BMC Complementary Medicine and Therapies最新文献

{"title":"Antidermatophytic activity of Curcuma longa against Trichophyton spp.: compound identification and molecular docking to lanosterol 14α-demethylase.","authors":"A B Z Naimur Rahman, Md Fahad Patwary, Shinjon Ahmed, Mehraz Hossen, Md Hasibul Hossain, Md Shariful Islam, Rifat Rahman, Swagato Dutta, Khandokar Fahmida Sultana, Mohammad Salim Hossain, Firoz Ahmed, Sabuj Baran Dhar","doi":"10.1186/s12906-025-05049-9","DOIUrl":"10.1186/s12906-025-05049-9","url":null,"abstract":"<p><p>The increasing incidence of dermatophytic infections and rising resistance to conventional antifungal agents necessitates the exploration of alternative therapies. This study investigates the antifungal potential of Curcuma longa rhizome extract against dermatophytes, particularly Trichophyton species, through a combination of in vitro and in silico techniques. The methanolic extract of Curcuma longa was evaluated for its antifungal efficacy using the disc diffusion method against Trichophyton mentagrophytes, Trichophyton indotineae, and Trichophyton interdigitale. The extract demonstrated significant antifungal activity, with inhibition zones ranging from 10 to 25 mm. Comparative analysis with fluconazole revealed that Curcuma longa extract was effective even against fluconazole-resistant strains. GC-MS analysis identified eleven major compounds, with Curlone (44.19%) as the dominant component. Molecular docking studies targeted lanosterol 14α-demethylase, a key enzyme in ergosterol biosynthesis, revealing strong binding affinities of Curlone, α-Curcumene, 3-Isobutylidene-6,7-dimethyl-3H-isobenzofuran-1-one, and 1-Bisabolone. These compounds demonstrated favorable interactions, suggesting their role in inhibiting fungal growth. Further, ADME and Toxicity analysis highlighted Curlone's superior pharmacokinetic and toxicity profile, making it a promising candidate for antifungal therapy. This study concludes that the extract of Curcuma longa shows promising potential as a natural alternative to traditional antifungal agents, and further investigation through in vivo studies is recommended.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"321"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients' experiences with acupuncture for diabetic polyneuropathy as part of a randomized controlled trial (ACUDPN) - a qualitative study.","authors":"Marie Bolster, Joanna Dietzel, Isabel Valentina Habermann, Sebastian Hörder, Benno Brinkhaus, Barbara Stöckigt","doi":"10.1186/s12906-025-05064-w","DOIUrl":"10.1186/s12906-025-05064-w","url":null,"abstract":"<p><strong>Background: </strong>This qualitative study aims to analyse the experiences, perceptions, and motivations of patients with Diabetic Peripheral Neuropathy (DPN), who received acupuncture treatments for the symptoms of DPN as part of a Randomized-Controlled Trial (RCT).</p><p><strong>Methods: </strong>Semi-structured interviews were carried out with participants of a two-arm RCT as part of a mixed-methods study. The interviews were conducted fact-to-face or via phone using a semi-structured interview guide with questions on living with DPN, the medical care for DPN prior to the study, the acupuncture treatments and the overall trial participation.</p><p><strong>Results: </strong>In total, 10 participants participated between January - December 2020 in this study. All but one participant had positive experiences with acupuncture and reported a reduction of DPN symptoms. They had varying experiences and needs and adopted a range of different coping mechanisms to manage their symptoms and condition prior to participating in the RCT. Many felt dissatisfied with the lack of current treatment options and insufficient medical care for DPN and wished to reduce medication. Acceptance of acupuncture was high, particularly among those wishing to reduce medication. The findings of the qualitative study are in line with the results of the RCT.</p><p><strong>Conclusions: </strong>Results the qualitative study indicate that acupuncture could be an acceptable and perceived effective treatment option for DPN patients. Declarations.</p><p><strong>Trial registration: </strong>RCT: ClinicalTrials.gov NCT03755960. Registered on 11 August 2018.