BMC Complementary Medicine and Therapies最新文献

{"title":"Comparative evaluation of the effects of Silymarin on the metastatic characteristics of MCF-7 and MDA-MB-231 breast cancer cells with two-dimensional and three-dimensional culture methods.","authors":"Tuğçe Aladağ, Fatma Firat, Hülya Çetin, Evrim Suna Arikan Söylemez","doi":"10.1186/s12906-026-05456-6","DOIUrl":"10.1186/s12906-026-05456-6","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is one of the most common cancers among women worldwide, and metastasis plays an important role in its lethality. Silymarin (SLY) is a natural compound that has exhibited potential anticancer effects. However, its effects on the metastatic properties of different breast cancer cell lines remain unknown. Therefore, this study aimed to investigate the effects of SLY on the metastatic properties of two breast cancer cell lines (MCF-7 and MDA-MB-231) and evaluate differences between two-dimensional (2D) and three-dimensional (3D) cell culture models.</p><p><strong>Methods: </strong>This study used 2D and 3D cell culture systems to evaluate the effects of SLY on cell proliferation, migration, and epithelial-mesenchymal transition (EMT). The effective dose of SLY was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cell viability assays in 2D and 3D cultures. In 2D cultures, wound healing assays, polymerase chain reaction (PCR) to evaluate mRNA levels and immunohistochemical analyses to evaluate protein expression. In 3D cultures, spheroids were formed, and Transwell migration assays, PCR for mRNA levels, and immunohistochemical analyses for protein expression were conducted.</p><p><strong>Results: </strong>SLY effectively modulated proliferation, migration, and EMT in both cell lines. Notably, the 3D microenvironment exerted differential effects on drug sensitivity: MCF-7 cells showed increased sensitivity to SLY in 3D culture, whereas MDA-MB-231 cells exhibited increased resistance compared to 2D models.</p><p><strong>Conclusions: </strong>These findings suggest that SLY exhibits promising antimetastatic potential in vitro, warranting further in vivo and clinical investigations to evaluate its efficacy as a supportive therapeutic candidate for breast cancer treatment. This study emphasizes the importance of 3D culture models for accurately evaluating the efficacy of anticancer drugs. Notably, SLY's effect on MMP-9 expression was found to be environment-dependent, showing a significant reduction specifically in the 3D spheroid model, which highlights its potential antimetastatic efficacy in more biomimetic settings.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148418834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the antibacterial and antifungal activity of 80% methanol crude extract and hexane, chloroform, butanol, and aqueous fractions of Suregada procera against selected microbial strains.","authors":"Abebe Dagne, Getinet Nibret, Dehnnet Abebe, Shewaneh Ayele","doi":"10.1186/s12906-026-05466-4","DOIUrl":"10.1186/s12906-026-05466-4","url":null,"abstract":"<p><strong>Background: </strong>Medicinal plants are potential sources for developing novel antibiotics due to the declining effectiveness and associated side effects of synthetic drugs. This study aimed to evaluate the antibacterial and antifungal activities of 80% methanol crude extract and hexane, chloroform, butanol, and aqueous fractions of Suregada procera.</p><p><strong>Methods: </strong>The dried roots of Suregada procera were macerated with 80% methanol and successively fractionated using hexane, chloroform, butanol, and aqueous solvents. The antibacterial and antifungal activities of both crude extract and the fractions were determined using agar well diffusion and broth dilution methods. One-way analysis of variance was used to analyze the data, followed by Tukey's post-hoc test. Ciprofloxacin 5 µg and amphotericin B 12.5 µg served as positive controls, while 1% dimethyl sulfoxide (DMSO) served as the negative control.</p><p><strong>Results: </strong>The Suregada procera crude extract exhibited the largest zone of inhibition (12.67 ± 0.33) against Staphylococcus epidermidis and Trichophyton mentagrophytes at 200 mg/mL. Among the six bacterial strains, Enterococcus faecalis was the most susceptible to hexane and aqueous fractions at 0.33 mg/mL. In contrast, the butanol fraction exhibited the highest inhibitory activity against Trichophyton mentagrophytes at 0.5 mg/mL.