BMC Complementary Medicine and Therapies最新文献

{"title":"Anti-leukemia activity of the ethyl acetate extract from Gynostemma pentaphyllum (Thunb.) leaf against FLT3-overexpressing AML cells and its phytochemical characterization.","authors":"Khin Khin Gyi, Songyot Anuchapreeda, Nutjeera Intasai, Montree Tungjai, Siriporn Okonogi, Arihiro Iwasaki, Toyonobu Usuki, Singkome Tima","doi":"10.1186/s12906-025-04903-0","DOIUrl":"10.1186/s12906-025-04903-0","url":null,"abstract":"<p><strong>Background: </strong>Gynostemma pentaphyllum (Thunb.), a traditional adaptogenic herb, is known for its bioactive components with potential anti-cancer properties. Acute myeloid leukemia (AML) progression is significantly influenced by Feline McDonough Sarcoma (FMS)-like tyrosine kinase 3 (FLT3) signaling, while Wilms' tumor 1 (WT1) serves as a key prognostic marker. This study investigates the anti-leukemia activities of active G. pentaphyllum leaf extracts and their components, focusing on the inhibition of FLT3 and WT1 activity.</p><p><strong>Methods: </strong>G. pentaphyllum extracts were prepared through maceration, yielding three crude fractional extracts. The cytotoxicity of the extracts was screened against various leukemia cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The most cytotoxic extract was further fractionated and purified via column chromatography. The anti-proliferative and apoptotic induction activities of the active extract and its fraction were evaluated through cell cycle and apoptosis analyses using flow cytometry. Changes in mitochondrial membrane potential (ΔΨm) were assessed by spectrofluorometry. To confirm anti-leukemia activity, the expression levels of FLT3, WT1 and apoptotic-related protein were analyzed using Western blotting. The major active compounds within the active fractions were identified and characterized using Electrospray Ionization Mass Spectrometry (ESI-MS) and Nuclear Magnetic Resonance (NMR) spectroscopy.</p><p><strong>Results: </strong>The ethyl acetate fractional extract (F-EtOAc) demonstrated the highest cytotoxicity, particularly against FLT3-overexpressing EoL-1 (IC₅₀ = 40.82 ± 0.8 µg/mL) and MV4-11 (IC₅₀ = 35.54 ± 4.1 µg/mL) AML cell lines. Fraction F10 was identified as the most active fraction, significantly inhibited FLT3 and WT1 protein expression and induced G0/G1 cell cycle arrest in a dose-dependent manner. Additionally, F10 induced dose-dependent apoptosis through disruption of ΔΨm, p53 up-regulation and caspase-3 activation. Further purification of F10 identified dehydrovomifoliol as its major bioactive compound.</p><p><strong>Conclusion: </strong>These findings suggest that the ethyl acetate extract of G. pentaphyllum contains bioactive compounds with anti-leukemia potential, warranting further investigation to evaluate its efficacy against AML.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"172"},"PeriodicalIF":3.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Ninjin'yoeito and physical exercise on serum corticosterone and hippocampal BDNF/proBDNF and neuroinflammation in post-stroke depression in rats.","authors":"Harutoshi Sakakima, Nao Nojima, Akira Tani, Kazuki Nakanishi, Teruki Matsuoka, Ryoma Matsuzaki, Shogo Kakimoto, Yuki Kato, Yuta Tachibe, Masaki Inadome, Takuya Kawatani, Shotaro Otsuka, Keita Mizuno, Ikuro Maruyama","doi":"10.1186/s12906-025-04915-w","DOIUrl":"10.1186/s12906-025-04915-w","url":null,"abstract":"<p><strong>Background: </strong>Ninjin'yoeito (NYT), a traditional Japanese Kampo medicine, improves the depression and anxiety in humans and animals, rendering it a novel therapeutic option for post-stroke depression (PSD). Furthermore, physical exercise is an important nonpharmacological therapy for major depressive disorder. The components of NYT or exercise exert antidepressant effects through the increased expression of neurotrophic factors and reduced neuroinflammation in the brain. However, the mechanisms underlying the antidepressant effects of NYT and exercise in PSD remain unclear. Therefore, we examined the effects of NYT and physical exercise in a rat model of PSD.