Biomedical Research-tokyo最新文献_第8页

New conjugated monoclonal antibodies: Area of a promising therapy in metastatic breast cancer. 新的偶联单克隆抗体:转移性乳腺癌的一个有希望的治疗领域。

IF 1.2 4区医学

Biomedical Research-tokyo Pub Date : 2021-01-01 DOI: 10.35841/0970-938X.32.1.15-18

EL Hazzaz Reda, Oualla Karima, Darif Khadija, Sqalli Houssaini Med, Amaadour Lamiae, B. Zineb, A. Samia, M. Nawfel

{"title":"New conjugated monoclonal antibodies: Area of a promising therapy in metastatic breast cancer.","authors":"EL Hazzaz Reda, Oualla Karima, Darif Khadija, Sqalli Houssaini Med, Amaadour Lamiae, B. Zineb, A. Samia, M. Nawfel","doi":"10.35841/0970-938X.32.1.15-18","DOIUrl":"https://doi.org/10.35841/0970-938X.32.1.15-18","url":null,"abstract":"Following advances in molecular biology and better understanding of the mechanisms of carcinogenesis, new therapies have been developed with new agents that target tumor cells with minimal effects on normal cells. Monoclonal antibodies represent the model of success of this approach; they are directed against antigens selectively expressed by tumor cells. The conjugation of these monoclonal antibodies with potent cytotoxic drugs makes it possible to improve their efficacy while maintaining a favorable tolerance profile. T-DM1 (Trastuzumab Emtansine) is the first example of advanced development of a conjugated antibody. It works by associating an antitumor activity specific to trastuzumab with the efficient delivery of a potent cytotoxic, delivered selectively and targeted to cancer cells overexpressing HER2. Unlike trastuzumab emtansine, trastuzumab deruxtecan has a released payload that easily crosses the cell membrane, which potentially allows for a potent cytotoxic effect on neighboring tumor cells regardless of target expression. In addition, the released payload has a short half-life, which is designed to minimize systemic exposure. DESTINY breast-01 study has demonstrated the efficacy of trastuzumab deruxtecan in patients with HER2- positive metastatic breast cancer previously treated with trastuzumab emtansine. Trastuzumab deruxtecan is FDA-approved. Sacituzumab govitecan (sacituzumab govitecan-hziy) is a conjugated monoclonal antibody developed by site-specific conjugation of the active metabolite of irinotecan, SN-38 (govitecan). It has demonstrated promising activity in advanced lines for triple-negative breast cancer in a phase I/II study and recently in ASCENT trial phase III. Conjugated monoclonal antibodies have been shown to be effective in different subtypes of metastatic breast cancer.","PeriodicalId":9138,"journal":{"name":"Biomedical Research-tokyo","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84047698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of application of navigation system to odontogenic benign tumors with maxilla. 导航系统在上颌骨牙源性良性肿瘤中的应用。

IF 1.2 4区医学

Biomedical Research-tokyo Pub Date : 2021-01-01 DOI: 10.35841/0970-938X.32.2.37-41

Julia Koseki, Takahiro Abe, Y. Miyamoto, M. Kashiwagi, Makiko Ishibashi, Asako Taniguchi, H. Suenaga, H. Abe, Masanobu Abe, K. Hoshi

引用次数: 0

Genomic profiling of multiple tissues in two patients with multiple endocrine neoplasia type 1. 2例1型多发性内分泌瘤多组织的基因组分析。

IF 1.2 4区医学

Biomedical Research-tokyo Pub Date : 2021-01-01 DOI: 10.2220/biomedres.42.89

Akane Naruoka, Sumiko Ohnami, Takeshi Nagashima, Masakuni Serizawa, Keiichi Hatakeyama, Keiichi Ohshima, Shumpei Ohnami, Kenichi Urakami, Yasue Horiuchi, Yoshimi Kiyozumi, Hiroyuki Matsubayashi, Masato Abe, Takuma Ohishi, Toru Kameya, Takashi Sugino, Tetsuro Onitsuka, Mitsuhiro Isaka, Yasuhisa Ohde, Teiichi Sugiura, Takaaki Ito, Katsuhiko Uesaka, Yasuto Akiyama, Masatoshi Kusuhara, Ken Yamaguchi