</p><p><strong>Conclusion: </strong>The results of the present study support the traditional use of Suregada procera against bacterial and fungal pathogens.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148418806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"No tears or brain words\": A case report on single-session dance/movement therapy for individuals with schizophrenia spectrum disorders.","authors":"Jacelyn Biondo, Nancy Gerber","doi":"10.1186/s12906-026-05448-6","DOIUrl":"10.1186/s12906-026-05448-6","url":null,"abstract":"<p><strong>Background: </strong>Individuals diagnosed with schizophrenia spectrum disorders (SSDs) face a multitude of challenges in their lifetime including complex symptomatology, co-morbid health concerns, profound levels of stigmatization, and diminished access to quality care. Additionally, they are often the victims of unjust systemic biases and discrimination when they are able to engage with the healthcare system. This confluence of injustices leads to disparate physical and mental health outcomes for this vulnerable population. Globally, schizophrenia affects over 24 million, many of whom are experiencing healthcare disparities posing a significant public health concern. Dance/movement therapy (DMT) is an equitable healthcare provision situated in a strengths-based and trauma-informed psychotherapeutic framework. Dance/movement therapy can support the symptomatic needs of SSDs including alternate reality orientations, thought and behavioral disorganization, and diminished interpersonal engagement.</p><p><strong>Methodology: </strong>We present an intrinsic case report nested within a larger randomized controlled trial that implemented a convergent parallel mixed method design. Data were collected simultaneously; however, initially analyzed individually first, then merged. Pre- and post-intervention quantitative data were collected through the Brief Psychiatric Rating Scale (BPRS). Qualitative data were collected post-intervention through semi-structured individual interviews.</p><p><strong>Case presentation: </strong>This intrinsic case report examines the experience of a 37-year-old African American cisgender male, with high symptom acuity of schizoaffective disorder, who engaged in a single-session DMT intervention.</p><p><strong>Results: </strong>Following the intervention, the participant exhibited a decrease in symptomatology as evidenced by the BPRS in total scores as well as subscales of psychological distress, positive symptoms, negative symptoms, and resistance. Moreover, following the DMT session the participant expressed having had a transformative experience, feeling like a contributing member of the group process. He also reported feeling a sense of pride, and experiencing the ability to engage in healthy relationships, and noted shared and meaningful experiences in his group process.</p><p><strong>Discussion: </strong>Community-driven, non-verbal treatment options such as DMT, can provide opportunities for individuals with symptom acuity of SSDs. Future research should explore the potential for DMT, an inclusive and equitable treatment option, to support individuals with SSDs.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148418873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygonatum sibiricum polysaccharides regulate chondrocyte inflammation and metabolism via S100A9 inhibition-mediated autophagy promotion to ameliorate osteoarthritis.","authors":"Shida Kuang, Qiyou Ding, Li Lin, Linhu Li, Zhewen Liu, Qinghu He, Qingfeng Du","doi":"10.1186/s12906-026-05467-3","DOIUrl":"10.1186/s12906-026-05467-3","url":null,"abstract":"<p><strong>Background: </strong>Polygonatum sibiricum (P. sibiricum) polysaccharides (PSP), the main bioactive component in the roots of the medicinal and edible plant P. sibiricum, have been shown to exhibit strong anti-inflammatory activity. However, the role of PSP in alleviating osteoarthritis (OA)-related cartilage degeneration and the underlying mechanism-particularly its association with autophagy-remain elusive. This study aimed to investigate how PSP influences autophagy in the cartilage and chondrocytes, and to clarify the mechanisms involved.