Journal of stem cell research & therapeutics最新文献

{"title":"Autologous bone marrow concentrate (bmc) for the treatment of osteoarthritis (o.a) of the knee, hip, and shoulder in former n.f.l. players","authors":"K. Pettine, Richard K. Suzuki, M. Murphy, Kathryn Moncivais, Meghana Malur","doi":"10.15406/JSRT.2018.04.00106","DOIUrl":"https://doi.org/10.15406/JSRT.2018.04.00106","url":null,"abstract":"Osteoarthritis (O.A) affects over 50 million Americans. This includes mostly O.A of the shoulder, hip, and knee. Shoulder osteoarthritis (O.A) has been demonstrated in cadaver and radiographic studies to affect up to 33% of patients over the age of 60 [1]. Patients with shoulder O.A have pain, crepitus, decreased ability to place their hand at a desired point in space and loss of motion, severely impairing activities of daily living. The nonsurgical treatments for shoulder O.A include the use of analgesics, non-steroidal anti-inflammatory medications, and shoulder exercises to maintain range of motion. The surgical treatment for shoulder O.A is total shoulder arthroplasty [1,2].","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84429342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem cell therapy: in treatment of neurodegenerative diseases","authors":"S. K. Varma, K. MohsinaHyder, Swati Som, S. P. Dhanabal","doi":"10.15406/JSRT.2018.04.00105","DOIUrl":"https://doi.org/10.15406/JSRT.2018.04.00105","url":null,"abstract":"Stem cells are undifferentiated cells that have the ability of proliferation, regeneration, conversion to differentiated cells and tissue production. Regeneration means that these cell shave the ability of asymmetric division, which one of the resulting cells remains as stem cell while another cell, which is called daughter cell, becomes one cell of germ layer. Stem cells may remain inactive for a long time till they enter cell division again [1,2]. Stem cells are divided into two groups: embryonic and adult stem cells. Embryonic stem cells are derived from the zygote cell which is fertilized in vitro and usually is 4-5 day embryo that is in the form of a hollow ball called blastocyst. A Blastocyst is composed of three parts: the trophoblast layer that is surrounding blastocyst, a hollow cavity inside the blastocyst and inner cell mass that changes in the embryo. Since zygote cells can differentiate into placenta and fetal cells, sometimes they are considered as the only true totipotent stem cells. Because the inner cell mass of the blastocyst does not have the ability to differentiate into placenta cells, it is called the pluripotent cell. Non-differentiated cells other than embryonic stem cells can be found in differentiated cells of specific tissues after birth. These cells are called adult or non-embryonic stem cells, but a more accurate word for them is “somatic stem cells” because these cells also exist in children and umbilical cord. They are divided into two main categories: hematopoietic stem cells that can differentiate into blood cells and mesenchymal stem cells that are less differentiated. Nose, muscle, liver, skin, brain, retina and limbus of the eye are the other sources of adult stem cells. One of the most important advantages of adult stem cells over embryonic stem cells is because of the fact that they can be obtained without the need for destruction of embryo [3]. Different types of stem cells are shown in Figure 1. The pluripotent stem cell differentiates into the multipotent cell of 3 different germ layers (ectoderm, mesoderm and endoderm layer). The multipotent cell differentiates into unipotent cell of a specific cell lineage within its germ layer. If differentiation process is successful, the resulting cells will be called as progenitor cells or stem cell-like cells that have the capability of regeneration [4,6]. Stem cell therapy has been evaluated in various blood diseases (such as lymphoblastic leukemia, myeloid leukemia, thalassemia, multiple myeloma, cell cycle anemia). The aim of this review is to evaluate cell therapy in different diseases.