BMC Complementary Medicine and Therapies最新文献

{"title":"Efficacy and safety of ayurvedic intervention (Sarpgandha Mishran) vs amlodipine for Stage-I primary hypertension- study protocol for a prospective Double-Dummy, Double-Blind, placebo-controlled Randomized Clinical Trial.","authors":"Babita Yadav, Bcs Rao, Rajiv Narang, Sophia Jameela, Shruti Khanduri, Sakshi Sharma, Drishya Dinesh, Arti Srivastava, Richa Bhardwaj, Bharti Gupta, N Srikanth, Dharamvir Singh Arya","doi":"10.1186/s12906-025-04802-4","DOIUrl":"10.1186/s12906-025-04802-4","url":null,"abstract":"<p><strong>Background: </strong>Hypertension presents as a modifiable risk factor for cardiovascular diseases, with approximately two-thirds of the global hypertensive population concentrated in low- and middle-income nations. Sarpagandha Mishran is an Ayurveda intervention utilized for the management of hypertension. The objective of the study is to assess the clinical efficacy and safety of Sarpgandha Mishran in the Management of Stage-I Hypertension.</p><p><strong>Methods: </strong>This clinical trial employs a prospective design characterized by a double-dummy, double-blind, placebo-controlled methodology being conducted at Cardiology Outpatient Department of the AIIMS, New Delhi. A total of 150 participants (75 per group), diagnosed with Stage-I essential hypertension will be randomized and allocated in a 1:1 allocation ratio, to either Ayurveda group or Conventional Care group. Participants in Group I will receive Ayurvedic intervention, Sarpagandha Mishran 500 mg capsules orally twice daily, in addition to a matching placebo of Amlodipine 5 mg capsules orally once daily. Group II will receive a matching placebo of Sarpagandha Mishran 500 mg capsules along with Amlodipine 5 mg capsules orally once daily. All participants will also be administered Hydrochlorothiazide 12.5 mg tablets orally once daily for a duration of 12 weeks. The primary endpoint of this study involves evaluating changes in SBP and DBP from baseline to week 12. Secondary outcome includes assessing changes in IL-6, Serum Pro-BNP, oxidative stress markers, lipid profile, and the SF-36 Health Survey Score. Safety assessments will be done through recording of AE/ADR and assessments of liver function tests and renal function tests parameters.</p><p><strong>Discussion: </strong>The present study is poised to furnish comprehensive insights into the clinical efficacy and safety profile of Sarpagandha Mishran in the management of Grade 1 hypertension. By adopting a rigorous scientific methodology, this investigation aims to contribute robust evidence that may significantly impact the formulation of future guidelines for integrative treatment protocols in hypertension management.</p><p><strong>Trial registration: </strong>The trial is prospectively registered with the Clinical Trial Registry of India [CTRI/2021/12/038589], dated 13.12.2021.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"88"},"PeriodicalIF":3.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer and cancer preventive activities of shogaol and curcumin from Zingiberaceae family plants in KG-1a leukemic stem cells.","authors":"Pawaret Panyajai, Natsima Viriyaadhammaa, Sawitree Chiampanichayakul, Yasuhisa Sakamoto, Siriporn Okonogi, Toshiro Moroishi, Songyot Anuchapreeda","doi":"10.1186/s12906-025-04829-7","DOIUrl":"10.1186/s12906-025-04829-7","url":null,"abstract":"<p><strong>Background: </strong>Leukemic stem cells (LSCs) present a significant challenge in the treatment of leukemia in patients because they exhibit a drug-resistant phenotype, making them difficult to eliminate. Searching for a new anticancer drug is crucial for improving leukemia treatment. Plants from the Zingiberaceae family are frequently used in traditional medicines due to their safety and accessibility. This study explores the anticancer activity, cancer preventive properties, and apoptosis inducing mechanisms of active compounds derived from these plants.