</p><p><strong>Methods: </strong>The molecular weight of PSP was measured using high-performance gel permeation chromatography (HPGPC), and the monosaccharide composition was analyzed using 1-phenyl-3-methyl-5-pyrazolone (PMP)-HPLC. Chondrocytes overexpressing p65/ S100 calcium-binding protein A9 (S100A9) were generated through the use of lentiviral vectors for gene overexpression. Autophagosomes of chondrocytes were detected by transmission electron microscope, and the expression levels of proteins associated with chondrocytes was identified through WB, immunofluorescence and ELISA. In vivo, the C57BL/6 mice model of OA was created by means of partial medial meniscectomy. Overexpressed lentivirus was injected into the joint cavity and transfected to articular cartilage, constructing an S100A9 overexpression model.</p><p><strong>Results: </strong>The results demonstrated that PSP can ameliorate interleukin-1β (IL-1β)-induced metabolic dysregulation and inflammatory responses in the chondrocyte extracellular matrix by enhancing chondrocyte autophagy, thereby restoring the impaired autophagy induced by IL-1β. RNA-seq analysis revealed that PSP inhibited the expression of S100A9 in IL-1β-induced chondrocytes. Further mechanistic evidence indicated that PSP promoted chondrocyte autophagy via the S100A9/nuclear factor κB (NF-κB) signaling pathway, thus alleviating chondrocyte inflammation and matrix metabolic disorders.</p><p><strong>Conclusions: </strong>Both in vivo and in vitro evidence supports that PSP promotes chondrocyte autophagy by suppressing the S100A9/NF-κB pathway to achieve the outcome of OA improvement. This discovery highlights the potential of PSP as a valuable natural plant-derived compound in OA treatment.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148418812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo and in silico wound healing potential of Cannabis Sativa seed oil through inflammation mediators.","authors":"Sinem İnal, Kamil Serdar İnal, Fehmi Metehan Benli, Sedat Gökmen, Berrin Şentürk, Pelin Kasap, Şahane Funda Arslanoğlu, Tolga Güvenç, Dilek Güvenç","doi":"10.1186/s12906-026-05462-8","DOIUrl":"10.1186/s12906-026-05462-8","url":null,"abstract":"<p><strong>Background: </strong>This study investigates the wound healing potential of Cannabis Sativa seed oil (CSSO), derived from the industrial hemp variety 'NARLI'. The rich essential fatty acid profile of CSSO presents promising therapeutic opportunities; however, its specific in vivo efficacy and targeted molecular mechanisms in wound management remain underexplored. This study aimed to evaluate the in vivo tissue regeneration dynamics and the in silico anti-inflammatory mechanisms of CSSO derived from the 'NARLI' hemp variety in an excision wound model.</p><p><strong>Methods: </strong>Using an excision wound model, 42 rats were divided into two groups: control (untreated) and CSSO-treated. Wound healing was assessed through clinical wound area measurement, histopathological evaluation, immunohistochemistry (IHC), and molecular docking analyses. Wound area measurements were taken on days 7, 14, and 21.</p><p><strong>Results: </strong>On day 21, CSSO-treated animals showed a significantly higher wound closure rate (93%) compared to the control group (87.55%) (p = 0.005). Histopathological analysis revealed enhanced neovascularization, increased collagen deposition (p = 0.008), reduced inflammatory cell infiltration (p = 0.020), and increased epithelial proliferation in the CSSO group. Immunohistochemistry findings showed a marked decrease in proinflammatory cytokines TNF-α and IL-1β (p = 0.023) and TGF-β (p = 0.030), and a notable upregulation of angiogenesis and proliferation markers VEGF (p = 0.031) and Ki-67 (p = 0.001). Molecular docking analyses revealed that CSSO-derived fatty acids showed binding affinities (-5.3 to -7.5 kcal/mol) with anti-inflammatory-related proteins (COX-2 and NLRP3) and (-3.1 to -6.1 kcal/mol) binding affinities with wound healing-related proteins (SIRT1 and GSK3β), suggesting a possible mechanistic basis underlying the wound healing potential of CSSO.</p><p><strong>Conclusions: </strong>Topical application of CSSO was associated with improved wound healing outcomes in rats, including enhanced wound closure and favourable histopathological and immunohistochemical changes. Further studies are needed to confirm these findings and clarify the mechanisms involved.