Brain connectivity最新文献

{"title":"Particulate Matter Exposure and Default Mode Network Equilibrium During Early Adolescence.","authors":"Clara G Zundel, Samantha Ely, Cole Brokamp, Jeffrey R Strawn, Tanja Jovanovic, Patrick Ryan, Hilary A Marusak","doi":"10.1089/brain.2023.0072","DOIUrl":"10.1089/brain.2023.0072","url":null,"abstract":"<p><p><b><i>Background:</i></b> Air pollution exposure has been associated with adverse cognitive and mental health outcomes in children, adolescents, and adults, although youth may be particularly susceptible given ongoing brain development. However, the neurodevelopmental mechanisms underlying the associations among air pollution, cognition, and mental health remain unclear. We examined the impact of particulate matter (PM_2.5) on resting-state functional connectivity (rsFC) of the default mode network (DMN) and three key attention networks: dorsal attention, ventral attention, and cingulo-opercular. <b><i>Methods:</i></b> Longitudinal changes in rsFC within/between networks were assessed from baseline (9-10 years) to the 2-year follow-up (11-12 years) in 10,072 youth (<i>M ± SD</i> = 9.93 + 0.63 years; 49% female) from the Adolescent Brain Cognitive Development (ABCD^®) study. Annual ambient PM_2.5 concentrations from the 2016 calendar year were estimated using hybrid ensemble spatiotemporal models. RsFC was estimated using functional neuroimaging. Linear mixed models were used to test associations between PM_2.5 and change in rsFC over time while adjusting for relevant covariates (e.g., age, sex, race/ethnicity, parental education, and family income) and other air pollutants (O₃, NO₂). <b><i>Results:</i></b> A PM_2.5 × time interaction was significant for within-network rsFC of the DMN such that higher PM_2.5 concentrations were associated with a smaller increase in rsFC over time. Further, significant PM_2.5 × time interactions were observed for between-network rsFC of the DMN and all three attention networks, with varied directionality. <b><i>Conclusion:</i></b> PM_2.5 exposure was associated with alterations in the development and equilibrium of the DMN-a network implicated in self-referential processing-and anticorrelated attention networks, which may impact trajectories of cognitive and mental health symptoms across adolescence.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"307-318"},"PeriodicalIF":2.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11387001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probabilistic Tractography-Based Tremor Network Connectivity in Tremor Dominant Parkinson's Disease and Essential Tremor plus.","authors":"Shweta Prasad, Archith Rajan, Madhura Ingalhalikar, Rose Dawn Bharath, Jitender Saini, Pramod Kumar Pal","doi":"10.1089/brain.2023.0066","DOIUrl":"10.1089/brain.2023.0066","url":null,"abstract":"<p><p><b><i>Background:</i></b> The basal ganglia-thalamocortical (BGTC) and cerebello-thalamocortical (CTC) networks are implicated in tremor genesis; however, exact contributions across disorders have not been studied. <b><i>Objective:</i></b> Evaluate the structural connectivity of BGTC and CTC in tremor-dominant Parkinson's disease (TDPD) and essential tremor plus (ETP) with the aid of probabilistic tractography and graph theory analysis. <b><i>Methods:</i></b> Structural connectomes of the BGTC and CTC were generated by probabilistic tractography for TDPD (<i>n</i> = 25), ETP (ET with rest tremor, <i>n</i> = 25), and healthy control (HC, <i>n</i> = 22). The Brain Connectivity Toolbox was used for computing standard topological graph measures of segregation, integration, and centrality. Tremor severity was ascertained using the Fahn-Tolosa-Marin tremor rating scale (FTMRS). <b><i>Results:</i></b> There was no difference in total FTMRS scores. Compared with HC, TDPD had a lower global efficiency and characteristic path length. Abnormality in segregation, integration, and centrality of bilateral putamen, globus pallidus externa (GPe), and GP interna (GPi), with reduction of centrality of right caudate and cerebellar lobule 8, was observed. ETP showed reduction in segregation and integration of right GPe and GPi, ventrolateral posterior nucleus, and centrality of right putamen, compared with HC. Differences between TDPD and ETP were a reduction of strength of the right putamen, and lower clustering coefficient, local efficiency, and strength of the left GPi in TDPD. <b><i>Conclusions:</i></b> Contrary to expectations, TDPD and ETP may not be significantly different with regard to tremor pathogenesis, with definite overlaps. There may be fundamental similarities in network disruption across different tremor disorders with the same tremor activation patterns, along with disease-specific changes.