Open access journal of ophthalmology最新文献_第10页

Post Penetrating Keratoplasty Glaucoma: An Overview 穿透性角膜移植术后青光眼:综述

Open access journal of ophthalmology Pub Date : 2019-01-01 DOI: 10.23880/oajo-16000183

A. Raj

引用次数: 0

Retinopathy Stages Detection using Circular Hough Transformation 利用圆形霍夫变换检测视网膜病变分期

Open access journal of ophthalmology Pub Date : 2019-01-01 DOI: 10.23880/oajo-16000179

Jyoti D. Patil

引用次数: 1

A Rare Case Report: Traumatic Isolated Medial Rectus Dehiscence and its Surgical Outcome 外伤性孤立性内直肌裂开一例及其手术结果

Open access journal of ophthalmology Pub Date : 2019-01-01 DOI: 10.23880/OAJO-16000178

A. Tamhane

引用次数: 0

To Investigate the Morphologic Alterations in and Around the Optic Disc by Optical Coherence Tomography (OCT) in Eyes with Different Degree of Myopia 利用光学相干断层扫描(OCT)研究不同程度近视眼视盘内部及周围的形态学变化

Open access journal of ophthalmology Pub Date : 2019-01-01 DOI: 10.23880/oajo-16000187

Santosh Kumar

引用次数: 0

Pigmentary Glaucoma versus Angular Closure 色素性青光眼与角闭性青光眼

Open access journal of ophthalmology Pub Date : 2019-01-01 DOI: 10.23880/OAJO-16000177

V. González

引用次数: 0

The Retinal Glide. A New Surgical Technique for the Myopic Traction Maculopathy Associated with Macular Retinal Detachment 视网膜滑动。一种治疗伴黄斑视网膜脱离的近视牵引性黄斑病变的新手术技术

Open access journal of ophthalmology Pub Date : 2019-01-01 DOI: 10.23880/oajo-16000185

Guerra Garcia Roberto A

引用次数: 0

Chlamydia Trachomatis Infections: A Hidden Cause of Meibomian Gland Dysfunction 沙眼衣原体感染:睑板腺功能障碍的隐藏原因

Open access journal of ophthalmology Pub Date : 2019-01-01 DOI: 10.23880/oajo-16000182

G. Satpathy

{"title":"Chlamydia Trachomatis Infections: A Hidden Cause of Meibomian Gland Dysfunction","authors":"G. Satpathy","doi":"10.23880/oajo-16000182","DOIUrl":"https://doi.org/10.23880/oajo-16000182","url":null,"abstract":"Purpose: Meibomian gland dysfunction (MGD) is a common eye problem, which is asymptomatic in the early stage, but if left untreated for a prolonged period can exacerbate to dry eye syndrome. Role of bacteria in the pathophysiology of MGD is always controversial. This pilot study was undertaken to find the association of Chlamydia trachomatis apart from the normal biota of the eyelid with MGD in a tertiary care hospital in India. Methods: A total of 112 MGD patients with follicular conjunctival inflammation with either of the symptoms such as; Meibomitis (22), Dry eye (42), Watering (19), Blepharitis (9), Chalazion/ Hardoleum (20) were referred to the Chlamydial laboratory for further investigation. Conjunctival swabs of both eyes were subjected to direct immunofluorescence assay (DFA) for C. trachomatis antigen detection. Results: Of the 112 MGD patients, 62 (55.30%) were found positive for C. trachomatis with DFA, out of which 54(87%) had good clinical response for topical azithromycin (1% eye drop), topical lubricants and warm compresses. Conclusions: We concluded from this study that, C. trachomatis is one of the causes for MGD with follicular conjunctival inflammation and topical azithromycin is a good choice for treatment and improving the signs and symptoms of the infection. As the role of chlamydia in MGD is not clear, this study will disclose an exciting fact about the pathophysiology of the disease, which will in turn improve treatment strategy to some extent to combat with the common but frustrating","PeriodicalId":91939,"journal":{"name":"Open access journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86161780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potentials of Gene Therapy for Diabetic Retinopathy: The Use of Nucleic Acid Constructs Containing a TXNIP Promoter. 基因治疗糖尿病视网膜病变的潜力:使用含有TXNIP启动子的核酸构建体。

Open access journal of ophthalmology Pub Date : 2018-01-01 Epub Date: 2018-03-21 DOI: 10.23880/oajo-16000147

