formed. After reliability and validity test, the content validity index of the scale is 0.942, Cronbach's α coefficient is 0.944, test-retest reliability is 0.886, and split-half reliability is 0.841. Two factors extracted from exploratory factor analysis explained 58.655% of the total variation, and confirmatory factor analysis showed that the model fit well.</p><p><strong>Conclusions: </strong>The developed scale demonstrates sound reliability and validity and provides a practical tool for assessing sexual fear in CHD patients, supporting early identification and personalized intervention.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"387"},"PeriodicalIF":2.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent pericardial effusion due to Hennekam lymphangiectasia-lymphedema syndrome: a case report and literature review.","authors":"Ran Zhang, Junyan Zhang, Li Rao, Zhongxiu Chen, Mian Wang","doi":"10.1186/s12872-025-04842-1","DOIUrl":"10.1186/s12872-025-04842-1","url":null,"abstract":"<p><p>Diagnosing and treating recurrent pericardial effusion (PE) have been challenging in clinical practice. This study presents a middle-aged male with long-term refractory PE without apparent cause and non-specific symptoms, and eventually diagnosed as Hennekam lymphangiectasia with lymphedema syndrome (HKLLS). He underwent anti-tuberculosis diagnostic treatment and non-steroidal anti-inflammatory drugs for nonspecific PE, and thoracic duct exploration, terminal adhesion lysis, and anastomosis of the tributary vertebral vein of the thoracic duct for suspected protein-losing enteropathy and intestinal lymphangiectasia in other hospitals 17 and 11 years ago, but with no satisfactory outcomes. During the disease course, laboratory tests showed decreased blood albumin and increased stool α1-antitrypsin, while endoscopy biopsies were normal. The patient's complex medical history underscores the diagnostic challenges. The whole-exome sequencing identified two mutations within the collagen and calcium-binding EGF-like domain-containing protein 1 (CCBE1) gene, diagnosing HKLLS type 1. This case enriches the understanding of the link between HKLLS and recurrent PE, highlighting the significance of whole-exome sequencing in diagnosing recurrent PE when traditional methods fall short. It also reminds clinicians to consider rare genetic disorders like HKLLS in the differential diagnosis of recurrent PE, even without typical symptoms.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"389"},"PeriodicalIF":2.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the global, regional, and national burden of cardiovascular diseases attributed to high systolic blood pressure from 1990 to 2021 and projections to 2045: a systematic analysis based on GBD 2021 data.","authors":"Tenglong Hu, Xinyue Yang, Yanyan Du, Yangyu Zhao, Lei Chen, Na Sun, Qiang Sun, Wenyan Liang, Xiqing Wei, Zhiqiang Zhang","doi":"10.1186/s12872-025-04807-4","DOIUrl":"10.1186/s12872-025-04807-4","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD) remains the leading cause of death and disability worldwide, and high systolic blood pressure (HSBP) is considered among its most critical modifiable risk factors. This study analyzed the temporal trends of the global burden of CVD attributed to HSBP from 1990 to 2021, examined its relationships with age, period, and birth cohort, and projected future trends to 2045.</p><p><strong>Methods: </strong>The study employed a joinpoint regression model to evaluate the temporal trends of CVD burden attributed to HSBP from 1990 to 2021 and used an Age-Period-Cohort (APC) model to analyze the effects of age, period, and cohort. Additionally, a Bayesian Age-Period-Cohort (BAPC) model was applied to project the disease burden trends up to 2045.</p><p><strong>Results: </strong>From 1990 to 2021, the absolute number of deaths and DALYs (disability-adjusted life years) of CVD attributed to HSBP increased significantly. However, the age-standardized mortality rate (ASMR) and age-standardized DALY rate (ASDR) showed a consistent declining trend. The study highlights significant regional differences, with the disease burden increasing most markedly in regions with a middle Socio-Demographic Index (SDI) and decreasing most significantly in high SDI regions. Additionally, the study revealed gender differences, with the decline in ASMR and ASDR was more pronounced in females, while males exhibited a higher overall disease burden than females. Projections from the BAPC model indicate that from 2022 to 2045, the absolute number of deaths and DALYs will continue to rise, while ASMR and ASDR will decline further.