BMC Gastroenterology最新文献

{"title":"Diagnostic challenges of inflammatory submucosal tumor-like lesions: a multicenter propensity score-matching analysis.","authors":"Mengting Yu, Jiao Li, Yongfeng Yan, Xiaoxiang Wang, Yanhui Mao, Dandan Jiang, Zhengkui Zhou, Yuanyuan Chen, Xiaobin Sun","doi":"10.1186/s12876-025-03897-w","DOIUrl":"10.1186/s12876-025-03897-w","url":null,"abstract":"<p><strong>Background: </strong>Gastrointestinal submucosal tumors (SMTs) are frequently encountered in clinical practice, with diverse etiologies and overlapping endoscopic features. Inflammatory SMT-like lesions (I-SMTLs), though rare and benign, mimic SMTs endoscopically but are fundamentally inflammatory. Limited research exists on their specific diagnostic characteristics.</p><p><strong>Methods: </strong>This multicenter retrospective study analyzed 59 I-SMTLs among 1,226 pathologically confirmed SMTs from five hospitals in China. The diagnostic efficacy of endoscopic ultrasound (EUS) for I-SMTLs was assessed, and comparison with non-inflammatory SMT-like lesions (non-I-SMTLs) was made using propensity score matching (PSM) balanced for sex, age, lesion location and size. Correlation between endoscopic and pathological characteristics were quantified using Cramer's V coefficient.</p><p><strong>Results: </strong>I-SMTLs accounted for 4.81% (59/1,226) of SMTs, with 98.31% (58/59) measuring under 2 cm. EUS demonstrated low sensitivity (3.39-4.00%) and a high misdiagnosis rate (96.61%) for I-SMTLs, with over 55% misdiagnosed as potentially malignant and 15% remaining inconclusive. In the PSM cohort (59 I-SMTLs, 118 non-I-SMTLs), I-SMTLs were more frequently located in submucosa (71.19% vs. 42.37%), exhibited mixed-echoic category (18.64% vs. 1.69%), heterogeneous echogenicity (62.71% vs. 21.19%) and unclear boundaries (42.37% vs. 13.56%). Correlation analysis showed cases with smooth muscle hyperplasia in pathology were more likely to arise from the muscularis propria or muscularis mucosae (Cramer's V = 0.490), and cases with fibrous tissue alterations were more likely to exhibit mixed or hyperechoic patterns (Cramer's V = 0.545) and heterogeneous echotexture (Cramer's V = 0.336) on EUS.</p><p><strong>Conclusions: </strong>I-SMTLs pose significant diagnostic challenges. Distinguishing EUS features, including submucosal location, mixed-echoic patterns, heterogeneous textures, and unclear boundaries, may improve diagnostic accuracy and facilitate appropriate clinical decision-making.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"346"},"PeriodicalIF":2.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive analysis of ferroptosis-related long non-coding RNA and its association with tumor progression and ferroptosis in gastric cancer.","authors":"Shenglan Huang, Kan Liu, Queling Liu, Si Tao, Hua Wang","doi":"10.1186/s12876-025-03951-7","DOIUrl":"https://doi.org/10.1186/s12876-025-03951-7","url":null,"abstract":"<p><p>Gastric cancer (GC) is one of the most common malignant tumors with a poor prognosis. Ferroptosis is an distinct type of non-apoptotic cell death that is closely associated with tumor prognosis. Thus, we aimed to develop an novel prognosis risk model based on ferroptosis-related lncRNAs and excavate novel diagnostic markers. In this study, eight ferroptosis-related lncRNAs were obtained for constructing the prognosis model in GC based on TCGA database. The patients in the high-risk group had worse survival than those in the low-risk group, and the risk-grouping could be used as an independent prognostic factor for OS. Receiver operating characteristic curve analysis demonstrated this risk model was superior to traditional clinicopathological features in predicting GC prognosis. GSEA revealed that these lncRNAs were mainly involved in cell adhesion, cancer pathways, and immune function regulation. The key gene HAGLR of this risk signature was up-regulated in GC tissues and cells. Function assays showed that knockdown of HAGLR could effectively inhibit the GC cells proliferation and migration, whereas silencing HAGLR accelerated apoptosis and ferroptosis cell death process. In conclusion, we established a novel ferroptosis-related prognostic risk signature including eight lncRNAs, which may improve prognostic predictive accuracy for patients with GC.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"349"},"PeriodicalIF":2.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formation of non-cholesterol gallstones in populations within clonorchiasis endemic regions is closely related to Clonorchis sinensis infection.","authors":"Xiaobing Luo, Ruihong Ma, Hongying Cai, Xiangyu Su, Sangui Wang, Tie Qiao","doi":"10.1186/s12876-025-03939-3","DOIUrl":"https://doi.org/10.1186/s12876-025-03939-3","url":null,"abstract":"<p><strong>Background: </strong>Numerous risk factors are linked to gallbladder stone disease (GBSD). Nonetheless, the relationship between Clonorchis sinensis (C. sinensis) and this condition remains to be clarified.