BMC Gastroenterology最新文献

{"title":"Comparative analysis of tenofovir alafenamide and entecavir on renal function and serum lipids in liver transplant recipients: a controlled retrospective cohort study.","authors":"Hüseyin Döngelli, Nilay Danış, Tarkan Ünek, Tufan Egeli, Cihan Ağalar, Mücahit Özbilgin, Hülya Ellidokuz, Mesut Akarsu","doi":"10.1186/s12876-025-04262-7","DOIUrl":"10.1186/s12876-025-04262-7","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"645"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated CircYthdc2 expression is correlated with aggressive features and poor progression-free survival in hepatocellular carcinoma.","authors":"Yin Gong, Xiangcheng Li, Mingming Wang","doi":"10.1186/s12876-025-04231-0","DOIUrl":"10.1186/s12876-025-04231-0","url":null,"abstract":"<p><strong>Objective: </strong>Liver hepatocellular carcinoma (LIHC) is a major contributor to cancer-related mortality. While early detection is crucial for improving outcomes, current diagnostic methods lack optimal sensitivity and specificity. Circular RNAs (circRNAs) have emerged as promising biomarkers due to their stability and tissue-specific expression.</p><p><strong>Methods: </strong>Bioinformatic analysis was performed using UALCAN database to examine YTHDC2 methylation and expression patterns. Tissue and serum samples were collected from 72 LIHC patients and matched controls. CircYTHDC2 expression was assessed in tissues, serum, and cell lines via qRT-PCR. CircYTHDC2's diagnostic potential was evaluated through ROC analysis and stability testing. Associations between circYTHDC2 levels, clinicopathological features, and survival were analyzed.</p><p><strong>Results: </strong>Bioinformatic analysis revealed reduced YTHDC2 promoter methylation and elevated expression in LIHC tissues. CircYTHDC2 showed significant upregulation in LIHC tissues, serum, and cell lines compared to controls. ROC analysis demonstrated high diagnostic accuracy for circYTHDC2 in tissues (AUC = 0.846) and serum (AUC = 0.788). CircYTHDC2 exhibited remarkable stability against RNase degradation. Elevated circYTHDC2 levels significantly correlated with advanced BCLC stage, larger tumor size, intrahepatic metastasis, and portal invasion. High circYTHDC2 expression was associated with shorter progression-free survival (P = 0.025). Additionally, we found circYTHDC2 bound to YTHDC2 and was positively regulated by YTHDC2 in an m6A-dependent manner.</p><p><strong>Conclusion: </strong>CircYTHDC2 represents a stable, clinically viable biomarker for LIHC, demonstrating significant diagnostic accuracy and prognostic value. Its strong correlation with aggressive tumor features and survival outcomes suggests potential utility in clinical management of LIHC patients.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"658"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factor analysis and nomogram development for survival prediction in obese patients with severe acute pancreatitis: a retrospective study.","authors":"Qingcheng Zhu, Xueqin Shan, Dingyu Tan, Mingfeng Lu, Yan Xu","doi":"10.1186/s12876-025-04266-3","DOIUrl":"10.1186/s12876-025-04266-3","url":null,"abstract":"<p><strong>Background: </strong>Currently, there is a lack of nomograms specifically designed to predict mortality risk in obese patients with severe acute pancreatitis (SAP). The aim of our study is to develop a predictive model tailored to this population, enabling more accurate anticipation of overall survival.</p><p><strong>Methods: </strong>The study included obese patients diagnosed with SAP between January 1, 2016, and December 31, 2023. Risk factors were identified through least absolute shrinkage and selection operator regression analysis. Subsequently, a novel nomogram model was developed through multivariable logistic regression analysis. An independent cohort was used for external validation. The predictive performance of the nomogram was evaluated using metrics such as the receiver operating characteristic curve, calibration curve, and decision curve analysis (DCA).</p><p><strong>Results: </strong>A total of 394 patients were included in the study, with 341 in the survival group and 53 in the deceased group. The results of the multivariate logistic analysis revealed that age, total bilirubin, blood urea nitrogen, potassium, activated partial thromboplastin time, and malignancy were independent predictors for the survival of obese patients with SAP. The nomogram exhibited superior performance compared to the Sequential Organ Failure Assessment (SOFA) score (P = 0.011). In the external validation cohort, the nomogram maintained good discrimination and showed improved reclassification over SOFA. Additionally, the calibration curve demonstrated satisfactory predictive accuracy, while DCA highlighted the clinical utility of the nomogram.