Biorheology最新文献_第6页

Rheological characterization of an in vitro model for salmonid chyme to quantify changes in feed composition. 鲑鱼食糜体外模型流变学表征以量化饲料成分的变化。

IF 1.1 4区医学

Biorheology Pub Date : 2018-01-01 DOI: 10.3233/BIR-18167

Mark Schumann, Alexander Brinker, Christian Friedrich

{"title":"Rheological characterization of an in vitro model for salmonid chyme to quantify changes in feed composition.","authors":"Mark Schumann, Alexander Brinker, Christian Friedrich","doi":"10.3233/BIR-18167","DOIUrl":"https://doi.org/10.3233/BIR-18167","url":null,"abstract":"Background: Developments in the production of aquacultural salmonid feeds in the last 20 years have led to extruded diets with extremely low water content and a shift from mainly marine fish based ingredients towards plant content. These changes expose the industry to the vagaries of the highly dynamic plant protein market. Resulting variations in the precise composition of aqua feeds may carry unpredictable consequences for water quality, since some plant ingredients cause undesirable reductions in the mechanical stability of faeces. Dietary supplements known as binders that enhance the stability of faeces have the potential to mitigate these issues, but may also bring negative effects.Objective and methods: The present study employs an in vitro model to perform the first fundamental rheological characterization of salmonid chyme, and a factorial experiment designed to investigate the impacts of the presence of rheologically active substances.Results: The highest mean viscosity values were measured for a treatment containing a 2:1 ratio of tara gum:xanthan gum, resulting in chyme four times more viscous than a control formulation containing the same amount of water. Shear resistance was quantified by analyses of slopes fitting the frequency sweep measurements.Conclusions: These data open a new statistical approach to monitoring the consequences of market-driven changes in aqua feed composition and their impacts on the nutrition, health or performance of farmed fish.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"54 5-6","pages":"167-184"},"PeriodicalIF":1.1,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/BIR-18167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36014596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Characterization of the visco-elastic properties of hyaluronic acid. 透明质酸粘弹性的表征。

IF 1.1 4区医学

Biorheology Pub Date : 2018-01-01 DOI: 10.3233/BIR-180174

Beatriz Lázaro, Prudencio Alonso, Andrea Rodriguez, Manuel La Nuez, Florencio Marzo, Julio G Prieto

{"title":"Characterization of the visco-elastic properties of hyaluronic acid.","authors":"Beatriz Lázaro, Prudencio Alonso, Andrea Rodriguez, Manuel La Nuez, Florencio Marzo, Julio G Prieto","doi":"10.3233/BIR-180174","DOIUrl":"https://doi.org/10.3233/BIR-180174","url":null,"abstract":"Background: Hyaluronic acid (HA) is a polysaccharide present in almost all animal tissues, in which it carries out important biological functions, among them, the protection of the joints by lubricating them and dampening the tension in them.Objective: This study compares the viscoelastic properties of several commercial preparations of HA, to determine their suitability for use as viscosupplementation therapy in joint pathology (osteoarthritis).Methods: 4 HA hydrogels: Durolane®, Synocrom_Forte_One®, Synvisc_One® and Viscoplus_Matrix® and 4 HA solutions: Ostenil®, Ostenil_Plus®, Viscoplus_Gel® and Orthovisc® were analyzed to compare their viscoelatsic rheological parameters using an oscillatory-rotational rheometer.Results: With respect to the 4 HA hydrogels, comparison of crossover frequencies allowed division into two main groups: Synvisc_One® and Viscoplus_Matrix®, with crossover frequencies in the order of magnitude of 10-2 Hz, while Synocrom_Forte_One® and Durolane® showed crossover frequencies on the order of 10-1 Hz. Only one of the 4 HA solutions, Viscoplus_Gel®, showed a crossover frequency on the order of 10-2, whereas Ostenil_Plus® and Orthovisc® showed crossover frequencies on the order of 10-1, and Ostenil® remained as a predominantly viscous fluid for frequencies as high as 4.8 Hz.Conclusions: The viscoelastic properties of the HA preparations can be ordered according to the values of G∗ (the rigidity, or vector sum of the elastic modulus G' and the viscous modulus G'') at both transition points (0.5 and 2.5 Hz) as follows: Viscoplus_Matrix® > Viscoplus_Gel® > Durolane® > Synocrom_Forte_One® > Ostenil_Plus® > Synvisc_One® > Orthovisc® > Ostenil®.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"55 1","pages":"41-50"},"PeriodicalIF":1.1,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/BIR-180174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36629212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Increased erythrocyte aggregation following an acute bout of eccentric isokinetic exercise does not exceed two days. 急性偏心等速运动后红细胞聚集增加不超过两天。

