{"title":"神经可塑性蛋白65在神经系统中的功能和功能障碍","authors":"Q. Yuan, Huanhuan Li","doi":"10.15406/jsrt.2017.03.00098","DOIUrl":null,"url":null,"abstract":"Cell adhesion molecules (CAMs) have essential roles in forming functional networks in the nervous system. CAMs can be classified into several families including immunoglobulin super family (IgSF), cadherin family, integrins and selections [1]. Neuroplastins are transmembrane glycoprotein’s that belong to IgSF. Neuroplastin65 (NP65) and neuroplastin55 (NP55) are produced by NPTN gene by alternative splicing [2]. NP55 is widely distributed in various tissues. However, NP65 is restrictively expressed in the nervous system.","PeriodicalId":91560,"journal":{"name":"Journal of stem cell research & therapeutics","volume":"25 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Functions and dysfunctions of neuroplastin65 in the nervous system\",\"authors\":\"Q. Yuan, Huanhuan Li\",\"doi\":\"10.15406/jsrt.2017.03.00098\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cell adhesion molecules (CAMs) have essential roles in forming functional networks in the nervous system. CAMs can be classified into several families including immunoglobulin super family (IgSF), cadherin family, integrins and selections [1]. Neuroplastins are transmembrane glycoprotein’s that belong to IgSF. Neuroplastin65 (NP65) and neuroplastin55 (NP55) are produced by NPTN gene by alternative splicing [2]. NP55 is widely distributed in various tissues. However, NP65 is restrictively expressed in the nervous system.\",\"PeriodicalId\":91560,\"journal\":{\"name\":\"Journal of stem cell research & therapeutics\",\"volume\":\"25 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-09-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of stem cell research & therapeutics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15406/jsrt.2017.03.00098\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of stem cell research & therapeutics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/jsrt.2017.03.00098","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
细胞粘附分子(CAMs)在神经系统功能网络的形成中起着重要作用。CAMs可分为免疫球蛋白超家族(immunoglobulin super family, IgSF)、钙粘蛋白家族(cadherin family)、整合素和选择蛋白等几个家族[1]。神经质体是属于IgSF的跨膜糖蛋白。neuroplasin65 (NP65)和neuroplasin55 (NP55)是由NPTN基因通过选择性剪接产生的[2]。NP55广泛分布于各种组织中。然而，NP65在神经系统中是限制性表达的。
Functions and dysfunctions of neuroplastin65 in the nervous system
Cell adhesion molecules (CAMs) have essential roles in forming functional networks in the nervous system. CAMs can be classified into several families including immunoglobulin super family (IgSF), cadherin family, integrins and selections [1]. Neuroplastins are transmembrane glycoprotein’s that belong to IgSF. Neuroplastin65 (NP65) and neuroplastin55 (NP55) are produced by NPTN gene by alternative splicing [2]. NP55 is widely distributed in various tissues. However, NP65 is restrictively expressed in the nervous system.
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