</p><p><strong>Methods: </strong>Ten crude ethanolic extracts from each plant of the Zingiberaceae family were obtained using maceration techniques. The cytotoxicity of all extracts anticancer was assessed in comparison to anticancer drugs (cyclophosphamide, cytarabine, doxorubicin, and idarubicin) using MTT assay on cancer cell lines (KG-1a, K562, A549, MCF-7, and HeLa) and peripheral blood mononuclear cells (PBMCs). Cancer prevention properties of the effective extracts and their active compounds were evaluated by measuring the levels of tumor necrosis factor-alpha (TNF-α), interleukin-2 (IL-2), and nitric oxide (NO) using commercial kits. Cell cycle and cell death analyses were conducted using flow cytometry. Moreover, the effects of effective extracts and their active compounds on WT1 and CD34 expressions, as well as the apoptosis mechanism induced by the active compounds in KG-1a cells, were determined by Western blotting.</p><p><strong>Results: </strong>The cytotoxicity tests revealed that crude ethanolic extracts from Curcuma longa, C. zedoaria, and Zingiber officinale exhibited effective cytotoxicity against cancer cell lines while demonstrating lower impact on PBMCs. The active compounds of C. longa and C. zedoaria are curcuminoids, while those in Z. officinale are shogaol and gingerol. Notably, the IC₂₀ values of curcuminoids and shogaol exhibited cancer prevention properties and reduced WT1 protein expression, thereby inhibiting cell proliferation. Furthermore, shogaol and curcumin demonstrated the ability to arrest the cell cycle at the G₂/M phase and induce apoptosis through the Akt pathway.</p><p><strong>Conclusion: </strong>These findings highlight shogaol and curcumin as promising compounds for leukemia treatment.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"87"},"PeriodicalIF":3.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antitumor activity of gamma-irradiated Rosa canina L. against lung carcinoma in rat model: a proposed mechanism.","authors":"Omayma A R Abo-Zaid, Fatma S M Moawed, Eman S Eldin, Mostafa A Farrag, Esraa S A Ahmed","doi":"10.1186/s12906-025-04813-1","DOIUrl":"10.1186/s12906-025-04813-1","url":null,"abstract":"<p><strong>Background: </strong>Lung cancer is one of the most prevalent malignancies globally and is the leading cause of cancer-related mortality. Although cisplatin is a widely utilized chemotherapeutic agent, its clinical efficacy is often hampered by significant toxicity and undesirable side effects. Rosa canina, a medicinal plant, has demonstrated a range of beneficial biological activities, including anti-inflammatory, anticancer, immunomodulatory, antioxidant, and genoprotective effects.</p><p><strong>Methods: </strong>This study aimed to investigate the potential of Rosa canina to enhance the anticancer efficacy of cisplatin in a dimethyl benz(a)anthracene-induced lung cancer model using female rats. The animals were administered Rosa canina, cisplatin, or a combination of both treatments. The expression levels of critical signaling molecules were evaluated, including phosphoinositide-3-kinase (PI3K), Akt, mammalian target of rapamycin (mTOR), cleaved poly (ADP-ribose) polymerase (PARP-1), myeloid differentiation factor 88 (MyD88), and tumor necrosis factor receptor-associated factor (TRAF), in addition to various autophagic markers. Furthermore, we assessed the levels of toll-like receptor 2 (TLR2), nuclear factor kappa B (NF-κB), and apoptotic markers in lung tissue, complemented by histopathological examinations.</p><p><strong>Results: </strong>The combined treatment of Rosa canina extract and cisplatin significantly inhibited lung cancer cell proliferation by downregulating PARP-1 and the TLR2/MyD88/TRAF6/NF-κB signaling pathway, as well as the PI3K/Akt/mTOR pathway. Moreover, this combination therapy promoted autophagy and apoptosis, evidenced by elevated levels of autophagic and apoptotic markers.</p><p><strong>Conclusion: </strong>Overall, the findings of this study suggest that Rosa canina enhances the anticancer effects of cisplatin by inhibiting cancer cell proliferation while simultaneously inducing autophagy and apoptosis. Thus, Rosa can be used as adjuvant to cisplatin chemotherapy to overcome its limitations which may be considered a new approach during lung cancer treatment strategy.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"86"},"PeriodicalIF":3.