BMC Gastroenterology最新文献

{"title":"Global burden of colon and rectal cancer and attributable risk factors in 204 countries and territories from 1990 to 2021.","authors":"Xuyuan Zhang, Haoyu Fan, Sen Han, Ting Zhang, Yanxia Sun, Liuyang Yang, Wenliang Li","doi":"10.1186/s12876-025-03948-2","DOIUrl":"https://doi.org/10.1186/s12876-025-03948-2","url":null,"abstract":"<p><strong>Objective: </strong>Colon and rectal cancers (CRCs) are among the most common malignancies worldwide. While previous studies have examined the disease burden and risk factors of CRC at regional levels, they lack the granularity needed for country-specific policy development. Using updated data from the Global Burden of Disease (GBD) 2021 study, this research explores the national-level spatial distribution of CRC burdens linked to key risk factors and analyzes temporal trends in their contributions. The findings aim to support the formulation of precise public health policies to effectively reduce CRC incidence.</p><p><strong>Methods: </strong>Based on data from the GBD study 2021, we examined CRC-related incidence, prevalence, mortality, disability-adjusted life years (DALYs), and associated risk factors. Age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and DALY rate (ASDR) were obtained and analyzed from 1990 to 2021. We used regression analysis and stratification across the four World Bank regions to assess geographical variations and the effect of economic development levels. We further assessed the contribution of various risk factors to CRC-related deaths and DALYs, while analyzing the distribution and temporal trends of the top three contributing risk factors.</p><p><strong>Results: </strong>On a global scale, the ASDR for CRC declined from 357.33 per 100,000 in 1990 to 283.24 per 100,000 in 2021 (95% confidence interval [CI]: -0.82 to -0.64). In 2021, the regions classified by the World Bank as high income exhibited the highest ASDR in 2021, at 347.35 per 100,000, while the lower-middle-income regions reported the lowest ASDR, at 179.48 per 100,000. During this period, the global ASMR fell from 15.56 to 12.40 per 100,000, while the ASIR rose from 24.04 to 25.60 per 100,000. However, these trends were not consistent across different World Bank income regions. Key risk factors contributing to CRC included high red meat consumption, obesity, insufficient calcium intake, and alcohol consumption, with variations observed among the World Bank income groups.</p><p><strong>Conclusion: </strong>Although the global burden of colorectal cancer (CRC) has declined from 1990 to 2021, particularly in high-income regions, the incidence rate continues to rise. The increase is more pronounced among individuals aged 50 years and older, who also bear a higher absolute incidence than younger populations. High red meat consumption, high body mass index (BMI), and low calcium intake remain the leading global risk factors for CRC. Effective weight management and the promotion of healthy lifestyles are essential strategies for reducing CRC risk across sexes, while smoking and alcohol control are particularly critical for alleviating the burden among males.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"332"},"PeriodicalIF":2.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical predictive score of high liver iron content in metabolic hyperferritinemia: a retrospective cohort pilot study.","authors":"Mohamed Lotfi Boughzala, Bruno Pereira, Marc Ruivard, Hervé Lobbes","doi":"10.1186/s12876-025-03891-2","DOIUrl":"https://doi.org/10.1186/s12876-025-03891-2","url":null,"abstract":"<p><strong>Background: </strong>In metabolic hyperferritinemia, most patients do not require bloodletting as the liver iron content is mildly increased. We aimed to develop a clinical predictive score of high liver iron content in metabolic hyperferritinemia to guide the prescription of magnetic resonance imaging of the liver.</p><p><strong>Methods: </strong>We conducted a single-center retrospective cohort study including consecutive patients with metabolic hyperferritinemia who underwent a liver iron content evaluation at diagnosis. Excessive alcohol consumption was an exclusion criterion. A multivariate analysis followed by a 1000 bootstrap replicate analysis with an expectation-maximization algorithm was used to identify the predictive factors of high liver iron content. A ROC curve analysis was built to study the performance of the score based on the odds-ratio provided by the multivariate analysis.