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"340-350"},"PeriodicalIF":2.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141315972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Understanding Brain Connectivity.","authors":"Jennifer L Whitwell, Steven Laureys","doi":"10.1089/brain.2024.0047","DOIUrl":"10.1089/brain.2024.0047","url":null,"abstract":"","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"305-306"},"PeriodicalIF":2.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural Signature of Rhyming Ability During Story Listening in Preschool-Age Children.","authors":"John S Hutton, Jonathan Dudley, Thomas DeWitt, Tzipi Horowitz-Kraus","doi":"10.1089/brain.2023.0083","DOIUrl":"10.1089/brain.2023.0083","url":null,"abstract":"<p><p><b><i>Purpose:</i></b> Rhyming is a phonological skill that typically emerges in the preschool-age range. Prosody/rhythm processing involves right-lateralized temporal cortex, yet the neural basis of rhyming ability in young children is unclear. The study objective was to use functional magnetic resonance imaging (fMRI) to quantify neural correlates of rhyming abilities in preschool-age children. <b><i>Method:</i></b> Healthy pre-kindergarten child-parent dyads were recruited for a study visit including MRI and the Preschool and Primary Inventory of Phonological Awareness (PIPA) rhyme subtest. MRI included an fMRI task where the child listened to a rhymed and unrhymed story without visual stimuli. fMRI data were processed using the CONN functional connectivity (FC) toolbox, with FC computed between 132 regions of interest (ROI) across the brain. Associations between PIPA score and FC during the rhymed versus unrhymed story were compared accounting for age, sex, and maternal education. <b><i>Results:</i></b> In total, 45 children completed MRI (age 54 ± 8 months, 37-63; 19M 26F). Median maternal education was college graduate. FC between ROIs in posterior default mode (imagery) and right fronto-parietal (executive function) networks was more strongly positively associated with PIPA score during the rhymed compared with the unrhymed story [<i>F</i>(2,39) = 10.95, p-FDR = 0.043], as was FC between ROIs in right-sided language (prosody) and dorsal attention networks [<i>F</i>(2,39) = 9.85, p-FDR = 0.044]. <b><i>Conclusions:</i></b> Preschool-age children with better rhyming abilities had stronger FC between ROIs supporting attention and prosody and also between ROIs supporting executive function and imagery, suggesting rhyme as a catalyst for attention, visualization, and comprehension. These represent novel neural biomarkers of nascent phonological skills.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"294-303"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Connectivity: Embracing the Nexus of Mind and Matter.","authors":"Steven Laureys","doi":"10.1089/brain.2024.0036","DOIUrl":"10.1089/brain.2024.0036","url":null,"abstract":"","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"261-262"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Roundtable Discussion on Brain Connectivity.","authors":"Steven Laureys, Marc Raichle, Karl Friston, Susan Whitfield-Gabrieli, Jennifer Whitwell, Vince Calhoun, Linda Douw, Melanie Boly","doi":"10.1089/brain.2024.0037","DOIUrl":"10.1089/brain.2024.0037","url":null,"abstract":"","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"263-273"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141178972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personal Income Performance Correlates with Brain Structural Network Modularity but Not Intelligence Quotient.","authors":"Fanny Nusbaum, Salem Hannoun, Berardino Barile, Ilaria Suprano, Sabine Mouchet, Dominique Sappey-Marinier","doi":"10.1089/brain.2023.0077","DOIUrl":"10.1089/brain.2023.0077","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> This study aims to use diffusion tensor imaging (DTI) in conjunction with brain graph techniques to define brain structural connectivity and investigate its association with personal income (PI) in individuals of various ages and intelligence quotients (IQ). <b><i>Methods:</i></b> MRI