</p><p><strong>Conclusions: </strong>This study conducted a comprehensive analysis of CVD attributed to HSBP globally, highlighting significant sex, age, and regional differences in disease burden as well as their temporal trends. The findings underscore the importance of targeted prevention strategies, particularly for high-risk populations. This study provides valuable insights for policymakers to formulate effective interventions to reduce the global disease burden.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"390"},"PeriodicalIF":2.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic ketoacidosis and hyperosmolar hyperglycemic state in diabetes patients with heart failure: insight from the National inpatient sample.","authors":"Hasan Alroobi, Soha Dargham, Ziyad Mahfoud, Amin Jayyousi, Jassim Al Suwaidi, Charbel Abi Khalil","doi":"10.1186/s12872-025-04832-3","DOIUrl":"10.1186/s12872-025-04832-3","url":null,"abstract":"<p><strong>Background: </strong>Diabetic Ketoacidosis (DKA) and Hyperosmolar Hyperglycemic State (HHS) are acute, life-threatening hyperglycemic conditions in diabetes. We aim to assess in-hospital cardiovascular outcomes of DKA and HHS in type 2 diabetes (T2D) patients with heart failure (HF) and compare both complications.</p><p><strong>Methods: </strong>The National Inpatient Sample database was used to gather data on T2D patients admitted for HF (primary diagnosis) from 2008 to 2019. The secondary diagnoses were DKA or HHS. The outcomes investigated were mortality, ischemic stroke, acute renal failure, and cardiogenic shock.</p><p><strong>Results: </strong>Diabetes HF patients with DKA were younger than those without HHS-DKA, more likely to be females, and had a higher prevalence of coronary artery disease and chronic kidney disease. DKA was associated with higher adjusted risk of mortality (aOR = 2.75[2.42-3.13)], ischemic stroke (aOR = 2.51[1.80-3.49]), acute renal failure (aOR = 1.54[1.45-1.64]), and cardiogenic shock (aOR = 2.53[2.19-2.92]. Diabetes HF patients with HHS were also younger but had more comorbidities than those without HHS-DKA. However, HHS was only associated with an increased adjusted risk of acute renal failure (aOR = 1.59[1.49-1.70]. When both hyperglycemic groups were compared, DKA patients were younger and had fewer comorbidities. However, they had a higher adjusted risk of mortality (aOR = 2.90[2.22-3.79] and cardiogenic shock (aOR = 2.86 [2.13-3.83], but not acute renal failure or stroke.</p><p><strong>Conclusions: </strong>DKA and HHS are associated with worse cardiovascular outcomes in heart failure patients with type 2 diabetes. Further, when both conditions were compared, the mortality risk and cardiogenic shock were higher in DKA compared to HHS. Implementing tailored fluid and electrolyte management, optimizing insulin protocols, and enhancing monitoring with early intervention could be lifesaving for these high-risk patients.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"384"},"PeriodicalIF":2.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum uric acid and coronary artery disease risk: a 10-year prospective cohort study in healthy adults.","authors":"Mohammadtaghi Sarebanhassanabadi, Shakiba Mahvash, Pedro Marques-Vidal, Seyed Reza Mirjalili, Seyedeh Mahdieh Namayandeh, Hamideh Mihanpour, Aida Mirshamsi, Ali Mirshamsi","doi":"10.1186/s12872-025-04866-7","DOIUrl":"10.1186/s12872-025-04866-7","url":null,"abstract":"<p><strong>Background: </strong>The role of serum uric acid (SUA) as an independent risk factor for coronary artery disease (CAD) remains controversial, particularly in understudied Middle Eastern populations with distinct metabolic and dietary profiles.</p><p><strong>Objective: </strong>To investigate the association between SUA levels and 10-year CAD incidence in a healthy Iranian cohort, adjusting for cardiometabolic confounders and exploring sex-specific relationships.</p><p><strong>Methods: </strong>A 10-year prospective cohort study was conducted using data from the Yazd Healthy Heart Project. Cluster-random sampling recruited adults aged 20-74 years free of baseline cardiovascular disease. Participants with existing coronary artery disease, insufficient data, or loss to follow-up were excluded. Serum uric acid levels were stratified into quartiles, and Cox proportional hazards models adjusted for demographic, lifestyle, and metabolic variables were analyzed using SPSS (version 27.0).