</p><p><strong>Methods: </strong>Rats were divided into five groups: PSD, PSD with NYT, PSD with exercise (Ex), PSD with NYT and exercise (NYT + Ex), and control (sham). PSD was induced by the microinjection of endothelin-1 into the left medial prefrontal cortex and chronic unpredictable mild stress 3 days per week. A diet containing 3% NYT was administered to rats one day after stroke induction. Exercise was conducted using a motorized treadmill for three days per week, starting three days after the stroke. The therapeutic interventions lasted for four weeks. Serum corticosterone levels, depression-like behavior, and hippocampal pathophysiology, including the expression of brain-derived neurotrophic factor (BDNF), precursor BDNF (proBDNF), doublecortin (DCX), NeuN, glial cell activation, and tumor necrosis factor-α (TNF-α), were examined.</p><p><strong>Results: </strong>Serum corticosterone levels were lower in the treatment group than those in the PSD group. Notably, serum corticosterone levels were significantly lower in the NYT group than those in the PSD group. BDNF expression in the CA1 region was significantly higher in the Ex group than that in the PSD group. The NYT + Ex group showed a significantly higher hippocampal BDNF/proBDNF ratio than the other groups. DCX and NeuN expression levels were significantly higher in the NYT + Ex group than those in the NYT and PSD groups. Hippocampal glial cell activation and TNF-α expression increased in the PSD group and decreased in the intervention groups.</p><p><strong>Conclusions: </strong>NYT ameliorates serum corticosterone levels and hippocampal neuroinflammation in PSD. Additionally, this study suggested that NYT, together with exercise therapy, may improve neurogenesis, the BDNF/proBDNF ratio, and neuroinflammation in the hippocampus in PSD.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"171"},"PeriodicalIF":3.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressant effect of Radix bupleuri - Radix paeoniae alba herb pair on chronic unpredictable mild stress rats based on cortical metabolomics.","authors":"Kanglin Cai, Xinyu Chen, Yongkai Cao, Liangdi Ran, Qinpeng Bu, Dajun Hu, Zhitao Feng, Meiqun Cao","doi":"10.1186/s12906-025-04898-8","DOIUrl":"https://doi.org/10.1186/s12906-025-04898-8","url":null,"abstract":"<p><strong>Objective: </strong>Depression is a serious mental disorder, and its incidence rate has increased rapidly. Radix Bupleuri (root of Bupleurum chinensis DC. BR)-Radix Paeoniae Alba (root of Paeonia lactiflora Pall. PRA) herb pair has been historically used for treating depression in Traditional Chinese Medicine (TCM) while the mechanisms need to be fully revealed.</p><p><strong>Methods: </strong>The effects of the BR-PRA herb pair were investigated using a rat model of chronic unpredictable mild stress (CUMS). First, the depressive-like behavior of rats was evaluated by open field test (OFT), elevated plus-maze test (EMP), and forced swimming test (FST). Secondly, histomorphological changes in the CA1 and CA3 regions of the hippocampus were analyzed by hematoxylin-eosin, nissl, and Golgi staining. Ultra high-performance liquid chromatograph tandem quadrupole mass spectrometry (UHPLC-QTRAP-MS/MS) was performed to reveal potential antidepressant mechanisms.</p><p><strong>Results: </strong>Following CUMS exposure, rats displayed depressive-like behavior, and neuronal death in the hippocampal region was observed. Consequently, these abnormal changes were reversed by BR-PRA herb-pair intervention. A total of 26 different metabolites related to depression were identified by metabolomics, mainly involving eleven metabolic pathways of pentose phosphate pathway, purine metabolism, and amino sugar and nucleotide sugar metabolism. BR-PRA herb-pair improved four metabolites, including homocitrulline, N-acetyllysine, corticosterone, and N-acetylglutamate. It also may affect the development of depression by interfering with the hypothalamus-pituitary-adrenal axis (HPA axis), amino acid metabolism related to lysine and glutamate, and modulation of oxidative stress.</p><p><strong>Conclusion: </strong>BR-PRA herb-pair alleviated depressive-like behavior in CUMS rats, recovered hippocampus damage, and regulated cerebral cortex metabolism, which may be related to the HPA axis, amino acid metabolism related to lysine and glutamate, and modulation of oxidative stress.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"168"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the silence: factors influencing complementary therapy disclosure among diabetic outpatients in Taiwan.","authors":"Hsiao-Yun Chang","doi":"10.1186/s12906-025-04897-9","DOIUrl":"https://doi.org/10.1186/s12906-025-04897-9","url":null,"abstract":"<p><strong>Background: </strong>As more patients turn to complementary therapies (CTs) alongside conventional medicine, the lack of communication between patients who use CTs and their conventional healthcare professionals (HCPs) can pose significant risks, including the potential for serious drug interactions.