IF 1.1 4区医学

Biorheology Pub Date : 2018-01-01 DOI: 10.3233/BIR-180175

Emine Kilic-Toprak, Fatma Unver, Ozgen Kilic-Erkek, Halil Korkmaz, Yasin Ozdemir, Burak Oymak, Alten Oskay, Melek Bor-Kucukatay

{"title":"Increased erythrocyte aggregation following an acute bout of eccentric isokinetic exercise does not exceed two days.","authors":"Emine Kilic-Toprak, Fatma Unver, Ozgen Kilic-Erkek, Halil Korkmaz, Yasin Ozdemir, Burak Oymak, Alten Oskay, Melek Bor-Kucukatay","doi":"10.3233/BIR-180175","DOIUrl":"https://doi.org/10.3233/BIR-180175","url":null,"abstract":"Background: Isokinetic exercise is used to reduce strength imbalance and to enhance performance.Objective: The aim of this study was to investigate the acute effects of a single bout of eccentric isokinetic exercise on hemorheology (erythrocyte deformability and aggregation), total oxidant/antioxidant status (TOS/TAS) and oxidative stress index (OSI) in active individuals.Methods: The study comprises 11 active, healthy, male subjects (mean age of 19.45 ± 0.31 years, BMI 22.05 ± 0.51 kg/m2). They performed single, unilateral eccentric contractions of knee flexors and extensors with dominant leg on a dynamometer. Isokinetic hamstring, quadriceps strength were recorded at eccentric (30, 120° s-1) angular velocities. Eight active age-matched healthy male subjects were included as a control group, who did not receive exercise. Blood samples were obtained before, immediately after and two days after the exercise session. Hemorheological parameters were measured by an ektacytometer. TOS/TAS were determined using a commercial kit.Results: A session of eccentric isokinetic exercise did not affect erythrocyte deformability and oxidative stress indices, whereas red blood cell (RBC) aggregation was increased initially and returned to pre-exercise levels after two days following exercise.Conclusion: Our results suggest that, increased RBC aggregation following an acute bout of isokinetic exercise may result in increased plasma skimming that augments tissue perfusion and clearance of metabolites within a period of two days following exercise.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"55 1","pages":"15-24"},"PeriodicalIF":1.1,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/BIR-180175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36809660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Remodeling of the arterial wall: Response to restoration of normal blood flow after flow reduction. 动脉壁重塑:对血流减少后恢复正常血流的反应。

IF 1.1 4区医学

Biorheology Pub Date : 2018-01-01 DOI: 10.3233/BIR-17146

Kozaburo Hayashi, Daichi Kakoi, Akihisa Makino

{"title":"Remodeling of the arterial wall: Response to restoration of normal blood flow after flow reduction.","authors":"Kozaburo Hayashi, Daichi Kakoi, Akihisa Makino","doi":"10.3233/BIR-17146","DOIUrl":"https://doi.org/10.3233/BIR-17146","url":null,"abstract":"Background: Although many studies have shown that arteries change diameter in response to chronic change in blood flow (BF), keeping wall shear stress (WSS) at physiologically normal levels, relatively little is known about the effects of flow restoration after flow reduction and also the role of vascular smooth muscle (VSM) during such a remodeling process.Objective: To elucidate the biomechanical responses of the arterial wall to the restoration of normal BF after flow reduction and compare the results with our previous results observed in response to decreased BF alone.Methods: Carotid artery BF in the Wistar rat was decreased by ligation and then restored to normal levels by release of the ligation. The effects of BF changes on the biomechanical properties of the carotid arterial wall were determined from measurements of diameters and pressures of excised artery segments.Results: During BF reduction and restoration, WSS was maintained at physiological levels by changes in the internal diameter. No significant changes in the incremental elastic modulus were found in response to changes in BF. VSM tone was significantly enhanced during the changes in BF.Conclusions: Arteries change diameters in response to BF reduction and also flow restoration to normal after flow reduction, keeping WSS at physiologically normal levels. The lack of changes in vascular elasticity suggests that there were no significant changes in major wall constituents, such as elastin and collagen. VSM may play the dominant role in observed arterial remodeling and adaptation.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"54 2-4","pages":"95-108"},"PeriodicalIF":1.1,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/BIR-17146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35774166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Effects of aging and gender on micro-rheology of blood in 3 to 18 months old male and female Wistar (Crl:WI) rats. 年龄和性别对3 ~ 18月龄Wistar雄性和雌性大鼠血液微流变学的影响。