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulatory effects of Kratom extract on the gut microbiota of rats: implications for health.","authors":"Nattaya Thongsepee, Sumet Amonyingcharoen, Pholasit Chamod, Wanwisa Himakhun, Kant Sangpairoj, Pongsakorn Martviset, Pathanin Chantree, Phornphan Sornchuer","doi":"10.1186/s12906-025-04836-8","DOIUrl":"10.1186/s12906-025-04836-8","url":null,"abstract":"<p><strong>Background: </strong>Kratom (Mitragyna speciosa), a plant native to Southeast Asia, is commonly used as a supplement for fatigue, pain relief, mood enhancement, and euphoria. Kratom extract exhibits diverse pharmacological properties, including antioxidant, anti-inflammatory, and gastrointestinal effects, with studies showing its ability to modulate gut microbiota and stimulate beneficial bacteria growth. Given these properties, kratom treatment may produce significant effects in a rat model, warranting further investigation.</p><p><strong>Methods: </strong>Male Wistar rats were administered kratom extract orally on a daily basis for 28 days. Fresh fecal samples were collected and analyzed for changes in gut microbiome composition using 16S rRNA sequencing. Hematological parameters and lipid profiles were also measured to evaluate any systemic effects.</p><p><strong>Results: </strong>The administration of kratom extract did not significantly affect hematological parameters or lipid profiles. However, notable changes were observed in gut microbiota composition, with significant increases in specific bacteria such as Candidatus Stoquefichus and Prevotellaceae UCG-001, and a decrease in Corynebacterium. LEfSe and cladogram analyses corroborated the higher prevalence of Candidatus Stoquefichus, Prevotellaceae UCG-001, and Erysipelatoclostridiaceae in the kratom treatment group compared to controls.</p><p><strong>Conclusions: </strong>Kratom extract significantly alters gut microbiome composition in rats, promoting beneficial bacteria while also elevating certain taxa associated with negative health outcomes. These mixed effects highlight the need for further research on the long-term implications of kratom use for gut health and its broader health consequences, as well as potential therapeutic applications.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"85"},"PeriodicalIF":3.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vitro evaluation of the effect of okra (Abelmoschus esculentus L.) extract on periodontal cells: a comprehensive study of cellular and molecular impacts.","authors":"Umut Ulaş Tosun, Sema Tuğçe Aydın, Ayşegül Tiryaki, Dilruba Baykara, Aleyna Yakut, Erkan Rayaman, Turgut Taşkın, Canan Ekinci Doğan, Oğuzhan Gündüz, Ömer Birkan Ağralı","doi":"10.1186/s12906-025-04828-8","DOIUrl":"10.1186/s12906-025-04828-8","url":null,"abstract":"<p><strong>Background: </strong>This research assessed the potential role of okra (Abelmoschus esculentus L.) extract on periodontal tissue wound healing by evaluating its effects on human periodontal ligament fibroblast (hPDLF), human gingival fibroblast (hGF), and human osteoblast (hOB) cells in vitro.</p><p><strong>Methods: </strong>The viability effect of okra extract on hPDLF, hGF, and hOB cells was determined using the MTT assay protocol. The highest viability concentrations were applied to hPDLF and hOB cells, and the expression levels of on type 1 collagen (COL1), bone morphogenetic protein 2 (BMP2), axis inhibition protein 2 (AXIN2), and fibroblast growth factor 2 (FGF2) proteins were determined through ELISA. The extract was also tested for antioxidant (CUPRAC, DPPH, FCR, and FRAP tests), acetylcholinesterase (AChE) inhibition, and antimicrobial properties, and its content was determined by HPLC-DAD.</p><p><strong>Results: </strong>The viability results showed no significant difference between the okra extract-treated and control groups for all cell types. In hPDLF cells, higher expression levels of COL1 and AXIN2 in the okra extract-treated group compared to the control group, while BMP2 expression level was lower. In hOB cells, the extract-treated group had higher levels of COL1, BMP2, and AXIN2 expression than the control group.</p><p><strong>Conclusion: </strong>It can be posited that okra extract may activate the Wnt/β-catenin signalling pathway and may have a beneficial impact on wound healing in periodontal tissues. However, extensive long-term in-vivo research on the activation of signalling pathways by okra extract in periodontal wound healing is required.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"84"},"PeriodicalIF":3.