BMC Complementary Medicine and Therapies最新文献

{"title":"The effects of policosanol supplementation on creatinine: a systematic review and dose-response meta-analysis of randomized controlled trials.","authors":"Mohammad Reza Amini, Sara Sadeghi Majd, Marieh Salavatizadeh, Farhang Djafari, Gholamreza Askari, Azita Hekmatdoost","doi":"10.1186/s12906-025-04911-0","DOIUrl":"10.1186/s12906-025-04911-0","url":null,"abstract":"<p><strong>Objective: </strong>Policosanol, a compound generated from sugar cane, consists of alcohols such as octacosanol, hexacosanol, and triacontanol, which possess antioxidant properties. Evaluating the impact of this antioxidant on serum creatinine in clinical settings is essential because of the contradictory findings. This comprehensive review and dose-response meta-analysis attempts to evaluate the impact of policosanol supplementation on creatinine levels.</p><p><strong>Methods: </strong>A comprehensive search was performed in bibliographic databases such as Cochrane, PubMed, Google Scholar, Scopus, and Web of Science, covering the period from inception to November 2023. The necessary data was retrieved, and pertinent randomized controlled trials (RCTs) that satisfied the inclusion criteria were included. Weighted mean differences (WMDs) were the reported measure of the pooled effects. To find between-study heterogeneities, the I-squared test was employed.</p><p><strong>Results: </strong>A total of 2427 participants were involved in the twenty-one RCTs that were included. A meta-analysis showed that policosanol had no significant change in creatinine levels in participants consuming policosanol compared to placebo consumers (WMD = 0.21 µmol/l; 95% CI = - 0.85 to 1.26; P = 0.70). Policosanol consumption for durations ≥ 24 weeks significantly decreased creatinine, according to subgroup studies. There was a non-linear correlation between changes in creatinine levels and the dosage of prescription policosanol (P _{non_linearity} = 0.002). However, the treatment time did not have a significant impact on creatinine levels in a non-linear manner (P _{non_linearity} = 0.24).</p><p><strong>Conclusion: </strong>Policosanol supplementation has no significant effect on creatinine levels.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"182"},"PeriodicalIF":3.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective, and memory enhancement effects of Salvia aristata and its phenolic constituents: an in vitro, and in vivo study.","authors":"Farid Dabaghian, Mohammad-Reza Delnavazi, Roshanak Hariri, Tahmineh Akbarzadeh, Zahra Tayarani-Najaran, Mohammad Reza Shams Ardekani, Mohammad Sharifzadeh, Mahnaz Khanavi","doi":"10.1186/s12906-025-04902-1","DOIUrl":"10.1186/s12906-025-04902-1","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cholinergic dysfunction, neuroinflammation, oxidative stress, and memory impairment. The Salvia genus has been used since ancient times for its anti-inflammatory and neuroprotective properties. In this study, we aimed to investigate the effects of Salvia aristata hydroalcoholic extract (SAHE) and dichloromethane extract (SADE) on various aspects of memory and AD.</p><p><strong>Methods: </strong>Column chromatography was utilized in the phytochemical analysis to isolate and purify bioactive compounds. The structures of the isolated compounds were determined through spectroscopic techniques, including 1D and 2D NMR, along with IR, UV, and HRESIMS for the new compound. Cholinesterase inhibitory activity was assessed using a modified Ellman's method. Additionally, the antioxidant activity and metal chelation capacity of SAHE and SADE were evaluated using the DPPH assay and spectroscopic methods, respectively. Moreover, the neuroprotective effects in PC12 cells were investigated using the AlamarBlue assay, and the ability to mitigate scopolamine-induced memory impairment in rats was assessed using the Morris water maze (MWM) test.</p><p><strong>Results: </strong>In this study, we isolated and structurally elucidated an undescribed compound, namely salvinarin (2), as well as four known compounds including linariin (1), pectolinarin (3), scutellarein 4'-O-methyl-7-O-rutinoside (4), and 5-O-coumaroylquinic acid (5) from SAHE for the first time. In vitro analyses revealed that SAHE, SADE, and linariin exhibited significant neuroprotective effects against H₂O₂-induced cytotoxicity in PC12 cells. Notably, SAHE demonstrated potent acetylcholinesterase (AChE) inhibition (IC₅₀ = 322.83 ± 1.11 µg/mL), significant antioxidant activity (IC₅₀ = 99.16 ± 1.24 µg/mL), and strong metal chelating capacity toward Cu²⁺, Zn²⁺, and Fe²⁺. Moreover, oral administration of SAHE (400 mg/kg/day) significantly ameliorated memory impairment induced by scopolamine in a rat model. This improvement was evident in parameters such as traveled distance (p < 0.001), escape latency (p < 0.001), and time spent in the target quadrant (p < 0.01) in the Morris water maze test.