Fibroblast-like cells derived from ips cells of patients with the familial forms of parkinson’s disease can serve an effective feeder for derivation and cultivation of new ips cells lines

Abstract

Generation of induced pluripotent stem cells (iPSC) is considered one of the major biological discoveries of the 21st century. IPSC were originally obtained in 2006-2007 by Japanese scientists first from mouse fibroblasts, and later from adult human fibroblasts [1,2]. IPSC have provided a unique platform for studying pathogenesis of different diseases and opened the door to their clinical application in regenerative medicine [2]. The employment of iPSC does not entail ethical issues, since adult human tissues are used just as a source for their generation. Regenerative medicine has great expectations for that particular cell type, since immune rejection represents one of the main complications in tissue and organ grafting.