examinations were performed on 55 male subjects (mean age: 40.1 ± 9.4 years). Graph data and metrics were generated, and DTI images were analyzed using tract-based spatial statistics (TBSS). All subjects underwent the Wechsler Adult Intelligence Scale for a reliable estimation of the full-scale IQ (FSIQ), which includes verbal comprehension index, perceptual reasoning index, working memory index, and processing speed index. The performance score was defined as the monthly PI normalized by the age of the subject. <b><i>Results:</i></b> The analysis of global graph metrics showed that modularity correlated positively with performance score (<i>p</i> = 0.003) and negatively with FSIQ (<i>p</i> = 0.04) and processing speed index (<i>p</i> = 0.005). No significant correlations were found between IQ indices and performance scores. Regional analysis of graph metrics showed modularity differences between right and left networks in sub-cortical (<i>p</i> = 0.001) and frontal (<i>p</i> = 0.044) networks. TBSS analysis showed greater axial and mean diffusivities in the high-performance group in correlation with their modular brain organization. <b><i>Conclusion:</i></b> This study showed that PI performance is strongly correlated with a modular organization of brain structural connectivity, which implies short and rapid networks, providing automatic and unconscious brain processing. Additionally, the lack of correlation between performance and IQ suggests a reduced role of academic reasoning skills in performance to the advantage of high uncertainty decision-making networks.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"284-293"},"PeriodicalIF":2.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141287783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural Brain Connectivity and Treatment Improvement in Mood Disorder.","authors":"Sébastien Dam, Jean-Marie Batail, Gabriel H Robert, Dominique Drapier, Pierre Maurel, Julie Coloigner","doi":"10.1089/brain.2023.0063","DOIUrl":"10.1089/brain.2023.0063","url":null,"abstract":"<p><p><b><i>Background:</i></b> The treatment of depressive episodes is well established, with clearly demonstrated effectiveness of antidepressants and psychotherapies. However, more than one-third of depressed patients do not respond to treatment. Identifying the brain structural basis of treatment-resistant depression could prevent useless pharmacological prescriptions, adverse events, and lost therapeutic opportunities. <b><i>Methods:</i></b> Using diffusion magnetic resonance imaging, we performed structural connectivity analyses on a cohort of 154 patients with mood disorder (MD) and 77 sex- and age-matched healthy control (HC) participants. To assess illness improvement, the patients with MD went through two clinical interviews at baseline and at 6-month follow-up and were classified based on the Clinical Global Impression-Improvement score into improved or not-improved (NI). First, the threshold-free network-based statistics (NBS) was conducted to measure the differences in regional network architecture. Second, nonparametric permutations tests were performed on topological metrics based on graph theory to examine differences in connectome organization. <b><i>Results:</i></b> The threshold-free NBS revealed impaired connections involving regions of the basal ganglia in patients with MD compared with HC. Significant increase of local efficiency and clustering coefficient was found in the lingual gyrus, insula, and amygdala in the MD group. Compared with the NI, the improved displayed significantly reduced network integration and segregation, predominately in the default-mode regions, including the precuneus, middle temporal lobe, and rostral anterior cingulate. <b><i>Conclusions:</i></b> This study highlights the involvement of regions belonging to the basal ganglia, the fronto-limbic network, and the default mode network, leading to a better understanding of MD disease and its unfavorable outcome.