</p><p><strong>Purpose: </strong>To explore the factors influencing the disclosure of CTs use to conventional HCPs.</p><p><strong>Methods: </strong>A cross-sectional survey design was employed to enroll 307 outpatients diagnosed with diabetes from both the northern and southern regions of Taiwan, covering the period from October 2022 to March 2023. The survey questionnaire included demographics, the patterns of CTs use, the experiences of CTs use, the Understanding the Benefit-Risks of CTs Use Scale, and the Diabetes Empowerment Scale. The data were analyzed using IBM SPSS Statistics version 28.0.</p><p><strong>Results: </strong>Only one-third of outpatients with diabetes disclosed their use of CTs to conventional HCPs. Several factors emerged as influential in this disclosure: understanding the benefits and risks of CTs use (OR = 1.10), the reasons for initial CTs use (OR = 1.58), integration of both conventional and complementary medicines (OR = 15.03), and the use of manipulative-based therapies (OR = 6.82).</p><p><strong>Conclusion: </strong>Understanding the factors that influence the disclosure of CTs use is essential for conventional HCPs. This understanding allows them to identify outpatients who may hesitate to disclose their CTs use and ensures they have a comprehensive understanding of their patients' CTs use, thereby facilitating effective communication.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"169"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the latest evidence: an updated systematic review and meta-analysis and GRADE assessment on the effectiveness of acupressure in managing labor pain.","authors":"Mona Larki, Leila Karimi, Shayesteh Jahanfar, Solmaz Mohammadi, Somayeh Makvandi","doi":"10.1186/s12906-025-04908-9","DOIUrl":"https://doi.org/10.1186/s12906-025-04908-9","url":null,"abstract":"<p><strong>Background: </strong>Labor pain is a significant challenge during childbirth, highlighting the necessity for effective pain management strategies. Acupressure has been recognized as a non-pharmacological method; however, its efficacy requires comprehensive evaluation. This updated systematic review and meta-analysis seeks to consolidate the most recent evidence regarding the effectiveness of Acupressure in alleviating labor pain and to evaluate the quality of this evidence using the GRADE framework.</p><p><strong>Methods: </strong>An updated systematic review was conducted by querying multiple databases for randomized controlled trials (RCTs) that evaluated the impact of Acupressure on labor pain. Studies were included based on predefined eligibility criteria. The risk of bias was assessed using the Cochrane risk-of-bias method for randomized trials (RoB). Meta-analyses were performed to determine the overall effect size, and the GRADE approach was applied to assess the certainty of the evidence. Meta-analyses of all the data were done using RevMan 5.4.</p><p><strong>Results: </strong>A total of 37 studies met the inclusion criteria. The meta-analysis revealed that Acupressure significantly reduces labor pain compared to touch (MD = -1.19, 95% CI -1.66 to -0.72, p < 0.00001), Sham (MD = -1.41, 95% CI -2.55 to -0.27, p = 0.01), and no intervention group (MD = -2.32, 95% CI -2.87 to -1.76, p < 0.00001). Although both SP6 and LI4 Acupressure points reduced pain, SP6 had more of an impact compared to previous reviews. The funnel plot comparing the effect of Acupressure with a touch on labor pain intensity suggested a possible publication bias. The GRADE assessment indicated a moderate to low level of certainty regarding these results.</p><p><strong>Conclusions: </strong>Acupressure seems to be a viable method for alleviating labor pain, supported by moderate to low-quality evidence. Additionally, it is advisable to conduct well-designed RCTs to enhance the validity of these findings and investigate the underlying mechanisms that contribute to the effectiveness of Acupressure in this setting.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"170"},"PeriodicalIF":3.