</p><p><strong>Conclusions: </strong>Considering all findings, including significant neuroprotective, antioxidant, and metal-chelating properties, alongside notable efficacy in enhancing memory in rat models, S. aristata could be a potential candidate for memory improvement.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"181"},"PeriodicalIF":3.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of the impact of ginger extract and alpinetin on pregnancy outcomes in animal models.","authors":"Jonquile T Williams, Kendra A Tiani, Margaret J Foster, Amanda J MacFarlane, Regan L Bailey, Patrick J Stover, Martha S Field","doi":"10.1186/s12906-025-04904-z","DOIUrl":"10.1186/s12906-025-04904-z","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The objective of this systematic review was to evaluate existing scientific evidence regarding the effectiveness and safety of preparations of bioactive compounds of the Zingiberaceae family in animal models during gestation and lactation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A systematic protocol was registered with the Open Science Framework (OSF) ( https://doi.org/10.17605/OSF.IO/ADU68 ). The literature search was conducted on selected databases such as MEDLINE, Embase, Center for Agricultural and Biosciences International, and the International Pharmaceutical Abstracts databases. The full search strategy is included in the Supplementary Materials. Main keywords related to population included terms related to pregnancy and lactation; keywords related to intervention included key terms for alpinetin, ginger, and Zingiberaceae plants. We included maternal (i.e., dam) and neonatal (i.e., pup) outcome(s) reported in studies with ginger preparations in various forms given during pregnancy or lactation compared to placebo. Risk of bias was assessed using the Systematic Review Center for Laboratory animal experimentation (SYRCLE) risk of bias tool.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Twelve studies published between 2000 and 2022 were included in the review. Ginger and its bioactive compounds, [6]-gingerol, [8]-gingerol, [10]-gingerol, and [6]-shogaol, were found to have protective effects against gestational and developmental toxicities. This included mitigating and preventing organ toxicity (e.g., liver and kidney), improved gestational weight gain, and improved placental function; fetal benefits included prevention of organ damage (e.g., liver, kidney, cardiac), improved fetal growth, reduced oxidative stress, and reduced death. In studies involving toxic exposures such as heavy metals and pesticides, ginger mitigated adverse effects on maternal and fetal health, improving outcomes such as placental function birth weight, and organ development (e.g., liver, kidney, cardiac). Alpinetin, a flavonoid rich in ginger plants, showed anti-inflammatory effects in lactation by reducing cytokine levels and improving mammary tissue health. Studies on fetal development reported improvements in birth weight, growth metrics, and reductions in death rates when ginger was administered at moderate doses, specifically ginger tea 20 g/L-50 g/L or gingerol 25 mg/kg/body weight. However, higher doses (specifically, 50 mg alligator pepper, 2,000 mg/kg body weight Zingiber officinale) caused adverse reproductive outcomes such as reduced weight gain (&lt; 50%), maternal toxicity, disrupted estrous cycle, and increased fetal death. Sensitivity analysis confirmed that lower dosages of rhizome-derived ginger preparations (Zingiber officinale) (&lt; 200 mg/kg/day) were safer.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The majority of the included studies reported protective effects of lower dose Zingiberaceae preparations (&lt; 200 mg/kg/day) on gestational and develop","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"179"},"PeriodicalIF":3.