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"239-251"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysconnectivity of the Nucleus Accumbens and Amygdala in Youths with Thought Problems: A Dimensional Approach.","authors":"Chen-Fang Chung, Jules R Dugré, Stéphane Potvin","doi":"10.1089/brain.2023.0082","DOIUrl":"10.1089/brain.2023.0082","url":null,"abstract":"<p><p><b><i>Background:</i></b> Youths with thought problems (TP) are at risk to develop psychosis and obsessive-compulsive disorder (OCD). Yet, the pathophysiological mechanisms underpinning TP are still unclear. Functional magnetic resonance imaging (fMRI) studies have shown that striatal and limbic alterations are associated with psychosis-like and obsessive-like symptoms in individuals at clinical risk for psychosis, schizophrenia, and OCD. More specifically, nucleus accumbens (NAcc) and amygdala are mainly involved in these associations. The current study aims to investigate the neural correlates of TP in youth populations using a dimensional approach and explore potential cognitive functions and neurotransmitters associated with it. <b><i>Methods:</i></b> Seed-to-voxels functional connectivity analyses using NAcc and amygdala as regions-of-interest were conducted with resting-state fMRI data obtained from 1360 young individuals, and potential confounders related to TP such as anxiety and cognitive functions were included as covariates in multiple regression analyses. Replicability was tested in using an adult cohort. In addition, functional decoding and neurochemical correlation analyses were performed to identify the associated cognitive functions and neurotransmitters. <b><i>Results:</i></b> The altered functional connectivities between the right NAcc and posterior parahippocampal gyrus, between the right amygdala and lateral prefrontal cortex, and between the left amygdala and the secondary visual area were the best predictors of TP in multiple regression model. These functional connections are mainly involved in social cognition and reward processing. <b><i>Conclusions:</i></b> The results show that alterations in the functional connectivity of the NAcc and the amygdala in neural pathways involved in social cognition and reward processing are associated with severity of TP in youths.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"226-238"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult Neoneurogenesis and Oligodendrogenesis in Multiple Sclerosis: A Systematic Review of Human and Animal Studies.","authors":"Andreas Liampas, Vasilis-Spyridon Tseriotis, Artemios Artemiadis, Panagiotis Zis, Chrysanthi Argyropoulou, Nikolaos Grigoriadis, Georgios M Hadjigeorgiou, George Vavougyios","doi":"10.1089/brain.2023.0081","DOIUrl":"10.1089/brain.2023.0081","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> The subventricular zone promotes remyelination through activation differentiation of oligodendroglial precursor cells (OPCs) and neural stem cells (NSCs) into mature oligodendrocytes and thus in the adult brain. In multiple sclerosis (MS) this regenerative capability is halted resulting in neurodegeneration. We aimed to systematically search and synthesize evidence on mechanisms and phenomena associated with subventricular zone (SVZ) dysfunction in MS. <b><i>Materials and Methods:</i></b> Our systematic review was reported according to the PRISMA-ScR statement. MEDLINE, SCOPUS, ProQuest, and Google Scholar were searched using the terms \"subventricular zone\" and \"multiple sclerosis,\" including English-written <i>in vivo</i> and postmortem studies. <b><i>Results:</i></b> Twenty studies were included. Thirteen studies on models of experimental autoimmune encephalomyelitis (EAE) reported among others strong stathmin immunoreactivity in the SVZ of EAE models, the role of MOG immunization in neurogenesis impairment, the effect of parenchymal OPCs and NSCs in myelin repair, and the importance of ependymal cells (E1/E2) and ciliated B1 cells in SVZ stem cell signaling. CXCR4 signaling and transcriptional profiles of SVZ microglia, Gli1 pathway, and galactin-3 were also explored. Studies in humans demonstrated microstructural SVZ damage in progressive MS and the persistence of black holes near the SVZ, whereas postmortem confirmed the generation of polysialic acid-neural cell adhesion molecule and NG2-positive progenitors through SVZ activation, SVZ stathmin immunoreactivity, Shh pathway, and Gal-3 upregulation. <b><i>Discussion:</i></b> Oligodendrogenesis defects translate to reduced remyelination, a hallmark of MS that determines its end-phenotype and disease course. <b><i>Conclusion:</i></b> The role of inflammation and subsequent SVZ microenvironment disruption is evident in MS pathology.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"209-225"},"PeriodicalIF":3.4,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}