Open access journal of ophthalmology最新文献_第3页

Comparative Modeling and Molecular Interaction Study for the Management of AMD and CRVO Ocular Disorder AMD和CRVO眼病治疗的比较模型和分子相互作用研究

Open access journal of ophthalmology Pub Date : 2023-01-02 DOI: 10.23880/oajo-16000263

Srivastava P

{"title":"Comparative Modeling and Molecular Interaction Study for the Management of AMD and CRVO Ocular Disorder","authors":"Srivastava P","doi":"10.23880/oajo-16000263","DOIUrl":"https://doi.org/10.23880/oajo-16000263","url":null,"abstract":"Age Related Macular Degeneration (AMD) and Central Retinal Vein Occlusion (CRVO) are the rare and leading cause of blindness among patients with ocular problem. Many proteins are reported in the progression of these ocular disorders. Proteins which are directly involved in the development of this disorder reported in the literature, their sequence related information retrieved from biological databases. In silico technique was implemented in order to characterize the properties and structures of the proteins using ProtParam. For studying about the potential phosphorylation sites in protein generally NetPhos server was used whereas for denoting the location of signal peptide cleavage sites and their presence the server which is used is SingalP server. For prediction of secondary structure prediction of proteins is done by using SOPMA. The SOSUI server performs the identification of trans-membrane regions. The 3D dimensional structure was modeled using Swiss Model Workspace and Modeller. Ramachandran plot was used to validate the stereochemical properties of the predicted structures because it is a very important step after 3D structure prediction. Docking of screened phytochemicals with selected proteins was performed by AutoDock. Docking study revealed that Curcumin (binding energy: -8.35) and Berberine (binding energy: -7.14) can be used as better therapeutic lead molecule for the cure of CRVO and AMD respectively.","PeriodicalId":91939,"journal":{"name":"Open access journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82926207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated Lower Motor Neuron Facial Nerve Palsy as a Presenting Sign in COVID-19 Associated Orbital Mucormycosis Patients: A Retrospective Observational Study 分离的下运动神经元面神经麻痹是COVID-19相关眼眶毛霉菌病患者的表现:一项回顾性观察研究

Open access journal of ophthalmology Pub Date : 2023-01-02 DOI: 10.23880/oajo-16000270

A. R

{"title":"Isolated Lower Motor Neuron Facial Nerve Palsy as a Presenting Sign in COVID-19 Associated Orbital Mucormycosis Patients: A Retrospective Observational Study","authors":"A. R","doi":"10.23880/oajo-16000270","DOIUrl":"https://doi.org/10.23880/oajo-16000270","url":null,"abstract":"Purpose: The main purpose of this study is to emphasize that isolated facial nerve involvement can be the first presenting symptom in patients suspected of COVID-associated Mucormycosis (CAM). Methods: This study is a retrospective observational study conducted at a tertiary care referral center which included patients with a history of CAM, who presented with isolated facial nerve palsy as initial presentation between March 2021 to March 2022 along with their follow-up. All the patients were managed with combined modality treatment with antifungal therapy and debridement of the necrotic tissue and fungal debris. Results: There were 184 eyes of 148 patients diagnosed with CAM. All patients developed rhino-orbital mucormycosis (ROM) following the COVID-19 infection and the duration between diagnosis of COVID-19 and ROM was 36±23 days. 42(28%) patients presented with isolated Facial Nerve Palsy (FNP) as the initial presentation. The mean age was 48.5 years (range 38 to 67years) with a male predominance of 29 (69%). All were unilateral cases and were of Lower motor neuron type presentation. All the patients (100%) were treated with systemic Liposomal amphotericin-B and sinus debridement. At a mean follow-up of 13.1 months, 19 (45%) of the patients had improvement in Facial Nerve function and 23 (55%) had static functioning. None of them had worsened. With medical intervention and tarsorrhaphy, the corneal condition was improved in all patients. Conclusion: Isolated FNP is an unusual but important sign in the presentation of mucormycosis which can be misdiagnosed with a cerebrovascular accident leading to delay in the management. This is a large case series with isolated FNP in CAM cases. A high index of suspicion for mucormycosis in diabetic patients presenting with isolated facial palsy can save the life and salvage the eye.","PeriodicalId":91939,"journal":{"name":"Open access journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84659313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How to Safeguard Against Litigations and Consumer Cases during the Medical Practice? 医疗执业中如何防范诉讼和消费案件?