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical analysis and biological effects of Zingiber cassumunar extract and three phenylbutenoids: targeting NF-κB, Akt/MAPK, and caspase-3 pathways.","authors":"Thidaporn Gundom, Wanida Sukketsiri, Pharkphoom Panichayupakaranant","doi":"10.1186/s12906-025-04907-w","DOIUrl":"10.1186/s12906-025-04907-w","url":null,"abstract":"<p><strong>Background: </strong>Zingiber cassumunar Roxb., belonging to the Zingiberaceae family, is a medicinal herb commonly found in tropical regions, particularly in Southeast Asia. This research aims to investigate the preventive effects and anti-inflammatory properties of a phenylbutenoid extract (PE) obtained from the rhizomes of Z. cassumunar.</p><p><strong>Method: </strong>The PE extract was prepared using green microwave extraction and subsequently analyzed by high-performance liquid chromatography. To evaluate its anti-inflammatory activity, lipopolysaccharide (LPS)-stimulated RAW264.7 cell models were used to measure the release of nitric oxide (NO), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) using the Griess assay and enzyme-linked immunosorbent assay, respectively. Additionally, the inhibitory effects of PE on apoptosis and reactive oxygen species (ROS) production were evaluated in hydrogen peroxide-induced C2C12 myoblast cells. The expression of inflammation- and apoptosis-related proteins was evaluated using western blotting.</p><p><strong>Results: </strong>The results indicated that the PE was enriched with (E)-(3,4-dimethoxyphenyl)butadiene (DMPBD), (E)-1-(3,4-dimethoxyphenyl)but-3-en-1-ol (compound D), and (E)-1-(3,4-dimethoxyphenyl)but-3-en-1-yl acetate (compound D acetate). The PE contained a total phenylbutenoid content of 1.42% w/w. The PE exhibited potent anti-inflammatory properties, with half maximal inhibitory concentration (IC₅₀) values of 7.2 µg/mL for NO, 23.4 µg/mL for TNF-α, and 19.8 µg/mL for IL-1β. In comparison, DMPBD exhibited lower activity against NO and TNF-α (IC₅₀ values of 16.3 and 37.2 µg/mL, respectively) but similar efficacy against IL-1β (IC₅₀ of 17.7 µg/mL) in LPS-induced RAW264.7 cells. All test compounds significantly decreased the percentage of apoptotic cells and suppressed intracellular ROS production in hydrogen peroxide-induced C2C12 myoblast cells. Notably, PE exhibited the highest potency in reducing apoptotic cells, with the lowest IC₅₀ value of 11.6 µg/mL. PE inhibited the expression of p-p38/p38, pERK/ERK, and pAkt/Akt in the LPS-induced inflammatory response in RAW264.7 cells. Additionally, PE significantly suppressed the cleaved/pro-caspase-3 ratio without affecting Bax and Bcl-2 protein levels.</p><p><strong>Conclusion: </strong>These findings suggest that PE and its phenylbutenoids exhibit anti-inflammatory effects through the inhibition of p38, ERK, and Akt signaling pathways, and anti-apoptotic effects via the inhibition of the caspase-3 pathway, highlighting their therapeutic potential for managing inflammatory and degenerative conditions.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"180"},"PeriodicalIF":3.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes and cost-effectiveness of collaborative treatment with Korean and Western medicine in patients with facial palsy: a multicenter prospective observational study.","authors":"Shiva Raj Acharya, Linae Kim, NamKwen Kim","doi":"10.1186/s12906-025-04910-1","DOIUrl":"10.1186/s12906-025-04910-1","url":null,"abstract":"<p><strong>Background: </strong>Effective and cost-efficient treatment approaches are crucial in healthcare to optimize patient outcomes. This study evaluates and compares the clinical outcomes and cost-effectiveness of Korean and Western medicine collaborative treatment (CT) with usual care (UC) for patients with facial palsy (FP).</p><p><strong>Methods: </strong>A two-arm comparative, multicenter, prospective, observational study was conducted at 11 nationwide hospitals participating in the fourth phase of the national pilot project for CT. A total of 130 FP patients were enrolled at baseline, with follow-up assessments at 4 weeks and 12 weeks post-baseline. Clinical outcomes were evaluated using the House-Brackmann Grading Scale (HBGS), Numeric Rating Scale (NRS), EuroQol-5 Dimensions (EQ-5D-5L), and EuroQol-Visual Analogue Scale (EQ-VAS) at all three time points of the study. The cost-effectiveness evaluation was assessed using Cost per QALYs (Quality-Adjusted Life Years), Incremental Cost-Effectiveness Ratio (ICER), and Net Monetary Benefit (NMB).