</p><p><strong>Methods: </strong>The antibody against C. sinensis in serum and the glucose, triglyceride, and cholesterol levels were investigated in 220 patients with GBSD and 251 controls. Bile components were analysed in patients with gallbladder polyps (GP, n = 18), gallstones (GS, n = 265), and GS combined with C. sinensis infection (GSI, n = 243). Additionally, the gallbladder ejection fraction (%E), residual gallbladder volume (RGV) at 1 h after a fatty meal, and fasting gallbladder volume (FGV) were compared among the GP (n = 43), GS (n = 311), and GSI (n = 277) groups.</p><p><strong>Results: </strong>The results indicated positive antibody against C. sinensis (OR: 1.759, 95% CI: 1.163-2.662) and hyperglycaemia (glucose concentration ≥ 6.10 mmol/L, OR: 2.263, 95% CI: 1.227-4.172) were risk factors for GBSD. There were more non-cholesterol stones in GSI patients (216/241, 89.6%) than in GS patients (137/281, 48.8%) (P < 0.0001). Microscopic observations revealed that mucus containing glycogen coated the C. sinensis eggs and the proportion of dead eggs gradually increased in bile, sediment, and stones alongside rising calcium salt content. Total bile acid and cholesterol concentrations were lower in GSI patients than in GP patients or GS patients (P < 0.05). Moreover, increased FGV and RGV and decreased %E were observed in GSI patients compared with GP patients (P < 0.001).</p><p><strong>Conclusions: </strong>The formation of non-cholesterol gallstones in populations residing in endemic areas is related to the deposition, death, and calcification of eggs in the gallbladder, changes in bile components, and decreased gallbladder motility caused by C. sinensis infection.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"345"},"PeriodicalIF":2.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative immune prognostic index predicts the prognosis and postoperative adjuvant chemotherapy benefits of esophageal squamous cell carcinoma after minimally invasive esophagectomy.","authors":"Jin Huang, Chao Chen, Yan-Ming Shen, Yun-Fan Luo, Zhao-Min Sun, Jie Chen, Shao-Jun Xu, Ji-Hong Lin, Shu-Chen Chen","doi":"10.1186/s12876-025-03959-z","DOIUrl":"https://doi.org/10.1186/s12876-025-03959-z","url":null,"abstract":"<p><strong>Background: </strong>The utility of the immune prognostic index (IPI) for esophageal squamous cell carcinoma (ESCC) has yet to be established after minimally invasive esophagectomy (MIE). The purpose of this study was to investigate the value of IPI in predicting the prognosis and postoperative adjuvant chemotherapy (AC) benefits of ESCC patients.</p><p><strong>Methods: </strong>Between January 2011 and December 2018, 613 ESCC patients underwent MIE at our center and were divided into two groups: low IPI and high IPI.Log-rank tests were used to compare the overall survival (OS) and disease-free survival (DFS) of patients in different groups based on Kaplan-Meier survival analysis. Differences in clinical characteristics between groups were eliminated by propensity score matching (PSM) analysis. To identify independent risk factors influencing OS and DFS, the Cox proportional risk model was used.</p><p><strong>Results: </strong>In comparison to the high IPI group, the low IPI group had a better 5-year OS and DFS in both the entire and matched cohorts (P < 0.05). IPI was found to be an independent prognostic factor for OS and DFS in a multivariate analysis of the entire cohort and the matched cohort (P < 0.05). In subgroup analyses of most clinicopathological factors, high IPI was associated with a higher risk of death or recurrence in the matched cohorts. When combined with 8th TNM staging, the 5-year OS and DFS of stage II or III patients with low IPI in the AC group were not different from those in the non-AC group (P > 0.05), and AC of stage III patients with high IPI significantly prolonged 5-year OS and DFS (OS: 37.4% vs 26.2%, P = 0.018; DFS: 33.6% vs 19.8%, P = 0.042).</p><p><strong>Conclusion: </strong>Preoperative IPI is a promising predictor of ESCC after MIE. For stage III ESCC patients with high IPI, AC can significantly reduce the risk of death or recurrence.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"344"},"PeriodicalIF":2.