BMC Gastroenterology最新文献

{"title":"Clinical application of pre-rehabilitation concept on comfort colonoscopy in Chinese elderly patients: a randomised controlled trial.","authors":"Lun Zhang, Xiaoling Lv, Qin Zhu, Jianying Zhou, Hanlei Huang, Yiqian Huang, Caijuan Si","doi":"10.1186/s12876-025-04059-8","DOIUrl":"10.1186/s12876-025-04059-8","url":null,"abstract":"<p><strong>Background: </strong>The concept of pre-rehabilitation has been clinically implemented across various surgical fields; however, studies investigating its application in colonoscopy remain limited. This study aimed to evaluate the effectiveness, safety, and patient satisfaction of the pre-rehabilitation concept in bowel preparation for comfort colonoscopy among elderly Chinese patients.</p><p><strong>Methods: </strong>The enrolled patients were randomly allocated into the pre-rehabilitation and control groups. Prior to colonoscopy, patients in the pre-rehabilitation group received supplementary oral administration of ENSURE (Enteral Nutritional Powder) and psychological counseling provided by specialty nurses. The control group received only Polyethylene Glycol Electrolytes Powder. The primary outcome was the quality of bowel preparation, assessed using the Boston Bowel Preparation Scale. Secondary outcomes included the polyp detection rate, incidence of adverse effects, and patient satisfaction.</p><p><strong>Results: </strong>A total of 485 patients who were admitted for colonoscopy during hospitalization were included in the analysis. There were no statistically significant differences between the two groups with respect to age, sex, and body mass index (BMI). The Boston total score in the pre-rehabilitation group was significantly higher than that in the control group (P < 0.001). The colon polyp detection rates in the two groups were 78.5% and 67.3%, respectively (P = 0.006). Patients in the pre-rehabilitation group reported higher satisfaction with colonoscopy procedures and experienced a lower incidence of hypoglycemic reactions.</p><p><strong>Conclusions: </strong>The combination of additional enteral nutrition supplements and psychological counseling can enhance the quality of bowel preparation, decrease the incidence of hypoglycemia, and improve patient satisfaction. This intervention measure is both feasible and worthy of clinical application and promotion.</p><p><strong>Trial registration: </strong>This study was registered in the Chinese Clinical Trial Registry on 14/05/2025 (clinical trial registration number: ChiCTR2500102405). Retrospectively registered.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"457"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12211789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory and nutritional markers predict response and prognosis of patients with locally advanced gastric cancer receiving neoadjuvant immunochemotherapy.","authors":"Yiwen Sun, Mengjie Liang, Xingzhou Wang, Wenting Dong, ZhenShui Wu, Feng Sun, Xiaofeng Lu, Feng Wang, Song Liu, Meng Wang, Shichao Ai, Xiaofei Shen, Wenxian Guan","doi":"10.1186/s12876-025-03874-3","DOIUrl":"10.1186/s12876-025-03874-3","url":null,"abstract":"<p><strong>Background: </strong>Metabolism plays an important role in the occurrence and development of gastric cancer, including in neoadjuvant immunochemotherapy. However, whether nutrition-related indicators can predict the efficacy of neoadjuvant immunochemotherapy and the prognosis of gastric cancer patients has not been addressed. This study systematically screens various nutritional indicators to explore their efficacy in predicting responses to neoadjuvant immunochemotherapy and patients' prognosis in locally advanced gastric cancer (LAGC).</p><p><strong>Methods: </strong>We retrospectively analyzed 134 LAGC patients who underwent radical resection after neoadjuvant immunochemotherapy. According to postoperative tumor regression grade (TRG), these patients were divided into good responder group (TRG1-0) and poor responder group (TRG3-2) (AJCC/CAP guidelines). Inflammatory and/or nutritional markers were compared for their efficacy on predicting patients' pathological tumor regression response. The univariate and multivariate logistic regression were carried out to identify the independent factors for predicting pathological tumor regression response, and a predictive nomogram model was further established.</p><p><strong>Results: </strong>Among the total 134 LAGC patients, tumor specimens from 71 and 63 patients had TRG1-0 and TRG3-2 tumor responses, respectively. Multivariate analysis showed that controlling nutritional status (CONUT) score and nutrition risk screening 2002 (NRS2002) score were independent predictors of pathological tumor regression response (OR, 0.68; 95% CI, 0.50-0.91; P = 0.010 and OR, 0.66; 95% CI, 0.45-0.96; P = 0.031, respectively). With the use of ROC curve analysis, the optimal critical level of CONUT score and NRS2002 score were both 3. The CONUT-NRS2002 combined score was constructed. Patients with lower CONUT-NRS2002 had a better pathological response than those with higher CONUT-NRS2002 (P = 0.003). Moreover, Patients with higher CONUT-NRS2002 scores had poorer prognosis (P < 0.05). The nomogram based on CONUT score and NRS2002 score demonstrated good predictive ability and clinical application value.