</p><p><strong>Results: </strong>The mean HBGS, NRS and EQ-VAS scores significantly improved in both groups over time (each, p < 0.05). Compared to UC, CT demonstrated significantly higher EQ-5D-5L scores (0.94 ± 0.11 vs. 0.91 ± 0.13), and this effect remained significant even after adjusting for age, sex, duration, and income level (β = 0.06, p < 0.05). From a limited societal perspective, the total cost difference between the two groups was not statistically significant; however, the QALYs gained were significantly higher in patients who received CT than those who received UC (0.010 QALYs vs. 0.008 QALYs). The ICER for CT was estimated at 28.1 million Korean Won (KRW) per QALY. The probability that CT would be more cost-effective than UC exceeded 50% at a WTP threshold of 30.5 million KRW per QALY.</p><p><strong>Conclusions: </strong>Our study highlights that CT enhances a better quality of life and is more cost-effective for FP treatment, suggesting it is a valuable alternative to usual care. Further large-scale clinical trials and cost-effectiveness studies are warranted to explore its broader application and validate these findings.</p><p><strong>Trial registration: </strong>The study design was registered with the Clinical Research Information Service (CRIS) of South Korea at https://cris.nih.go.kr/ (KCT0007682) on September 07, 2022.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"178"},"PeriodicalIF":3.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential of Gonolobus condurango as a histone deacetylase inhibitor in triple-negative breast cancer cell lines: in vitro study.","authors":"Beate Vajen, Vera Schäffer, Marlies Eilers, Brigitte Schlegelberger, Britta Skawran","doi":"10.1186/s12906-025-04896-w","DOIUrl":"https://doi.org/10.1186/s12906-025-04896-w","url":null,"abstract":"<p><strong>Background: </strong>Triple-negative breast cancer (TNBC) is a subtype associated with poor prognosis, low survival rates, and high expression of histone deacetylases (HDAC). Treatment with HDAC inhibitors (HDACi) induces the acetylation of histones and thereby the expression of tumor suppressive miRNAs that regulate proliferation, apoptosis, migration, and differentiation. Gonolobus condurango (GC) has been reported to exhibit HDAC inhibitory effects, and this study aims to investigate whether GC acts as a HDACi in TNBC cell lines.</p><p><strong>Methods: </strong>Expression and acetylation analyses were performed on the TNBC cell lines HCC38, HCC1395, and HCC1937. Cells were treated with HDAC inhibitors Trichostatin A (TSA), suberoylanilide hydroxamic acid (SAHA), or Romidepsin as well as with GC Urtincture and different dilutions of GC. Tumor-relevant functional effects were analyzed using WST-1-based proliferation and Caspase-3/7 based apoptosis assays. Induction of expression of tumor-suppressive miRNAs hsa-miRNA-192-5p (miR-192) and hsa-miR-194-2 (miR-194) was analyzed by qRT-PCR.</p><p><strong>Results: </strong>Meta-analyses of gene expression showed a significant reduction in HDAC1 and HDAC2 expression in triple-negative breast cancer samples. The TNBC cell lines (HCC38, HCC1395, and HCC1937) used for in vitro assays also exhibited reduced expression of HDAC1, HDAC2, HDAC3, and HDAC4 and low acetylation levels. Treatment with the HDAC inhibitors TSA, SAHA, or Romidepsin induced acetylation, while GC did not. TSA and GC Urtincture induced apoptosis in HCC38, whereas GC dilutions had no effect. Treatment with TSA forced the expression of tumor suppressive miRNAs miR-192 and miR-194, but neither GC Urtincture nor any GC dilution induced the expression of these miRNAs.</p><p><strong>Conclusion: </strong>Several classes of HDAC inhibitors have been shown to be potent and specific anticancer agents. In this study, Gonolobus condurango showed no HDAC inhibitory effect in the TNBC cell lines. Identifying new HDAC inhibitors is important, but they must be well characterized before being used as therapeutic agents in humans.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"177"},"PeriodicalIF":3.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fermented Mistletoe (Viscum album L.) extract elicits markers characteristic for immunogenic cell death driven by endoplasmic reticulum stress in vitro.","authors":"Ulrike Weissenstein, Sibylle Tschumi, Bettina Leonhard, Stephan Baumgartner","doi":"10.1186/s12906-025-04909-8","DOIUrl":"https://doi.org/10.1186/s12906-025-04909-8","url":null,"abstract":"<p><strong>Background: </strong>Immune evasion is a characteristic hallmark of cancer. Immunotherapies aim to activate and support the body's immune system to recognize and fight tumor cells. Induction of immunogenic cell death (ICD) and the associated activation of danger signaling pathways can increase the immunogenicity of tumor cells. Therapeutic ICD stimuli activate endoplasmic reticulum stress pathways and apoptosis leading to the cellular expression of damage-associated molecular patterns (DAMPs). The aim of our in vitro study was to investigate whether mistletoe extracts induce characteristics of immunogenic tumor cell death in cancer cell lines.