{"title":"Genomic profiling of multiple tissues in two patients with multiple endocrine neoplasia type 1.","authors":"Akane Naruoka, Sumiko Ohnami, Takeshi Nagashima, Masakuni Serizawa, Keiichi Hatakeyama, Keiichi Ohshima, Shumpei Ohnami, Kenichi Urakami, Yasue Horiuchi, Yoshimi Kiyozumi, Hiroyuki Matsubayashi, Masato Abe, Takuma Ohishi, Toru Kameya, Takashi Sugino, Tetsuro Onitsuka, Mitsuhiro Isaka, Yasuhisa Ohde, Teiichi Sugiura, Takaaki Ito, Katsuhiko Uesaka, Yasuto Akiyama, Masatoshi Kusuhara, Ken Yamaguchi","doi":"10.2220/biomedres.42.89","DOIUrl":"https://doi.org/10.2220/biomedres.42.89","url":null,"abstract":"<p><p>Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant tumor syndrome. This hereditary cancer is caused by germline variants in MEN1. Two patients with MEN1 were identified via whole exome sequencing and gene expression profile analysis, conducted for 5,063 patients with various types of cancers. We obtained multiple tumors from each patient; tumors derived from these two MEN1 patients had a loss of the normal MEN1 allele and frequently chromosomal copy number changes. Thus, we investigated whether structural variants were present in the MEN1 patient genomes. Whole-genome sequencing revealed no catastrophic rearrangements, and the tumor samples had very low somatic variants. The two patients had germline variants in MEN1 and some chromosomal copy number changes including on chromosome 11. The only pathogenic variant detected was the MEN1 germline variant, and chromosomal rearrangements led to tumorigenesis in somatic cells. Furthermore, the MEN1 tumor samples displayed a specific signature characterized by T:A>C:G transition. Studies of multiple tumors obtained from single patients are rare in hereditary cancer syndromes, and our results provide insights that the second hit of the tumor suppressor gene MEN1 may be caused by a gross genome rearrangement, not a small insertion and deletion, nor a change in epigenetic regulation.</p>","PeriodicalId":9138,"journal":{"name":"Biomedical Research-tokyo","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25589574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Executive functions in patients with different types of headaches. 不同类型头痛患者的执行功能。

IF 1.2 4区医学

Biomedical Research-tokyo Pub Date : 2021-01-01 DOI: 10.35841/0970-938X.32.3.S10-S16

M. C. Lucendo, C. RosarioIsabel, O. Pilatuna, Diego Arm, O. S. Pazos, Juan Alberto Coloma, C. González, César Rotawisky, Carlos Steven Marmolejo Escobar, Sebastián Ospina Otalvaro, Karen Julieth Quebrada Mera, Valentina Triana Díaz, P. Lenis, Delia Cristina Hernández, Pablo Miguel Arango de la Pava, María Eugenia Barrera Robledo, Juliana Vergel, Valentina Herrera Montoya, N. Hernandez, Jeannette Sanchez

{"title":"Executive functions in patients with different types of headaches.","authors":"M. C. Lucendo, C. RosarioIsabel, O. Pilatuna, Diego Arm, O. S. Pazos, Juan Alberto Coloma, C. González, César Rotawisky, Carlos Steven Marmolejo Escobar, Sebastián Ospina Otalvaro, Karen Julieth Quebrada Mera, Valentina Triana Díaz, P. Lenis, Delia Cristina Hernández, Pablo Miguel Arango de la Pava, María Eugenia Barrera Robledo, Juliana Vergel, Valentina Herrera Montoya, N. Hernandez, Jeannette Sanchez","doi":"10.35841/0970-938X.32.3.S10-S16","DOIUrl":"https://doi.org/10.35841/0970-938X.32.3.S10-S16","url":null,"abstract":"Patients suffering from headache complain of the appearance of cognitive symptoms, although there is not much research in this regard, so the objective of the study was to analyze the deterioration in executive functions in patients with different types of headaches. The executive functions are processes related to the planning of the behaviour oriented to the achievement of a goal. A cross-sectional study was carried out, with a sample of 48 participants; 18 with vascular headache, 14 with tension headache, 16 with migraine. Significant differences have been found in the capacity for abstraction, which has discriminated between patients with vascular headache and tension headache, as well as between these and patients with migraine. Similarly, overall cognitive performance is different in patients with migraine compared with patients with vascular headache and tension headache. The type of headache and global cognitive impairment moderately affect the variability of abstraction capacity. Finally, the existence of a directly proportional relation of positive nature that indicates a dependent between the variables has been evidenced. It can be concluded that global cognitive deterioration affects the performance of abstraction capacity.","PeriodicalId":9138,"journal":{"name":"Biomedical Research-tokyo","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88141313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare presentation of endobronchial metastasis from renal cell carcinoma resected 120 months after nephrectomy. 一例肾细胞癌在肾切除术后120个月发生支气管内转移的罕见病例。

IF 1.2 4区医学

Biomedical Research-tokyo Pub Date : 2021-01-01 DOI: 10.35841/0970-938X.32.3.S17-S20

Emine Ozsari, S. Ozer, D. Oğuz

引用次数: 0

Effect on malondialdehyde, superoxide dismutase and reduced glutathione and its metabolizing enzymes in vitamin D deficient newly diagnosed Type- 2 diabetic patients. 维生素D缺乏对新诊断2型糖尿病患者丙二醛、超氧化物歧化酶、还原性谷胱甘肽及其代谢酶的影响