</p><p><strong>Results: </strong>217 patients (180 men, mean age 57 years old) were included. Fifty-five patients (25%) had high liver iron content (≥ 100 µmol/g). In univariate analysis, a family history of hyperferritinemia requiring phlebotomies was associated with high LIC, as well as an increase of transferrin saturation > 45% (p < 0.001). In multivariate regression, a family history of hyperferritinemia (OR 6.15, CI95 [2.11-17.92]), increased ferritin level ≥ 600 µg/L (OR 5.53, CI95 [1.43-21.42]) and increased transferrin saturation ≥ 45% (OR 2.63, CI95 [1.32-5.23]) were significantly associated with high liver iron content. A 15-point predictive score (area-under-the-curve 0.72, CI95 [0.64-0.79], p < 0.001) was built, providing an OR of 4.17 (CI95 [2.15-8.07], p < 0.001) for high liver iron content (sensitivity 60%, specificity 97%, negative predictive value 84%).</p><p><strong>Conclusion: </strong>in this pilot study, ferritin ≥ 600 µg/L, transferrin saturation ≥ 45% and a family history of hyperferritinemia requiring bloodletting provided a simple clinical score to predict high liver iron content in metabolic adult hyperferritinemia. The bootstrap analysis confirmed the robustness of our model.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"331"},"PeriodicalIF":2.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of MAFLD in the U.S. based on NHANES 2009-2018: differences in demographic characteristics, physical indices and lifestyle conditions.","authors":"Dan Ye, Jiaofeng Wang, Jiaheng Shi, Yiming Ma, Yanglei Li, Qingshang Li, Xiaona Hu, Jie Chen, Zhijun Bao","doi":"10.1186/s12876-025-03956-2","DOIUrl":"https://doi.org/10.1186/s12876-025-03956-2","url":null,"abstract":"<p><strong>Background: </strong>The incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) is high among U.S. adults, but studies on its occurrence in different ethnic and age groups are limited. The aim of the present study was to assess MAFLD occurrence among the U.S. adults by considering demographic characteristics, physical indices, and lifestyle conditions.</p><p><strong>Methods: </strong>This study utilized the National Health and Nutrition Examination Survey (NHANES) data 2009-2018 from 23,546 participants aged ≥ 20 years. Variables such as age, sex, race, body mass index (BMI), waist circumference (WC), blood pressure, sedentary behavior, sleep, and depression were analyzed.</p><p><strong>Results: </strong>Among 9933 participants, 3562 had MAFLD (34.1%), with notably higher percentages of Mexican-Americans (54.1%) and lower percentages of blacks (20.5%). The incidence of MAFLD was significantly greater (P < 0.001) in males (39%) than in females (29.2%), which was particularly evident within the 36-40 years age group. The MAFLD incidence exhibited an age-dependent pattern, initially increasing and subsequently declining (except for whites). Compared to white MAFLD patients, black MAFLD patients exhibited greater BMI, WC, systolic blood pressure (SBP), and diastolic blood pressure (DBP) values, whereas values for these measures were lower among Mexican-American patients. Logistic regression analysis adjusting for age and sex revealed that depression was more common among MAFLD patients (P < 0.001), except for severe depression (P > 0.05). Notably, the MAFLD incidence was not significantly associated with sedentary behavior or sleep duration.</p><p><strong>Conclusions: </strong>The MAFLD incidence varies across different racial, age, and sex groups, and targeted interventions are essential for reducing the burden of MAFLD. However, further research is necessary to explore the correlations among MAFLD incidence, sleep patterns, and an inactive lifestyle.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"329"},"PeriodicalIF":2.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride glucose waist circumference and non alcoholic fatty liver disease: a systematic review and meta analysis.","authors":"Ziyi Xin, Lanlan Feng, Qingwen Yu, Yongmin Shi, Ting Tang, Xuhan Tong, Siqi Hu, Yao You, Shenghui Zhang, Xingwei Zhang, Mingwei Wang, Jiake Tang","doi":"10.1186/s12876-025-03888-x","DOIUrl":"https://doi.org/10.1186/s12876-025-03888-x","url":null,"abstract":"<p><strong>Background: </strong>Insulin resistance (IR) plays a noticeable role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). The triglyceride glucose-waist circumference (TyG-WC) index, a novel measure for assessing IR, may hold significant predictive value for NAFLD. However, the relationship between TyG-WC and the risk of NAFLD remains elusive. To investigate this association, this comprehensive meta-analysis was conducted.</p><p><strong>Methods: </strong>A systematic electronic search was conducted using the PubMed, Embase, and Web of Science databases from their inception until July 2024 to identify observational studies assessing the relationship between TyG-WC and the risk of NAFLD. Joanna Briggs Institute's critical appraisal checklist was utilized to evaluate the quality of cross-sectional studies, while the Newcastle-Ottawa Scale (NOS) score was used to assess cohort studies. The principal summary outcomes included the mean difference (MD) and the corresponding 95% confidence interval (CI).