Association of biological aging and the prevalence of nonalcoholic fatty liver disease: a population-based study.

IF 2.5 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

BMC Gastroenterology Pub Date : 2025-05-13 DOI:10.1186/s12876-025-03955-3

Gang Liu, Qingsong Mao, Xinling Tian, Chenwei Zhang, Yukai Zhang, Jiarong He, Yuzhe Kong

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引用次数: 0

Abstract

Purpose: To examine the relationship between biological aging and the prevalence of NAFLD.

Method: We used the recommended sampling weights to account for the complex survey design of NHANES. The analysis, utilizing data from 2005 to 2016, aimed to investigate the impact of biological aging on NAFLD prevalence using various statistical methods. A restricted cubic spline (RCS) model was applied to explore the dose-response relationship, while logistic regression examined linear associations. The robustness of the association across different subgroups was also tested.

Result: The study included 2786 participants. We found significant associations between NAFLD and the following biological aging metrics: AL score (OR (95%CI) = 1.1932 (1.0597 ~ 1.3435), P = 0.0035), HD (OR (95%CI) = 1.2092 (1.0565 ~ 1.3839), P = 0.0058), and PA (OR (95%CI) = 1.7564 (1.1949 ~ 2.5818), P = 0.0042). All biological aging metrics were identified as independent predictors. PA was most associated with the prevalence of NAFLD. The associations persisted across most subgroups.

Conclusion: The prevalence of NAFLD was associated with biological aging, emphasizing the importance of addressing potential health risks related to aging.

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生物衰老与非酒精性脂肪肝患病率的关系：一项基于人群的研究

目的：探讨生物老化与NAFLD患病率的关系。方法：采用推荐的抽样权重来解释NHANES复杂的调查设计。该分析利用2005年至2016年的数据，旨在通过各种统计方法调查生物衰老对NAFLD患病率的影响。采用限制三次样条（RCS）模型探讨剂量-反应关系，逻辑回归检验线性关联。还对不同亚组之间的关联的稳健性进行了测试。结果：该研究包括2786名参与者。我们发现NAFLD与以下生物衰老指标之间存在显著相关性：AL评分(OR (95%CI) = 1.1932 (1.0597 ~ 1.3435), P = 0.0035), HD (OR (95%CI) = 1.2092 (1.0565 ~ 1.3839), P = 0.0058), PA (OR （95%CI) = 1.7564 (1.1949 ~ 2.5818), P = 0.0042）。所有生物衰老指标被确定为独立的预测指标。PA与NAFLD的患病率最相关。这种关联在大多数亚组中持续存在。结论：NAFLD的患病率与生物衰老有关，强调了解决与衰老相关的潜在健康风险的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Gastroenterology 医学-胃肠肝病学

CiteScore

4.20

自引率

0.00%

发文量

465

审稿时长

6 months

期刊介绍： BMC Gastroenterology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of gastrointestinal and hepatobiliary disorders, as well as related molecular genetics, pathophysiology, and epidemiology.