Open access journal of ophthalmology Pub Date : 2023-01-02 DOI: 10.23880/oajo-16000264

S. V

引用次数: 0

Modified Samuel Masket’s Technique 修改塞缪尔·马斯基特的技术

Open access journal of ophthalmology Pub Date : 2023-01-02 DOI: 10.23880/oajo-16000258

Dudani Ia

引用次数: 0

Sudden Death among Medical Professionals: How to Reverse this Trend? 医疗专业人员猝死:如何扭转这一趋势?

Open access journal of ophthalmology Pub Date : 2023-01-02 DOI: 10.23880/oajo-16000276

Pandey Sk

引用次数: 0

Fungal Orbital Cellulitis by Candida Albicans Following Snake Bite -A Rare Case 蛇咬后白色念珠菌引起的真菌性眼眶蜂窝织炎一例

Open access journal of ophthalmology Pub Date : 2023-01-02 DOI: 10.23880/oajo-16000269

Seth P

引用次数: 0

Impact of COVID-19 on Ophthalmic Pathology COVID-19对眼部病理的影响

Open access journal of ophthalmology Pub Date : 2023-01-02 DOI: 10.23880/oajo-16000274

Mehenaz Hanbazazh

引用次数: 0

Fast Food and Malnutrition can lead to Blindness and Structural Changes in the Central Nervous System (CNS) 快餐和营养不良会导致失明和中枢神经系统的结构变化

Open access journal of ophthalmology Pub Date : 2023-01-02 DOI: 10.23880/oajo-16000262

Abdelmseih M

引用次数: 0

Presbyopia 老花眼

Open access journal of ophthalmology Pub Date : 2023-01-02 DOI: 10.23880/oajo-16000259

Verma S

引用次数: 0

The Road to Perfectionism in the Surgical Field: How Resident/ Young Ophthalmologist can become Perfect Ophthalmic Surgeon? 外科领域的完美主义之路:住院医师/年轻眼科医生如何成为完美的眼科医生?

Open access journal of ophthalmology Pub Date : 2022-07-01 DOI: 10.23880/oajo-16000248

Pandey Suresh K

{"title":"The Road to Perfectionism in the Surgical Field: How Resident/ Young Ophthalmologist can become Perfect Ophthalmic Surgeon?","authors":"Pandey Suresh K","doi":"10.23880/oajo-16000248","DOIUrl":"https://doi.org/10.23880/oajo-16000248","url":null,"abstract":"Medicine is a field where one needs to consistently aim for perfection in order to build their competitive edge and retain optimum perfection. Surgery, ophthalmology and medicine all require a lifetime of learning, and learning requires repetition with aim of perfection. Entering into the surgical field (ophthalmology) is another critical stage where your life is on the verge of transformation as you make a career choice that is for the rest of your life. Moreover, ophthalmic surgery is a field that demands nothing less than perfection as even the most little mistake can lead compromised vision or even blindness. During recent years most of the ophthalmic residents are not getting sufficient surgical cases for learning/mastering the eye surgery in most of the training institutes in India. What are the qualities of perfect surgeon? How resident or young ophthalmologist can learn these qualities? Why do we need to become perfect surgeons – especially when it comes to eye surgery and ophthalmology? Ophthalmologic surgeries are very delicate, highly crucial in nature. Any minor mistake can lead the patient to irrevocable damage in form of blindness or other serious visual impairment. This makes eye surgeries riskier than any other and require perfect surgeons on the list to execute surgeries and minimize the damage risk. In this article the authors share some pearls for learning and mastering eye surgery to become a perfect ophthalmic surgeon.","PeriodicalId":91939,"journal":{"name":"Open access journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81275682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0