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"317"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Network pharmacology and in vitro investigation of L-mimosine: unveiling multi-targeted therapeutic potential against breast cancer.","authors":"Jyoti Kumari Yadav, Krupa Shah, Mohammadfesal Ghanchi, Gaurang Sindhav, Saumya Patel, Rakesh Rawal","doi":"10.1186/s12906-025-04905-y","DOIUrl":"10.1186/s12906-025-04905-y","url":null,"abstract":"<p><p>Breast cancer remains the leading cause of mortality among women globally, primarily due to its heterogeneity and complex pathophysiology. Conventional treatments such as surgery, radiation therapy, and chemotherapy often face limitations, including significant side effects and the development of drug resistance. Consequently, there is an urgent need to identify novel, effective natural compounds with anti-tumor properties. L-mimosine, a non-protein amino acid derived from the seeds of Leucaena leucocephala and Mimosa pudica, has demonstrated cytotoxic activity against various cancers, including sarcoma, melanoma, breast cancer, and lung cancer. However, its precise molecular mechanisms remain poorly understood. To elucidate these mechanisms, a network pharmacology approach was employed, complemented by molecular docking, molecular dynamics simulations, and in vitro experiments to evaluate the impact of L-mimosine on breast cancer cell proliferation. Breast cancer-associated targets and L-mimosine-interacting genes were retrieved from multiple databases. Pharmacokinetic and toxicity properties were assessed through ADMET analysis. Protein-protein interaction networks of overlapping genes were constructed, identifying key hub genes such as SRC, MAPK8, PRKACA, and AKT1. Among these, AKT1 demonstrated the highest docking scores in molecular docking studies, and molecular simulations confirmed the stability of L-mimosine binding to AKT1. In vitro assays validated that L-mimosine inhibits breast cancer cell proliferation by inducing DNA damage and apoptosis in a dose-dependent manner. Furthermore, L-mimosine was found to arrest MCF-7 cells in the S phase of the cell cycle, as analyzed through cell cycle assays. This research highlights L-mimosine's potential as a promising anticancer agent against breast cancer by promoting apoptosis and interfering with cancer cell cycle progression.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"318"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility study of an embodied and embedded mindfulness- and compassion-based intervention for non-suicidal self-injury disorder.","authors":"Emma Schmelefske, Megan Per, Leena Anand, Bassam Khoury, Nancy Heath","doi":"10.1186/s12906-025-04962-3","DOIUrl":"10.1186/s12906-025-04962-3","url":null,"abstract":"<p><strong>Background: </strong>Non-suicidal self-injury (NSSI) is associated with suicide risk, as well as a number of psychological disorders. This, coupled with its high prevalence rate, make it imperative that effective treatments for those who engage in NSSI are investigated and made available to the public. Despite this, few interventions specifically targeting NSSI have been researched. This study aimed to address this gap in the existing research by investigating the feasibility and acceptability of an embodied and embedded mindfulness and compassion treatment (EEMCT) for individuals who engage in self-injury.</p><p><strong>Methods: </strong>Six participants attended eight weekly two-hour group therapy sessions. Feasibility and acceptability were assessed using qualitative and quantitative methods. Outcomes measured included urges to self-injure, as well as mental health symptoms commonly associated with NSSI (i.e., depression, anxiety, difficulty with emotion regulation, perceived stress). Outcomes were measured at pre-intervention, post-intervention, and six months follow-up.</p><p><strong>Results: </strong>Quantitative results supported the acceptability of the intervention. Mixed results were found for the intervention's feasibility. Participants gave feedback about the intervention in semi-structured interviews. They noted benefits of the intervention (e.g., learning self-kindness and awareness of thoughts and feelings), as well as several ways in which the intervention could be improved (e.g., more take-home practice material, shorter meditations). For several participants, clinically meaningful change was seen in anxiety from pre-intervention to post-intervention and from pre-intervention to follow-up. Some participants also showed meaningful decreases in depressive symptoms and emotion regulation from pre-intervention to follow-up.