</p><p><strong>Conclusions: </strong>CONUT score and NRS2002 score are independent factors of pathological tumor regression response in LAGC patients after neoadjuvant immunochemotherapy. The constructed CONUT-NRS2002 combined score has a good potential in predicting pathological tumor regression response and prognosis of LAGC patients after neoadjuvant immunochemotherapy, serving as a new predictive indicator.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"478"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic retroperitoneal necrosectomy in patients with necrotizing pancreatitis: addressing the limitations of traditional treatment options.","authors":"Jinjian Li, Zihao Huang, Bo Shen, Hong Yu","doi":"10.1186/s12876-025-04001-y","DOIUrl":"10.1186/s12876-025-04001-y","url":null,"abstract":"<p><strong>Background: </strong>Laparoscopic retroperitoneal necrosectomy (LRN) is a novel minimally invasive approach for treating infected necrotizing pancreatitis. Our study aims to evaluate the safety and effectiveness of LRN for pancreatic necrosis at a single center.</p><p><strong>Methods: </strong>This retrospective study analyzed 120 patients who had laparoscopic retroperitoneal necrosectomy (LRN) for necrotizing pancreatitis at Sir Run Run Shaw Hospital from November 2017 to May 2023, with a six-month follow-up. Patients included had no prior surgeries. We evaluated the incidence of postoperative complications and mortality rates. Furthermore, subgroup analyses were performed to assess mortality and complications, utilizing univariate and multivariate regression analyses to identify associated risk factors.</p><p><strong>Results: </strong>Among the 120 patients, complications classified as Clavien-Dindo grade ≥ III occurred in 34.2%, and 8.3% experienced surgery-related mortality. In the multivariate regression analysis of complications classified as Clavien-Dindo grade ≥ III, length of stay (LOS) in the ICU (OR = 1.026;95% confidence interval [CI], 1.005 to 1.047; P = 0.015), and the presence of extrapancreatic infections (OR = 3.656;95% confidence interval [CI], 1.443to 9.261; P = 0.006) were identified as risk factors. A total of 77 patients with severe acute pancreatitis (according to the modified Atlanta classification) were included in the study. After 48 h of treatment, the SOFA score significantly decreased (5.92 ± 4.56 vs. 4.06 ± 3.44; P < 0.01), and the CT severity index (CTSI) also significantly decreased at one week post-surgery (7.57 ± 2.29 vs. 6.23 ± 2.28; P < 0.01). CRP levels (144.34 ± 77.45 vs. 87.94 ± 67.63; P < 0.01) and WBC count (10.97 ± 6.84 vs. 9.95 ± 6.79; P = 0.048) significantly decreased within one week after surgery. Among the 23 patients with preoperative hemodynamic instability, 13 required only a single surgery, while 4 required conversion to open surgery. At 48 h post-surgery, the SOFA score significantly decreased (8.74 ± 5.71 vs. 6.17 ± 4.94; P = 0.021), and the CTSI at one week was also considerably lower (8.26 ± 2.03 vs. 6.78 ± 2.04; P < 0.01).</p><p><strong>Conclusion: </strong>LRN allows over 70% of patients to avoid multiple surgeries while achieving excellent therapeutic outcomes. Furthermore, it is particularly effective for critically ill patients with hemodynamic instability, offering a distinct advantage over alternative treatments. Thus, LRN represents a promising therapeutic approach deserving of broader adoption.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"472"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12211385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-linear relationship between the hepatic steatosis index and glycemic progression: evidence from a large-scale retrospective cohort study in a Chinese population.","authors":"Changchun Cao, Yongyang Huo, Yong Han, Haofei Hu, Fubing Zha, Yulong Wang","doi":"10.1186/s12876-025-04068-7","DOIUrl":"10.1186/s12876-025-04068-7","url":null,"abstract":"<p><strong>Background: </strong>The hepatic steatosis index (HSI) is a validated tool for assessing hepatic steatosis. While previous investigations have explored the link between HSI and prediabetes and diabetes, the connection between HSI and glycemic progression is still being explored. This research seeks to clarify the association between HSI and glycemic progression risk among a Chinese demographic.</p><p><strong>Methods: </strong>The research encompassed a group of 76,314 Chinese adults from the Rich Healthcare Group who were free of prediabetes at the outset. Cox proportional hazard models were utilized to investigate the connection between the HSI and glycemic progression. Additionally, cubic spline function and smooth curve fitting in the Cox regression framework were applied to identify potential non-linear associations between HSI and glycemic progression.