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148418894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifungal Activity of a Postbiotic Cell-free Supernatant of Lactiplantibacillus plantarum from Pulicaria jaubertii against Aspergillus fumigatus and Candida albicans.","authors":"Faisal Mohammed Abdul Al-Nihmi, Emad Abdu Ali Alserkal","doi":"10.1186/s12906-026-05460-w","DOIUrl":"10.1186/s12906-026-05460-w","url":null,"abstract":"<p><strong>Background: </strong>The increasing prevalence of antifungal resistance necessitates the exploration of novel therapeutic agents from natural reservoirs. Bacteria derived from medicinal plants serve as an underexploited repository of biologically active secondary metabolites. This study investigated the chemical profile and antifungal potential of the cell-free supernatant (CFS) derived from Lactiplantibacillus plantarum (L. plantarum) strain isolated from the medicinal plant Pulicaria jaubertii (P. jaubertii) (Asteraceae) in Yemen.</p><p><strong>Methods: </strong>L. plantarum was isolated from surface-sterilized leaves of P. jaubertii and cultured to obtain CFSs. The chemical composition of the CFS was characterized using Fourier-transform infrared (FT-IR) spectroscopy. Antifungal efficacy was evaluated against clinically significant isolates of Aspergillus fumigatus (A. fumigatus) and Candida albicans (C. albicans) using agar incorporation and agar well-diffusion methods, respectively.</p><p><strong>Results: </strong>FT-IR spectroscopy indicated that the CFS is a complex mixture containing functional groups of organic acids, peptides, and carbohydrates. It exhibited dose-dependent antifungal activity, achieving 71.9% and 90.0% growth inhibition against A. fumigatus and C. albicans, respectively, at 30% (v/v). Notably, a sharp increase in efficacy occurred between 20 and 25% (v/v). We hypothesize that this threshold effect may reflect a multi-mechanistic mode of action, potentially driven by the interplay between the acidic and peptidic constituents.</p><p><strong>Conclusions: </strong>These findings underscore the potential of L. plantarum CFS as a promising, sustainable source of multicomponent antifungal agents. This study highlights the value of integrating plant biodiversity with microbial chemistry to develop postbiotic interventions that address critical fungal challenges.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13523470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated network pharmacology, molecular simulations, biophysical validation, and experimental validation to reveal the pharmacological effects and targets of Senkyunolide A against inflammation and oxidative stress.","authors":"Yue Liu, Guang Yang, Xiansu Chi, Liuding Wang, Yunfan Zhang, Xiao Liang, Yunling Zhang","doi":"10.1186/s12906-026-05459-3","DOIUrl":"10.1186/s12906-026-05459-3","url":null,"abstract":"<p><p>Inflammatory response and oxidative stress interact with each other and are involved in the pathogenesis of various chronic diseases. Senkyunolide A (SenA) is a phthalide compound isolated from the traditional Chinese medicine Chuanxiong Rhizoma (Ligusticum chuanxiong Hort.). At present, the anti‑inflammatory and anti‑oxidative stress effects of SenA remain unclear. In this study, we adopted an integrated strategy combining network pharmacology, bioinformatics analysis, molecular docking, molecular dynamics simulation, bio‑layer interferometry (BLI), and in vitro experiments to explore the anti‑inflammatory and anti‑oxidative stress effects and potential targets of SenA. Through network pharmacology and bioinformatics analysis, we identified four core target genes (Il1b, Ptgs2, Nos2, and Hmox1) of SenA against LPS‑induced inflammation in RAW264.7 cells. Direct binding of SenA to IL‑1β and PTGS2 was confirmed by molecular docking, molecular dynamics simulation, and BLI assays. In vitro experiments showed that SenA pretreatment effectively inhibited LPS‑induced inflammatory response and oxidative stress in RAW264.7 cells, as evidenced by reduced expression of pro‑inflammatory cytokines (TNF‑α, IL‑6, and IL‑1β), decreased levels of NO, ROS, and MDA, increased GSH levels, and alleviated cell swelling and mitochondrial damage. In addition, SenA pretreatment downregulated the mRNA expression levels of the core target genes Il1b, Ptgs2, Nos2, and Hmox1. In conclusion, our findings demonstrate that SenA exerts significant anti‑inflammatory and anti‑oxidative stress effects and may serve as a candidate compound for the treatment of inflammation‑related diseases.