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90072748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topiramate induced lithium toxicity","authors":"Afaque H Khan","doi":"10.15406/JSRT.2018.04.00104","DOIUrl":"https://doi.org/10.15406/JSRT.2018.04.00104","url":null,"abstract":"Numerous studies have described that mechanism of action of Topiramate has wide spectrum pharmacological properties. He has been used as mood stabilizers in bipolar and schizoaffective disorder, anorexia bulimia, epilepsy, migraine, essential tremors and cluster headache. It is also effective in treatment resistant bipolar disorder by augmentation of effects of lithium. It has been reported in recent literature that topiramate also use in binge eating disorder (BED) and for weight loss [1]. Topiramate reduces the frequency of the voltage sensitive sodium channels and play a key role in treatment of epilepsy. Topiramate potentiates the effects of inhibitory effects of Gama amino butyric acid-A in the brain. Topiramate has been also found, enhance the effects of Gaba stimulated chloride influx in cerebral which also increase frequency of activation of Gaba-A receptor in brain and exhibits an anticonvulsants action. Topiramate is also known to have inhibitory action on excitatory pathways of AMPA and glutamate receptors and contributes as an anticonvulsant agent. TPM also inhibits high voltage activated calcium channels and decrease their neurotransmitter release and inhibit calcium dependent second messenger system. TPM also has inhibitory action at carbonic anhydrate at proximal tubular level. TPM has been considered weak CAinhibitor and this property has no therapeutic values in treatment of epilepsy and other conditions. This action determines some of its side effects such as hyponatremia, metabolic acidosis and increase risk of nephrolithiasis [2].","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77227957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engraftment of dopamine neuron precursor cells derived from adult mesenchymal stem cells: preliminary in vivo study","authors":"Judith Zavala, Demetrio Arcos, J. Cuevas, M. Gonzalez-Garza","doi":"10.15406/jsrt.2017.03.00103","DOIUrl":"https://doi.org/10.15406/jsrt.2017.03.00103","url":null,"abstract":"Cell therapy has been proposed as an alternative for treatment of neurodegenerative disorder. Parkinson’s Diseases (PD) are caused by specific and selective loss of nigrostriatal dopaminergic neurons [1]. The possibility of replacing those cells has been explored through the transplantation of embryonic stem cells (ESCs), fetal stem cells, induced pluripotential stem cells (iPSCs), and mesenchymal stem cells (MSCs) in animal models and clinical trials [1,2]. The aim of this study was to explore the possibility of transplanting adult MSCs pre-differentiated into dopaminergic neurons and look for their capability to brain engraftment and the possible improvement of PD symptoms in a PD rat model.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76623994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroblast-like cells derived from ips cells of patients with the familial forms of parkinson’s disease can serve an effective feeder for derivation and cultivation of new ips cells lines","authors":"E. Novosadova, E. S. Manuilova, E. Arsenyeva, V. Tarantul, S. Illarioshkin, I. Grivennikov","doi":"10.15406/JSRT.2017.3.00102","DOIUrl":"https://doi.org/10.15406/JSRT.2017.3.00102","url":null,"abstract":"Generation of induced pluripotent stem cells (iPSC) is considered one of the major biological discoveries of the 21st century. IPSC were originally obtained in 2006-2007 by Japanese scientists first from mouse fibroblasts, and later from adult human fibroblasts [1,2]. IPSC have provided a unique platform for studying pathogenesis of different diseases and opened the door to their clinical application in regenerative medicine [2]. The employment of iPSC does not entail ethical issues, since adult human tissues are used just as a source for their generation. Regenerative medicine has great expectations for that particular cell type, since immune rejection represents one of the main complications in tissue and organ grafting.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75878828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal stem cells derived from rat bone marrow (rbm msc): techniques for isolation, expansion and differentiation","authors":"P. Sangeetha, K. MaitiS., D. Mohan, S. Shivaraju, R. Raguvaran, Malik Abu Rafee, Bindhuja Bv, Naveen Kumar, Raguvanshi Pds","doi":"10.15406/JSRT.2017.03.00101","DOIUrl":"https://doi.org/10.15406/JSRT.2017.03.00101","url":null,"abstract":"In the past decade, the field of stem cells and cell-based therapies has undergone a remarkable evolution. The potential of stem cell to differentiate into various types of cells has revolutionized their use in clinics for the treatment of a variety of clinical conditions. Mesenchymal stem cells can be cultured and grown for many generations under appropriate conditions in the laboratory and