</p><p><strong>Conclusions: </strong>Overall, the results of this study suggest that EEMCT may be helpful and acceptable to individuals who engage in NSSI; however, more research is needed to confirm these findings. Suggestions for improving the feasibility of the intervention are discussed.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"320"},"PeriodicalIF":3.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12403964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory effects of the flavonoids extracted from Pollen Typhae on palmitic acid-induced NLRP3 inflammasome activation in macrophages involving AMPK-mediated lipid metabolism.","authors":"Wei Ren, Yushan Yang, Huiming Duan, Wei Nong, Aihua Tang, Hongsheng Lin, Lu Li, Chunling Wang, Xiaotao Feng","doi":"10.1186/s12906-025-05024-4","DOIUrl":"https://doi.org/10.1186/s12906-025-05024-4","url":null,"abstract":"<p><strong>Background: </strong>Pollen Typhae (PT), a traditional Chinese medicine herb utilized in diabetes management, exerts anti-inflammatory effects through its flavonoids, yet the active constituents and mechanisms remain unclear.</p><p><strong>Methods: </strong>PT total flavone (PTF) was extracted from PT and identified the compounds by UHPLC-MS. Network pharmacology and molecular docking were used to predict the underlying targets and anti-inflammatory mechanisms of PTF. The prediction was validated in RAW264.7 macrophages. IL-1β and IL-18 in culture supernatants were analyzed by ELISA. The protein and gene expression were checked by western blotting and Real-time PCR, respectively. Intracellular ROS production was detected by DCFH-DA method. Intracellular lipids were analyzed by ELISA and Enzyme assay. The Caspase-1 activity was evaluated by bioluminescent method.</p><p><strong>Results: </strong>PTF was identified 47 flavonoid compounds, including typhaneoside (TYP). Network pharmacology and molecular docking indicated that the flavonoid compounds might regulate inflammatory response, fatty acid metabolism, and the NOD-like receptor, AMPK pathways. PTF and TYP inhibited palmitic acid (PA)-induced NLRP3 inflammasome activation in lipopolysaccharide-primed RAW264.7 macrophages, leading to decreased secretion of IL-1β and IL-18. Furthermore, PTF and TYP improved intracellular lipid metabolism in PA-induced macrophages, indicating decreased free fatty acid and triglyceride contents, reduced protein expression of CD36, PPARγ, FAS, DGAT1, and CPT-1, as well as declined ROS with increased ATP production. Additionally, PTF and TYP increased the p-AMPK/AMPK ratio and upstream p-LKB1/LKB ratio. Activated AMPK, in turn, ameliorated lipid metabolism dysfunction, thus abolishing PA-induced ROS production and NLRP3 inflammasome activation. Antioxidant and improving lipid metabolism by suppressing ACC also inhibited NLRP3 inflammasome activation, respectively. Importantly, AMPK inhibition attenuated or abolished the inhibitory effects of PTF or TYP on ROS production, IL-1β and IL-18 secretion, and Caspase-1 activity.</p><p><strong>Conclusion: </strong>The findings highlight the ability of PTF and its active component TYP to inhibit PA-induced NLRP3 inflammasome activation in macrophages involving AMPK-mediated lipid metabolism, implying the potential use of PT flavonoid compounds as anti-diabetic inflammation lead compounds.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"315"},"PeriodicalIF":3.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and patterns of complementary and alternative medicine use among cancer patients in Jordan: a decade comparison.","authors":"Nedal Al-Rawashdeh, Mohammad Alqudimat, Ibrahim Alananzeh, Nour Kasasbeh, Khawlah Ammar, Amal Al-Omari","doi":"10.1186/s12906-025-05065-9","DOIUrl":"https://doi.org/10.1186/s12906-025-05065-9","url":null,"abstract":"<p><strong>Background: </strong>Complementary and alternative medicine (CAM) encompasses healthcare practices beyond conventional medical care. Despite advancements in oncology treatment, CAM use remains prevalent among patients with cancer. In Jordan, while CAM usage is common, particularly involving herbalists and spiritual healers, data on its patterns among patients with cancer are limited. This study compared CAM use among cancer patients in Jordan between 2013 and 2022, aiming to identify changing trends, associated factors, and implications for clinical practice and patient education.