</p><p><strong>Results: </strong>Over 15,420 person-years, 225 incident CAD cases occurred (14.5% cumulative incidence). In crude analysis, the highest SUA quartile (Q4: > 5.2 mg/dL) was associated with increased CAD risk (HR = 1.66, 95% CI: 1.14-2.43). However, this association attenuated after adjustment for confounders (fully adjusted HR = 1.03, 95% CI: 0.62-1.69). Sex-stratified analysis revealed a transient association in women (crude HR = 2.13, 95% CI: 1.14-3.96), which dissipated post-adjustment, while no significant association was observed in men.</p><p><strong>Conclusion: </strong>Elevated SUA levels were not independently associated with CAD risk in this healthy Middle Eastern cohort. Initial associations were attributable to confounding by metabolic factors such as obesity, dyslipidemia, and hypertension. These findings underscore the importance of contextualizing SUA's role within population-specific risk profiles and highlight the need for nuanced risk stratification strategies.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"386"},"PeriodicalIF":2.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress hyperglycemia ratio linked to all-cause mortality in critically ill patients with ischemic heart disease.","authors":"Tao Liu, Lili Wang, Hao Zhang, Qiming Dai","doi":"10.1186/s12872-025-04831-4","DOIUrl":"10.1186/s12872-025-04831-4","url":null,"abstract":"<p><strong>Background: </strong>The stress hyperglycaemia ratio (SHR), a quantitative indicator of hyperglycaemia in stress, has been shown to correlate with poor disease prognosis. However, the relationship between SHR and short-term prognosis in critically ill patients with ischemic heart disease (IHD) remains unclear.</p><p><strong>Methods: </strong>This retrospective study analyzed data of 2559 critically ill patients with IHD from the Medical Information Mart for Intensive Care III database. Endpoints were in-hospital mortality and intensive care unit (ICU) mortality. Kaplan-Meier survival curves, Cox proportional hazards models, restricted cubic spline, subgroup analysis, and receiver operating characteristic curves were used to explore the association between SHR and mortality in critically ill patients with IHD.</p><p><strong>Results: </strong>A total of 99 (3.87%) in-hospital deaths and 62 (2.42%) ICU deaths were recorded. In multivariate Cox proportional hazards models, higher SHR was independently associated with in-hospital mortality (hazard ratio (HR): 1.93 [95% confidence interval (CI): 1.42-2.61], P-value < 0.0001) and ICU mortality (HR, 1.70; 95% CI, 1.17-2.47; P-value = 0.01). Restricted cubic splines showed that SHR was linearly positive correlated with both in-hospital mortality and ICU mortality. Subgroup analysis revealed the robustness of the results. The area under the curve of SHR for predicting in-hospital mortality and ICU mortality was 0.715 and 0.711, respectively.</p><p><strong>Conclusion: </strong>SHR was significantly positively correlated with in-hospital mortality and ICU mortality in patients with critical IHD. It might enhance the predictive accuracy of existing clinical disease scores and guide personalized blood glucose control.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"374"},"PeriodicalIF":2.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of platelet mass index in the prediction of angiographic no-reflow in patients with acute ST-segment elevation myocardial infarction.","authors":"Erdoğan Sökmen, Muhammet Salih Ateş","doi":"10.1186/s12872-025-04811-8","DOIUrl":"10.1186/s12872-025-04811-8","url":null,"abstract":"<p><strong>Background and objective: </strong>No-reflow phenomenon (NR) is a serious complication with increased morbidity and mortality in percutaneous coronary interventions in patients with acute ST-segment elevation myocardial infarction (STEMI). Studies on the relationship between the NR and mean platelet volume (MPV) and platelet count (PLT) are controversial. Platelet mass index (PMI) is a novel inflammation and platelet index, calculated as PLT multiplied by MPV. So, it would be prudent to assume that a high PMI is likely to be associated with NR. PMI's low cost and rapid availability may aid NR risk stratification. Our aim was to assess the relationship between PMI and no-reflow in acute STEMI patients.