Brain connectivity最新文献

{"title":"Cerebello-Cerebral Resting-State Functional Connectivity in Poststroke Aphasia.","authors":"Joan Stilling, Ji Hyun Kim, Sarah Cust, Zafer Keser, Jamie L Murter, Donna C Tippet, Argye E Hillis, Rajani Sebastian","doi":"10.1089/brain.2023.0087","DOIUrl":"10.1089/brain.2023.0087","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> The influence of the cerebellum in poststroke aphasia recovery is poorly understood. Despite the right cerebellum being identified as a critical region involved in both language and cognitive functions, little is known about functional connections between the cerebellum and bilateral cortical hemispheres following stroke. This study investigated the relationship between chronic poststroke naming deficits and cerebello-cerebral resting-state functional connectivity (FC). <b><i>Methods:</i></b> Twenty-five cognitively normal participants and 42 participants with chronic poststroke aphasia underwent resting-state functional magnetic resonance imaging. Participants with aphasia also underwent language assessment. We conducted regions of interest (ROI)-to-ROI analyses to investigate the FC between the right cerebellar Crus I/II (seed ROI; Cereb1r/Cereb2r) and bilateral cortical language regions and compared these results to cognitively normal controls. Single-subject connectivity parameters were extracted and used as independent variables in a stepwise multiple linear regression model associating Boston Naming Test (BNT) score with FC measures. <b><i>Results:</i></b> FC analyses demonstrated correlations between the right cerebellar Crus I/II and both left and right cortical regions for both cognitively normal controls and stroke participants. Additionally, aphasia severity and lesion load had an effect on the cerebello-cerebral network connectivity in participants with aphasia. In a stepwise multiple linear regression, controlling for aphasia severity, time poststroke and lesion load, FC between the right Cereb2-left Cereb1 (standardized beta [std B]= -0.255, <i>p</i> < 0.004), right Cereb2-right anterior MTG (std B = 0.259, <i>p</i> < 0.004), and the right Cereb2-left anterior STG (std <i>B</i> = -0.208, <i>p</i> < 0.018) were significant predictors of BNT score. The overall model fit was <i>R</i>² = 0.786 (<i>p</i> = 0.001). <b><i>Conclusion:</i></b> Functional connections between the right cerebellum and residual bilateral cerebral hemisphere regions may play a role in predicting naming ability in poststroke aphasia.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"40-54"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142614630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"New Horizons in Brain Connectivity: A Fresh Start for 2025\".","authors":"Haibo Di, Steven Laureys","doi":"10.1089/brain.2024.0106","DOIUrl":"https://doi.org/10.1089/brain.2024.0106","url":null,"abstract":"","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":"15 1","pages":"1-2"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Modular Degeneracy on Neuroimaging Data.","authors":"Elisabeth C Caparelli, Hong Gu, Yihong Yang","doi":"10.1089/brain.2023.0090","DOIUrl":"10.1089/brain.2023.0090","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> The concept of community structure, based on modularity, is widely used to address many systems-level queries. However, its algorithm, based on the maximization of the modularity index Q, suffers from degeneracy problem, which yields a set of different possible solutions. <b><i>Methods:</i></b> In this work, we explored the degeneracy effect of modularity principle on resting-state functional magnetic resonance imaging (rsfMRI) data, when it is used to parcellate the cingulate cortex using data from the Human Connectome Project. We proposed a new iterative approach to address this limitation. <b><i>Results:</i></b> Our results show that current modularity approaches furnish a variety of different solutions, when these algorithms are repeated, leading to different number of subdivisions for the cingulate cortex. Our new proposed method, however, overcomes this limitation and generates more stable solution for the final partition. <b><i>Conclusion:</i></b> With this new method, we were able to mitigate the degeneracy problem and offer a tool to use modularity in a more reliable manner, when applying it to rsfMRI data.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"19-29"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct Neural Mechanisms Underlying Dual-Task Priority During Gait Across Cognitive and Motor Networks.","authors":"Eunkyung Kim, Seo Jung Yun, Byung-Mo Oh, Han Gil Seo","doi":"10.1089/brain.2024.0014","DOIUrl":"10.1089/brain.2024.0014","url":null,"abstract":"<p><p><b><i>Background:</i></b> Prioritization strategy during gait significantly influences gait performance and successful gait relies on interactions between cognitive and motor functions. This study aimed to examine the within- and between-network connectivities of cognitive and motor networks associated with dual-task priority during gait. <b><i>Methods:</i></b> Twenty-nine healthy individuals (66.86 ± 8.53 years) underwent the timed-up-and-go (TUG) test alone, TUG with a cognitive task, and the cognitive task alone. The cognitive task involved sequentially subtracting three from a random number between 50 and 100. The resting-state functional magnetic resonance imaging was acquired on the same day. Using independent component analysis, the dorsal attention network (DAN), frontoparietal network (FPN), primary motor network (PM), and lateral motor network were assessed. The participants were divided into cognitive and motor priority groups based on the modified attention allocation index (mAAI). Group comparisons of within- and between-network connectivity were conducted using permutation tests. Additionally, correlation analysis was employed to investigate the association between-network connectivity and task priority. <b><i>Results:</i></b> The cognitive priority group showed cognitive dual-task facilitation. In comparison to the motor priority group, they also showed comparable motor dual-task costs and lower combined dual-task costs. They exhibited increased within-network connectivity in the left FPN and enhanced between-network connectivity between the right FPN and both the DAN and PM. These between-network connectivities were negatively correlated with mAAI scores. <b><i>Conclusion:</i></b> The results suggest distinct neural mechanisms across cognitive and motor networks based on individuals' dual-task strategies. This may have implications for understanding gait performance in complex contexts.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"30-39"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontal Cortex Acts as Causality Transition Hub from Mirror Network to Mentalizing Network During Action Intention Understanding.","authors":"Li Zhang, Lei Zhang, Jing Wang, Yanmei Zhu","doi":"10.1089/brain.2024.0032","DOIUrl":"10.1089/brain.2024.0032","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> While understanding other's action intention, mirror and mentalizing systems of human brain are successively activated in action perception and intention inference processes. <b><i>Methods:</i></b> To reveal the relationship between mirror and mentalizing systems during the two stages, this electroencephalogram study adopted the method of time-varying orthogonalized partial directed coherence (OPDC) to assess causal interaction between mirror and mentalizing networks during a \"hand-cup interaction\" action intention understanding task. <b><i>Results:</i></b> Task-related causal connectivity was found in gamma frequency band (30-45 Hz), primarily manifested as directed edges from sensorimotor to frontal areas in poststimulus 400-600 ms interval and directed links from frontal to parietal and temporal regions in 600-800 ms period. The analysis of event-related potential and source currents suggests that the change of inter-regional causality is related with functional transition of the brain from mirror matching to intention inference. The OPDC network modeling further finds that frontal area contains more inflow nodes in mirror network, whereas more outflow nodes in mentalizing network, with high betweenness centrality in temporally changing functional communities. Compared with intention-oriented actions, identification of unintelligible action intention particularly induces stronger OPDC from right superior frontal to inferior frontal gyrus and from sensorimotor to right frontotemporal regions during mentalizing inference process. <b><i>Conclusion:</i></b> These findings collectively suggest that, in the time ordering of information transfer within the directed networks, frontal area plays an important role of bridging hub between mirror and mentalizing systems, from maintaining and supervising perceptual information for mirror matching to controlling the mentalizing process for decoding other's action intention.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"3-18"},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgment of Reviewers 2024.","authors":"","doi":"10.1089/brain.2024.91224.revack","DOIUrl":"https://doi.org/10.1089/brain.2024.91224.revack","url":null,"abstract":"","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":"15 1","pages":"55"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific Associations in the Alpha Frequency Between the Subcomponents of Rumination and the Subsystems of the Default Mode Network Among Bipolar I Disorder Patients.","authors":"Hao Tang, Jiabo Shi, Siqi Zhang, Yu Chen, Tingting Xiong, Xumiao Wang, Zhilu Chen, Zhongpeng Dai, Zhijian Yao, Qing Lu","doi":"10.1089/brain.2023.0086","DOIUrl":"10.1089/brain.2023.0086","url":null,"abstract":"<p><p><b><i>Introduction:</i></b> Rumination in bipolar disorder (BD) is well documented. Recent neuroimaging studies highlight the role of the default mode network (DMN) in rumination, while few studies have evaluated the DMN activity in BD rumination, particularly the underlying neuroelectrophysiology. <b><i>Methods:</i></b> A total of 44 patients with depressed bipolar I disorder (BD-I) and 46 healthy controls underwent resting-state magnetoencephalography. Two core hubs of the DMN, the posterior cingulate cortex (PCC), and anterior medial prefrontal cortex, together with the dorsal medial prefrontal cortex (dmPFC) and the medial temporal lobe (MTL) subsystems, were identified as the regions of interest. The power envelope method was used to determine the alpha band's cross-subsystem functional connectivity (FC). After comparing the rumination and DMN FC between the groups, Spearman partial correlation analysis was performed to evaluate the relationship between aberrant FC and rumination in BD-I patients. <b><i>Results:</i></b> BD-I patients demonstrated more global rumination, including higher subcomponent scores of brooding and reflection. In addition, the alpha frequency FC of the PCC-dmPFC and dmPFC-MTL subsystems within the DMN was dramatically increased in the BD-I group. The former was strongly associated with reflection, whereas the latter was related to brooding. <b><i>Conclusion:</i></b> The findings suggest that the reflection and brooding components of rumination are selectively related to the alpha frequency FC of the PCC-dmPFC and dmPFC-MTL subsystems, respectively. These associations highlight the significance of DMN activities in rumination among BD-I patients and have implications for future rumination interventions.