still retain a stable morphology and chromosome complement [1]. Bone marrow obtained mesenchymal stem cells are the most studied stem cell type that is capable of differentiating into variety of cell lineages. Differences in differentiation ability to osteogenic, chondrogenic and adipogenic lineages of MSCs harvested from Murine species of various age groups and the number of passage of these cultured cells has been reported. Osteogenic and chondrogenic potential reduced with each and every age group and adipogenic differentiation ability reduced only in cells obtained from oldest donors [2]. The technique of bone marrow collection and stem cell culture vary for different species [3]. Culturing of rodent bone marrow derived stem cell is a little bit difficult when compared to its human counterpart [4]. Here we described a simple and easy technique of stem cells isolation and differentiation from adult Wistar rats.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91280760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in induced pluripotent stem cell (ipsc) based therapeutics","authors":"Santosh Gupta, Vineeta Sharma, R. Verma","doi":"10.15406/JSRT.2017.03.00100","DOIUrl":"https://doi.org/10.15406/JSRT.2017.03.00100","url":null,"abstract":"Abbreviations: iPSC, induced pluripotent stem cells; ESC, embryonic stem cells; SCNT, somatic cell nuclear transfer; TFs, transcription factors; Sox2, sex determining region y-box 2; Klf4, krueppel-like factor 4; Utf1, undifferentiated embryonic cell transcription factor 1; Sall4, sal-like protein 4; hTERT, telomerase reverse transcriptase; HAT, histone acetyltransferase; CBP, creb binding protein; MSC, mesenchymal stem cells; PDAC, pancreatic cancer cell model; BMEC, brain micro vascular endothelial cells; HD, huntington disease","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77301432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem cell therapy: an adjunct in the treatment of mdr tuberculosis","authors":"Kamal Uddin Zaidi, F. Khan, V. Thawani","doi":"10.15406/JSRT.2017.03.00099","DOIUrl":"https://doi.org/10.15406/JSRT.2017.03.00099","url":null,"abstract":"Tuberculosis (TB) is one of the most ancient diseases of mankind and has co-evolved with humans for several million years [1]. There are also evidences of the presence of the disease in pre-historic Asia, but it was only towards the end of 19th century that the peaks of incidence were observed in India and China [2]. Modern approach for diagnosis and treatment of TB is complicated. Specific perceptive of pathogenesis of TB is still unknown [3]. Furthermore, HIV co-infection substantially increases the risk of progression from latent TB to active TB and is the leading cause of mortality in HIV infected person in India [4,5].","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83960090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functions and dysfunctions of neuroplastin65 in the nervous system","authors":"Q. Yuan, Huanhuan Li","doi":"10.15406/jsrt.2017.03.00098","DOIUrl":"https://doi.org/10.15406/jsrt.2017.03.00098","url":null,"abstract":"Cell adhesion molecules (CAMs) have essential roles in forming functional networks in the nervous system. CAMs can be classified into several families including immunoglobulin super family (IgSF), cadherin family, integrins and selections [1]. Neuroplastins are transmembrane glycoprotein’s that belong to IgSF. Neuroplastin65 (NP65) and neuroplastin55 (NP55) are produced by NPTN gene by alternative splicing [2]. NP55 is widely distributed in various tissues. However, NP65 is restrictively expressed in the nervous system.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81536406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender, age and differences in stem cell expression and efficacy","authors":"J. K. Williams, S. Mariya, I. Suparto","doi":"10.15406/jsrt.2017.3.00097","DOIUrl":"https://doi.org/10.15406/jsrt.2017.3.00097","url":null,"abstract":"Submit Manuscript | http://medcraveonline.com examples of age and gender differences in the risk of chronic conditions such as heart disease, osteoporosis and urogenital dysfunction. There are also differences in the ability of different genders and ages to respond to treatments. It stands to reason there may be age and gender differences in their ability to regenerate tissues in response to cell therapy. This review will address the evidence for and against these potential differences.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79958997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}