BMC Gastroenterology最新文献

{"title":"The effect of longitudinal trajectories of triglyceride-glucose index on the incident metabolic dysfunction-associated steatotic liver disease.","authors":"Xinri Wu, Quan Chen, Caiqin Zhang, Xin Hong","doi":"10.1186/s12876-025-04301-3","DOIUrl":"10.1186/s12876-025-04301-3","url":null,"abstract":"<p><strong>Background: </strong>The triglyceride-glucose (TyG) index is a reliable marker of insulin resistance and has been linked to metabolic disorders. Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease, particularly among older adults. The association between long-term changes in TyG levels and the risk of incident MASLD remains unclear. This study aimed to investigate the relationship between TyG index trajectories and the development of MASLD in the elderly.</p><p><strong>Methods: </strong>We conducted a prospective cohort study involving 28,535 older adults who underwent annual health checkups from 2018 to 2021 with complete triglyceride and fasting blood glucose data. Group-based trajectory modeling was used to identify three distinct TyG trajectories: the low-stable, moderate-stable, and high-stable groups. MASLD incidence was assessed during follow-up visits in 2022 and 2023. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident MASLD across the trajectory groups. To minimize confounding, sensitivity analyses were conducted by excluding participants with a baseline body mass index (BMI) > 28 kg/m² and those using antihypertensive, antidiabetic, or lipid-lowering medications. Additionally, restricted cubic spline regression was applied to examine the dose-response relationship between baseline TyG index and MASLD risk.</p><p><strong>Results: </strong>A total of 28,535 participants was included, comprising 13,456 males (47.16%) and 15,079 females (52.84%). The incidence rates of MASLD were 7.10% in the low-stable group, 16.10% in the moderate-stable group, and 23.20% in the high-stable group, increasing significantly with rising TyG trajectories (P < 0.001). After adjusting for age, sex, blood pressure, BMI, and lipid profiles, Cox regression models showed that the moderate-stable and high-stable groups had significantly higher risks of MASLD compared to the low-stable group, with HRs of 1.847 (95% CI: 1.699-2.008) and 2.361 (95% CI: 2.116-2.634), respectively (P < 0.001). A nonlinear dose-response relationship was also observed, with a sharp increase in MASLD risk when TyG index exceeded 8.54.</p><p><strong>Conclusion: </strong>Consistently elevated TyG trajectories are associated with a significantly increased risk of incident MASLD, with the risk escalating progressively as TyG levels rise.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"689"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal insufficiency is a risk factor for severely burned patients: a case-control study among 185 victims in Kunshan explosion.","authors":"Runzhi Huang, Jiajie Zhou, Tiansheng Chen, Yang Chen, Hanlin Sun, Maosheng Yu, Dayuan Xu, Yuntao Yao, Bingnan Lu, Junqiang Li, Shuyuan Xian, Guosheng Wu, Long Xu, Linhui Li, Xirui Tong, Hengkai Yu, Yifan Liu, Chenqi Tang, Shizhao Ji","doi":"10.1186/s12876-025-04279-y","DOIUrl":"10.1186/s12876-025-04279-y","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"674"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the degree of Helicobacter pylori infection and miR-155 and miR-543 expression levels in gastric cancer.","authors":"Ziwei Wang, Xinxin Zhou, Mosang Yu, Xin Hu","doi":"10.1186/s12876-025-04220-3","DOIUrl":"10.1186/s12876-025-04220-3","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"669"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum biomarkers of intestinal barrier dysfunction predict postoperative endoscopic recurrence in Crohn's disease patients.","authors":"Luxuan Tan, Yi Li, Chengliang Ding, Jingjing Qian, Xiufang Cui","doi":"10.1186/s12876-025-04273-4","DOIUrl":"10.1186/s12876-025-04273-4","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"668"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of serum trimethylamine n-oxide and lipopolysaccharide levels in the pathogenesis of chronic gastritis infected with Helicobacter pylori.","authors":"Ugur Kaplankaya, Erhan Onalan, Tugce Kaymaz, Burkay Yakar, Ruveyda Atilla, Aykut Bulu, Senanur Onalan Yıldırım, Mehmet Ferit Gursu, Emir Donder, Mustafa Hayırlıdağ","doi":"10.1186/s12876-025-04272-5","DOIUrl":"10.1186/s12876-025-04272-5","url":null,"abstract":"<p><strong>Background: </strong>Helicobacter pylori (HP) infection can cause chronic, intense inflammation of the gastric mucosa, which can lead to stomach cancer. Trimethylamine N-oxide (TMAO) is a dietary metabolite that increases HP virulence and inflammatory process. In this study, we aimed to find out how serum TMAO, lipopolysaccharide (LPS) and pepsinogen levels are affected in patients with HP-induced chronic gastritis.</p><p><strong>Methods: </strong>Forty-five age- and sex-matched patients diagnosed with chronic gastritis caused by H. Pylori and 45 healthy controls were included in this cross-sectional study. The diagnosis of H. Pylori-associated chronic gastritis was confirmed by endoscopy and biopsy. Serum TMAO, LPS, pepsinogen 1 and pepsinogen 2 levels were studied by the ELISA method.</p><p><strong>Results: </strong>Serum TMAO level of patients with HP gastritis was 48.61 (2.29-120.66) and that of the control group was 7.89 (1.22-76.40). Serum TMAO levels were statistically significantly higher in patients with HP-related chronic gastritis than in the control group (p < 0.001). Serum LPS levels were statistically significantly higher in patients with HP-related chronic gastritis than in the control group (p = 0.008). Serum pepsinogen 1 levels were statistically significantly higher in patients with HP-related chronic gastritis than in the control group (p = 0.001).</p><p><strong>Conclusion: </strong>The present study found elevated serum TMAO, LPS and pepsinogen 1 levels in patients with H. Pylori gastritis. These serum markers can be used as a non-invasive method in the evaluation of chronic gastritis infected with H. pylori.