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of complementary and alternative medicine among cancer patients in Hawaii.","authors":"April Hamachi, Jobel Matriz, Jami Fukui","doi":"10.1186/s12906-025-04912-z","DOIUrl":"https://doi.org/10.1186/s12906-025-04912-z","url":null,"abstract":"<p><p>Complementary and alternative medicine (CAM) are medical products and practices that are not part of standard medical care. Various studies demonstrate benefits of CAM use in alleviating cancer related side effects. However, data involving the use of CAM therapies among cancer patients is limited. Hawaii has a unique and diverse population and trends in CAM use could reveal important aspects of cancer care. We distributed questionnaires to various cancer treatment centers across Oahu. The questionnaires were optional and anonymous. We evaluated 126 questionnaires and analyzed CAM use. We collected participant data including: cancer type, treatments used (surgery, radiation, chemotherapy) and patient demographics (age, gender, ethnicity, income, religion). We found that at least one CAM therapy is used by a majority of patients 72/126 (57.1%), while 54 (42.9%) do not use any CAM therapy. Among the CAM therapies, meditation and herbal supplements were most commonly used 26 (36.1%), followed by massage 25 (34.7%), yoga 18 (25%), CBD 17 (23.6%), THC 16 (22.2%), and acupuncture 14 (19.4%). Stress reduction was the most common symptom benefit noted for meditation, herbal supplement, massage, and yoga. Anxiety was another symptom benefit reported for meditation. THC and CBD are used for sleep, however, CBS was also used for pain reduction together with acupuncture. Among the patients who use CAM therapy (n = 72), 80.6% are female (n = 58) while only 8.3% are male (n = 6). Furthermore only, 18.3% (n = 23) of our respondents have spoken to a clinician about CAM. We discovered that stress reduction is a symptom benefit associated with the most commonly used CAM therapies by cancer patients in Hawaii. Other symptom benefits involve anxiety, pain, and sleep. The modalities utilized were similar to nonpharmacologic therapies recommended by the NCCN guidelines for cancer survivorship, with the exception of herbal supplements. There is a lack of physician discussion regarding CAM use, which could impact the cancer burden in Hawaii.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"167"},"PeriodicalIF":3.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese herbal medicines for rhinosinusitis: a text-mining study with comparisons to contemporary research and clinical guidance.","authors":"Jing Cui, Brian H May, Wenmin Lin, Qiulan Luo, Anthony Lin Zhang, Xinfeng Guo, Chuanjian Lu, Yunying Li, Charlie C Xue","doi":"10.1186/s12906-025-04895-x","DOIUrl":"https://doi.org/10.1186/s12906-025-04895-x","url":null,"abstract":"<p><strong>Background: </strong>Rhinosinusitis is an inflammation of the paranasal sinuses and nasal cavity. It is managed with intra-nasal steroids, nasal saline irrigation, oral antibiotics and/or biologics. Chinese herbal medicines (CHMs) have long been used for nasal disorders, including rhinosinusitis, and feature in Chinese clinical guidelines for rhinosinusitis. Systematic reviews suggest some CHM formulations may be beneficial for the management of this condition.</p><p><strong>Methods: </strong>This text mining study used an established methodology to search a database containing the full texts of more than 1,150 classical and pre-modern Chinese medicine books to identify references to disorders similar to rhinosinusitis, and the CHMs used as interventions. Ten search terms relevant to names of disorders in classical books and the major symptoms of rhinosinusitis were identified. Search results were downloaded, categorised, and analysed descriptively in SPSS®. Qualitative comparisons were made with the modern clinical Chinese medicine literature.</p><p><strong>Results: </strong>Searches found 436 oral CHM formulae with 3,059 ingredients, 81 nasal or other topical CHMs with 142 ingredients, and 112 single natural products from classical pharmacopoeia used orally and/or topically. The earliest reference to a disorder similar to rhinosinusitis was in a Chinese medical book written approximately 2,000 years ago. Three oral CHM formulae from the search have been tested in randomised controlled trials and one is included in a clinical guideline. A sample of 13 modern specialist textbooks on Chinese otorhinolaryngology still recommended nine of the oral classical formulae. Three of the seven herbs frequently included in the classical pharmacopoeia are still listed in the official Chinese pharmacopoeia for rhinosinusitis. Nasal formulae found in classical searches differed to those tested in randomised controlled trials, although the most frequent ingredient in the classical formulae was also frequent in modern formulae. The pharmacological actions of the seven most frequently used herbs included anti-inflammatory, anti-allergic, antioxidant and/or anti-bacterial effects that may have contributed to their observed effects.