BMC Cardiovascular Disorders最新文献

{"title":"Delayed presentation of traumatic giant left anterior descending artery pseudoaneurysm as acute coronary syndrome and cardiogenic shock: a case report.","authors":"Mustafa Uçar","doi":"10.1186/s12872-026-06324-4","DOIUrl":"10.1186/s12872-026-06324-4","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery pseudoaneurysms are rare vascular abnormalities that may develop after percutaneous coronary intervention, infection, or trauma. Although many cases remain asymptomatic, pseudoaneurysms may occasionally present with life-threatening complications. Delayed presentation of traumatic coronary pseudoaneurysm as acute coronary syndrome (ACS) complicated by cardiogenic shock is extremely uncommon.</p><p><strong>Case presentation: </strong>A 74-year-old man presented with chest pain, dyspnea, hypotension, and signs of cardiogenic shock. Electrocardiography demonstrated anterior myocardial infarction. Emergency coronary angiography revealed proximal occlusion of the left anterior descending artery (LAD) associated with a giant pseudoaneurysm and severe circumflex artery stenosis. Given the patient's hemodynamic instability and high surgical risk related to multiple comorbidities, percutaneous treatment was selected. Following restoration of coronary flow, a covered stent was implanted to seal the pseudoaneurysm. Subsequently, complex bifurcation intervention using the double kissing crush technique was performed. Residual pseudoaneurysm filling was completely eliminated with prolonged balloon inflation. Further history revealed a motor vehicle accident five months before presentation, suggesting a presumed traumatic etiology. The patient recovered uneventfully and was discharged on the fifth day.</p><p><strong>Conclusions: </strong>This case highlights an unusual delayed presentation of traumatic giant LAD pseudoaneurysm as ACS complicated by cardiogenic shock. Careful clinical history taking may help identify traumatic etiologies. Complex percutaneous coronary intervention with covered stent implantation may represent a feasible treatment option in carefully selected high-risk patients.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced prediction of cardiovascular-kidney-metabolic syndrome using eight machine learning models and 24 composite indices.","authors":"Minghao Li, Junyuan Xiang, Fang Xiao, Qianxiang Wang, Lin Liu, Yujia Huo, Chunyu Zhang, Li Deng, Jian Feng","doi":"10.1186/s12872-026-06318-2","DOIUrl":"10.1186/s12872-026-06318-2","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to construct and validate a machine learning classifier for cross-sectionally stratifying existing cardiovascular-kidney-metabolic (CKM) syndrome stages using routine composite inflammatory, metabolic and anthropometric indices, and to interpret core driving biomarkers via SHAP analysis.</p><p><strong>Methods and results: </strong>We analyzed data from 12,106 participants from the National Health and Nutrition Examination Survey (NHANES). Among 24 initial biomarkers, 10 were selected after addressing multicollinearity and applying feature selection. Several machine learning algorithms were evaluated, with the LightGBM model demonstrating the highest performance (ROC AUC: 0.88). External validation using the China Health and Retirement Longitudinal Study (CHARLS) dataset confirmed the model's generalizability (ROC AUC: 0.84). SHapley Additive exPlanations (SHAP) analysis revealed that metabolic markers-specifically eGDR, METS_VF, TyG, and TyG_BMI-were consistently the strongest predictors across CKM stages, whereas inflammatory indicators showed more limited utility.</p><p><strong>Conclusion: </strong>Key metabolic composite indices exhibit significant associations with CKM staging and may serve as practical, clinically feasible tools for risk stratification. The model's robust performance across distinct populations (U.S. and China) supports its potential clinical utility. Further validation in diverse populations and prospective studies is needed to confirm their predictive value and translational potential.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Individualized nursing intervention enhances health outcomes and quality of life in patients with heart failure.","authors":"Fengli Liu, Jiansi Zhang, Zhi Liu","doi":"10.1186/s12872-026-06190-0","DOIUrl":"10.1186/s12872-026-06190-0","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) is associated with high morbidity, readmissions, and impaired quality of life. Because patient responses vary, tailored, nurse-led strategies, particularly in nutrition, activity, and psychosocial support, may address needs that routine care does not fully meet.</p><p><strong>Objective: </strong>To assess the effectiveness of an individualized, nurse-led intervention integrating nutrition, graded exercise, and psychosocial support in patients with HF.