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the risk of lymph node metastasis in colon cancer: development and validation of an online dynamic nomogram based on multiple preoperative data.","authors":"Longlian Deng, Lemuge Che, Haibin Sun, Riletu En, Bowen Ha, Tao Liu, Tengqi Wang, Qiang Xu","doi":"10.1186/s12876-025-03958-0","DOIUrl":"https://doi.org/10.1186/s12876-025-03958-0","url":null,"abstract":"<p><strong>Background: </strong>Predicting lymph node metastasis (LNM) in colon cancer (CC) is crucial to treatment decision-making and prognosis. This study aimed to develop and validate a nomogram that estimates the risk of LNM in patients with CC using multiple clinical data from patients before surgery.</p><p><strong>Methods: </strong>Clinicopathological data were collected from 412 CC patients who underwent Radical resection of CC. The training cohort consisted of 300 cases, and the external validation cohort consisted of 112 cases. The LASSO and multivariate logistic regression were used to select the predictors and construct the nomogram. The discrimination and calibration of the nomogram were evaluated by the ROC curve and calibration curve, respectively. The clinical application of the nomogram was assessed by decision curve analysis(DCA) and clinical impact curves(CIC).</p><p><strong>Results: </strong>Eight independent factors associated with LNM were identified by multivariate logistic analysis: LN status on CT, tumor diameter on CT, differentiation, ulcer, intestinal obstruction, anemia, blood type, and neutrophil percentage. The online dynamic nomogram model constructed by independent factors has good discrimination and consistency. The AUC of 0.834(95% CI: 0.755-0.855) in the training cohort, 0.872(95%CI: 0.807-0.937) in the external validation cohort, and Internal validation showed that the corrected C statistic was 0.810. The calibration curve of both the training set and the external validation set indicated that the predicted outcome of the nomogram was highly consistent with the actual outcome. The DCA and CIC indicate that the model has clinical practical value.</p><p><strong>Conclusion: </strong>Based on various simple parameters collected preoperatively, the online dynamic nomogram can accurately predict LNM risk in CC patients. The high discriminative ability and significant improvement of NRI and IDI indicate that the model has potential clinical application value.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"350"},"PeriodicalIF":2.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the \"Collagen-Macrophage\" sub-category of patients with colorectal cancer as an extension of the CMS4 subtype with THBS2 as a therapeutic target.","authors":"Shuwen Chen, Zhaoyan Jiang, Wanxuan Song, Chuqiao Lu, Yanbing Lin, Shiyao Xu, Kunxin Xie, Li Wan, Xiaoqin Yuan","doi":"10.1186/s12876-025-03918-8","DOIUrl":"https://doi.org/10.1186/s12876-025-03918-8","url":null,"abstract":"<p><p>We identified a subset of patients with colorectal cancer (CRC) enriched with \"collagen-TAMs,\" designated the CM class, using large integrated colon cancer transcriptome and single-cell transcriptome datasets. This classification system could be used as an extension of the traditional CMS classification system for CRC to guide more accurate classification and treatment.We also screened CAF-derived THBS2 as a potential biomarker for CM and found that it plays an important role in CRC disease models in vitro and in vivo, promoting tumor development and metastasis as well as TAM recruitment. Targeting THBS2 combined with PD-1 therapy effectively improved the therapeutic effect of immunotherapy in vivo. The CM classification provides a new perspective for CRC treatment, and THBS2, which is highly expressed in CM cases, can be used as a new potential combined target for immunotherapy.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"342"},"PeriodicalIF":2.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic value of AST-lymphocyte ratio index in liver cancer patients treated with TACE: a systematic review and single-center retrospective study.","authors":"Yali Tian, Lina Ma, Shuaiwei Liu, Xiaoyang Bai, Nawaz Shah, Le Zhang, Xia Wang, Yuxi Zhang, Xiangchun Ding","doi":"10.1186/s12876-025-03949-1","DOIUrl":"10.1186/s12876-025-03949-1","url":null,"abstract":"<p><strong>Background and aims: </strong>AST-lymphocyte ratio index (ALRI) has been proposed as a potentially prognostic indicator of liver cancer patients underwent transcatheter arterial chemoembolization (TACE) in studies, but the numbers were small and the results were controversial. In this study, we systematically assessed the prognostic value of ALRI in liver cancer patients treated with TACE by integrating meta-analysis with single-center clinical analysis.