</p><p><strong>Results: </strong>Multivariable analysis demonstrated that with each incremental unit in the HSI, there was a corresponding 5.4% rise in the risk of glycemic progression among females (HR: 1.054, 95%CI: 1.038-1.071) and a 3.7% increase in males (HR: 1.037, 95% CI: 1.028-1.046). Both genders exhibited a non-linear connection between HSI and the risk of glycemic progression. The inflection points for HSI were determined to be 36.595 for females and 34.328 for males. Within the female population, a significant positive association with glycemic progression risk was noted when HSI levels were below 36.595 (approximately 8.0% increased risk per unit) (HR: 1.080, 95%CI: 1.061-1.099, P < 0.0001), whereas this correlation was not statistically significant at HSI levels exceeding 36.595 (HR: 0.988, 95%CI: 0.960-1.016, P = 0.4010). In the male population, hazard ratios were 1.026 (95%CI: 1.013-1.038) (approximately 2.6% increased risk per unit) below the inflection point and 1.045 (95%CI: 1.034-1.056) (approximately 4.5% increased risk per unit) above it.</p><p><strong>Conclusion: </strong>Elevated HSI demonstrated a positive, non-linear correlation with the risk of glycemic progression, suggesting that maintaining lower HSI levels may mitigate the risk of developing glycemic progression.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"484"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12211869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of advanced liver fibrosis in the general population of the Paris region according to FIB-4 score and liver risk score.","authors":"Henri Tran, Stefano Caruso, Anne-Laure Mazialivoua, Cecile Fargeat, Odile Rousselet, Adrien Ko, Vincent Leroy, Patrick Ingiliz","doi":"10.1186/s12876-025-03992-y","DOIUrl":"10.1186/s12876-025-03992-y","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"454"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Timing of endoscopy in patients with acute variceal bleeding in cirrhosis: an updated systematic review and meta-analysis.","authors":"Shicheng Luo, Kaini Wu, Xiaodong Zhou","doi":"10.1186/s12876-025-04088-3","DOIUrl":"10.1186/s12876-025-04088-3","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"488"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12211783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TyG-BMI as a superior predictor of MAFLD and pre-MAFLD in Chinese adults: a cross-sectional study.","authors":"Xinru Huang, Yanyun Hu, Lining Dong, Liying Zhu, Jie Li, Ji Hu, Wei Shao, Yongde Peng, Fang Liu","doi":"10.1186/s12876-025-04087-4","DOIUrl":"10.1186/s12876-025-04087-4","url":null,"abstract":"<p><strong>Background: </strong>Metabolic-associated fatty liver disease (MAFLD), a highly prevalent global liver disorder, requires early diagnosis and treatment to delay progression, yet lacks simple diagnostic tools. We aimed to evaluate the validity of the triglyceride-glucose index (TyG) and its related indexes in predicting MAFLD and pre-MAFLD among Chinese individuals.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 9,627 Chinese participants (mean age 46.53 ± 11.87 years; 62.1% males) categorized into three groups based on MAFLD diagnostic criteria. Baseline characteristics were analyzed using one-way ANOVA and Kruskal-Wallis tests. To evaluate independent associations, we performed logistic regression analyses of anthropometric markers and TyG-related indexes with MAFLD status. Furthermore, the dose-response relationship between the TyG and related indexes and MAFLD risk was examined using restricted cubic splines (RCS). Finally, receiver operating characteristic (ROC) curve analysis quantified the predictive performance of each index for MAFLD and pre-MAFLD.</p><p><strong>Results: </strong>Mean blood pressure, anthropometric indicators, and median TyG index and related parameters were significantly higher in the MAFLD group compared to the non-MAFLD group (p <.001). The pre-MAFLD group exhibited intermediate metabolic values between the non-MAFLD and MAFLD groups. Logistic regression analyses revealed anthropometric indicators, TyG index and related indicators were independent risk factors for MAFLD, adjusted for age, gender, blood pressure, blood glucose, and liver function markers. RCS analyses showed a nonlinear positive association between TyG index and related indexes and MAFLD risk (p for nonlinear <.0001). TyG-BMI demonstrated the highest area under the curve (AUC) for both MAFLD (0.874, 95%CI 0.867-0.881) and pre-MAFLD (0.823, 95%CI 0.810-0.836), with optimal cutoffs of 217.41 and 202.54, respectively.