IF 1.1 4区医学

Biorheology Pub Date : 2018-01-01 DOI: 10.3233/BIR-17148

Viktoria Somogyi, Katalin Peto, Adam Deak, Bence Tanczos, Norbert Nemeth

{"title":"Effects of aging and gender on micro-rheology of blood in 3 to 18 months old male and female Wistar (Crl:WI) rats.","authors":"Viktoria Somogyi, Katalin Peto, Adam Deak, Bence Tanczos, Norbert Nemeth","doi":"10.3233/BIR-17148","DOIUrl":"https://doi.org/10.3233/BIR-17148","url":null,"abstract":"Background: Age- and gender-related alterations of hemorheological parameters have not been completely elucidated to date. Experiments on older animals may give valuable information on this issue. However, the majority of rheological studies have been performed in young rodents.Objective: We aimed to investigate the influence of aging and gender on hemorheological parameters in rats.Methods: Coeval male (n=10) and female (n=10) Wistar (Crl:WI) rats were followed-up over 15 months. Blood samples were obtained from the lateral tail vein at 3, 4, 5, 9, 12, 15 and 18 months of age. Hematological parameters, red blood cell deformability (elongation under shear), osmotic gradient deformability and erythrocyte aggregation were tested. Body weight and the estrus cycle (in females) were also examined.Results: Erythrocyte aggregation showed age- and gender-related variations. Red blood cell deformability was greater in females and gradually decreased over the 15-month period in both genders. Erythrocyte aggregation was greater in male rats at most ages, but did not show consistent changes with age.Conclusions: The micro-rheological parameters showed age-related alterations with gender differences. The effect of the estrous cycle cannot be excluded in female rats. The results provide reference data for studies of aging in rats and of the mechanism related to age and gender differences in hemorheology.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"54 5-6","pages":"127-140"},"PeriodicalIF":1.1,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/BIR-17148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35933664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Possible erythrocyte contributions to and exacerbation of the post-thrombolytic no-reflow phenomenon. 红细胞对溶栓后无血流现象的可能贡献和加剧。

IF 1.1 4区医学

Biorheology Pub Date : 2018-01-01 DOI: 10.3233/BIR-17144

Shang-Jen Yu, James P Buerck, Edgar A O'Rear, Thomas L Whitsett

{"title":"Possible erythrocyte contributions to and exacerbation of the post-thrombolytic no-reflow phenomenon.","authors":"Shang-Jen Yu, James P Buerck, Edgar A O'Rear, Thomas L Whitsett","doi":"10.3233/BIR-17144","DOIUrl":"https://doi.org/10.3233/BIR-17144","url":null,"abstract":"Background: Reperfusion injury often occurs with therapeutic intervention addressing the arterial occlusions causing acute myocardial infarction and stroke. The no-reflow phenomenon has been ascribed to leukocyte plugging and blood vessel constriction in the microcirculation.Objective: To assess possible red cell contributions to post-thrombolytic no-reflow phenomenon.Methods: Blood clots were formed by recalcifying 1 ml of citrated fresh human venous blood and then lysed by adding 1,000 units of streptokinase (SK) at several intervals within 1 hour. Red cell deformability was tested by both a microscopic photometric and a filtration technique, viscosity by a cone and plate viscometer, and erythrocyte aggregation by an optical aggregometer.Results: Two sampling methods were devised for the microscopic photometric test, both of which indicated increases of erythrocyte stiffness after being lysed from the clot by SK. In accompanying experiments, the viscosity, aggregation and filterability of the post-lytic erythrocytes were assessed. Results indicated increased viscosity in Ringer's, decreased aggregation index and filterability through a 5 μm pore size Nuclepore membrane.Conclusion: Findings demonstrated that post-lytic changes in red cell deformability do occur which could contribute to the no-reflow phenomenon.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"54 2-4","pages":"81-93"},"PeriodicalIF":1.1,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/BIR-17144","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35734653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cross-sectional distributions of normal and abnormal red blood cells in capillary tubes determined by a new technique. 用一种新技术测定毛细管中正常和异常红细胞的横截面分布。