</p><p><strong>Methods: </strong>A cross-sectional survey was administered to adult cancer patients in Jordan in 2013 and 2022. In 2013, participants were recruited from four facilities, including the King Hussein Cancer Center (KHCC), whereas in 2022, recruitment was exclusively at KHCC. Patients completed a validated semi-structured questionnaire covering sociodemographic information, CAM usage patterns, communication with healthcare providers, and perceptions of CAM.</p><p><strong>Results: </strong>The prevalence of CAM use has decreased from 49.4% (n = 400) in 2013 to 32.8% (n = 124) in 2022. Natural health products such as herbs, vitamins, and special foods remained the most commonly used CAM therapies in both surveys. Despite the overall decrease in CAM usage, the frequency among users increased, with daily use reported by 65.9% in 2022 compared to 55.3% in 2013. The perceived benefits of CAM have significantly declined from 86.6% in 2013 to 31.9% in 2022. Communication about CAM use with healthcare providers remains low, although it slightly improves from 35.2% in 2013 to 46.3% in 2022. In 2013, younger age at diagnosis and treatment completion were independently associated with higher CAM use. In contrast, 2022 data identified lack of health insurance as the sole independent predictor of CAM use (Adjusted Odds Ratio = 1.820, 95% CI: 1.007-3.289).</p><p><strong>Conclusion: </strong>Over the past decade, CAM use among Jordanian patients with cancer has significantly decreased, although current users engage more intensively. The decline in perceived benefits and the persistent communication gap with healthcare providers underscores the necessity for educational programs targeting both patients and clinicians. Such interventions could enhance dialogue regarding CAM, ensure safer integration with conventional treatments, and potentially improve patient outcomes by preventing harmful interactions.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"314"},"PeriodicalIF":3.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative chemical composition and antimicrobial activity of essential oils from leaves and seeds of star apple (Chrysophyllum cainito L.).","authors":"Oluwatoyin Babatunde, Emmanuel Oloruntoba Yeye, Olatunde Sunday Oladeji, Adejoke Kolade, Adefioye Jose Olusolabomi, Isiaka Mohammed","doi":"10.1186/s12906-025-05026-2","DOIUrl":"https://doi.org/10.1186/s12906-025-05026-2","url":null,"abstract":"<p><p>In this study, the essential oils of seeds and leaves from Star Apple (Chrysophyllum cainito L) were profiled and screened for their antimicrobial potential. The volatile oils were isolated by means of hydro-distillation process using a Clevenger-type apparatus. The oils were analysed by gas chromatography coupled with mass spectrometry (GC-MS). Antimicrobial activity of the isolated essential oils was investigated by agar well diffusion method against seven bacterial isolates and two fungal isolates. The docking studies of the essential oil compounds and the reference drug were carried out using Maestro software. Docking calculation were executed on the Schrodinger suite molecular docking platform. A total of thirty-one chemical constituents were identified in essential oil of leaves with β-ocimene (12.37%), TMTT 1,3,7,11-Tridecatetraene (9.73%), α-farnesene (9.19%) and cyclofenchene (7.16%) as major components. Twenty-eight compounds were characterised in the seeds oil with citral (36.60%), Geranial, (28.50%) and (E)-3,7-Dimethylocta-3,6-dienal (10.82%) as main constituents. The two oils contained beta and alpha ocimene, cyclofenchene and pelargonaldehyde in common. The lowest MIC observed with essential oil of the leaves was 0.781251 mg/mL for Staphylococcus aureus and 1.625 mg/mL for Escherichia coli. The lowest MIC recorded for essential oil of the seeds was 12.5 mg/mL for Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae. Essential oil obtained from leaves exhibited higher antimicrobial and antifungal activities against all tested organisms than essential oil of seeds. Compound 11 with -3.303 kcal/mol, with the best docking score of all compound from the leaf and seed of all the sitemaps and this is close to that of reference compound on sitemap three with docking score of -5.055 kcal/mol. Also, the anti E. coli activities of both leaf and seed EOs could be associated with inhibitory activities of the compound on the active sites of the protein. In conclusion, the essential oils extracted from the leaves and seeds of Chrysophyllum cainito demonstrated notable antimicrobial potential, with the leaf oil exhibiting superior activity, likely due to its richer chemical profile and stronger interaction of its constituents with microbial target sites, as supported by both in vitro and in silico analyses.