Acute versus acute-on-chronic liver failure: comparative analysis of clinical outcomes in Beijing, China.

IF 2.5 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

BMC Gastroenterology Pub Date : 2025-09-03 DOI:10.1186/s12876-025-04234-x

Hebing Guo, Ningning Yin, Jingyuan Liu, Ang Li

{"title":"Acute versus acute-on-chronic liver failure: comparative analysis of clinical outcomes in Beijing, China.","authors":"Hebing Guo, Ningning Yin, Jingyuan Liu, Ang Li","doi":"10.1186/s12876-025-04234-x","DOIUrl":null,"url":null,"abstract":"Background: Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) pose significant threats to patient outcomes, frequently resulting in multiple organ dysfunction syndrome (MODS) and elevated mortality rates. This study investigates MODS outcomes among ALF and ACLF patients in China, identifying key factors that influence mortality and prognosis.Methods: A retrospective cohort analysis was conducted at a specialized tertiary hospital in Beijing, covering the period from June 2009 to May 2022, which included 585 patients:195 with ALF and 390 with ACLF.Results: Among these, 61% of ALF patients and 45.1% of ACLF patients developed MODS. ALF patients exhibited a higher incidence of organ failures and significantly higher median admission critical illness scores. Multivariate logistic regression analysis identified age, number of organ failures, and platelet count as independent predictors of 90-day mortality. Kaplan-Meier survival hazards analysis revealed significantly higher 90-day cumulative mortality rates for ALF patients compared to ACLF patients (33.8% vs. 25.9%, p = 0.009).Conclusion: Approximately 50% of liver failure patients progress to MODS, with ALF patients demonstrating a higher incidence of MODS and poorer 90-day prognoses.","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":"25 1","pages":"637"},"PeriodicalIF":2.5000,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406371/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Gastroenterology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12876-025-04234-x","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) pose significant threats to patient outcomes, frequently resulting in multiple organ dysfunction syndrome (MODS) and elevated mortality rates. This study investigates MODS outcomes among ALF and ACLF patients in China, identifying key factors that influence mortality and prognosis.

Methods: A retrospective cohort analysis was conducted at a specialized tertiary hospital in Beijing, covering the period from June 2009 to May 2022, which included 585 patients:195 with ALF and 390 with ACLF.

Results: Among these, 61% of ALF patients and 45.1% of ACLF patients developed MODS. ALF patients exhibited a higher incidence of organ failures and significantly higher median admission critical illness scores. Multivariate logistic regression analysis identified age, number of organ failures, and platelet count as independent predictors of 90-day mortality. Kaplan-Meier survival hazards analysis revealed significantly higher 90-day cumulative mortality rates for ALF patients compared to ACLF patients (33.8% vs. 25.9%, p = 0.009).

Conclusion: Approximately 50% of liver failure patients progress to MODS, with ALF patients demonstrating a higher incidence of MODS and poorer 90-day prognoses.

Abstract Image

查看原文本刊更多论文

急性与急性伴慢性肝衰竭：中国北京临床结果的比较分析

背景：急性肝衰竭（ALF）和急性伴慢性肝衰竭（ACLF）对患者预后构成重大威胁，经常导致多器官功能障碍综合征（MODS）和死亡率升高。本研究调查了中国ALF和ACLF患者的MODS结局，确定了影响死亡率和预后的关键因素。方法：对2009年6月至2022年5月北京某三甲专科医院585例患者进行回顾性队列分析，其中ALF患者195例，ACLF患者390例。结果：其中，61%的ALF患者和45.1%的ACLF患者发生MODS。ALF患者表现出更高的器官衰竭发生率和显著更高的入院危重疾病评分中位数。多因素logistic回归分析发现，年龄、器官衰竭数量和血小板计数是90天死亡率的独立预测因素。Kaplan-Meier生存风险分析显示，ALF患者的90天累积死亡率显著高于ACLF患者（33.8% vs. 25.9%, p = 0.009）。结论：大约50%的肝功能衰竭患者进展为MODS， ALF患者MODS发生率较高，90天预后较差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Gastroenterology 医学-胃肠肝病学

CiteScore

4.20

自引率

0.00%

发文量

465

审稿时长

6 months

期刊介绍： BMC Gastroenterology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of gastrointestinal and hepatobiliary disorders, as well as related molecular genetics, pathophysiology, and epidemiology.