</p><p><strong>Methods: </strong>This prospective, single-center, parallel-group study involved adults with HF (n = 110 per group), who were assigned to groups using an odd-even allocation method. The control group (CG) received routine nursing care. The observation group (OG) received the same routine care plus a 3-month individualized program comprising customized nutritional counseling, staged exercise guidance, and structured psychosocial support with follow-up. Baseline and follow-up assessments consisted of measuring time to symptom resolution, cardiac function, arterial blood gases, nutritional status, psychological status, quality of life, and adverse events between the two groups.</p><p><strong>Results: </strong>Compared with routine nursing care (CG), individualized nurse-led care (OG) had shortened time to symptom improvement (dyspnea 2.05 ± 0.61 vs. 2.57 ± 0.76 days; p < 0.001), improved cardiac function (LVEF, CO ↑; LVEDD, LVESD ↓; 6MWT ↑; all p < 0.05), enhanced gas exchange (PaCO₂ ↓, PaO₂ ↑; both p < 0.05), and better nutritional status (p < 0.05). Additionally, the OG had improved psychological status (p < 0.05), enhanced quality of life (SF-36 75.43 ± 9.03 vs. 66.43 ± 9.09; p < 0.05), and fewer adverse events (6.36% vs. 20.0%; χ²=7.462; p = 0.006).</p><p><strong>Conclusion: </strong>An individualized nurse-led intervention is associated with multidomain benefits in patients with HF, supporting the integration of personalized nursing strategies into routine HF care pathways.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world management and outcomes of myocardial infarction in a transitional country: insights from an 11-year observational study of 13,099 patients.","authors":"Gani Bajraktari, Defrim Morina, Besfort Kryeziu, Albion Luzha, Afrim Poniku, Pranvera Ibrahimi, Arlind Batalli, Edita Pllana-Pruthi, Ardian Nikaj, Artan Bajraktari, Edmond Haliti, Shpend Elezi, Michael Y Henein","doi":"10.1186/s12872-026-06259-w","DOIUrl":"10.1186/s12872-026-06259-w","url":null,"abstract":"<p><strong>Background and aim: </strong>Acute myocardial infarction (AMI) remains a leading cause of death globally, despite substantial advances in prevention, diagnosis and reperfusion therapy. In transitional health systems, in-hospital mortality is higher due to limited reperfusion capacity and infrastructure limitations. Kosovo introduced primary percutaneous coronary intervention (PPCI) in 2014, achieving nationwide 24/7 coverage in 2018. We evaluated 11-year trends in AMI management in Kosovo and identified independent predictors of in-hospital mortality.</p><p><strong>Methods: </strong>We analyzed 13,099 consecutive patients hospitalized with AMI between 2014 and 2024 at Kosovo's main tertiary cardiology center. Patients were classified as ST-elevation MI (STEMI) or non-ST-elevation MI (NSTEMI). Multivariable logistic regression was used to identify independent predictors of in-hospital mortality.</p><p><strong>Results: </strong>Patient's mean age was 63.8 ± 11.5 years, and 29% were women. STEMI accounted for 55% of cases. Overall in-hospital mortality was 9.0%, declining from 19.3% in 2014 to 7.7% in 2024. Mortality was higher in STEMI than NSTEMI (12% vs. 6%, p < 0.001). In multivariable analysis, cardiogenic shock, advanced age, female sex, reduced left ventricular ejection fraction, admission hyperglycaemia, and absence of PPCI were independently associated with higher mortality.</p><p><strong>Conclusions: </strong>In-hospital AMI mortality in Kosovo declined substantially over 11 years, coinciding with the expansion of 24/7 PPCI. STEMI remained the highest-risk presentation, and cardiogenic shock was the dominant predictor of death. These findings highlight the critical importance of timely reperfusion and system-level strengthening of acute cardiac care in transitional healthcare settings.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of the serum sodium to log(D-dimer) ratio for the risk of all-cause death in patients with chronic heart failure with different ejection fractions.","authors":"Yujuan Peng, Wei Zhang, Yunhong Yang, Tao Shi, Fazhi Yang, Sirui Yang, Xinuo Ma, Ping Xia, Lixing Chen","doi":"10.1186/s12872-026-05609-y","DOIUrl":"10.1186/s12872-026-05609-y","url":null,"abstract":"<p><strong>Background: </strong>The ratio of serum sodium to log(D-dimer) (log-SDR) in different types of chronic heart failure (CHF) is not well established.</p><p><strong>Methods: </strong>A total of 1,221 hospitalized CHF patients from the First Affiliated Hospital of Kunming Medical University between January 2017 and October 2021 were retrospectively analyzed. Patients were categorized into log-SDR-L group (log-SDR < 47.90) and log-SDR-H group (log-SDR ≥ 47.90).Prognostic assessments included Kaplan-Meier survival analysis, Cox survival analyses and time-dependent Receiver operating characteristic (ROC) curves analysis to evaluate predictive performance.