</p><p><strong>Methods: </strong>We conducted a systematic literature search across multiple databases and evaluated the quality of included studies using the Newcastle-Ottawa Scale. We employed a fixed-effect model to calculate the pooled hazard ratio (HR) and 95% confidence interval (CI). Publication bias were evaluated using funnel plot, Begg's and Egger's tests. Concurrently, we integrated clinical data from 127 HCC patients treated with TACE at our center, employed X-tile software to ascertain the optimal cutoff value for ALRI, and analyzed the relationship between ALRI and clinical characteristics as well as overall survival (OS), using chi-square tests, Kaplan-Meier survival curves, and Cox proportional hazards models.</p><p><strong>Results: </strong>The meta-analysis included 7 studies, and the pooled hazard ratio (HR) indicated that elevated ALRI was significantly associated with poorer OS in liver cancer patients underwent TACE (HR = 1.75, 95% CI: 1.46-2.1, P<0.01), with no significant heterogeneity (P = 0.542, I² = 0.00%). Clinical analysis of 127 patients further supported this finding, with patients in the high ALRI group showed significantly lower OS compared to those in the low ALRI group (1-year OS rate: 96.7% vs. 87.9%, 2-year OS rate: 61.5% vs. 42.7%; C² = 28.006, P<0.01). Multivariate Cox regression analysis revealed that number of tumors, tumor size and ALRI were all independent prognostic factors for OS (ALRI HR = 6.456, 95%CI: 2.247-18.55, P < 0.01).</p><p><strong>Conclusions: </strong>An increase in ALRI may serve as an independent prognostic indicator of poor outcomes in liver cancer patients undergoing TACE. While it offers benefits such as being non-invasive and cost-effective, further large-scale, multicenter, prospective studies are essential to validate the efficacy of ALRI and establish standardized cutoff values for clinical application.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"348"},"PeriodicalIF":2.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strain elastography for detecting advanced Fontan-associated liver disease: a retrospective study.","authors":"Koji Imoto, Takeshi Goya, Yuki Azuma, Tomonobu Hioki, Tomomi Aoyagi, Hazumu Nagata, Akiko Nishizaki, Takamori Kakino, Ayako Ishikita, Kenichiro Yamamura, Ichiro Sakamoto, Masatake Tanaka, Kohtaro Abe, Yoshihiro Ogawa","doi":"10.1186/s12876-025-03965-1","DOIUrl":"https://doi.org/10.1186/s12876-025-03965-1","url":null,"abstract":"<p><strong>Background: </strong>The Fontan procedure has improved the prognosis of patients with a functional single ventricle; however, late complications-including Fontan-associated liver disease (FALD)-have surfaced as clinical concerns. FALD with signs of portal hypertension has been defined as advanced FALD (aFALD) due to its poor prognosis. Recently, noninvasive tests (NITs) have been found to predict liver fibrosis in FALD. Liver stiffness measurement excluding strain elastography (SE) was affected by hepatic congestion; however, to our knowledge, not many studies have evaluated the SE-derived Liver Fibrosis Index (LFI). This study aimed to determine the efficacy of NITs, especially LFI, for discriminating aFALD.</p><p><strong>Methods: </strong>In this retrospective study, 46 Japanese patients with FALD were included and classified into the aFALD (33 patients; 22 males and 11 females; median age: 28.0 years) and non-aFALD (13 patients; seven males and six females; median age: 22.0 years) groups based on the presence/absence of signs of portal hypertension.</p><p><strong>Results: </strong>The platelet count, FIB-4 index, Forns index, and LFI differed significantly between the two groups and demonstrated moderate accuracy for discriminating aFALD. The shear wave velocity (Vs) measured by Shear Wave Elastography (SWE) did not differ significantly between the two groups. The cut-off value of platelet counts below 185 × 10³/μL had 78.8% sensitivity and 92.3% specificity. While 25/26 (96.2%) of the patients with FALD who had platelet counts below 185 × 10³/μL were aFALD, 8/20 (40.0%) of the patients with FALD who had platelet counts above below 185 × 10³/μL were also aFALD, indicating the need for additional markers. In the patients with FALD who had platelet counts above 185 × 10³/μL, only SE indicated moderate diagnostic accuracy, and the LFI cut-off value of 2.21 had 100% sensitivity and 75.0% specificity.</p><p><strong>Conclusions: </strong>Using a two-step approach, discriminating aFALD with platelet counts below 185 × 10³/μL by platelets alone, and for those with higher platelet counts, requiring LFI > 2.21 could discriminate aFALD with high accuracy. Early detection of aFALD and early intervention, including testing for aFALD, may lead to an improved prognosis of aFALD.