</p><p><strong>Conclusions: </strong>TyG-related indices, particularly TyG-BMI, showed superior discriminative ability for MAFLD and pre-MAFLD compared to traditional anthropometric measures in this Yangtze River Delta population, demonstrating an S-shaped dose-response relationship with MAFLD risk. These findings support TyG-BMI as a potential first-line screening tool.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"495"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12211790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative clinical outcomes of transcystic vs. transductal laparoscopic common bile duct exploration: a retrospective study.","authors":"Xing-Guang Yang, Ming Hu, Wei-Feng Sun, Tian-Liang Zhang, Ji-Wu Yang, Hui-Qiong Zhao","doi":"10.1186/s12876-025-04063-y","DOIUrl":"10.1186/s12876-025-04063-y","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to compare the therapeutic outcomes of transcystic laparoscopic common bile duct exploration (TC-LCBDE) and transductive laparoscopic common bile duct exploration (TD-LCBDE) for the treatment of common bile duct stones accompanied by gallstones.</p><p><strong>Methods: </strong>A cohort of 102 patients with common bile duct stones accompanied by gallstones, admitted between April 2016 and February 2025, were retrospectively analyzed. Based on the surgical approach, the patients were divided into Group A (TC-Group, n = 51) and Group B (TD-Group, n = 51). Group A underwent TC-LCBDE, while Group B underwent TD-LCBDE. Key parameters were statistically analyzed, including operative duration, intraoperative blood loss, postoperative length of stay, average hospitalization cost, postoperative drainage tube indwelling time, and the incidence of postoperative complications.</p><p><strong>Results: </strong>Group A had a shorter postoperative length of stay compared to Group B (P < 0.05). The total hospitalization cost in Group A was also lower than that in Group B (P < 0.05). Additionally, the postoperative drainage tube indwelling time was shorter in Group A, with a statistically significant difference between the two groups (P < 0.05).</p><p><strong>Conclusion: </strong>TC-LCBDE is an optimal surgical approach for treating common bile duct stones with concomitant gallstones, offering faster postoperative recovery, lower hospitalization costs, shorter hospital stays, and reduced drainage tube indwelling time.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"496"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of extracorporeal immunoadsorption therapy for removal of HBsAg.","authors":"Meng Wang, Qi Zhou, Huan Wu, Yefu Wang","doi":"10.1186/s12876-025-04062-z","DOIUrl":"10.1186/s12876-025-04062-z","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"449"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12211808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic mechanism of β-alanine metabolic pathway affecting colorectal cancer prognosis.","authors":"Tingyu Zhao, Yali Jiang, Qi Liang, Sumeng Wang, Xiao Zhang, Siqi Ni, Yi Jiao, Lingxiang Liu","doi":"10.1186/s12876-025-04051-2","DOIUrl":"10.1186/s12876-025-04051-2","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) is a common cause of cancer-related mortality and is mainly influenced by metabolic dysfunction. The β-alanine metabolic pathway plays an important role in altering the aggressiveness and metabolic characteristics of the cancer cells. This study aimed to investigate the genetic role of the β-alanine metabolic pathway in CRC patient survival.</p><p><strong>Methods: </strong>Using a Cox regression model, we assessed the impact of 27 single-nucleotide polymorphisms (SNPs) from 31 genes in the β-alanine metabolic pathway on overall survival (OS) and progression-free survival (PFS) in 287 patients with CRC. Additional methods, including differential expression analysis, expression quantitative trait loci analysis, dual-luciferase reporter assay, and cell phenotype assay, were used to evaluate the genetic function of candidate SNPs in tumor progression.</p><p><strong>Results: </strong>We identified that SNP rs2811182 A > G allele located in DPYD was significantly associated with poorer prognosis of CRC, with hazard ratio (HR) of 0.63 for OS [95% confidence interval (CI) = 0.45-0.88, P = 7.12 × 10^-3] and 0.68 for PFS (95% CI = 0.52-0.89, P = 5.01 × 10^-3). Mechanistically, the G allele of rs2811182 increased DPYD transcriptional activity and expression by mediating the binding affinity of the transcription factor POU1F1. Importantly, the overexpression of DPYD reduced the malignant cell phenotypes of proliferation, migration, and invasion.</p><p><strong>Conclusions: </strong>This study indicates a pivotal genetic role for the β-alanine metabolic pathway, particularly rs2811182 in DPYD, in influencing CRC prognosis. These findings offer new perspectives for personalized treatment strategies and enhance our understanding of CRC pathogenesis.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"480"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144538622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}