</p><p><strong>Results: </strong>We collected data from 1008 patients with CHF. Kaplan-Meier survival analysis revealed that patients with high log-SDR levels had better overall survival (OS). After multivariate adjustment Cox proportional hazards analysis, the level of log-SDR was still independently related to mortality, regardless of CHF subtype.</p><p><strong>Conclusions: </strong>log-SDR is an important predictor of all-cause mortality in patients with HF, especially female HFrEF plus HFmrEF(HR:0.927, 95%CI:0.898-0.958, p < 0.001). Lower log-SDR levels are associated with an increased risk of all-cause mortality, irrespective of the HF subtype.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":"26 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13383445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cholesterol, high-density lipoprotein, and glucose index and modified indices in predicting cardiovascular diseases incidence among population with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study.","authors":"Zhen Zhao, Pengchong Du, Manning Jian, Yuanyuan Liu, Hongyi Pan, Qing Liu","doi":"10.1186/s12872-026-06295-6","DOIUrl":"10.1186/s12872-026-06295-6","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular-kidney-metabolic (CKM) syndrome, characterized by the interplay of metabolic risk factors, chronic kidney disease, and cardiovascular dysfunction, is a key driver of cardiovascular disease (CVD) incidence. The cholesterol, high-density lipoprotein, and glucose (CHG) index, which integrates total cholesterol, high-density lipoprotein, and fasting blood glucose, and its modified indices (combined with obesity indicators) have potential for CVD risk prediction. However, their role across CKM stages 0-3 remains unclear.</p><p><strong>Methods: </strong>A nationwide prospective cohort study included 5,404 participants with CKM stages 0-3, screened from 17,708 individuals screened between 2011 and 2020. CHG index and modified indices (CHG-BMI, CHG-Wc, CHG-WHtR) were calculated. Logistic regression, restricted cubic spline (RCS) analysis, subgroup analysis, and sensitivity analysis were used to evaluate associations with CVD incidence and identify exploratory threshold association.</p><p><strong>Results: </strong>During follow-up, 25.5% of participants developed CVD. CHG and modified indices were independently associated with increased CVD risk (all P < 0.001). In fully adjusted models, CHG as continuous data showed a 28% higher risk (OR = 1.28, 95% CI: 1.06-1.58) of outcome, and CHG-WHtR was 54% higher (OR = 1.28, 95% CI: 1.16-2.04). Meanwhile, the highest quartile (Q4) of CHG-WHtR was associated with a 43% higher risk (OR = 1.43, 95% CI: 1.03-1.98) compared to Q1, while CHG-BMI (OR = 1.68, 95% CI: 1.22-2.31) showed stronger associations. RCS analysis identified exploratory inflection points like CHG ≥ 5.15 and CHG-WHtR ≥ 2.41, above which CVD risk significantly increased (P < 0.005) and validated by bootstrap sampling. Subgroup analysis confirmed consistent associations across age, gender, and CKM stages subpopulations. Multiple sensitivity analysis supported the robustness of these associations across CKM stages.</p><p><strong>Conclusion: </strong>CHG index and its modified indices, particularly CHG-WHtR and CHG-Wc, are valuable indicators associated with reported incident CVD across CKM stages 0-3. Their stage-specific associations and exploratory threshold association support their utility in risk stratification for CKM syndrome.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The CALLY Index as an integrated inflammation-nutrition biomarker for risk stratification in HFpEF.","authors":"Jing Ge, Jinqi Liu, Yali Zhang, Dongdong Zhang, Shen Wu, Changjiang Xu, Dongying Zhang","doi":"10.1186/s12872-026-06300-y","DOIUrl":"10.1186/s12872-026-06300-y","url":null,"abstract":"<p><strong>Background: </strong>Heart failure with preserved ejection fraction (HFpEF) is a complex systemic syndrome characterized by inflammation, metabolic dysregulation, and immune imbalance. However, simple and integrative biomarkers for risk stratification remain limited. The C-reactive protein-albumin-lymphocyte (CALLY) index, reflecting inflammation, nutritional status, and immune function, has shown prognostic value in various diseases, but its role in HFpEF remains unclear.</p><p><strong>Methods: </strong>In this single-center retrospective cohort study, 308 patients with HFpEF were enrolled. The CALLY index was calculated as albumin × lymphocyte count / CRP. The primary endpoint was major adverse cardiovascular events (MACE), defined as all-cause death or heart failure rehospitalization. Cox proportional hazards models, restricted cubic spline (RCS), receiver operating characteristic (ROC) analysis, and Kaplan-Meier curves were applied.