Functions and dysfunctions of neuroplastin65 in the nervous system

Abstract

Cell adhesion molecules (CAMs) have essential roles in forming functional networks in the nervous system. CAMs can be classified into several families including immunoglobulin super family (IgSF), cadherin family, integrins and selections [1]. Neuroplastins are transmembrane glycoprotein’s that belong to IgSF. Neuroplastin65 (NP65) and neuroplastin55 (NP55) are produced by NPTN gene by alternative splicing [2]. NP55 is widely distributed in various tissues. However, NP65 is restrictively expressed in the nervous system.