IF 1.1 4区医学

Biorheology Pub Date : 2018-01-01 DOI: 10.3233/BIR-18166

Takahiro Sasaki, Junji Seki, Tomoaki Itano, Masako Sugihara-Seki

{"title":"Cross-sectional distributions of normal and abnormal red blood cells in capillary tubes determined by a new technique.","authors":"Takahiro Sasaki, Junji Seki, Tomoaki Itano, Masako Sugihara-Seki","doi":"10.3233/BIR-18166","DOIUrl":"https://doi.org/10.3233/BIR-18166","url":null,"abstract":"Background: In the microcirculation, red blood cells (RBCs) were observed to be confined to an axial stream surrounded by a marginal RBC depleted layer. This axial accumulation of RBCs is considered to arise from the RBC deformability.Objective: To quantitatively evaluate the effect of RBC deformability on their axial accumulation at a flow condition comparable to that in arterioles by developing a new observation system for accurate measurements of radial RBC positions in the cross section of capillary tubes.Methods: The cross-sectional distributions of normal and hardened RBCs as well as softened RBCs suspended in capillary tube flows were measured with high spatial resolution. A new observation system was developed in which enface views of the cross-section of the tube were obtained at small distances upstream of the outlet at various longitudinal positions in the tube.Results: The radial positions of individual RBCs were detected within 1 μm accuracy. It was found that normal and softened RBCs rapidly migrated away from the wall towards the tube axis, whereas glutaraldehyde-hardened RBCs were dispersed widely over the tube cross-section, depending on the concentration of glutaraldehyde solution.Conclusions: The newly devised observation system revealed quantitatively the essential role of RBC deformability in their axial accumulation.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"54 5-6","pages":"153-165"},"PeriodicalIF":1.1,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/BIR-18166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35973311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Viscoelastic properties of normal rat liver measured by ultrasound elastography: Comparison with oscillatory rheometry. 超声弹性成像测量正常大鼠肝脏的粘弹性特性:与振荡流变仪的比较。

IF 1.1 4区医学

Biorheology Pub Date : 2017-03-29 DOI: 10.3233/BIR-16091

Haoming Lin, Yuanyuan Shen, Xin Chen, Ying Zhu, Yi Zheng, Xinyu Zhang, Yanrong Guo, Tianfu Wang, Siping Chen

{"title":"Viscoelastic properties of normal rat liver measured by ultrasound elastography: Comparison with oscillatory rheometry.","authors":"Haoming Lin, Yuanyuan Shen, Xin Chen, Ying Zhu, Yi Zheng, Xinyu Zhang, Yanrong Guo, Tianfu Wang, Siping Chen","doi":"10.3233/BIR-16091","DOIUrl":"https://doi.org/10.3233/BIR-16091","url":null,"abstract":"BACKGROUND\u0000Ultrasound elastography has been widely used to measure liver stiffness. However, the accuracy of liver viscoelasticity obtained by ultrasound elastography has not been well established.\u0000\u0000\u0000OBJECTIVE\u0000To assess the accuracy of ultrasound elastography for measuring liver viscoelasticity and compare to conventional rheometry methods. In addition, to determine if combining these two methods could delineate the rheological behavior of liver over a wide range of frequencies.\u0000\u0000\u0000METHODS\u0000The phase velocities of shear waves were measured in livers over a frequency range from 100 to 400 Hz using the ultrasound elastography method of shearwave dispersion ultrasound vibrometry (SDUV), while the complex shear moduli were obtained by rheometry over a frequency range of 1 to 30 Hz. Three rheological models, Maxwell, Voigt, and Zener, were fit to the measured data obtained from the two separate methods and from the combination of the two methods.\u0000\u0000\u0000RESULTS\u0000The elasticity measured by SDUV was in good agreement with that of rheometry. However, the viscosity measured by SDUV was significantly different from that of rheometry.\u0000\u0000\u0000CONCLUSIONS\u0000The results indicate that the high frequency components of the dispersive data play a much more important role in determining the dispersive pattern or the viscous value than the low frequency components. It was found that the Maxwell model is not as appropriate as the Voigt and Zener models for describing the rheological behavior of liver.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"53 5-6 1","pages":"193-207"},"PeriodicalIF":1.1,"publicationDate":"2017-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/BIR-16091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42251479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Creep compliance rheology with a probe-like cylindrical geometry. 蠕变顺应流变性与探针样圆柱形几何。