</p><p><strong>Results: </strong>During follow-up, 87 patients (28.25%) experienced MACE. Multivariable Cox analysis identified the CALLY index (HR = 0.98, 95% CI: 0.96-0.99) and E/e' (HR = 1.08, 95% CI: 1.01-1.17) as independent predictors of MACE. RCS analysis demonstrated a nonlinear inverse association between the CALLY index and MACE risk. ROC analysis showed good predictive performance (AUC = 0.82). Patients with lower CALLY index (< 11.8) had significantly higher event rates (log-rank p < 0.001).</p><p><strong>Conclusions: </strong>The CALLY index is an independent predictor of long-term outcomes in HFpEF, integrating inflammation, nutrition, and immune status. It may serve as a simple and practical tool for risk stratification.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-hospital mortality and predictors among hospitalized adults with acute heart failure in Southern Ethiopia: retrospective cohort study.","authors":"Sura Markos, Mosa Ebrahim, Betrie Bikamo, Yusuf Haji, Bereket A Tegene","doi":"10.1186/s12872-026-06307-5","DOIUrl":"10.1186/s12872-026-06307-5","url":null,"abstract":"<p><strong>Background: </strong>Acute heart failure is a leading cause of hospital admissions and mortality in Africa. Data on in-hospital outcomes and predictors of mortality remain limited in southern Ethiopia. Understanding these factors is crucial for improving patient management and resource allocation.</p><p><strong>Objective: </strong>To determine the in-hospital mortality rate and identify factors associated with death among adults admitted with acute heart failure at Hawassa University Comprehensive Specialized Hospital.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study including 480 adult patients hospitalized with acute heart failure between September 2021 and September 2023. Clinical, laboratory, and treatment data were extracted from medical records using standardized definitions. Multivariate logistic regression was used to identify independent predictors of in-hospital mortality, expressed as adjusted odds ratios (AOR) with 95% confidence intervals (CI).</p><p><strong>Results: </strong>The median age of patients was 67 years, and 51% were female. In-hospital mortality was 17%, with most deaths occurring early during hospitalization (median time to death: 4 days; IQR: 2-5). Rheumatic heart disease (31%), cardiomyopathy (20%), and ischemic heart disease (15%) were the most common underlying etiologies. Heart failure with preserved ejection fraction occurred in 64% of patients, whereas reduced ejection fraction was more common among those with cardiomyopathy or ischemic heart disease. Independent predictors of in-hospital death were acute kidney injury (AOR 8.9, 95% CI 4.2-18.8), mechanical ventilator support (AOR 4.4, 95% CI 2.3-8.5), and cardiogenic shock (AOR 2.2, 95% CI 1.4-3.4).</p><p><strong>Conclusion: </strong>In-hospital mortality was high, with most deaths occurring early during admission. Acute kidney injury, cardiogenic shock, and mechanical ventilatory support were strong independent predictors of mortality. These findings support close monitoring and timely management of high-risk patients during hospitalization.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148519901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum Mitofusin-2 levels, cardiac biomarkers, and inflammatory indices in patients with myocardial infarction with non-obstructive coronary arteries.","authors":"Abdulkadir Çakmak, Burak Yazgan","doi":"10.1186/s12872-026-06308-4","DOIUrl":"https://doi.org/10.1186/s12872-026-06308-4","url":null,"abstract":"<p><strong>Background: </strong>Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a heterogeneous and clinically important phenotype in which improved risk stratification tools are needed, and mitochondrial dysfunction may contribute to its pathophysiology. We aimed to evaluate the association between serum Mitofusin-2 (MFN2) levels and cardiac biomarkers and hematologic inflammatory indices in MINOCA, and to determine their potential diagnostic and prognostic value.</p><p><strong>Methods: </strong>A total of 30 MINOCA patients presenting with acute coronary syndrome (ACS) and non-obstructive coronary arteries on urgent coronary angiography, and 30 controls without an ACS presentation who underwent elective coronary angiography and had normal coronary arteries were included. Serum MFN2 was measured by ELISA at day 0 in both groups and repeated at day 3 in the MINOCA group, together with routine biochemistry, complete blood count-derived inflammatory indices and angiographic scores.