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychophysiological effects of music on sadness in participants with and without depressive symptoms.","authors":"Xuanyi Wang, Tian Lu, Bian Zhou, Wanlin Chen, Jing Zheng, Hang Chen, Shulin Chen","doi":"10.1186/s12906-025-04824-y","DOIUrl":"10.1186/s12906-025-04824-y","url":null,"abstract":"<p><strong>Background: </strong>Sadness can be a harbinger of serious medical conditions and a primary manifestation of depressive symptoms. Music is a promising modality for regulating sadness, although its effect on participants, whether with or without long-term depressive symptoms, remains unknown. In this study, the effect of music on sadness regulation was investigated using psychological and physiological indicators between depressed and non-depressed individuals.</p><p><strong>Methods: </strong>Data were collected from 149 participants (18 to 29 years old). The participants were divided into two groups (depressed and non-depressed groups) based on their depressive symptoms, experienced sadness induction, and music intervention. Electrocardiogram signals were collected to measure heart rate variability (HRV).</p><p><strong>Results: </strong>(1) Music alleviated sadness (increasing positive emotions, valence and dominance, while decreasing arousal); (2) sadness increased the duration between consecutive heartbeats, and music decreased this duration; (3) participants with depressive symptoms showed lower HRV than those without, and music enhanced HRV for the depressed group; (4) no significant difference in the effects of music was found between the two groups; and (5) the regulatory impact of music on sadness was not influenced by prior music listening habits.</p><p><strong>Conclusions: </strong>The findings indicate that listening to music can be beneficial for both healthy and subclinical individuals when managing sadness. The findings underscore the importance of recognizing the role of music in promoting emotional well-being.</p><p><strong>Trial registration: </strong>This trial was retrospectively registered on ClinicalTrials.gov PRS (Protocol Registration and Results System) (number NCT06516666) on July 22, 2024 ( https://register.</p><p><strong>Clinicaltrials: </strong>gov/ ).</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"77"},"PeriodicalIF":3.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of cedrol against transient global cerebral ischemia/reperfusion injury in rat.","authors":"Samira Asgharzade, Amir Mahmoud Ahmadzadeh, Ali Mohammad Pourbagher-Shahri, Fatemeh Forouzanfar","doi":"10.1186/s12906-025-04827-9","DOIUrl":"10.1186/s12906-025-04827-9","url":null,"abstract":"<p><strong>Background: </strong>The natural compound cedrol possess anti-inflammatory and antioxidant properties. We sought to assess the neuroprotective effect of cedrol in an animal model of transient global ischemia/reperfusion (I/R) injury.</p><p><strong>Method: </strong>To induce transient global cerebral I/R injury, bilateral carotid arteries were temporarily occluded for 20 min. A total of 40 male Wistar rats were randomly divided in to 5 groups; The control and global I/R groups, and the treatment groups that received cedrol at doses of 7.5, 15, and 30 mg/kg/day for a week, following the global I/R induction. The passive avoidance test was used for assessing memory function, and then hippocampal tissues were collected to assess levels of malondialdehyde (MDA), total thiol, nitric oxide (NO), and the activity of superoxide dismutase (SOD), along with the concentration of brain-derived neurotrophic factor (BDNF).</p><p><strong>Result: </strong>Our findings revealed that global I/R injury impaired rats' performance in the passive avoidance test and increased levels of MDA and NO. Moreover, it decreased the total thiol level, SOD activity, and BDNF level in the hippocampus. Administration of cedrol significantly improved memory function, reduced oxidative stress, NO level and increased BDNF level in the hippocampus.</p><p><strong>Conclusion: </strong>The results indicate that cedrol has neuroprotective properties in global I/R by reducing oxidative stress and enhancing the levels of BDNF.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"83"},"PeriodicalIF":3.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Context sensitive mindfulness: lessons from graduates of a professional training in South Africa.","authors":"Simon Whitesman, Robert Mash","doi":"10.1186/s12906-025-04775-4","DOIUrl":"10.1186/s12906-025-04775-4","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to evaluate the implementation of mindfulness based interventions, in different community settings in South Africa, by graduates of a two-year mindfulness training course, and to explore the challenges involved in adapting to the local context.