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"686"},"PeriodicalIF":2.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemerin as a biomarker of inflammatory bowel diseases: a meta-analysis.","authors":"Zhi Tian, Qun Xiang, Meichun Long, Jiangtao Liao, Fang Wang, Xuefeng Li","doi":"10.1186/s12876-025-04132-2","DOIUrl":"10.1186/s12876-025-04132-2","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"662"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study of the protective association of hard water on ulcerative colitis and Crohn's disease: a cross-sectional and cohort study of 481,468 participants in the UK Biobank.","authors":"Kexin Ye, Tianyu Zhou, Zhenhe Jin, Wenxi Jiang, Zhaoxue Liu, Zhe Shen","doi":"10.1186/s12876-025-04230-1","DOIUrl":"10.1186/s12876-025-04230-1","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"666"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences and clinical significance of liver - kidney function parameters, inflammatory markers and peripheral blood T lymphocyte subsets in patients with HBV - related acute - on - chronic liver failure.","authors":"Yongqing Dou, Li Zhang, Huijun Wang","doi":"10.1186/s12876-025-04112-6","DOIUrl":"10.1186/s12876-025-04112-6","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to explore the changes and clinical significance of hepatic-renal functions, inflammatory markers, and peripheral blood T lymphocyte subsets in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF).</p><p><strong>Methods: </strong>80 HBV treated in First Hospital of Shanxi Medical University from November 2020 to May 2023 were selected as the objects of study, and divided into observation group (n = 40) and control group (n = 40) based on whether ACLF occurred. The liver and kidney function parameters, inflammatory factors, and peripheral blood T lymphocyte subsets (CD3 + and CD4 + T-cell percentages) were detected in both groups, and the associations of HBV-DNA load with the changes in the liver cirrhosis index hyaluronic acid (HA), AST, BUN, high-sensitivity C-reactive protein (hs-CRP), and peripheral blood T lymphocyte index cluster of CD3⁺ percentage were analyzed.</p><p><strong>Results: </strong>HBV-DNA load was significantly higher in the observation group than in the control group, HA and procollagen type III (PCIII) levels were higher, as were ALT, AST, TBIL, BUN, Cr, hs-CRP, and TNF-α levels, and the CD4 + and CD3 + percentages were lower in the observation group than in the control group. The amount of HBV-DNA was positively connected with the changes in HA, AST, BUN and hs-CRP, but negatively associated with the changes in CD3⁺ percentage. The increases in the HBV-DNA load, liver cirrhosis indexes, hepatic function indexes, renal function indexes and inflammatory factors were independent risk factors, while the increase in the peripheral blood T lymphocyte percentage was the safeguarding element for the pathogenesis of HBV-ACLF.</p><p><strong>Conclusion: </strong>The risk of ACLF becomes higher in hepatitis B patients with the increase in HBV-DNA load and the inflammatory reaction of the body, and the decline in immune function of T lymphocytes.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"663"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term efficacy of transarterial chemoembolization in the treatment of recurrent hepatocellular carcinoma.","authors":"Chao Chen, Yanqiao Ren, Yi Li, Shanshan Jiang, Xiangjun Dong, Guofeng Zhou","doi":"10.1186/s12876-025-04258-3","DOIUrl":"10.1186/s12876-025-04258-3","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"657"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of urinary metal exposure with H. pylori seropositivity and mortality in the U.S. Population: NHANES 1999-2000 analysis.","authors":"Xiang-Da Meng, Yu-Jun Xiong, Shuo Yang","doi":"10.1186/s12876-025-04223-0","DOIUrl":"10.1186/s12876-025-04223-0","url":null,"abstract":"<p><strong>Background: </strong>The relationship between urinary heavy metal concentrations and overall mortality remains understudied, particularly among individuals with Helicobacter pylori (H. pylori) infection. This study aimed to explore the associations between urinary concentrations of specific metals and H. pylori seropositivity, as well as to evaluate their respective associations with all-cause mortality in both H. pylori-infected and non-infected subpopulations.</p><p><strong>Methods: </strong>Data were derived from the 1999-2000 cycles of the National Health and Nutrition Examination Survey (NHANES), resulting a final analytical cohort of 1,086 participants. Multivariable logistic regression models were applied to identify predictors of H. pylori infection. Cox proportional hazards models and restricted cubic spline analyses were used to investigate associations between urinary metal concentrations and all-cause mortality, stratified by H. pylori status.</p><p><strong>Results: </strong>Restricted cubic spline analyses revealed a significant association between urinary thallium levels and all-cause mortality in H. pylori-positive individuals (P for nonlinearity = 0.2731), with a nonlinear relationship observed in H. pylori-negative participants (P for nonlinearity = 0.0127). Elevated urinary tungsten concentrations were independently associated with H. pylori seropositivity (P overall = 0.0074). Notably, among H. pylori-negative participants, the highest tungsten quartile (Q4) showed a significant mortality risk increase (HR = 3.054, 95% CI: 1.083-8.608), while in H. pylori-positive individuals, tungsten was significantly associated with mortality only in continuous models (HR = 3.129, 95% CI: 1.031-9.493).</p><p><strong>Conclusion: </strong>Elevated urinary tungsten levels were significantly linked to H. pylori infection, while the relationship between tungsten and mortality differed by infection status: a dose-response association was observed in H. pylori-negative individuals, while a nonlinear association emerged in H. pylori-positive participants.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"649"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}