</p><p><strong>Results: </strong>Left ventricular ejection fraction (LVEF) was significantly lower, and both Gensini and SYNTAX scores were significantly higher compared with controls (p < 0.05). At admission, no significant differences were observed in inflammatory indices between the control and MINOCA-0 groups, whereas by day 3 in MINOCA, neutrophil-to-lymphocyte ratio (NLR), C-reactive protein/albumin ratio (CAR), pan-immune-inflammation value (PIV), systemic inflammatory index (SII), monocyte-to-lymphocyte ratio (MLR), and systemic inflammation response index (SIRI) increased significantly and prognostic nutritional index (PNI), Glascow prognostic score (GPS), and lymphocyte-to-monocyte ratio (LMR) decreased significantly (p < 0.05). Serum MFN2 levels increased significantly on day 3 compared with day 0 within the MINOCA group (p < 0.0001). MFN2 showed a strong negative correlation with aspartate aminotransferase (AST) in both groups at day 0, and additionally demonstrated inverse associations with lymphocyte count in MINOCA (day 0-3). In Receiver Operating Characteristic (ROC) analyses, MFN2 did not show significant predictive/discriminative value for hospitalization for MINOCA either at presentation or when day 0 and day 3 MINOCA measurements were combined.</p><p><strong>Conclusion: </strong>MFN2 demonstrates a delayed rise during early hospitalization in MINOCA but lacks diagnostic discrimination at presentation, supporting its evaluation as a longitudinal (rather than acute) biomarker candidate.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Life's Crucial 9 and the prevalence of coronary heart disease in U.S. adults: the potential role of the systemic inflammatory response index.","authors":"Ji Ouyang, Jiayuan Song, Yingjie Wu, Zishen Guo, Xiaoqian Liao, Zhixi Hu","doi":"10.1186/s12872-026-06314-6","DOIUrl":"10.1186/s12872-026-06314-6","url":null,"abstract":"<p><strong>Background: </strong>This studyaimed to examine the association between Life's Crucial 9 (LC9) score and the prevalence of coronary heart disease (CHD) among U.S. adults, as well as explore the potential statistical contribution of Systemic Inflammatory Response Index (SIRI) in this association.</p><p><strong>Methods: </strong>Data were obtained from 23,508 participants in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. LC9 score quartiles were used to summarize continuous and categorical variables, which were then reported as weighted means ± standard deviations or weighted frequencies and proportions, respectively. Differences among groups were examined using weighted t-tests and weighted chi-square tests. The relationship between LC9 scores, Ln-SIRI values, and the prevalence of CHD was investigated using weighted logistic regression models following the natural logarithmic transformation of skewed SIRI results. Furthermore, restricted cubic spline regression was utilized to investigate plausible nonlinear connections, subgroup and likelihood ratio tests investigated interaction effects, and weighted quantile sum (WQS) regression was incorporated to determine the relative contributions of LC9 components to CHD. An exploratory non-causal mediation analysis using 1,000 bootstrap samples was conducted to assess SIRI as a potential statistical explanatory variable in the association between LC9 and the prevalence of CHD.</p><p><strong>Results: </strong>In Model 3, a 10-point increase in the LC9 score correlated with a 24% decrease in the odds of CHD prevalence; participants in the Q4 group had 59% lower odds of CHD compared with those in the Q1 group (P < 0.001 trend). Each Ln-SIRI unit was associated with 56% higher odds of CHD, with Q4 showing 2.02-fold higher odds than Q1 (P < 0.001 trend). Restricted cubic spline regression revealed linear relationships between LC9, Ln-SIRI, and the prevalence of CHD. In particular, LC9 was negatively associated with CHD, whereas Ln-SIRI was positively associated with CHD. Age significantly moderated the association between LC9 and CHD (P for interaction < 0.05), with stronger inverse associations in younger adults. WQS regression identified glucose (weight = 0.34) and tobacco (weight = 0.33) as key CHD-associated factors. Exploratory non-causal mediation analysis revealed that about 6.5% of the LC9-CHD relationship was statistically accounted for by SIRI (P < 0.001), with the majority of factors associated with the link remaining unexplained. This indicates that other factors may be the primary contributors to the LC9-CHD relationship.</p><p><strong>Conclusion: </strong>This study showed that higher LC9 scores were significantly associated with lower odds of prevalent self-reported CHD, while higher SIRI was associated with higher odds.</p>","PeriodicalId":9195,"journal":{"name":"BMC Cardiovascular Disorders","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13663155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}