BMC Anesthesiology最新文献

{"title":"Effects of intraperitoneal magnesium sulfate on perioperative inflammatory response in rats with pneumoperitoneum.","authors":"Deniz Kaya Bilir, Nedim Çekmen, Merih Tepeoğlu, Huriye Eda Özturan Özer","doi":"10.1186/s12871-025-03139-2","DOIUrl":"10.1186/s12871-025-03139-2","url":null,"abstract":"<p><strong>Background: </strong>Laparoscopy, while minimally invasive, leads to local and systemic inflammatory responses due to pneumoperitoneum. Recent studies highlight the anti-inflammatory effects of magnesium and its deficiency's link to inflammation. This study aimed to investigate the dose-dependent local and systemic anti-inflammatory effects of Mg²⁺ on PP-related perioperative inflammatory response in an animal model.</p><p><strong>Methods: </strong>Thirty-six rats were divided into four groups: MG250, MG500, pneumoperitoneum group (PG), and control group (CG). PG, MG250, and MG500 underwent pneumoperitoneum for 60 min at 12 mmHg. MG250 and MG500 received 250 mg/kg and 500 mg/kg of i.p. MgSO4 respectively, while PG received 0.9% saline. No additional procedures were performed on CG. Serum and peritoneal tissue samples were collected from all groups. Tissue samples were examined for inflammatory cell infiltration, congestion, and cellularoedema. Systemic inflammation was evaluated by measuring TNF-α, IL-1, IL-10, and MPO levels in serum samples.</p><p><strong>Results: </strong>Comparisons between CG and PG revealed that pneumoperitoneum amplified the local inflammatory response. Regarding systemic markers, only MPO levels were higher in PG compared to CG (p < 0.001). In MG250, both histopathological findings and MPO levels showed a lower inflammatory response compared to PG. No significant differences were observed between MG500 and PG.</p><p><strong>Conclusions: </strong>The application of i.p. MgSO4 during the perioperative period may exhibit anti-inflammatory effects at an appropriate dose. However, further large-scale, prospective, and randomized studies are necessary to better understand the local and systemic effects of Mg²⁺ doses.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9190,"journal":{"name":"BMC Anesthesiology","volume":"25 1","pages":"336"},"PeriodicalIF":2.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing selection for sedated gastroscopy after SARS-CoV-2 infection: a retrospective cohort study.","authors":"Ning Yu, Xiangyu Ji, Min Wang, Li Feng, Jian Sun, Lijie Qi, Li Wang, Yinhuan Liu, Zangong Zhou","doi":"10.1186/s12871-025-03210-y","DOIUrl":"10.1186/s12871-025-03210-y","url":null,"abstract":"<p><strong>Background: </strong>Sedated gastroscopy poses risks for patients with upper respiratory infections. The optimal timing for performing sedated gastroscopy in patients with acute SARS-CoV-2 infection is uncertain.</p><p><strong>Methods: </strong>We retrospectively collected data from patients who underwent sedated gastroscopy at the Affiliated Hospital of Qingdao University between December 19th 2022 and January 20th 2023. The exposure variable was SARS-CoV-2 infection status, categorized as COVID-19-negative, two weeks post-COVID-19, and three weeks post-COVID-19. The primary outcome was gastroscopy failure, and the secondary outcomes included acute laryngitis, decreased patient satisfaction, and decreased endoscopist satisfaction. Multivariate logistic regression was used to assess the association between SARS-CoV-2 infection status and outcomes.</p><p><strong>Results: </strong>Among the 386 patients included, 98 were COVID-19-negative, 57 were two weeks post-COVID-19, and 231 were three weeks post-COVID-19. Multivariate logistic regression revealed that being two weeks post-COVID-19 significantly increased the risk of gastroscopy failure (adjusted OR: 2.17, 95% CI: 1.47-3.46, P < 0.001), acute laryngitis (adjusted OR: 6.21; 95% CI: 3.01-13.04; P < 0.001), and decreased patient satisfaction (adjusted OR: 1.28; 95% CI: 1.39-4.02; P < 0.001) compared with COVID-19-negative status. No statistically significant difference was found in postoperative outcomes between three weeks post-COVID-19 and COVID-19-negative status.