</p><p><strong>Methods: </strong>A total of 212 acute STEMI patients were enrolled in this retrospective study and the patients were stratified into two subgroups as no-reflow group (n = 45) and reflow group (n = 167). Patient data regarding demographics, clinical, angiographic and laboratory parameters were retrieved from the digital hospital archives. No-reflow was defined angiographic thrombolysis in myocardial infarction (TIMI) flow grade ≤ 2. PMI was calculated as platelet count multiplied by mean platelet volume (MPV).</p><p><strong>Results: </strong>Mean age of the no-reflow and reflow groups was 59.3 ∓ 8.6 and 59.1 ∓ 12.6 years, respectively (p > 0.05). PMI was greater in the no-reflow group [2585(2278-3000) vs. 2054(1594-2344), respectively, p < 0.001]. PMI was correlated with WBC count (r = 0.290, p < 0.001), Hemoglobin (r=-0.281, p < 0.001), neutrophil count (p = 0.303, p < 0.001), platelet count (r = 303, p < 0.001), MPV (r = 0.195, p = 0.006), platelet distribution width (p = 0.215, r = 0.002), and PCT (r = 0.970, p < 0.001), and Syntax score-2 (r = 0.162, p = 0.024). In mulvariate logistic regression analysis, PMI [OR: 1.008(1.003-1.012), p = 0.001], age [OR: 1.111 (1.036-1.253), p = 0.007], and WBC count [OR: 0.018(0.001-0.581), p = 0.024] were independently associated with NR.</p><p><strong>Conclusion: </strong>PMI has been a simple and readily available parameter that could be a promising indicator to estimate NR in patients with acute STEMI.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"376"},"PeriodicalIF":2.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical utility of dynamic chest radiography as an auxiliary tool for atrial fibrillation detection in heart failure: a pilot study.","authors":"Hiroaki Hiraiwa, Shin Nagai, Ryota Ito, Kiyota Kondo, Shingo Kazama, Toru Kondo, Shiro Adachi, Kenji Furusawa, Akihito Tanaka, Ryota Morimoto, Takahiro Okumura, Toyoaki Murohara","doi":"10.1186/s12872-025-04820-7","DOIUrl":"10.1186/s12872-025-04820-7","url":null,"abstract":"<p><strong>Background: </strong>Dynamic chest radiography (DCR) can estimate haemodynamic parameters in patients with heart failure (HF). Atrial fibrillation (AF) often coexists with HF; however, owing to its sometimes paroxysmal nature and minimal or absent symptoms, many patients with AF remain undiagnosed. Additional tools for AF diagnosis may be beneficial; therefore, we evaluated the ability of DCR to distinguish patients with HF in sinus rhythm (SR) from those with AF.</p><p><strong>Methods: </strong>In this small-sample pilot study, 20 patients with HF (median age, 67 years; males, 85%) underwent 12-lead electrocardiography and DCR on the same day. Aortic arch (Ao), right atrial (RA), right and left pulmonary artery (PA), and left ventricular (LV) apex pixel values (PVs) were measured. Seventeen patients were in SR and three demonstrated AF on 12-lead electrocardiography before DCR.</p><p><strong>Results: </strong>The PV and PV change rate waveforms of the Ao, RA, PAs, and LV apex were regular in SR and irregular with AF. The difference between patients in SR and those with AF was particularly clear in the LV apex PV change rate waveforms. In addition, the heart rates (HRs) of patients in SR and with AF could be calculated from the PV change rate waveforms and were similar to those calculated by 12-lead electrocardiography.</p><p><strong>Conclusions: </strong>DCR can detect AF in patients with HF and may be able to infer HR.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"381"},"PeriodicalIF":2.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and determinants of apparent treatment-resistant hypertension among patients in South African primary care: a single-centre observational study.","authors":"Kellicia Courtney Govender, Mergan Naidoo","doi":"10.1186/s12872-025-04813-6","DOIUrl":"10.1186/s12872-025-04813-6","url":null,"abstract":"<p><strong>Introduction: </strong>The surge in cardiovascular disease across Sub-Saharan Africa is largely driven by hypertension along with other cardiometabolic risk factors. South Africa, like other low-middle-income countries, faces a disproportionate burden due to the increasing prevalence of hypertension, exacerbated by low awareness, treatment, and control rates. Treatment-resistant hypertension (TRH) is a complex clinical entity and poses significant obstacles to achieving therapeutic goals. The prevalence of TRH in South Africa and its associated factors remain underexplored despite its significant cardiovascular and economic burden. Accordingly, we aimed to evaluate the prevalence, clinical and biochemical profiles, and therapeutic patterns associated with TRH among hypertensives in primary care.