</p><p><strong>Conclusion: </strong>Key demographic and laboratory parameters associated with the survival of obese SAP patients have been identified. These parameters were used to develop an accurate, user-friendly nomogram, potentially serving as an effective and valuable clinical tool for clinicians.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"651"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of withdrawal time on the adenoma detection rate in elderly patients during unsedated colonoscopy: a retrospective multicenter study.","authors":"Fu-Qiang Liu, Ying-Hao He, Han Yan, Jin-Wen Liao, Wen-Juan Ding, Yu-Ting Huang, Zhi-Qiang Du, Xiang-Rong Zhou, Zheng Jiang","doi":"10.1186/s12876-025-04257-4","DOIUrl":"10.1186/s12876-025-04257-4","url":null,"abstract":"<p><strong>Background: </strong>Colonoscopy withdrawal time is recognized as a key factor influencing the adenoma detection rate (ADR). Current clinical guidelines recommend a minimum colonoscopy withdrawal time of 6 min. However, the optimal withdrawal time for unsedated colonoscopy in elderly patients and its impact on ADR remain uncertain.</p><p><strong>Methods: </strong>In this retrospective multicenter study, we collected the withdrawal time (excluding bowel cleansing and polyp resection time) of unsedated colonoscopy in elderly patients, to analyze the relationship between withdrawal time in 1-minute increments and ADR, and the effect of withdrawal time > 8 min compared with withdrawal time ≤ 8 min on ADR. Multivariate linear regression analysis was employed to assess the optimal withdrawal time influencing ADR.</p><p><strong>Results: </strong>A total of 1119 samples (mean age, 70.32 ± 7.17 years; 57.28% male) were included in the analysis, with a median withdrawal time of 9 min (interquartile range [IQR], 7-13). The ADR was highest at a withdrawal time of 8 min (67.02%), while the adenocarcinoma detection rate (ACDR) peaked at a withdrawal time of 8 min (17.02%). In addition, patients with withdrawal time > 8 min exhibited a higher ADR than those with ≤ 8 min (odds ratio (OR), 1.63; 95% confidence interval (CI), 1.28-2.06; P < 0.001).</p><p><strong>Conclusions: </strong>This retrospective multicenter study demonstrates that in elderly patients with contraindications to sedation, achieving a minimum withdrawal time of 8 min during unsedated colonoscopy is critical for optimizing ADR.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"660"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of a 7-day vonoprazan, sitafloxacin, and amoxicillin triple therapy as a fourth-line salvage regimen for refractory Helicobacter pylori infection.","authors":"Tanawat Geeratragool, Supathep Tansirichaiya, Witchuda Kamolvit, Thanapat Atthakitmongkol, Wasawat Leartsiwawinyu, Iyarit Thaipisuttikul, Pritsana Chuenprapai, Somchai Leelakusolvong, Chanin Limwong, Monthira Maneerattanaporn","doi":"10.1186/s12876-025-04226-x","DOIUrl":"10.1186/s12876-025-04226-x","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"664"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a dihydroartemisinin-related prognostic signature and its contribution to cancer associated fibroblast of the tumor microenvironment of pancreatic cancer.","authors":"Jinglin Lai, Tongning Zhong, Citing Zhang, Chongzhou Fang, Defeng Lei, Yong Xie, Xu Liu, Zhengquan Lai, Zilong Yan, Weipeng Ai, Jianhua Qu, Biao Zheng","doi":"10.1186/s12876-025-04241-y","DOIUrl":"10.1186/s12876-025-04241-y","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"656"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-molecular-weight heparin alleviates L-arginine-induced acute pancreatitis by modulating lipid metabolism and inflammatory responses in a rat model.","authors":"Jianmei Zeng, Kejin Li, Limao Xu, Chengfeng Wu, Fei Wang, Juan Huang","doi":"10.1186/s12876-025-04219-w","DOIUrl":"10.1186/s12876-025-04219-w","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"644"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human epidermal growth factor receptor 2 expression and socio-demographic, clinical, and histopathological characteristics in gastric carcinoma at St Francis Hospital Nsambya, Uganda.","authors":"Steven Wanda, Gorretti Nassali, Brian Bbosa, Francis Basimbe, Joviah Akulu, Davis Nsamba, Praise Nimusiima, Joshua Muhumuza, Emmanuel Othieno, Maxwel Dancan Okuku","doi":"10.1186/s12876-025-04274-3","DOIUrl":"10.1186/s12876-025-04274-3","url":null,"abstract":"<p><strong>Introduction: </strong>Gastric carcinoma is a significant global health burden with diverse clinicopathological features and molecular alterations influencing prognosis and treatment. Human epidermal growth factor receptor 2 (HER2) overexpression is a critical biomarker in gastric carcinoma, guiding targeted therapeutic interventions. This study aimed to assess HER2 expression and its association with clinicopathological characteristics of gastric carcinoma.