Journal of stem cell research & therapeutics最新文献

Echinacea purpurea, a pathway to increased immunity 紫锥菊，一种增强免疫力的途径

Journal of stem cell research & therapeutics Pub Date : 2023-09-04 DOI: 10.15406/jsrt.2023.08.00161

Maria Cecilia Ciaccio Vendola

引用次数: 0

Inhibition of cancer promoting proteins 抑制促癌蛋白

Journal of stem cell research & therapeutics Pub Date : 2018-11-01 DOI: 10.15406/JSRT.2018.04.00125

J. C. Lisboa

引用次数: 0

An in-vitro study of Amniotic membrane, Villous chorion and Wharton’s jelly-derived Mesenchymal stem cells and their potential for cardiac repair 羊膜、绒毛绒毛膜和沃顿氏凝胶来源的间充质干细胞及其心脏修复潜力的体外研究

Journal of stem cell research & therapeutics Pub Date : 2018-10-18 DOI: 10.15406/JSRT.2018.04.00124

Jaian, Kannaiyan, Veeramanik, An, Eyini Muthukumarasamy, Balaji Paulraj

{"title":"An in-vitro study of Amniotic membrane, Villous chorion and Wharton’s jelly-derived Mesenchymal stem cells and their potential for cardiac repair","authors":"Jaian, Kannaiyan, Veeramanik, An, Eyini Muthukumarasamy, Balaji Paulraj","doi":"10.15406/JSRT.2018.04.00124","DOIUrl":"https://doi.org/10.15406/JSRT.2018.04.00124","url":null,"abstract":"Myocardial disorders such as acute myocardial infarction endanger millions of people and cause a substantial number of deaths each year; 1 of every 6 deaths all over the world. After an acute myocardial infarction (MI), the heart has a limited capacity of self-renewal undergoing remodelling with resulting left ventricular dysfunction (LVD).1,2 Despite the improvement in several pharmacological, interventional and surgical therapeutic measures, the prognosis for heart failure patients remains very poor. Although an early wave of clinical trials has generated marginal success; medical researchers and regulators face new issues and uncertainties involving longterm safety and efficacy. Put together these observations; account for the continued search for new optional treatments. Among many alternatives, cellular therapy has gained a growing interest as the new field exploiting cells to generate biological substitute, improve tissue function and thereby restoring the damaged tissue with high proliferability and differentiability.3,4 It is also being focused as a potential alternative to complicated tissue or organ transplantation because several factors have been cited as causes for disparities in organ donation and its successful transplantation such as lack of education, religious beliefs, distrust of the health care system, lack of communication between healthcare providers and minority patients and desire of minority members to donate their organs only to members of their same ethnic classification.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81172313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Attempt to regenerate the dog’s tooth using the method of a new direction in biology‒Linguistic‒Wave Genetics 尝试用生物学新方向——语言波遗传学的方法再生狗的牙齿

Journal of stem cell research & therapeutics Pub Date : 2018-10-11 DOI: 10.15406/jsrt.2018.04.00123

G. Pp, Vlasov Gp, Poltavtseva Ra, Voloshin Ll, Leonova-Gariaeva Ea

引用次数: 0

Prevention and treatment of cerebral palsy caused by intrapartum damage with novel hypoxia index 应用新型缺氧指数预防和治疗产时损伤所致脑瘫

Journal of stem cell research & therapeutics Pub Date : 2018-10-05 DOI: 10.15406/JSRT.2018.04.00122

K. Maeda

引用次数: 0

Primary necrotizing fasciitis of the chest wall 原发性坏死性胸壁筋膜炎

Journal of stem cell research & therapeutics Pub Date : 2018-09-14 DOI: 10.15406/JSRT.2018.04.00121

K. Moustaide, A. Nassiri, N. Aqil, H. Baybay, S. Gallouj, F. Mernissi

引用次数: 1

Review and report of the role of Breast Milk Stem Cell in balancing immunomodulation after cardio pulmonary bypass 母乳干细胞在心肺分流术后免疫调节平衡中的作用综述与报道

Journal of stem cell research & therapeutics Pub Date : 2018-09-10 DOI: 10.15406/JSRT.2018.04.00120

R. Menon, G. Kaushik

引用次数: 0

Melanoma stem cells: the past, present and future 黑色素瘤干细胞:过去，现在和未来

Journal of stem cell research & therapeutics Pub Date : 2018-08-24 DOI: 10.15406/jsrt.2018.04.00119