</p><p><strong>Methods: </strong>An observational analytical study was conducted at a district hospital in KwaZulu-Natal, South Africa, from March to April 2024. Data from 400 systematically randomised hypertensive patients aged > 30 years were analysed. Participants underwent automated office blood pressure monitoring, anthropometric assessments and completed structured interviews on health behaviours and medication adherence. Clinical parameters and antihypertensive medication profiles were reviewed. Determinants of apparent TRH were identified using multivariate logistic regression.</p><p><strong>Results: </strong>The mean age of the participants was 64.4 years (SD = 10.8), with a female preponderance (n = 260,65%), and nearly two-thirds comprised of Black Africans (35.3%) and Indians (30.5%). The prevalence of apparent TRH was 18.8%, comprising 11% uncontrolled and 7.8% controlled TRH. Factors significantly associated with TRH included Black African ethnicity (Odds Ratio (OR) = 2.33, p < 0.001), waist circumference (OR = 1.03, p < 0.001), left ventricular hypertrophy (OR = 3.57, p < 0.001), chronic kidney disease (OR = 3.12, p < 0.001), and dyslipidaemia (OR = 2.46, p = 0.039). Mineralocorticoid receptor antagonists were underused (10.8%).</p><p><strong>Conclusion: </strong>This first report of apparent TRH prevalence in South African primary care underscores its complex association with cardiometabolic risk factors and the disproportionate burden among Black Africans. These findings highlight the urgent need for targeted, multifaceted interventions and the development of locally relevant TRH-specific guidelines to mitigate cardiovascular risks among this high-risk population.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"373"},"PeriodicalIF":2.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diastolic global longitudinal strain and acute ischemic stroke: a hidden relationship?","authors":"Melis Ozkan, Sefa Tatar, Osman Serhat Tokgöz","doi":"10.1186/s12872-025-04841-2","DOIUrl":"10.1186/s12872-025-04841-2","url":null,"abstract":"<p><p>There is a bidirectional interaction between acute ischemic stroke (AIS) and the cardiovascular system. This study aimed to investigate the relationship between diastolic global longitudinal strain (GLS) and AIS. The prospective case-control study included 80 patients diagnosed with AIS and 45 control patients. It is well known that vascular risk factors have a significant impact on global longitudinal strain (GLS). Therefore, the control group was selected from cardiology outpatient clinic patients with vascular risk profiles similar to those of stroke patients. GLS measurements on echocardiography within the first 72 h after stroke onset were recorded. Demographic, clinical, and laboratory findings at admission were evaluated for both the patient and control groups. GLS values were significantly lower in both the patient group (-15.41% ± 3.60) and the control group (-10.70% ± 2.55) compared to the lower limit of normal GLS values reported in the literature (GLS lower limit = -18%, respectively, t = 6.207, p < 0.001; t = 19.178, p < 0.001). The GLS values were significantly higher in the stroke group than the control group (respectively, (-15.41% ± 3.60; (-10.70% ± 2.55); t = -7,698, p < 0.001), while no significant difference was observed between the groups in terms of ejection fraction (EF) (t: -1.612, p: 0.11). Acute ischemic stroke was identified as an independent factor associated with increased GLS (B = 3.761; 95% CI: 1.995-5.527; p < 0.001), and higher GLS values were found to be independent predictors of mildly to moderately better clinical outcomes, as measured by the modified Rankin Scale (F = 4.074; p: 0.047) in patients with acute ischemic stroke. These findings suggest that increased GLS may shed light on compensatory mechanisms aimed at preserving the penumbra in patients with acute ischemic stroke.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"25 1","pages":"383"},"PeriodicalIF":2.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}