IF 1.2 4区医学

Biomedical Research-tokyo Pub Date : 2021-01-01 DOI: 10.35841/0970-938X.32.1.1-6

Kuldip Singh

{"title":"Effect on malondialdehyde, superoxide dismutase and reduced glutathione and its metabolizing enzymes in vitamin D deficient newly diagnosed Type- 2 diabetic patients.","authors":"Kuldip Singh","doi":"10.35841/0970-938X.32.1.1-6","DOIUrl":"https://doi.org/10.35841/0970-938X.32.1.1-6","url":null,"abstract":"Background: India, with 32 million diabetic individuals, currently has the highest incidence of diabetes worldwide. Recently, World Health Organization (WHO) reported that these numbers are predicted to increase to 80 million by the year 2030. Vitamin D regulates glucose metabolism and oxidative stress is a well-established factor of this multi-factorial disease. Aim: Present, study was designed to evaluate certain oxidative stress markers like malondialdehyde, superoxide dismutase, reduced glutathione, glutathione reductase, Glutathione Peroxidase (GPx) along with total antioxidant activity in vitamin D deficient newly diagnosed Type 2 diabetics. Methods: 150 vitamin D deficient newly diagnosed type 2 diabetics’ and equal number of healthy subjects of both genders were recruited. Fasting blood was collected for evaluation of glucose, 25(OH) D and oxidative stress markers. Results: Significant (P<0.01) increase in malondialdehyde by 51.03% while a significant decrease in oxidative stress markers like SOD, GSH, GR, GPx and total antioxidant activity by 27.91 (P<0.05), 26.14% (P<0.05), 32.04% (P<0.01), 25.41% (P<0.05) and 35.85% (P<0.01) respectively was recorded in vitamin D deficient newly diagnosed type 2 diabetics with respect to healthy controls. Conclusions: A fore mentioned observations suggested that vitamin-D deficient newly diagnosed Type-2 diabetics of North-West Indian’s are associated with oxidative stress, a hallmark of various diseases like Diabetes Mellitus, cardiovascular diseases, osteoporosis etc. Therapeutic interventions in combinations of lifestyle and dietary modification might be beneficial to prevent further risk of development of Diabetes Mellitus and cardiovascular diseases like atherosclerosis in North-West Indians.","PeriodicalId":9138,"journal":{"name":"Biomedical Research-tokyo","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79910112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of various anomalies of costal element at cervico-thoracic junction in and around lucknow region of uttar pradesh: A radiological study. 在北方邦勒克瑙地区及其周围的颈胸交界处，各种肋部异常的患病率:一项放射学研究。

IF 1.2 4区医学

Biomedical Research-tokyo Pub Date : 2021-01-01 DOI: 10.35841/0970-938X.32.1.7-14

A. Rani, J. Chopra, Rana Ravneesh Singh, P. Bajpai

{"title":"Prevalence of various anomalies of costal element at cervico-thoracic junction in and around lucknow region of uttar pradesh: A radiological study.","authors":"A. Rani, J. Chopra, Rana Ravneesh Singh, P. Bajpai","doi":"10.35841/0970-938X.32.1.7-14","DOIUrl":"https://doi.org/10.35841/0970-938X.32.1.7-14","url":null,"abstract":"Morphological diversities of the costal element at the cervico-thoracic junction adversely affect the positioning of its various neurovascular and soft tissue structures which form the etiological basis of symptoms in many cases of a non-traumatic type of Thoracic Outlet Syndrome (TOS). These rib variants represent disturbances of early organogenesis and are associated with stillbirths, childhood cancers, and several other congenital malformations. The present study aims to document the current prevalence, gender preferences, and laterality associations of various costal anomalies at the thoracic outlet in the reference population. A retrospective cross-sectional analytical study was conducted on 1474 PA skiagrams of the cervico-thoracic region, which comprised 919 males and 555 females of zero days to 73-year age. In 13.02% population, costal element exhibited anomalous development. Anomalies of the costal process of C7 vertebra showed higher(12.20%) prevalence compared to the thoracic first(0.81%). Elongation of the cervical 7 transverse process was most common(10.71%) followed by cervical rib(1.49%), rudimentary first rib (0.54%), and fusion of first and second ribs(0.27%). Cervical 7 costal anomalies showed a significant inclination towards females. No significant association with laterality and sidedness was observed for any of the anomalies. The study highlights a higher prevalence of an elongated transverse process of C7 compared to cervical rib and first rib anomalies in the reference population.","PeriodicalId":9138,"journal":{"name":"Biomedical Research-tokyo","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78121977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A study to assess the medication adherence among patients with chronic diseases 慢性疾病患者药物依从性评价研究

IF 1.2 4区医学

Biomedical Research-tokyo Pub Date : 2021-01-01 DOI: 10.35841/0970-938X.32.4.84-84

Aswathi Sukumar

引用次数: 0

Pharmacological based study of poly herbal formulation. 中药复方的药理基础研究。

IF 1.2 4区医学

Biomedical Research-tokyo Pub Date : 2021-01-01 DOI: 10.35841/0970-938X.32.4.92-93

R. Khan, A. Khan, Mushtaq Ahmed, H. Alkreathy

引用次数: 0

Nicotinamide mononucleotide augments the cytotoxic activity of natural killer cells in young and elderly mice. 烟酰胺单核苷酸增强了年轻和老年小鼠自然杀伤细胞的细胞毒活性。

IF 1.2 4区医学

Biomedical Research-tokyo Pub Date : 2021-01-01 DOI: 10.2220/biomedres.42.173

Kazuyoshi Takeda, Ko Okumura

引用次数: 4