</p><p><strong>Conclusions: </strong>Results for classical interventions and the modern clinical literature overlapped for the higher frequency oral formulae and their ingredients, showing evidence of temporal continuity in their use for rhinosinusitis management. Gaps in the clinical and experimental evidence were identified, so there remains scope for further research into these CHMs to develop new interventions for rhinosinusitis.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"165"},"PeriodicalIF":3.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of oral hygiene management containing Cibotium Barometz J. Smith extract on peri-implant mucositis: a randomized clinical trial.","authors":"Yu-Rin Kim, Seoul-Hee Nam","doi":"10.1186/s12906-025-04900-3","DOIUrl":"https://doi.org/10.1186/s12906-025-04900-3","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study was to confirm the improvement of peri-implant mucositis (PIM) in patients using the toothpick method (TPM) containing a natural ingredient: Cibotium barometz J. Smith (CB).</p><p><strong>Methods: </strong>As a randomized, blind, controlled trial study, there were 21 participants in the CB TPM group (CBG), 20 participants in the chlorhexidine group (CG), and 19 participants in the saline group (SG). All three groups were examined both before and after TPM. We performed a paired t-test to determine the differences between the mean values of the three groups. We used ANOVA to evaluate the mean differences in clinical indicators, saliva tests, and periodontal bacteria.</p><p><strong>Results: </strong>There were no significant differences in sociodemographic characteristics and oral health status between the three groups, thus ensuring homogeneity among the participants. Occult blood in the saliva test increased for SG and CG and decreased for CBG. Compared to the before-TPM condition, leukocyte and protein levels decreased for CG and CBG after TPM (p < 0.05). As a result of checking the effect size (Cohen's d) before and after TPM according to the three groups, three species of bacteria were identified that showed a significant effect only on CBG, and two species were identified that showed a significant effect on CBG and CG (Cohen's d ≥ 0.8).</p><p><strong>Conclusion: </strong>This study confirmed the efficacy of CB-applied TPM on PIM patients and demonstrated its potential as a non-surgical treatment option. Therefore, practitioners could extensively use CB-applied TPM as a mechanical tool and safe chemical and biological removal agent for post-implant management in clinical settings.</p><p><strong>Trial registration: </strong>The trial was registered in the International Clinical Trial Registry Platform (ICTRP) under the registration number KCT0008626 on 17/07/2023 and was retrospectively registered.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"164"},"PeriodicalIF":3.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary medicine among individuals experiencing homelessness in Switzerland: a quantitative and qualitative descriptive study.","authors":"Véronique S Grazioli, Evelyne Hangartner, Patrick Bodenmann, Luana Schaad, Léa Grosjean, Justin Nikles, David J T Campbell, Laurent Hyvert, Tshahé Anongba Varela, Susan E Collins, Caroline Leblanc, Christine Loignon, Chantal Berna","doi":"10.1186/s12906-024-04727-4","DOIUrl":"https://doi.org/10.1186/s12906-024-04727-4","url":null,"abstract":"<p><strong>Background: </strong>People experiencing homelessness (PEH) are disproportionately affected by health issues yet remain underserved by the health care system. Emerging findings suggest that complementary medicine (CM) approaches might help address the low access to earlier treatment and the complex needs of this population. Very little research has explored this topic in Europe. Thus, this study aimed to explore perceptions, experiences, and interests in CM among PEH in Switzerland.</p><p><strong>Methods: </strong>Participants (N = 123) were PEH in French-speaking Switzerland who completed a questionnaire assessing their use of and interest in CM. A subsample of the survey participants (n = 18) and 14 professionals working in the homeless-serving sector participated in semi-structured interviews exploring perceived utility of CM for PEH. Descriptive statistics and conventional content analysis were used to analyze quantitative and qualitative data, respectively.