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of shared meditation involving cancer patients, health professionals and third persons on well-being and psychosocial skills: a randomised study.","authors":"Virginie Prevost, François Christy, Alexandra Leconte, Marie Fernette, Carine Segura, Titi Tran, Bénédicte Clarisse","doi":"10.1186/s12906-026-05449-5","DOIUrl":"10.1186/s12906-026-05449-5","url":null,"abstract":"<p><strong>Background: </strong>Mindfulness-based interventions are recommended for improving well-being. We evaluated the potential added value of shared meditation involving patients with cancer, health professionals, and third persons compared with patient-only meditation.</p><p><strong>Methods: </strong>We designed a randomised controlled trial (CONSORT guidelines) to assess the benefit of shared meditation, where patients with cancer (target population) were assigned to receive the meditation programme in groups involving caregivers and thirds persons (experimental arm) or in groups of patients only (control arm). The study involved 97 volunteers: 65 patients, 16 caregivers, and 16 third persons (neither carers nor patients). Patients were randomised between 'Shared' meditation (33 patients), and 'Patient' meditation (32 patients). A dedicated programme on mindfulness and compassion (12 weekly 2 h-sessions and 2 half-day retreats) was administered. The primary endpoint was the sense of self-efficacy (Generalized Self-Efficacy Scale (GSES)). Perceived stress was measured by the Perceived Stress Scale (PSS), one of those subscales also focused on self-efficacy. Qualities of mindfulness, self-compassion, participants' perception of change in their quality of life, and satisfaction following the programme were also assessed.</p><p><strong>Results: </strong>Both patient arms experienced substantial improvement in self-efficacy scores (GSES) following the programme, without a significant difference between the arms. As secondary endpoints, perceived stress and mindfulness qualities were significantly improved in both arms, as well as several self-compassion dimensions (self-kindness, sense of common humanity, and mindfulness dimensions). Patients in the shared meditation arm showed a significant improvement in self-efficacy (PSS) and a reduction in feelings of isolation (self-compassion scale), which was not significant in patients in the patient-only arm. Patients greatly appreciated shared meditation, as evidenced by adherence to the programme and satisfaction assessments. Participants reported a perception of improvement in their quality of life.</p><p><strong>Conclusion: </strong>The added value of shared meditation compared to patient-only meditation was not demonstrated in terms of sense of self-efficacy (GSES). Shared meditation specifically improved perceived self-efficacy (PSS subscale) and reduced the feeling of isolation. This approach could constitute a useful tool for patients to better cope with cancer and to break out of the context of illness, with the understanding that suffering is part of shared human experience.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov. NCT06041607, registered on 09/18/2023. https://clinicaltrials.gov/study/NCT06041607 .</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effects of haptonomy application and mindfulness-based stress reduction on psychological well-being, perceived stress, and fear of childbirth in primiparous women: a randomized controlled trial.","authors":"Burcu Küçükkaya, Simge Öztürk, Ebru Ci̇rban Ekrem","doi":"10.1186/s12906-026-05452-w","DOIUrl":"10.1186/s12906-026-05452-w","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to examine and compare the effects of haptonomy and a mindfulness-based stress reduction program (MBSR) on psychological well-being, perceived stress, and fear of childbirth among primiparous pregnant women.