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"313"},"PeriodicalIF":3.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical efficacy of auricular acupuncture in the treatment of frequent episodic tension-type headache: a single-blind randomized controlled trial.","authors":"Xiaxia Jin, Ziwen Xu, Tao Gao, Gaofeng Wang, Wendi Dong, Junyi Jin, Yongmei Yan","doi":"10.1186/s12906-025-05063-x","DOIUrl":"https://doi.org/10.1186/s12906-025-05063-x","url":null,"abstract":"<p><strong>Background: </strong>Frequent episodic tension-type headache (FETTH) is a significant public-health concern. Scientific research has demonstrated that acupuncture can improve the clinical symptoms of FETTH.</p><p><strong>Purpose: </strong>This study aimed to compare the efficacy and safety of auricular acupuncture and sham acupuncture in treating FETTH.</p><p><strong>Methods: </strong>This was a randomized controlled trial. Participants with FETTH were randomly assigned in a 1:1 ratio to receive auricular acupuncture or sham acupuncture for 4 weeks, with follow-up lasting for up to 24 weeks. The primary outcomes were measured using the headache index and visual analog scale (VAS) score. Secondary outcomes included the Hamilton Anxiety Scale (HAMA) score, Hamilton Depression Scale (HAMD) score, blood flow velocity in the anterior cerebral artery (ACA), middle cerebral artery (MCA), and posterior cerebral artery (PCA) (V_ACA, V_MCA, and V_PCA, respectively), and the usage of acute headache medications. Adverse events were also recorded to assess safety.</p><p><strong>Results: </strong>Compared with the sham acupuncture group, the auricular acupuncture group showed significant improvements in VAS score (2 (1.25, 2) vs. 3 (2, 3.5) at 24 h, P < 0.001; 2 (1.25, 2) vs. 2 (2, 3) at the 2nd week, P = 0.004; 2 (1, 2) vs. 2 (1.5, 3) at the 4th week, P = 0.015), headache index (4 (2, 7) vs. 7 (4, 9) at the 4th week, P = 0.016), HAMA score (11.69 ± 2.70) vs. (14.24 ± 3.20) at the 4th week, P < 0.001; (9.83 ± 2.71) vs. (11.95 ± 2.59) at the 8th week, P = 0.001; (9.67 ± 2.65) vs. (11.76 ± 3.00) at the 24th week, P = 0.002), HAMD score ((14.25 ± 2.68) vs. (15.89 ± 3.48) at the 4th week, P = 0.027,) V_ACA (85.5 (85, 86) vs. 83 (83, 84) at the 4th week, P < 0.001), V_PCA (82 (81, 83) vs. 78 (77, 79) at the 4th week, P < 0.001), and usage of acute headache medications (8 (7, 10) vs. 9 (8, 11) at the 4th week, P = 0.030). The incidence of adverse events was similar between the two groups (P = 1.000).</p><p><strong>Conclusion: </strong>This study found that auricular acupuncture effectively improved the clinical symptoms of FETTH and had relatively fewer side effects.</p><p><strong>Trial registration: </strong>The study was retrospectively registered in the International Traditional Medicine Clinical Trial Registry (ITMCTR2025000363) on January 20, 2025.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"311"},"PeriodicalIF":3.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel comprehensive strategy for research on wine-processed mechanism of corni fructus guided by variation in the chemical components and network analysis.","authors":"Shilin Sun, Yuping Chen, Yu Zhang, Yukun Niu, Mengxin Yang, Xinming Jia, Yiqin Song, Qingwei Dong, Xin Qi, Jiahui Ma, Qian Zhang, Yiran Jin, Yingfeng Du","doi":"10.1186/s12906-025-05046-y","DOIUrl":"https://doi.org/10.1186/s12906-025-05046-y","url":null,"abstract":"<p><strong>Background: </strong>Corni Fructus, a plant with both medicinal and edible properties, is renowned for its aromatic flavor and hepatoprotective and renoprotective effects, offering significant nutritional value and broad application potential. Wine-processed Corni Fructus (WCF) is a primary processed form of Corni Fructus, widely utilized in food supplements. Traditional Chinese medicine suggests that wine-processing enhances its hepatoprotective and renoprotective properties, yet the underlying mechanisms remain unclear.