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"341"},"PeriodicalIF":2.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"M64HCl, a focal adhesion kinase activator, promotes intestinal mucosal healing in rats.","authors":"Guiming Liu, Ahmed Adham R Elsayed, Louis Boafo Kwantwi, Ricardo Gallardo-Macias, Vadim J Gurvich, Marc D Basson","doi":"10.1186/s12876-025-03937-5","DOIUrl":"https://doi.org/10.1186/s12876-025-03937-5","url":null,"abstract":"<p><strong>Background: </strong>Intestinal mucosal injury may arise from various factors. While many drugs target the causative factors, none directly stimulate mucosal wound healing. We found that the specific focal adhesion kinase (FAK) activator, M64HCl, promotes intestinal mucosal healing in mice. This study aims to further validate the therapeutic impact of M64HCl on intestinal mucosal repair in rats as a second species.</p><p><strong>Methods: </strong>Wistar rats were assigned to one of four groups: normal control, 1-day injury + vehicle, 4-day injury + vehicle, or 4-day injury + M64HCl. Intestinal injury was induced by serosally applying 75% acetic acid. Immediately after injury, rats received either a continuous infusion of M64HCl (25 mg/kg/day) or its vehicle (saline). Four days post-injury, blood was drawn to measure M64HCl levels and assess liver and kidney function. The intestines were removed and opened, ulcer areas were photographed for size quantification, and tissues were fixed for histological and immunohistochemical analysis.</p><p><strong>Results: </strong>M64HCl substantially reduced ulcer area on gross examination, while histological analysis showed alleviation of pathological changes with M64HCl treatment. Immunohistochemical analysis confirmed increased immunoreactivity for phosphorylated FAK in the epithelium adjacent to the injury in M64HCl-treated rats. However, there was no change in the percentage of Ki67-positive cells in each crypt at the edge of the ulcer area. Serum creatinine, ALT, and AST levels did not differ between the 4-day injury groups with or without M64HCl treatment.</p><p><strong>Conclusions: </strong>M64HCl, a water-soluble FAK activator, promotes acetic acid-induced ulcer healing in rats and may be useful in treating gastrointestinal mucosal injury.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"347"},"PeriodicalIF":2.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of depressive symptoms and risk of chronic liver disease: evidence from CHARLS.","authors":"Xikun Yang, Jiangping Ma, Hui Li","doi":"10.1186/s12876-025-03943-7","DOIUrl":"https://doi.org/10.1186/s12876-025-03943-7","url":null,"abstract":"<p><strong>Background: </strong>It is unclear whether there is a association between the long-term depressive symptoms and chronic liver disease(CLD). The aim of present study was to investigate the relationship between the trajectories of depressive symptoms and CLD in middle-aged and older Chinese adults.</p><p><strong>Methods: </strong>The study included data from 7351 Chinese individuals, which from the China Health and Retirement Longitudinal Study (CHARLS). Latent Class Growth Model (LCGM) and Growth Mixture Model (GMM) identified five categories of depressive symptom trajectories from 2011 to 2015. Multiple logistic regression models were used to analyze the relationship between depressive symptom trajectories and CLD in 2015-2020.</p><p><strong>Results: </strong>We identified five distinct trajectories of depressive symptoms characterized by persistent low CES-D scores throughout follow-up (low-stable; 4621 cases [62.86%]); high starting CES-D scores but then declining (high-decreasing; 824 cases [11.21%]); persistent high CES-D scores during follow-up (high-stable; 508 cases [6.91%]); starting moderate CES-D scores but then increasing (moderate-increasing; 844 cases [11.48%]); and low starting CES-D scores that increased and then remitted through follow-up (remitting; 554 cases [7.54%]). A total of 420 (5.71%) participants developed chronic liver disease during follow-up. The ORs (95% CI) for the risk of developing chronic liver disease in participants on the moderate-increasing trajectory, high-decreasing trajectory, and high-stable trajectory were 1.44 (1.05-1.93), 1.59 (1.17-2.12), and 2.25 (1.62-3.08), respectively, compared with participants on the low-stable trajectory.</p><p><strong>Conclusion: </strong>In Chinese middle-aged and older adults, individuals with moderate-increasing, high-decreasing, and high-stable trajectories of depressive symptoms over time had an increased risk of developing CLD.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"338"},"PeriodicalIF":2.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}