</p><p><strong>Results: </strong>Quantitative findings showed that despite high levels of interest in CM, less than 30% of participants reported using CM at least once in the previous 6 months. The five CM modalities with the highest interest were osteopathy (61.5% interested or very interested), therapeutic massage (59.2%), nutritional supplements (57.1%), music therapy (50.8%), and acupuncture (49.1%). The qualitative findings reinforced the substantial interest in CM. They revealed that CM approaches were perceived as useful to mitigate some health and social issues frequently encountered in this population, ultimately contributing to improved health and well-being. Participants made recommendations for practices that would help engage and retain PEH in a CM program, such as making it accessible and equitable, and following certain steps to earn the trust of PEH. Finally, a minority of participants questioned the relevance of a CM program for this population, arguing instead that more urgent social and conventional medical needs must be addressed first.</p><p><strong>Conclusions: </strong>Taken together, these findings suggest that integrative medicine, which incorporates conventional and complementary approaches to medical and social services may represent a suitable offering for PEH to address their competing bio-psycho-social needs. Using a community-based participatory approach to co-develop such a program might help to ensure effectiveness and thereby increase health equity.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"166"},"PeriodicalIF":3.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential value of traditional Chinese medicine monomers in cerebral ischemia-reperfusion injury: a network meta-analysis based on animal model.","authors":"Xin Luo, Jing-Yuan Niu, Hui-Sheng Chen","doi":"10.1186/s12906-025-04899-7","DOIUrl":"10.1186/s12906-025-04899-7","url":null,"abstract":"<p><strong>Background: </strong>Cerebral ischemia-reperfusion injury (CIRI) is a complex pathological process, which can further aggravate the damage of ischemic tissues. Traditional Chinese medicine (TCM) monomers, bioactive compounds extracted from Chinese herbal medicines, have been demonstrated to have various protective effects against reperfusion injury. This network meta-analysis (NMA) aimed to investigate the optimal treatment strategy of TCM monomers for CIRI in animal models.</p><p><strong>Methods: </strong>Four databases including PubMed, Embase, Web of Science, and Cochrane were searched up to January 06, 2024. First, prospective registration was done at PROSPERO (ID: CRD42024496289), the quality of the included studies was evaluated with SYRCLE's risk of bias tool, and statistical analysis was conducted with Stata Version 18.0 and RStudio.</p><p><strong>Results: </strong>In total, 26 studies were included, involving 506 animals and 12 TCM monomers. The results of a meta-analysis demonstrated that, compared to the control group, puerarin, paeoniflorin, hydroxysafflor yellow A, sinomenine, and salvianolic acid significantly reduced mNSS scores. Furthermore, ginsenoside, scutellarin, and baicalein significantly reduced Longa scores. In addition, salvianolic acid treatment significantly decreased brain water content. Regarding infarct volume, bilobalide, baicalein and puerarin all demonstrated remarkable effects. The network meta-analysis suggested that paeoniflorin might be the most effective intervention in terms of mNSS score, with a surface under the cumulative ranking curve (SUCRA) value of 92.8%; Scutellarin might be the most effective intervention to reduce Longa score (SUCRA = 87.6%); And salvianolic acid might be the most effective intervention to reduce brain water content (SUCRA = 98.2%); For infarct volume specifically, bilobalide may be the most effective intervention (SUCRA = 95.5%). In our meta-regression, we found that dose and duration of treatment may contribute to heterogeneity among mNSS studies.</p><p><strong>Conclusion: </strong>TCM monomers could provide a favorable neuroprotection on CIRI, with heterogeneous protective effects. Given the small number and the differences in quality of included studies, more high-quality, programmatic animal studies were needed to validate our findings.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"163"},"PeriodicalIF":3.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}