</p><p><strong>Results: </strong>In total, 10 studies comprising 38,518 participants were included in this meta-analysis, of whom 37% were diagnosed with NAFLD. The analysis revealed a significant MD between NAFLD and non-NAFLD cases (MD, 137.41; [95% CI, 121.52-153.31]).</p><p><strong>Conclusion: </strong>A significant MD was identified between NAFLD and non-NAFLD cases. The TyG-WC index was found to be positively correlated with the risk of NAFLD, suggesting that it may serve as a potential indicator for NAFLD.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"328"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of C-reactive protein to lymphocyte ratio in NAFLD and mortality among NAFLD patients.","authors":"Jianxin Xi, Shengnan Wang, Jie Chen, Jason Chi Shing Law, Zhongqi Fan, Guoyue Lv","doi":"10.1186/s12876-025-03924-w","DOIUrl":"https://doi.org/10.1186/s12876-025-03924-w","url":null,"abstract":"<p><strong>Background: </strong>Non-alcoholic fatty liver disease (NAFLD) is recognized as the predominant chronic liver disorder globally. Inflammation is integral to the onset and progression of NAFLD. The C-reactive protein to lymphocyte ratio (CLR), a novel inflammatory marker, has yet to be explored in the context of NAFLD.</p><p><strong>Method: </strong>This investigation encompassed 4371 individuals from the National Health and Nutrition Examination Survey (NHANES) conducted between 2015-2018. Weighted logistic regression was employed to examine the correlation between CLR and NAFLD. Weighted Cox proportional hazards models were utilized to evaluate the association between CLR and all-cause and Cardiovascular disease (CVD) mortality in patients with NAFLD. Restricted cubic spline (RCS) curves were employed to assess the dose-response relationship. Threshold effect analysis was used to determine the existence of an inflection point.</p><p><strong>Result: </strong>After adjusting for all included covariates in Model 3, a positive correlation between lnCLR and NAFLD was identified (OR = 1.45, 95% CI = 1.16-1.81, P = 0.010). However, no significant association was observed between it and all-cause as well as CVD mortality among patients with NAFLD. The RCS curve illustrated a nonlinear association between CLR and NAFLD (P-nonlinear < 0.0001). Threshold effect analysis determined that the inflection point occurs at CLR = 1.667.</p><p><strong>Conclusion: </strong>CLR exhibited a nonlinear positive association with NAFLD. Higher CLR levels may increase the risk of NAFLD. However, CLR does not affect all-cause and CVD mortality in patients with NAFLD.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"327"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified triglyceride-glucose indices as novel predictors of metabolic dysfunction-associated fatty liver disease in US adolescents: a nationally representative study from NHANES 2017-2020.","authors":"Yigui Zou, Yu Dai, Ziyuan Li, Baixian Lin, Hu Chen, Zeling Zhuang, Wenwen Li, Qinghua Yang, Dongling Dai","doi":"10.1186/s12876-025-03915-x","DOIUrl":"https://doi.org/10.1186/s12876-025-03915-x","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated fatty liver disease (MAFLD) has become the most prevalent chronic liver condition in adolescents. The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, has shown promise in adult MAFLD detection but requires pediatric-specific validation, particularly when combined with anthropometric measures. This study investigated the association between modified TyG indices and MAFLD, and evaluated their predictive value in adolescents.</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from 532 adolescents (12-18 years) in the 2017-2020 National Health and Nutrition Examination Survey (NHANES) with complete records. MAFLD diagnosis was based on transient elastography plus metabolic criteria. The investigators employed multivariate linear regression and restricted cubic splines (RCS) to examine linear and nonlinear relationships between modified TyG indices and CAP values. Subgroup analyses were stratified by obesity status, and sensitivity analyses were performed on the NAFLD cohort (n = 527). Receiver operating characteristic (ROC) curve analysis, using Youden's index, evaluated the predictive performance of TyG indices for MAFLD identification.</p><p><strong>Results: </strong>Among 130 MAFLD adolescents (vs 402 controls), modified TyG indices demonstrated significantly stronger associations with CAP in fully adjusted models compared to the original TyG index. TyG-WC showed the highest diagnostic accuracy (AUC = 0.923, 95%CI:0.900-0.947), followed by TyG-BMI (AUC = 0.917) and TyG-WHtR (AUC = 0.915), while the original TyG index performed poorly (AUC = 0.673). Subgroup analyses revealed particularly strong associations in non-obese participants, and sensitivity analyses confirmed result robustness after excluding potential confounders. Optimal cutoff values provided clinically useful screening thresholds, with TyG-WC achieving 94% sensitivity at 665.94.