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted using consecutive sampling to retrieve gastric carcinoma tissue blocks that met the inclusion criteria. A total of 136 formalin-fixed, paraffin-embedded tissue blocks from patients aged 18 years and above (2013-2023) at St. Francis Hospital Nsambya were analyzed. HER2 expression was evaluated using immunohistochemistry (IHC) with a standardized test kit. Associations between HER2 expression and demographic and histopathological characteristics were analyzed.</p><p><strong>Results: </strong>Among 136 patients, the mean age was 59.63 years, with 48.53% aged 48-67 years. Most were male (63.24%) and from the Central region (60.70%). The intestinal subtype was the most common (78.68%), with 52.21% of tumors poorly differentiated, and tumors predominantly located in the antrum (32.35%), cardia (30.15%), and body (24.26%). Regarding HER2 expression, 11.76% were positive (3+), 2.21% equivocal (2+), and 86.03% negative (0 or 1+). HER2 positivity was significantly associated with residence in the Western region (aPR = 3.67; 95% CI: 1.33-10.11; p = 0.02) and with mixed-type tumors (aPR = 3.00; 95% CI: 1.70-5.30; p < 0.001).</p><p><strong>Conclusion: </strong>HER2 overexpression in gastric carcinoma was low. Nevertheless, the findings underscore the importance of routine HER2 testing and access to targeted therapy. Observed associations point to potential high-risk groups warranting further investigation in larger, multicenter studies.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"655"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the ApoB/ApoA1 ratio and both the severity and mortality of metabolic dysfunction-associated fatty liver disease.","authors":"Chao Fu, Yan Gong, Xiangyang Gao, Yuxin Li, Guanyun Wang, Bingqing Han, Shanshan Liu, Hao Zhang, Dengxin He, Fei Wang, Qiang Zeng","doi":"10.1186/s12876-025-04130-4","DOIUrl":"10.1186/s12876-025-04130-4","url":null,"abstract":"","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"650"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer disparities in lean vs. non-lean MASH: insight from a national inpatient sample.","authors":"Chukwunonso Ezeani, Chidiebele Omaliko, Petr Protiva, Yazan A Al-Ajlouni, Gyanprakash Ketwaroo, Basile Njei","doi":"10.1186/s12876-025-04187-1","DOIUrl":"10.1186/s12876-025-04187-1","url":null,"abstract":"<p><strong>Objective: </strong>To investigate cancer disparities between lean (BMI < 25 kg/m²; < 23 kg/m² for Asians) and non-lean metabolic dysfunction-associated steatohepatitis (MASH) by analyzing the prevalence of the 18 most common cancers in a large U.S.</p><p><strong>Cohort: </strong></p><p><strong>Methods: </strong>This retrospective cohort study utilized the National Inpatient Sample (2016-2020) with weighted data to project findings to the general population. Patients were categorized as lean or non-lean based on BMI during hospitalization, excluding alternative etiologies via validated algorithms. Outcomes included composite cancer prevalence (primary) and individual cancer prevalence (secondary). Multivariable logistic regression was applied to assess differences.</p><p><strong>Results: </strong>Among 34,955,252 U.S. hospitalizations, 539,275 patients had MASH (mean age: 64 years for lean vs. 58.8 years for non-lean; >60% female). Lean MASH hospitalizations had higher odds of lung (aOR 1.76, CI 1.33-2.10, P < 0.001), colon (aOR 1.23, CI 1.02-1.48, P = 0.027), kidney (aOR 1.27, CI 1.10-1.44, P = 0.001), liver (aOR 1.21, CI 1.12-1.31, P < 0.001), and cervical cancers (aOR 3.25, CI 1.07-9.86, P = 0.037), as well as non-Hodgkin's lymphoma (aOR 1.28, CI 1.08-1.51, P = 0.004), but lower odds of endometrial cancer (aOR 0.35, CI 0.25-0.50, P < 0.001).</p><p><strong>Conclusion: </strong>Lean MASH hospitalizations are linked to higher odds of several cancers despite lower BMI, underscoring the need for a nuanced understanding of cancer risks in MASH. BMI alone may not fully capture oncologic risk in this population.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"659"},"PeriodicalIF":2.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12465481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145173700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}