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"542-549"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Precision Therapies in Brain Connectivity.","authors":"Francisco Gómez, Jitka Annen, Steven Laureys","doi":"10.1089/brain.2024.0090","DOIUrl":"https://doi.org/10.1089/brain.2024.0090","url":null,"abstract":"","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":"14 10","pages":"511-512"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive Transcranial Magnetic Stimulation on Individualized Spots Based on Task functional Magnetic Resonance Imaging Improves Swallowing Function in Poststroke Dysphagia.","authors":"Meiyuan Chen, Ziyang Huang, Yi Chen, Xiaochuan Wang, Xiaojun Ye, Wenjie Wu","doi":"10.1089/brain.2024.0021","DOIUrl":"10.1089/brain.2024.0021","url":null,"abstract":"<p><p><b><i>Background:</i></b> Functional magnetic resonance imaging (fMRI) has not previously been used to localize the swallowing functional area in repetitive transcranial magnetic stimulation (rTMS) treatment for poststroke dysphagia; Traditionally, the target area for rTMS is the hotspot, which is defined as the specific region of the brain identified as the optimal location for transcranial magnetic stimulation (TMS). This study aims to compare the network differences between the TMS hotspot and the saliva swallowing fMRI activation to determine the better rTMS treatment site and investigate changes in functional connectivity related to poststroke dysphagia using resting-state fMRI. <b><i>Methods:</i></b> Using an information-based approach, we conducted a single case study to explore neural functional connectivity in a patient with poststroke dysphagia before, immediately after rTMS, and 4 weeks after rTMS intervention. A total of 20 healthy participants underwent fMRI and TMS hotspot localization as a control group. Neural network alterations were assessed, and functional connections related to poststroke dysphagia were examined using resting-state fMRI. <b><i>Results:</i></b> Compared to the TMS-induced hotspots, the fMRI activation peaks were located significantly more posteriorly and exhibited stronger functional connectivity with bilateral postcentral gyri. Following rTMS treatment, this patient developed functional connection between the brainstem and the bilateral insula, caudate, anterior cingulate cortex, and cerebellum. <b><i>Conclusion:</i></b> The saliva swallowing fMRI activation peaks show more intense functional connectivity with bilateral postcentral gyri compared to the TMS hotspots. Activation peak-guided rTMS treatment improves swallowing function in poststroke dysphagia. This study proposes a novel and potentially more efficacious therapeutic target for rTMS, expanding its therapeutic options for treating poststroke dysphagia.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"513-526"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Functional Coupling of the Bed Nucleus of the Stria Terminalis and Amygdala in Spider Phobic Fear.","authors":"Elisabeth Jehli, Niklaus Denier, Andrea Federspiel, Thomas Dierks, Werner Strik, Leila M Soravia, Matthias Grieder","doi":"10.1089/brain.2024.0031","DOIUrl":"10.1089/brain.2024.0031","url":null,"abstract":"<p><p><b><i>Background:</i></b> Individuals with spider phobic (SP) fear show hypervigilance and amygdala hyperactivity toward fear-associated stimuli, which may promote the development of other anxiety disorders. The amygdala is a key region within the fear network, which is connected to the anxiety system, where the bed nucleus of the stria terminalis (BNST) plays a crucial role. However, the BNST's involvement in phobic fear is unknown. Therefore, this study investigated the association of phobic fear and anxiety on these regions' functional connectivity (FC) in SP compared to healthy controls (HC). <b><i>Methods:</i></b> 7T-functional MRI resting-state FC of 30 individuals with SP and 45 HC was assessed to detect network differences between these groups. The association of phobic fear severity, trait anxiety, and social anxiety on FC was explored using linear regressions combined with seed-to-voxel analyses with amygdala and BNST as primary seeds, corrected for age and sex. <b><i>Results:</i></b> In SP, phobic fear was associated with reduced FC between the left amygdala and the right supramarginal gyrus. In contrast, anxiety severity was related to increased FC between the right BNST and the left inferior frontal gyrus. Moreover, social anxiety was related to decreased FC between bilateral BNST and left precuneus. <b><i>Conclusions:</i></b> These findings show changes in FC in SP, connecting fear with altered activity in the BNST and amygdala. The results suggest that persistent anxiety in phobic fear is associated with abnormal brain function in these regions, potentially explaining susceptibility to anxiety disorders and processes involved in phobic fear, such as threat perception, avoidance, and salience.</p>","PeriodicalId":9155,"journal":{"name":"Brain connectivity","volume":" ","pages":"527-541"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142280293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}