</p><p><strong>Methods: </strong>Three human breast cancer cell lines and one murine melanoma cell line (SKBR3, MDA-MB-231, MCF-7, and B16F10) were treated with aqueous, fermented Viscum album extract (VAE: Iscador Qu spec.) and taxol or tunicamycin as positive controls, respectively. To investigate whether VAE induces ribotoxic stress, we measured the ER stress regulators p-eIF2a, ATF4, and CHOP by Western blot. Cell surface exposure of DAMPs (calreticulin, heat shock proteins hsp70 and hsp90), apoptosis and induction of mitochondrial reactive oxygen species (ROS) were assessed by flow cytometry. HMGB1 and ATP were quantified by ELISA and chemiluminescence assay, respectively.</p><p><strong>Results: </strong>Treatment with VAE resulted in phosphorylation of eIF2α in all cancer cell lines tested and increased calreticulin (CRT) exposure on the surface of pre-apoptotic SKBR3 breast cancer and B16F10 mouse melanoma cells. VAE exerted a concentration-dependent effect in all cell lines, resulting in a significantly increased exposure of three DAMPs (CRT, hsp70 and hsp90) on the surface of early apoptotic cells. Furthermore, VAE elevated mitochondrial ROS production and the release of ATP. HMGB1 release was not induced by VAE.</p><p><strong>Conclusions: </strong>In this in vitro study, we demonstrated for the first time the potential of a mistletoe extract to induce surrogate markers of immunogenic cancer cell death. This is a primary step in investigating the potential of VAEs to contribute to ICD-induced tumor-specific immune activation.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"175"},"PeriodicalIF":3.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the Parkinson's disease using sim (Rhodomyrtus tomentosa) fruit water extract.","authors":"Ngo Binh Thao Nghi, Dao My Linh, Dang Thi Phuong Thao","doi":"10.1186/s12906-025-04844-8","DOIUrl":"https://doi.org/10.1186/s12906-025-04844-8","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a progressive nervous system disorder characterized by dysfunction or degeneration of dopaminergic neurons in the substantia nigra leading to motor symptoms. Parkinson's disease is more common in the elderly and severely reduces quality of life. There has been no cure for PD, the therapy is mainly based on symptomatic treatment. Because of the strong relationship between oxidative stress and PD, antioxidant compounds have been considered a novel therapy for PD treatment. However, long-term treatment with a compound may cause potential risks and adverse effects. Consequently, screening natural compounds with therapeutic properties has elicited significant interest, thereby contributing to the expansion of the pharmacological source for disease treatment.Sim (Rhodomyrtus tomentosa) is one kind of shrub, that belongs to the Myrtaceae family and has been used for a long time in traditional medicine of many Asian countries. All parts of sim can be used as medicine such as berried sim for treatment of diarrhea, and dysentery; leaves for wound healing, and roots for stomach cure. Previous studies suggested that sim fruit is rich in fiber, minerals, antioxidants, and anti-neurotoxic compounds. Utilizing antioxidant compounds from natural plants for PD therapy recently attracted attention. Because of its advantages, sim fruit has been supposed to be a potential candidate for drug screening. No scientific evidence has been reported proving sim fruit's PD treatment capacity. This study thus aimed to evaluate the potential of the sim fruit water extract (SFWE) for PD treatment using the dUCH knockdown Drosophila melanogaster model which owns hallmark PD symptoms such as dopaminergic neuron degeneration and locomotor dysfunction. Our results showed that SFWE has a strong antioxidant capacity with an IC50 value of 55.55 ± 2.012 µg/mL. As expected, when treated with SFWE at 1.25 mg/mL, ROS induced by knockdown of dUCH specifically at dopaminergic neurons (DA) were reduced. Notably, the degeneration of DA neurons on the PD fly model was ameliorated by sim fruit extract. Consequently, the movement-defected symptoms were also rescued when the PD fly model was fed with sim fruit extract. Interestingly, SFWE caused no significant difference in fruit flies' development and lifespan, suggesting it's safe to use. Taken together, our results strongly demonstrated that sim fruit, with its high antioxidant content, induced the decline of oxidative stress, and relieved symptoms, which is considered a potential candidate for PD treatment.