P. Chow, S. Moore, G. Kaushik

{"title":"Melanoma stem cells: the past, present and future","authors":"P. Chow, S. Moore, G. Kaushik","doi":"10.15406/jsrt.2018.04.00119","DOIUrl":"https://doi.org/10.15406/jsrt.2018.04.00119","url":null,"abstract":"Normal adult stem cells are characterized by their ability to selfrenew, as well as their ability to differentiate into various mature cell types. Cancer stem cells were first recognized by Bonnet et al, who showed a sub-portion of acute myelogenous leukemia (AML) stem cells could be identified and separated from AML cells in patients. This subset of AML cells were the only cells capable of transferring AML from the human patients to studied mice.1 The hypothesis of the existence of cancer stem cells gained more attention around 2001 when Reya et al pushed the notion that cancer stems cells are composed of a subset fraction of tumor cells that have the ability to maintain the tumor through self-renewal, conferring drug resistance, and inducing tumor relapse.2 These cancer stem cells have similar physiologic properties to normal adult stem cells, like self-renewal and differentiation. Normal stem cells had been shown to be resistant to cytotoxic agents compared to mature cell types, which is explained by anti-apoptotic mechanisms,3 quiescence,4 and high expression levels of ATP-binding cassette (ABC) transporters.5 Thus, the existence of cancer stem cells explains the reason why many treatments for metastatic tumors ultimately fail. Current treatments like chemotherapy and radiation can shrink, but not cure metastatic tumors. Frequently, these treatments do indeed target the bulk of tumor cells in the human body, but often, the drug therapy is unable to kill the cancer stem cells (due to inherited and/or acquired resistance), and thus the tumor can easily grow back. In recent years, cancer stem cells have been identified and isolated by characteristics of normal stem cells, like using tissue specific CD markers (The cluster of differentiation) and ABC transporter proteins.6 Research about targeted therapy in regard to these cancer stem cells has come in full swing over the past decade.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80770422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Mitochondrial Ca2+ levels lower down rate of metabolic diseases and cardiomyopathies 线粒体Ca2+水平降低代谢性疾病和心肌病的发病率

Journal of stem cell research & therapeutics Pub Date : 2018-08-17 DOI: 10.15406/JSRT.2018.04.00118

R. Upadhyay

{"title":"Mitochondrial Ca2+ levels lower down rate of metabolic diseases and cardiomyopathies","authors":"R. Upadhyay","doi":"10.15406/JSRT.2018.04.00118","DOIUrl":"https://doi.org/10.15406/JSRT.2018.04.00118","url":null,"abstract":"Mitochondrial is an important cell organelle that generates ATP that is used as sole energy molecule for all physiological and metabolic activities. It supplies cellular energy and assist in signaling, cell metabolism, cellular differentiation, cell survival and other cell-specific functions. Calcium uptake takes place through mitochondrial outer membrane by voltage-dependent anion channels. After formation of electrochemical gradient and equilibrium on both sides’ mitochondrial functions become normal. It is maintained during oxidative phosphorylation. Thus buffering of cytosolic Ca2+ levels regulate mitochondrial effector functions. Ca2+ transported into mitochondria regulates its metabolism and causes transient depolarisation of mitochondrial membrane. Imbalance in Ca2+ levels cause cardiac myocyte injury that is increased with the decline in pH.1 Dysregulated mitochondrial Ca2+ level and its imbalances generate ischemia neurodegenerative diseases, neuropsychiatric disorders and cancer.2 Accumulation of extra calcium in mitochondria also increases production and modulation of reactive oxygen species. Therefore, balanced Ca2+ buffering is required for normal mitochondrial functions, cell survival and longevity. Mitochondria also involve in control of cell cycle and cell growth. Hence, excessive calcium influx increases ROS generation, induces mitochondrial depolarization and triggers sever pathogenesis. Contrary to this low calcium level affects homoeostasis and redox signaling.3 It also gives rise stress particularly, nitrosative or oxidative stress. More often, excessive calcium uptake of calcium and accumulation of it in cardiac muscle cells result in mitochondrial dysfunctions that impose heart disease. Mitochondria play a central role in cell life and cell death. Availability of Ca2+ in cell from endoplasmic reticulum plays a pivotal role in cell proliferation.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90826674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Role of embryonic stem cell-hydroxyapatite construct with growth proteins for osteogenesis in the repair of bone defects in rabbit model 胚胎干细胞-羟基磷灰石复合成骨蛋白在兔骨缺损修复中的作用

Journal of stem cell research & therapeutics Pub Date : 2018-08-16 DOI: 10.15406/JSRT.2018.04.00117

B. Bhadane, Subodh Kumar Maiti, Divya K Mohan, S. Bag, Naveen Kumar

引用次数: 3