IF 1.1 4区医学

Biorheology Pub Date : 2017-03-29 DOI: 10.3233/BIR-16112

Kelly T Connelly, P. Sharif-Kashani, Matthew Farajzadeh, J. Hubschman, H. Kavehpour

{"title":"Creep compliance rheology with a probe-like cylindrical geometry.","authors":"Kelly T Connelly, P. Sharif-Kashani, Matthew Farajzadeh, J. Hubschman, H. Kavehpour","doi":"10.3233/BIR-16112","DOIUrl":"https://doi.org/10.3233/BIR-16112","url":null,"abstract":"BACKGROUND\u0000Rheology experiments have been performed on the vitreous humor, a soft gel that rests inside of the eye, to study its viscoelastic behavior and underlying macromolecular structure. A significant challenge for experimentalists is preserving the macromolecular structure when removing vitreous from in vivo conditions.\u0000\u0000\u0000OBJECTIVE\u0000We have developed a novel probe-like rheometer geometry that allows us to perform shear rheology experiments on the vitreous humor in situ. The aim of this study is to assess the feasibility of the probe geometry.\u0000\u0000\u0000METHODS\u0000Creep compliance responses of silicone oils, Xanthan gum solutions, and bovine and porcine vitreous humor were measured using the probe geometry and compared to measurements performed with standard geometries.\u0000\u0000\u0000RESULTS\u0000Viscosities calculated from the creep responses of silicone oils closely match between the probe and standard geometry. Viscosities and creep compliance values of Xanthan gum measurements achieve order of magnitude agreement between the probe and standard geometry. Significant differences are detected with the probe between bovine and porcine vitreous (p<0.001).\u0000\u0000\u0000CONCLUSIONS\u0000These results suggest the probe may feasibly measure viscosities of Newtonian fluids, and correctly detect differences in the creep response of complex fluids with varying viscoelastic behaviors.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"53 5-6 1","pages":"221-236"},"PeriodicalIF":1.1,"publicationDate":"2017-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/BIR-16112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43393891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Prediction of the level and duration of shear stress exposure that induces subhemolytic damage to erythrocytes. 预测剪应力暴露诱导红细胞亚溶血损伤的水平和持续时间。

IF 1.1 4区医学

Biorheology Pub Date : 2017-03-29 DOI: 10.3233/BIR-16120

Michael J. Simmonds, H. Meiselman

{"title":"Prediction of the level and duration of shear stress exposure that induces subhemolytic damage to erythrocytes.","authors":"Michael J. Simmonds, H. Meiselman","doi":"10.3233/BIR-16120","DOIUrl":"https://doi.org/10.3233/BIR-16120","url":null,"abstract":"BACKGROUND\u0000Current generation mechanical circulatory assist devices are designed to minimize high shears to blood for prolonged durations to avoid hemolysis. However, red blood cells (RBC) demonstrate impaired capacity to deform when exposed to shear stress (SS) well below the \"hemolytic threshold\".\u0000\u0000\u0000OBJECTIVE\u0000We endeavored to identify how changes in the magnitude and duration of SS exposure alter RBC deformability and subsequently develop a model to predict erythrocyte subhemolytic damage.\u0000\u0000\u0000METHODS\u0000RBC suspensions were exposed to discrete magnitudes of SS (1-64 Pa) for specific durations (1-64 s), immediately prior to RBC deformability being measured. Analyses included exploring the maximal RBC deformation (EImax) and SS required for half EImax (SS1/2). A surface-mesh was interpolated onto the raw data to predict impaired RBC deformability.\u0000\u0000\u0000RESULTS\u0000When SS was applied at <16Pa, limited changes were observed. When RBC were exposed to 32 Pa, mild impairments in EImax and SS1/2 occurred, although 64 Pa caused a dramatic impairment of RBC deformability. A clear relation between SS duration and magnitude was determined, which could predict impaired RBC deformability.\u0000\u0000\u0000CONCLUSION\u0000The present results provide a model that may be used to predict whether RBC deformability is decreased following exposure to a given level and duration of SS, and may guide design of future generations of mechanical circulatory assist devices.","PeriodicalId":9167,"journal":{"name":"Biorheology","volume":"53 5-6 1","pages":"237-249"},"PeriodicalIF":1.1,"publicationDate":"2017-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/BIR-16120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43867964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40