</p><p><strong>Methods: </strong>This was a descriptive exploratory qualitative study using semi-structured interviews. Ten graduates of a two-year training in mindfulness-based interventions (MBIs) were identified using purposeful criterion-based sampling based on their implementation of adapted MBIs in communities that represented the systemic social, economic and health challenges affecting a majority of South Africans.</p><p><strong>Results: </strong>Previous and ongoing trauma is pervasive in South Africa which significantly affects the quality of lived experience for many individuals and families. Teachers who offered mindfulness-based approaches within these communities needed to hold a high level of sensitivity to pre-existing and ongoing trauma and signs of traumatic abreaction to effectively and skilfully deliver these interventions. Context sensitive adaptations needed to be implemented to programme structure, such as length of sessions, prioritisation of curricular elements and duration of mindfulness practices, along with in-the-moment flexible responsiveness such as ending a formal practice ealier than planned, or responding to the emotional needs of an individual. This was supported by the creation of a robust and compassionate holding environment, a safe and secure space in which attuned relationality supported co- and self-regulation and the internalisation of mindfulness skills.</p><p><strong>Conclusion: </strong>Mindfulness can be a valuable practice in diverse settings in South Africa, including communities affected by previous and current trauma, and the training curriculum in this context requires high levels of sensitivity to these conditions and must prioritise a safe and compassionate environment in which to learn.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"80"},"PeriodicalIF":3.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of Zataria multiflora on respiratory symptoms, pulmonary functions, and oxidative stress parameters: a systematic review and meta-analysis.","authors":"Naheed Aryaeian, Fahimeh Agh, Ali Nouri, Seyed Mojtaba Ghoreishy, Amirhossein Ramezani Ahmadi, Narges Dehghanseresht, Narges Sadeghi, Mehrnaz Morvaridi","doi":"10.1186/s12906-025-04832-y","DOIUrl":"10.1186/s12906-025-04832-y","url":null,"abstract":"<p><strong>Background: </strong>Zataria multiflora (Z. multiflora), also known as Shirazi thyme, is recognized for its medicinal properties, including antioxidant, anti-inflammatory, and immunomodulatory effects. Its longstanding use in traditional medicine for respiratory ailments underscores its significance. Given the widespread prevalence of respiratory disorders and inconclusive outcomes from previous trials, this research aims to conduct a systematic review and meta-analysis to evaluate Z. multiflora's impact on respiratory symptoms, pulmonary function, and oxidative stress markers using available randomized controlled trials (RCTs).</p><p><strong>Methods: </strong>In this systematic review and meta-analysis, a comprehensive search of published literature was conducted up to January 2024, encompassing databases such as PubMed, Scopus, Web of Science, and the Cochrane Central for Randomized Clinical Trials. The assessment of the quality of each eligible study was conducted using the Cochrane risk-of-bias tool. The random-effects model was used in the meta-analysis to determine the weighted mean difference (WMD) with 95% confidence intervals (CIs). All statistical analyses were conducted using STATA (version 15).</p><p><strong>Results: </strong>A total of 9 studies involving 394 participants were included. The administration of Z. multiflora showed significant effects on cough (WMD: -0.99; 95% CI: -1.66, -0.33; P = 0.003), day wheezing (WMD: -1.18; 95% CI: -1.44, -0.92; P < 0.001), night wheezing (WMD: -0.74; 95% CI: -1.09, -0.37; P < 0.001), chest wheezing (WMD: -1.15; 95% CI: -1.65, -0.64; P < 0.001), forced expiratory volume (WMD: 11.38; 95% CI: 7.40, 15.35; P < 0.001), forced vital capacity (WMD: 16.01; 95% CI: 12.26, 19.75; P < 0.001), and peak expiratory flow (WMD: 8.78; 95% CI: 4.13, 13.43; P < 0.001) compared to the control group. Additionally, Z. multiflora significantly reduced malondialdehyde levels (SMD: -1.54; 95% CI: -2.17, -0.90; P < 0.001) and increased catalase levels (SMD: 0.97; 95% CI: 0.46, 1.46; P < 0.001).