</p>","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"173"},"PeriodicalIF":3.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern to: Evaluation of acute toxicity and gastroprotective activity of curcuma purpurascens BI. Rhizome against ethanol-induced gastric mucosal injury in rats.","authors":"Elham Rouhollahi, Soheil Zorofchian Moghadamtousi, Omer Abdalla Ahmed Hamdi, Mehran Fadaeinasab, Maryam Hajrezaie, Khalijah Awang, Chung Yeng Looi, Mahmood Ameen Abdulla, Zahurin Mohamed","doi":"10.1186/s12906-025-04901-2","DOIUrl":"https://doi.org/10.1186/s12906-025-04901-2","url":null,"abstract":"","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"176"},"PeriodicalIF":3.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing human-use experience for real-world evidence for the registration of traditional Chinese medicine products in China.","authors":"Mingge Xia, Yan Xue, Luwei Zhu, Xianwen Chen, Carolina Oi Lam Ung, Sheng Han, Yunfeng Lai, Hao Hu","doi":"10.1186/s12906-025-04906-x","DOIUrl":"10.1186/s12906-025-04906-x","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The registration application of traditional Chinese medicine (TCM) products as new drugs often meets the challenges of lacking clinical evidence from randomized controlled trials (RCT). In recent years, China has introduced a new evidence system for the review and approval of TCM products, which proposed using human-use experience (HUE) for real-world evidence (RWE) to support the safety and effectiveness of TCM.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;This study aimed to comprehensively analyse the regulatory concerns, policy guidances, and approved cases of using HUE to register TCM products.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Literature search and thematic analysis were conducted to identify and synthesize the regulatory concerns. A documentary analysis of policy guidances was employed to present the evolving regulatory framework for incorporating HUE into TCM registration in China. Case studies of approved TCM products using HUE to support registration were conducted, and the study design, study population, and postmarked requirements of these cases were analyzed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Four main themes and 12 sub-themes regarding regulatory concerns of applying HUE in the registration of TCM products were identified. The 4 main themes are HUE quality, HUE applicability, HUE governance, and HUE regulation. Six policy documents and seven technical guidances were released to facilitate the application of HUE in TCM registration, founding a practical regulatory framework for TCM product registration. In China, six cases that employed HUE to support registration were approved. Of these, five cases utilized HUE to support direct registration, while one utilized HUE to lay the foundation for subsequent phase III clinical trial. Regarding study design and data types, retrospective observational studies were the predominant approach and electronic health records from the hospital information systems were the most commonly used data source. Among the five cases of direct registration, three relied solely on retrospective observational studies, while two conducted small-sample prospective studies in conjunction with retrospective observational studies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;HUE can be advanced to generate RWE for the safety and effectiveness of TCM products, which provides potential support for registering new TCM products. Leveraging HUE for registration can shorten research and development period, reduce development costs, and promote innovation, ultimately driving the growth of the TCM industry. However, several challenges remain in using HUE to support the registration of TCM products in China, including difficulties in data accessibility, lack of standardized protocols for HUE collection and reporting, and obstacles in transforming TCM preparations from hospitals into new TCM products using HUE. Furthermore, ensuring high-quality HUE requires future attention to data applicability, data infrastructure, an","PeriodicalId":9128,"journal":{"name":"BMC Complementary Medicine and Therapies","volume":"25 1","pages":"174"},"PeriodicalIF":3.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}