</p><p><strong>Materials and methods: </strong>This prospective, assessor-blinded, three-arm randomized controlled trial was conducted between January 1, 2024, and October 1, 2024. A total of 120 primiparous pregnant women were randomly assigned to the haptonomy group (n = 40), MBSR group (n = 40), or control group (n = 40). At baseline, participants completed the Personal Information Form, Psychological Well-Being Scale (PWBS), Perceived Stress Scale (PSS), and Wijma Delivery Expectancy/Experience Questionnaire Version A (W-DEQ-A). PWBS, PSS, and W-DEQ-A were reassessed at weeks 4 and 8. The interventions were conducted individually through face-to-face sessions, supported by home-based video/audio materials. Data were analyzed using descriptive statistics, chi-square test, repeated-measures ANOVA, and Bonferroni post hoc analyses.</p><p><strong>Results: </strong>No statistically significant differences were observed between groups at baseline (p > .05). However, significant differences emerged at weeks 4 and 8 for all primary outcomes (p < .001). Compared with the control group, participants in both intervention groups demonstrated significantly higher psychological well-being scores and significantly lower perceived stress and fear of childbirth scores. At week 8, the haptonomy group demonstrated greater improvement than the MBSR group across all outcome measures.</p><p><strong>Conclusion: </strong>Both haptonomy and MBSR were effective in improving psychological well-being and reducing perceived stress and fear of childbirth among primiparous pregnant women. Haptonomy demonstrated greater effectiveness than MBSR across all primary outcomes.</p><p><strong>Trial registration: </strong>This trial was registered at ClinicalTrials.gov (NCT06699550; registered on November 19, 2024; retrospectively registered). The study protocol was finalized before participant recruitment; trial registration was completed subsequently due to administrative delays.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13602576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pistacia atlantica sub. Kurdica can improve insulin resistance in patients with non-alcoholic fatty liver disease: a randomized clinical trial.","authors":"Roghayeh Mostafaei, Seyed Mostafa Nachvak, Amir Saber, Behzad Mahaki, Nazanin Jalilian, Leila Behbood, Mohammad Gharib Salehi, Behzad Heidarpour, Roghaye Farhadi Hassankiadeh","doi":"10.1186/s12906-026-05249-x","DOIUrl":"10.1186/s12906-026-05249-x","url":null,"abstract":"<p><strong>Background: </strong>Nonalcoholic fatty liver disease (NAFLD), also termed metabolic dysfunction‑associated fatty liver disease is a problem across the world. The most important factor of the increase in NAFLD prevalence is the insulin resistance. This study is the first clinical trial with the aim of determining the effect of Pistacia atlantica Sub. Kurdica gum on glycemic indices especially insulin resistance in patients with nonalcoholic fatty liver disease.</p><p><strong>Methods: </strong>In this double-blind randomized clinical trial 50 patients with nonalcoholic fatty liver disease were randomized into two groups: those given syrup containing Pistacia atlantica sub. Kurdica gum (Group A), those on placebo (Group B). Over a two-month period, Group A given syrup containing 500 mg of P. atlantica sub. Kurdica gum per each tablespoon and Group B given syrup without P. atlantica sub. Kurdica gum. Anthropometric measures, biochemical indices and physical activity were evaluated at the beginning and end of the intervention.</p><p><strong>Results: </strong>We observed a significant decrease in fatty liver grade in group A (P = 0.03). The mean of fasting serum insulin and the insulin-resistance index (HOMA-IR) decreased significantly (P = 0.002, P < 0.001) and quantitative insulin sensitivity check index (QUICKI) increased from baseline in group A (P = 0.001). Fasting blood sugar (FBS) decreased significantly from baseline in group A (P = 0.019), but the mean changes between group not significant (P = 0.061). Weight had significant decrease in group A (P < 0.001).</p><p><strong>Conclusions: </strong>Pistacia atlantica sub. Kurdica gum can decrease insulin resistance, increase insulin sensitivity and subsequently improvement NAFLD in patient with nonalcoholic fatty liver disease. It is suggested that clinical trials be conducted in the long duration of the intervention, as well as a larger sample size.</p><p><strong>Trial registration: </strong>Registration number of Clinical trial: IRCT20231219060466N1 ( https://irct.behdasht.gov.ir/ ).</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}