</p><p><strong>Conclusion: </strong>Z. multiflora shows potential as a complementary treatment for respiratory diseases by improving symptoms, pulmonary functions, and reducing oxidative stress. However, due to the limited number of trials, findings should be interpreted cautiously, and further research is needed.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"82"},"PeriodicalIF":3.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of an age-modified mindfulness-based cognitive therapy (MBCT) in improving mental health in older people with depressive symptoms: a non-randomised controlled trial.","authors":"Yun-Han Wang, Yun-Lin Wang, Dara Kiu Yi Leung, Zuna Loong Yee Ng, Oscar Long Hung Chan, Stephanie Ming Yin Wong, Raymond Chi Leung Chan, Tianyin Liu, Gloria Hoi Yan Wong, Terry Yat Sang Lum","doi":"10.1186/s12906-025-04781-6","DOIUrl":"10.1186/s12906-025-04781-6","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Emerging evidence has shown that mindfulness-based cognitive therapy (MBCT) is effective in improving depressive symptoms in the older population. However, the accessibility to MBCT is limited by the shortage of psychotherapists or mindfulness teachers. One potential solution is to involve social workers, who have the knowledge and skills to promote individual and community well-being in various settings, in delivering modified MBCT to enhance its accessibility and sustainability. This study examined the effectiveness of an eight-week age-modified MBCT led by different mental health professionals (mindfulness teacher only vs. mindfulness teacher and social worker) in improving mental health outcomes as compared with a control group.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Older adults (N = 112) were recruited through five community-based centres for older adults and mental wellness in Hong Kong. Participants were allocated to one of three groups: (1) mindfulness teacher-led modified MBCT, (2) social worker/teacher co-led modified MBCT (50% led by social workers and 50% led by mindfulness teacher), or (3) control (care as usual). The age-modified MBCT consisted of eight weekly sessions, with age-related modifications including more sitting meditation, shortened duration of each session, and the removal of the retreat. Outcome variables (i.e., depressive symptoms, anxiety symptoms, perceived stress, and mindfulness) were assessed at baseline (T0), after the intervention (T1), and four weeks after the intervention (T2), through self-reported questionnaires. Linear mixed models were performed while controlling for demographic variables to examine changes in outcome variables between the groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Participants from the age-modified MBCT intervention groups (teacher-led and social worker/teacher co-led) showed significantly greater reductions in depressive symptoms and stress, as well as greater increase in mindful non-reactivity, compared to the control group post-intervention. No significant interaction effect of time and group was found for anxiety and both overall mindfulness and its other facets. The improvements in mental health and mindfulness outcomes post-intervention were not significantly different between the teacher-led and social worker/teacher co-led MCBT groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;Age-modified MBCT is beneficial in managing depressive and stress symptoms and in improving mindful non-reactivity among older adults at risk for depression. The findings support the feasibility and effectiveness of partial task-shifting in the delivery of MBCT to trained social workers. Future studies may explore the possibility for social workers in leading MBCTs independently to further improve its scalability and service accessibility for older adults in the community.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Trial registration: &lt;/strong&gt;ClinicalTrials.gov NCT05995587. Retrospectively registered on 16 August 2023.","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"81"},"PeriodicalIF":3.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}