</p><p><strong>Conclusion: </strong>This study demonstrates that modified TyG indices incorporating anthropometric parameters (particularly TyG-WC) significantly outperform the original TyG index for MAFLD detection in adolescents, with superior diagnostic accuracy (AUC 0.915-0.923). The robust predictive performance maintained in sensitivity analyses and non-obese subgroups supports their clinical utility as simple, non-invasive screening tools for pediatric MAFLD risk stratification.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"325"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visceral adiposity index as a predictor of metabolic dysfunction-associated steatotic liver disease: a cross-sectional study.","authors":"Tuo Zhou, Xiang Ding, Linjie Chen, Qianxiong Huang, Linfang He","doi":"10.1186/s12876-025-03957-1","DOIUrl":"https://doi.org/10.1186/s12876-025-03957-1","url":null,"abstract":"<p><strong>Background: </strong>The association between visceral adiposity index (VAI) and metabolic dysfunction-associated steatotic liver disease (MASLD) remains unestablished. Our study sought to investigate the potential relationship between VAI and MASLD risk.</p><p><strong>Methods: </strong>This study employed data from the 2017-2018 National Health and Nutrition Examination Survey (NHANES). Weighted multivariable regression models, subgroup analyses, and machine learning algorithms were used to evaluate associations and predictive performance.</p><p><strong>Results: </strong>Higher VAI tertiles correlated with increased MASLD risk (adjusted OR for T3 vs. T1: 7.08, 95% CI: 4.35-11.5; P-trend=0.003). Machine learning models demonstrated robust predictive accuracy, with random forest (AUC=0.869) and gradient boosting machine (AUC=0.868) outperforming non-invasive scores. However, lipid accumulation product (LAP, AUC=0.834) and fatty liver index (FLI, AUC=0.833) achieved superior diagnostic performance compared to VAI (AUC=0.736), while maintaining clinical interpretability through simplicity and routine parameter availability.</p><p><strong>Conclusions: </strong>While VAI demonstrated significant positive associations with MASLD risk, non-invasive scores like LAP and FLI emerged as superior diagnostic tools, balancing accuracy with clinical practicality.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"326"},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of active wound dressing on postoperative pain and wound healing in patients undergoing anorectal surgery.","authors":"Guangyuan Qie, Miao Wan, Mengdie Cui, Wen Xia, Qianqian Liu","doi":"10.1186/s12876-025-03922-y","DOIUrl":"https://doi.org/10.1186/s12876-025-03922-y","url":null,"abstract":"<p><strong>Aim: </strong>To study the effect of active wound dressing on postoperative pain and wound healing in patients undergoing anorectal surgery (AS).</p><p><strong>Methods: </strong>The clinical data of 110 AS patients from March 2023 to January 2024 were retrospectively screened. The study group (SG) included 55 patients who received active wound dressing post-operation, while the control group (CG) consisted of 55 patients who received conventional dressing, matched for baseline indices. Postoperative pain degree, wound healing rate, healing time, swelling disappearance time, dressing change times, granulation tissue formation time, growth factor levels, and inflammatory factor levels were compared between the groups.</p><p><strong>Results: </strong>There were notable variations in the time effect, inter-group effect and time × inter-group effect in the postoperative pain score and wound healing rate between the two groups (P < 0.05). The pain scores of the SG on the 1st, 3rd and 7th day after operation were lower (P < 0.05). The wound healing rate of the SG was higher on the 1st, 3rd and 7th day after operation (P < 0.05). The wound healing time, wound swelling disappearance time, dressing change times and granulation tissue formation time in the SG were shorter (P < 0.05). The levels of vascular endothelial growth factor, epidermal growth factor and basic fibroblast growth factor in the SG were higher (P < 0.05). The levels of IL -8 and TNF-α in the SG were lower (P < 0.05).</p><p><strong>Conclusion: </strong>Active wound dressing has been shown to alleviate postoperative pain in patients undergoing AS, promote wound healing, and effectively regulate levels of growth factors and inflammatory factors.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"320"},"PeriodicalIF":2.