</p><p><strong>Conclusions: </strong>Sedated gastroscopy three weeks post-COVID-19 may be safe.</p>","PeriodicalId":9190,"journal":{"name":"BMC Anesthesiology","volume":"25 1","pages":"337"},"PeriodicalIF":2.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The organ-protective effects of nitric oxide in adult patients undergoing cardiac surgery with cardiopulmonary bypass: a systematic review and meta-analysis.","authors":"Jieru Zhang, Han Zhang, Jing Wang, Tianlong Wang, Luyu Bian, Zhenzhen Li, Jian Wang, Yuan Teng, Gang Liu, Shujie Yan, Bingyang Ji","doi":"10.1186/s12871-025-03207-7","DOIUrl":"10.1186/s12871-025-03207-7","url":null,"abstract":"","PeriodicalId":9190,"journal":{"name":"BMC Anesthesiology","volume":"25 1","pages":"335"},"PeriodicalIF":2.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The electromyographic single twitch stimulation for monitoring the effect of rocuronium on vocal cord opening - a randomised controlled trial.","authors":"Jennifer Herzog-Niescery, Maximilian von der Gönna, Sarah Joline Werner, Thomas Peter Weber, Adrian Iustin Georgevici","doi":"10.1186/s12871-025-03201-z","DOIUrl":"10.1186/s12871-025-03201-z","url":null,"abstract":"<p><strong>Background: </strong>The European Society of Anaesthesiology and Intensive Care recommends the use of neuromuscular blocking drugs for tracheal intubation, but the monitoring is difficult, because the parameters are mostly relative values (e.g. Train-of-four ratio), which show no or only weak correlations to the vocal cord aperture. We investigated the predictive effect of the quantitative single twitch (0.3 ms duration supramaximal stimulus, frequency 0.1 Hz) to estimate vocal cord aperture (primary endpoint). Secondarily, we focused on rocuronium dose-related differences between single twitch amplitude and maximum vocal cord aperture.</p><p><strong>Methods: </strong>Thirty-six adult patients undergoing elective surgery with tracheal intubation using rocuronium were included. Patients received remifentanil and propofol for induction of anaesthesia before the neuromuscular block baseline was measured electromyographically using the single twitch stimulation pattern of the ulnar nerve from the abductor digiti minimi muscle. A video-laryngoscope was inserted to document baseline conditions before the patient received either 0.3 or 0.9 mg/kg IBW rocuronium. The vocal cord area was continuously videorecorded for four minutes, before the trachea was intubated.</p><p><strong>Results: </strong>Thirty-five patients completed the study; 18 received 0.3 and 17 received 0.9 mg/kg IBW rocuronium. Data showed a strong correlation between single twitch amplitude and vocal cord aperture (bootstrapped Pearson's coefficients, median ± IQR: -0.58 ± 0.22 in rocuronium 0.3 and -0.74 ± 0.18 in rocuronium 0.9 mg/kg IBW; p < 0.001), meaning that the single twitch amplitude may be a reliable predictor of vocal cord opening. The higher rocuronium dose caused a stronger correlation, lower inter-patient variability, and a steeper single twitch decrease, but the effect on the maximum vocal cord aperture was comparable to that in the 0.3 mg/kg IBW rocuronium group.</p><p><strong>Conclusions: </strong>The quantitative, electromyographic single twitch stimulation pattern can dose-independent predict vocal cord opening after rocuronium administration.</p><p><strong>Trial registration: </strong>The study was registered at the German Clinical Trials Register on the 10th of July 2020 (DRKS00021433) prior to enrolment of the patients.</p>","PeriodicalId":9190,"journal":{"name":"BMC Anesthesiology","volume":"25 1","pages":"333"},"PeriodicalIF":2.