</p><p><strong>Objective: </strong>In this study, a novel comprehensive strategy guided by variation in the chemical components and differences in biological activities was developed to explore the wine-processing mechanisms.</p><p><strong>Materials and methods: </strong>Firstly, the chemical constituents in vitro and in vivo were identified by liquid chromatography coupled to high-resolution mass spectrometry liquid chromatography-mass spectrometry (LC-MS). Furthermore, chemometric analysis was applied to investigate the chemical characteristics in the samples with different processing methods. The possible molecular mechanism differences were unraveled by network pharmacology.</p><p><strong>Results: </strong>A total of 53 and 61 components were identified in vitro of crude Corni Fructus (CCF) and WCF, respectively. In addition, 39 and 43 components were detected in rats' serum after CCF and WCF administered by gavage. Ten common targets were identified as key targets for the therapeutic effects of CCF and WCF on Chronic kidney diseases (CKD). The network analysis showed that 23 components in WCF may be the active substances that make it more effective than CCF for treating CKD.</p><p><strong>Conclusions: </strong>This study provides a theoretical basis for the pharmacological substances of WCF and CCF and gives insights into comparing their pharmacological differences. It further investigates the mechanisms underlying different processing techniques of Corni Fructus, supporting further exploration of its potential in CKD management.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"312"},"PeriodicalIF":3.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144942419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the efficacy of aromatherapy and complementary yoga on indicators of medication regimen complexity: A retrospective study.","authors":"Megumi H Yahara, Toshiko Sakamoto, Kazuhisa Maeda, Atsushi Kinoshita, Kenji Ikeda","doi":"10.1186/s12906-025-05041-3","DOIUrl":"10.1186/s12906-025-05041-3","url":null,"abstract":"<p><strong>Background: </strong>In Japan, with aging population, there is a growing emphasis on community-based integrated care system, focusing on supporting healthy lifestyles and promoting prevention in medicine, nursing care, and welfare. Meanwhile, the U.S. is witnessing the widespread implementation of healthcare incorporating the concept of integrative health (IH), which combines evidence-based complementary approaches with conventional healthcare approaches. In this study, the focus was on aromatherapy and yoga, both of which were expected to have a positive effect on patients as complementary approaches. The purpose of the study was to determine the impact of the complementary approaches on pharmacotherapy.</p><p><strong>Methods: </strong>This study was a single-facility, retrospective observational study. This study was conducted from March 3, 2022, to March 31, 2024. The data extraction of the patients was performed at the Maeda Clinic, and the analysis was performed at the collaborating institutions. Participants were enrolled, aged ≥ 20 years, who sought aromatherapy or yoga for 6-month. The primary endpoint was the MRCI-J score, which quantified the effect of variations in prescription drugs dosage form and usage before and after 6 months. The secondary endpoints were age, number of complementary approaches, number of clinic visits, change and rate of change in the number of prescription drugs, number of prescription drugs, and change and rate of change in the MRCI-J score, when grouped according to the increase in the MRCI-J score.</p><p><strong>Results: </strong>96 participants met the eligibility criteria. After 6 months, the complementary approaches were performed more frequently in the non-increased MRCI-J score group than in the increased MRCI-J score group (8.0 ± 5.8 vs. 5.3 ± 4.1; p < 0.01). The rate of change in the number of prescription drugs was significantly higher in the increased MRCI-J score group than in the non-increased MRCI-J score group (1.5 ± 0.77 vs.0.89 ± 0.18; p < 0.01).</p><p><strong>Conclusions: </strong>This study determined patient profiles receiving complementary approaches, and changes in prescription drugs. The frequency of complementary approaches might have affected the changes in prescription.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"310"},"PeriodicalIF":3.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12366082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}