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the effect of fecal SDC2, ADHFE1 and PPP2R5C gene methylation test for screening colorectal cancer in the Otog Front Banner.","authors":"Fan Zeng, Shiiu Chen, Xuli Zhu, Jinrun Chen, Maochong Lan, Runxiang Chen, Daya Zhang, Chen Chen, Shimei Huang, Da Li, Xiaodong Zhang, Feihu Bai","doi":"10.1186/s12876-025-03737-x","DOIUrl":"https://doi.org/10.1186/s12876-025-03737-x","url":null,"abstract":"<p><strong>Objective: </strong>The incidence of colorectal cancer (CRC) is gradually increasing, making the prevention and early detection of CRC a global priority. The purpose of this study is to evaluate the effect of fecal SDC2, ADHFE1, and PPP2R5C gene methylation on the screening of early CRC in the Otog Front Banner.</p><p><strong>Methods: </strong>This is a retrospective study that collected and analyzed data from the early colorectal cancer screening program conducted in five community health centers in the Otog Front Banner, from January 2023 to October 2023. The study collected stool samples from subjects meeting the inclusion and exclusion criteria, extracted genomic DNA from the feces, and modified it with sulfite. Methylation-specific polymerase chain reaction (MSP) was then used to detect the methylation status of the SDC2, PPP2R5C, and ADHFE1 genes, completing the early screening for colorectalcancer. Individuals with positive screening outcomes were advised to undergo a colonoscopy, and ultimately, all participants completed the questionnaire on high-risk factors for colorectal cancer . The chi-square test was utilized to analyze the positive rates of fecal SDC2, ADHFE1, and PPP2R5C gene methylation screenings, colonoscopy compliance, the positive predictive value of intestinal lesions, and to assess the risk factors associated with cancer.</p><p><strong>Results: </strong>A total of 9,135 effective screeners were included in this study, and 636 of them tested positive during the initial screening, yielding a positive rate of 6.9%. The positive predictive value was 50.9% for all intestinal lesions, 1.4% for colorectal cancer , and 9.7% for advanced adenoma.</p><p><strong>Conclusion: </strong>Fecal SDC2, ADHFE1, and PPP2R5C gene methylation detection methods can serve as primary screening tools, supplemented by colonoscopy, to effectively detect colorectal cancer and precancerous lesions. This strategy may prove to be an effective approach for conducting large-scale colorectal cancer screening in average-risk populations.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"324"},"PeriodicalIF":2.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interaction effect between childhood trauma and negative events during adulthood on development and severity of irritable bowel syndrome.","authors":"Zhiyu Dong, Xiaomei Wang, Liqian Xuan, Junwen Wang, Tingting Zhan, Ying Chen, Shuchang Xu, Danian Ji","doi":"10.1186/s12876-025-03919-7","DOIUrl":"https://doi.org/10.1186/s12876-025-03919-7","url":null,"abstract":"<p><strong>Background: </strong>Childhood trauma and negative events during adulthood were associated with the symptom severity of irritable bowel syndrome (IBS). However, the interaction effect of these negative events on IBS remains poorly understood.</p><p><strong>Methods: </strong>70 healthy individuals who completed Childhood Trauma Questionnaire (CTQ) and Life Event Scale (LES) and 88 IBS patients, diagnosed based on the Rome IV criteria, who completed CTQ, LES, IBS-Quality of Life (IBS-QOL), and IBS-Severity Scoring System (IBS-SSS) were retrospectively included. Logistic and linear regression analyses were used to investigate the interaction effect between childhood trauma and negative events during adulthood on IBS.</p><p><strong>Results: </strong>Female sex, childhood emotional abuse and neglect, and negative events during adulthood were associated with a higher prevalence of IBS. In IBS patients, childhood emotional abuse and neglect, as well as negative events during adulthood, were independently associated with more severe symptoms and worse quality of life. A significant interaction effect between childhood emotional trauma and negative events during adulthood was observed in IBS severity and quality of life, though no interaction effect was found in IBS development. Subsequent analyses revealed that the effect of negative events during adulthood on IBS severity and quality of life increased in IBS patients with childhood emotional trauma (IBS-SSS, β = 5.75, p < 0.001; IBS-QOL, β = 2.1, p < 0.001) compared with those without (IBS-SSS, β = 3.23, p < 0.001; IBS-QOL, β = 0.69, p = 0.011).</p><p><strong>Conclusions: </strong>Childhood emotional trauma and negative events during adulthood were associated with IBS development, higher IBS severity, and worse quality of life. Furthermore, childhood emotional trauma increased the negative effect of negative events during adulthood on IBS severity and quality of life.</p>","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"321"},"PeriodicalIF":2.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}