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12225377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of oropharyngeal leak pressure between the SaCoVLM™ video laryngeal mask and LMA supreme in adult elective surgery patients: a prospective randomized controlled trial.","authors":"Gaye Gamze Ozden, Burhan Dost, Cengiz Kaya, Esra Turunc, Ersin Koksal, Yasemin Burcu Ustun, Sezgin Bilgin, Sibel Baris","doi":"10.1186/s12871-025-03218-4","DOIUrl":"10.1186/s12871-025-03218-4","url":null,"abstract":"","PeriodicalId":9190,"journal":{"name":"BMC Anesthesiology","volume":"25 1","pages":"334"},"PeriodicalIF":2.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jet ventilation dynamics in rigid bronchoscope: insights from a simulated experimental model.","authors":"Mingyuan Yang, Zhuomin Deng, Xin He, Jing Guo, Shuwang Yang, Qinghao Cheng","doi":"10.1186/s12871-025-03200-0","DOIUrl":"10.1186/s12871-025-03200-0","url":null,"abstract":"<p><strong>Background: </strong>Jet ventilation has emerged as a critical technique in airway management during airway interventions involving rigid bronchoscopy. Given the open airway and the lack of objective data on jet ventilation flow dynamics, intraoperative airway management is currently guided primarily by SpO₂ monitoring and arterial blood gas analysis.</p><p><strong>Objective: </strong>To analyze the effects of jet ventilation modes (normal frequency jet ventilation (NFJV), high frequency jet ventilation (HFJV), and superimposed high frequency jet ventilation (SHFJV)), driving pressure, and frequency on airflow dynamics using a simulated airway model.</p><p><strong>Methods: </strong>A 3D-printed rigid bronchoscope and artificial airway were integrated with a jet ventilator, airflow analyzer, and test lung. Peak airway pressure (P_peak), positive end-expiratory pressure (PEEP) and tidal volume, were measured under various conditions.</p><p><strong>Results: </strong>The major trend observed was that as the frequency increases, both P_peak and tidal volume decrease, while PEEP increases; with higher driving pressure, there is an increase in P_peak, PEEP and tidal volume. During NFJV, maxim P_peak 26.0 (0.7) cmH₂O and tidal volume1399 (3) ml were observed at 1.5 bar and12 bpm, while minimum values 11.8 (0.4) cmH₂O and 488 (3) ml occurred at 0.7 bar and 24 bpm. During HFJV, P_peak, PEEP and tidal volume reached their lowest values at 4.7 (0.3) cmH₂O, 0.8 (0.2) cmH₂O and 24 (3) ml (set at 0.3 bar and 300 bpm). When driving pressure was set at 1.1 bar, both P_peak and tidal volume reached their highest values at 22.3 (0.4) cmH₂O and 280 (2) ml when jet frequency was100 bpm; while, the maximum PEEP reaches highest value of 6.1 (0.3) cmH₂O when jet frequency increased to 300 bpm. SHFJV demonstrated dynamic interactions, with tidal volume ranging from 614 (3) ml to 1105 (1) ml as driving pressure increased from 0.3 to 1.1 bar. At 1.1 bar and 100 bpm, P_peak achieved a value of 41.1 (0.3) cmH₂O and PEEP levels increase to 8.4 (0.3) cmH₂O set at 1.1 bar and 1500 bpm.</p><p><strong>Conclusions: </strong>NFJV provides a larger tidal volume and maintains stable peak pressure, whereas HFJV results in lower tidal volumes at high frequencies and low pressures, which may clinically result in CO₂ retention. SHFJV combines the benefits of both modes, showing potential for complex airway conditions. These findings emphasize the importance of protocolized parameter selection based on individualized airway mechanics.</p>","PeriodicalId":9190,"journal":{"name":"BMC Anesthesiology","volume":"25 1","pages":"332"},"PeriodicalIF":2.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative early physiologic warning scores in the parturients undergoing cesarean section: a prospective study.","authors":"Onurcan Balik, Pınar Karabacak, Ahmet Bi̇ndal, Mehmet Okan Özkaya, Berit Gökçe Ceylan","doi":"10.1186/s12871-025-03205-9","DOIUrl":"10.1186/s12871-025-03205-9","url":null,"abstract":"","PeriodicalId":9190,"journal":{"name":"BMC Anesthesiology","volume":"25 1","pages":"331"},"PeriodicalIF":2.