P S Lalit, Y Thangal, Y Fayi, S D Takhellambam

{"title":"Potentials of Gene Therapy for Diabetic Retinopathy: The Use of Nucleic Acid Constructs Containing a TXNIP Promoter.","authors":"P S Lalit, Y Thangal, Y Fayi, S D Takhellambam","doi":"10.23880/oajo-16000147","DOIUrl":"https://doi.org/10.23880/oajo-16000147","url":null,"abstract":"Diabetic retinopathy (DR) is considered as a chronic eye disease leading to blindness. DR is associated with hyperglycemia-induced oxidative stress, chronic low-grade inflammation and premature cell death. DR affects retinal capillaries, neuroretina and the retinal pigment epithelium. Recently, the thioredoxin-interacting protein TXNIP has been shown as a pro-oxidative stress, pro-inflammatory and pro-apoptotic protein, highly induced by diabetes and high glucose in all cells examined including the retina. TXNIP's actions involve binding to and inhibition of anti-oxidant and thiol-reducing capacities of thioredoxins (Trx) causing cellular oxidative stress and apoptosis. Trx1 is found in the cytosol and nucleus while Trx2 is the mitochondrial isoform. Several studies provided evidence that knockdown of TXNIP by siRNA or chemical blockade ameliorates early abnormalities of DR including endothelial dysfunction, pericyte apoptosis, Müller cell gliosis and neurodegeneration. Therefore, TXNIP is considered a potential target for preventing or slowing down the progression of DR. We recently proposed that nucleic acid constructs containing a proximal TXNIP promoter linked to a redox gene or shRNA that reduces oxidative stress and inflammation may be used to treat DR. The TXNIP promoter is sensitive to hyperglycemia therefore can drive expression of the linked gene or shRNA under high glucose environment such as seen in diabetes while remaining unresponsive at physiological glucose levels. Such a TXNIP-promoter linked gene or shRNA construct can be delivered to the retina by using adeno-associated viral vectors including AAV2 and AAV2/8 or an appropriate carrier via the intravitreal or sub retinal delivery for long-term gene therapies in DR.","PeriodicalId":91939,"journal":{"name":"Open access journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519956/pdf/nihms-993031.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37253617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The E368Q Mutant Allele of GJA8 is Associated with Congenital Cataracts with Intrafamilial Variation in a South Indian Family. GJA8的E368Q突变等位基因与南印度家族先天性白内障的家族内变异有关。

Open access journal of ophthalmology Pub Date : 2016-01-01 DOI: 10.23880/OAJO-16000106

G. Senthil Kumar, K. Dinesh Kumar, P. Minogue, V. M. Berthoud, R. Kannan, E. Beyer, S. Santhiya

{"title":"The E368Q Mutant Allele of GJA8 is Associated with Congenital Cataracts with Intrafamilial Variation in a South Indian Family.","authors":"G. Senthil Kumar, K. Dinesh Kumar, P. Minogue, V. M. Berthoud, R. Kannan, E. Beyer, S. Santhiya","doi":"10.23880/OAJO-16000106","DOIUrl":"https://doi.org/10.23880/OAJO-16000106","url":null,"abstract":"PURPOSE To determine the basis of the autosomal dominant congenital cataracts in a three generation south Indian pedigree. METHODS The proband and several family members underwent a complete ophthalmic examination. The coding regions of eight candidate genes (CRYAA, CRYBB2, CRYGC, CRYGD, GJA3, GJA8, AQP0, and PITX3) were amplified by PCR and directly sequenced. Wild type and mutant connexin50 (Cx50) were expressed by stable transfection of HeLa cells. Their cellular distributions and function were examined by immunofluorescence microscopy and by microinjection of gap junction permeant tracers, respectively. RESULTS Congenital cataracts (with some variations in phenotype) segregated as an autosomal dominant trait within a three generation pedigree. Three affected individuals (proband, sibling and mother) showed a sequence variation in the candidate gene GJA8 encoding Cx50: a c.1102G>C transversion encoding a substitution of glutamate for glutamine at position 368 (E368Q). This substitution was absent from an unaffected family member (paternal aunt) and 100 healthy controls of the same ethnicity. In transfected HeLa cells, both wild type Cx50 and E368Q localized to gap junction plaques, and supported similar levels of intercellular transfer of Neurobiotin. CONCLUSIONS The E368Q mutant allele of GJA8 is associated with autosomal dominant congenital cataracts with phenotypic variability. E368Q forms gap junction plaques and functional channels in transfected HeLa cells.","PeriodicalId":91939,"journal":{"name":"Open access journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74747225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The E368Q Mutant Allele of GJA8 is Associated with Congenital Cataracts with Intrafamilial Variation in a South Indian Family. GJA8的E368Q突变等位基因与南印度家族先天性白内障的家族内变异有关。

Open access journal of ophthalmology Pub Date : 2016-01-01 Epub Date: 2016-07-28

G Senthil Kumar, K Dinesh Kumar, P J Minogue, V M Berthoud, R Kannan, E C Beyer, S T Santhiya

{"title":"The E368Q Mutant Allele of GJA8 is Associated with Congenital Cataracts with Intrafamilial Variation in a South Indian Family.","authors":"G Senthil Kumar, K Dinesh Kumar, P J Minogue, V M Berthoud, R Kannan, E C Beyer, S T Santhiya","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To determine the basis of the autosomal dominant congenital cataracts in a three generation south Indian pedigree.Methods: The proband and several family members underwent a complete ophthalmic examination. The coding regions of eight candidate genes (CRYAA, CRYBB2, CRYGC, CRYGD, GJA3, GJA8, AQP0, and PITX3) were amplified by PCR and directly sequenced. Wild type and mutant connexin50 (Cx50) were expressed by stable transfection of HeLa cells. Their cellular distributions and function were examined by immunofluorescence microscopy and by microinjection of gap junction permeant tracers, respectively.Results: Congenital cataracts (with some variations in phenotype) segregated as an autosomal dominant trait within a three generation pedigree. Three affected individuals (proband, sibling and mother) showed a sequence variation in the candidate gene GJA8 encoding Cx50: a c.1102G>C transversion encoding a substitution of glutamate for glutamine at position 368 (E368Q). This substitution was absent from an unaffected family member (paternal aunt) and 100 healthy controls of the same ethnicity. In transfected HeLa cells, both wild type Cx50 and E368Q localized to gap junction plaques, and supported similar levels of intercellular transfer of Neurobiotin.Conclusions: The E368Q mutant allele of GJA8 is associated with autosomal dominant congenital cataracts with phenotypic variability. E368Q forms gap junction plaques and functional channels in transfected HeLa cells.","PeriodicalId":91939,"journal":{"name":"Open access journal of ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438206/pdf/nihms820988.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35015565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0