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of corticosteroids in critically ill patients: a systematic review and meta-analysis.","authors":"Lei Cao, Yingying Xiang, Zhuoxi Wu, Qi Chen, Fang Chen, Guiying Yang, Hong Li","doi":"10.1186/s12871-025-03196-7","DOIUrl":"10.1186/s12871-025-03196-7","url":null,"abstract":"<p><strong>Background: </strong>The overall benefits and potential risks of corticosteroids, frequently administered to critically ill patients remain uncertain. This systematic review and meta-analysis evaluated the efficacy and safety of corticosteroid therapy in critically ill patients with severe community-acquired pneumonia, sepsis or septic shock, or acute respiratory distress syndrome. We hypothesized that corticosteroids reduce short-term mortality in critically ill patients.</p><p><strong>Methods: </strong>We performed a search of Medline, Embase, and the Cochrane Central Register of Controlled Trials from database inception up to November 30, 2024. The search was limited to randomized controlled trials in human populations published in English. Dichotomous outcomes are reported as relative risk (RRs) and continuous outcomes as mean differences (MDs), both with 95% confidence intervals (CIs). The primary outcome was short-term mortality (28-day or nearest reported). Secondary outcomes included ICU/hospital length of stay, mechanical ventilation duration, ventilator-free days at 28 days, oxygenation index, reversed shock in sepsis or septic shock, and adverse events. We evaluated heterogeneity using I² and explored it using subgroup and meta-regression analyses.</p><p><strong>Results: </strong>Forty-three randomized controlled trials (n = 10853) were included. Corticosteroids reduced short-term mortality in critically ill patients compared to placebo (RR, 0.85; 95% CI, 0.77-0.94). Corticosteroid treatment for critically ill patients reduced intensive care unit (MD, - 2.02 days; 95% CI, - 3.14 - -0.90) and hospital (MD, - 2.66 days; 95% CI, - 4.58 - -0.74) lengths of stay, and duration of mechanical ventilation (MD, - 4.24 days; 95% CI, - 6.38 - -2.10); it increased ventilator-free days at 28 days (MD, 2.83 days; 95% CI, 1.20-4.47), improved oxygenation index (PaO₂/FiO₂) in patients undergoing mechanical ventilation (MD, 61.41 mmHg; 95% CI, 26.64-96.18), and reversed shock in sepsis or septic shock (RR, 1.20; 95% CI, 1.06-1.35). No significant differences were observed in infection rates (RR, 1.01; 95% CI, 0.92-1.12) and gastrointestinal bleeding (RR, 1.07; 95% CI, 0.86-1.33). Hyperglycemia was more prevalent in the corticosteroid group (RR, 1.10; 95% CI, 1.06-1.14).</p><p><strong>Conclusions: </strong>Subgroup analysis indicated that early initiation (≤ 72 h), low-dose (e.g., < 400 mg/day hydrocortisone equivalent), and prolonged (≥ 7 days) corticosteroid therapy was associated with reduced short-term mortality in critically ill patients with severe community-acquired pneumonia or acute respiratory distress syndrome. For septic shock, combination therapy (hydrocortisone plus fludrocortisone) may enhance efficacy.</p><p><strong>Clinical trial registration: </strong>PROSPERO: CRD42024517843.</p>","PeriodicalId":9190,"journal":{"name":"BMC Anesthesiology","volume":"25 1","pages":"319"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12211793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effects of remimazolam and propofol on postoperative delirium in elderly surgical patients: a meta-analysis.","authors":"Jiayu Huang, Zhenke Xiao, Junming Lao, Lingli Pan, Zhou Chen, Zehua Lin","doi":"10.1186/s12871-025-03197-6","DOIUrl":"10.1186/s12871-025-03197-6","url":null,"abstract":"","PeriodicalId":9190,"journal":{"name":"BMC Anesthesiology","volume":"25 1","pages":"329"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The safety and efficacy of two different airway management methods for patients undergoing fiberoptic bronchoscopy: a prospective, randomized, controlled clinical trial.","authors":"Ping Zhang, Zongwang Zhang, Guoying Liu, Jiali Ding, Qianqian Han, Xiangrong Du","doi":"10.1186/s12871-025-03179-8","DOIUrl":"10.1186/s12871-025-03179-8","url":null,"abstract":"","PeriodicalId":9190,"journal":{"name":"BMC Anesthesiology","volume":"25 1","pages":"298"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}